Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HA32_LEIBR

TriTrypDb:

LbrM.19.1060 , LBRM2903_190016700

Length:

520

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HA32

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HA32

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0008168	methyltransferase activity	4	1
GO:0016740	transferase activity	2	1
GO:0016741	transferase activity, transferring one-carbon groups	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	466	470	PF00656	0.535
CLV_NRD_NRD_1	110	112	PF00675	0.550
CLV_NRD_NRD_1	305	307	PF00675	0.437
CLV_NRD_NRD_1	312	314	PF00675	0.543
CLV_NRD_NRD_1	35	37	PF00675	0.540
CLV_PCSK_KEX2_1	109	111	PF00082	0.483
CLV_PCSK_KEX2_1	143	145	PF00082	0.729
CLV_PCSK_KEX2_1	16	18	PF00082	0.612
CLV_PCSK_KEX2_1	305	307	PF00082	0.400
CLV_PCSK_KEX2_1	311	313	PF00082	0.504
CLV_PCSK_PC1ET2_1	109	111	PF00082	0.459
CLV_PCSK_PC1ET2_1	143	145	PF00082	0.729
CLV_PCSK_PC1ET2_1	16	18	PF00082	0.393
CLV_PCSK_PC7_1	105	111	PF00082	0.401
CLV_PCSK_SKI1_1	105	109	PF00082	0.359
CLV_PCSK_SKI1_1	305	309	PF00082	0.356
DEG_MDM2_SWIB_1	266	273	PF02201	0.223
DEG_Nend_UBRbox_2	1	3	PF02207	0.671
DOC_MAPK_gen_1	109	118	PF00069	0.299
DOC_MAPK_gen_1	311	320	PF00069	0.351
DOC_MAPK_MEF2A_6	311	320	PF00069	0.381
DOC_PP2B_LxvP_1	318	321	PF13499	0.343
DOC_PP4_FxxP_1	229	232	PF00568	0.360
DOC_PP4_FxxP_1	307	310	PF00568	0.374
DOC_USP7_MATH_1	132	136	PF00917	0.668
DOC_USP7_MATH_1	152	156	PF00917	0.524
DOC_USP7_MATH_1	275	279	PF00917	0.341
DOC_USP7_MATH_1	335	339	PF00917	0.421
DOC_USP7_MATH_1	356	360	PF00917	0.441
DOC_USP7_MATH_1	63	67	PF00917	0.766
DOC_WW_Pin1_4	144	149	PF00397	0.667
DOC_WW_Pin1_4	397	402	PF00397	0.391
DOC_WW_Pin1_4	429	434	PF00397	0.627
DOC_WW_Pin1_4	61	66	PF00397	0.662
DOC_WW_Pin1_4	67	72	PF00397	0.704
DOC_WW_Pin1_4	9	14	PF00397	0.377
LIG_14-3-3_CanoR_1	153	157	PF00244	0.563
LIG_14-3-3_CanoR_1	202	210	PF00244	0.524
LIG_14-3-3_CanoR_1	30	35	PF00244	0.642
LIG_BRCT_BRCA1_1	345	349	PF00533	0.353
LIG_Clathr_ClatBox_1	287	291	PF01394	0.345
LIG_DLG_GKlike_1	3	11	PF00625	0.489
LIG_eIF4E_1	225	231	PF01652	0.309
LIG_FAT_LD_1	4	12	PF03623	0.392
LIG_FHA_1	10	16	PF00498	0.667
LIG_FHA_1	409	415	PF00498	0.511
LIG_FHA_1	444	450	PF00498	0.405
LIG_FHA_2	83	89	PF00498	0.547
LIG_LIR_Apic_2	227	232	PF02991	0.309
LIG_LIR_Apic_2	438	443	PF02991	0.391
LIG_LIR_Gen_1	293	304	PF02991	0.429
LIG_LIR_Gen_1	450	459	PF02991	0.507
LIG_LIR_LC3C_4	359	364	PF02991	0.355
LIG_LIR_Nem_3	293	299	PF02991	0.435
LIG_LIR_Nem_3	404	410	PF02991	0.383
LIG_LIR_Nem_3	450	456	PF02991	0.328
LIG_PCNA_PIPBox_1	301	310	PF02747	0.399
LIG_PCNA_PIPBox_1	365	374	PF02747	0.388
LIG_PCNA_yPIPBox_3	298	308	PF02747	0.383
LIG_Pex14_1	262	266	PF04695	0.419
LIG_Pex14_1	436	440	PF04695	0.489
LIG_Pex14_2	266	270	PF04695	0.214
LIG_SH2_NCK_1	181	185	PF00017	0.254
LIG_SH2_PTP2	440	443	PF00017	0.380
LIG_SH2_SRC	440	443	PF00017	0.402
LIG_SH2_STAP1	174	178	PF00017	0.368
LIG_SH2_STAT5	199	202	PF00017	0.449
LIG_SH2_STAT5	225	228	PF00017	0.301
LIG_SH2_STAT5	371	374	PF00017	0.360
LIG_SH2_STAT5	440	443	PF00017	0.402
LIG_SH2_STAT5	50	53	PF00017	0.607
LIG_SH2_STAT5	515	518	PF00017	0.382
LIG_SH3_3	114	120	PF00018	0.418
LIG_SH3_3	126	132	PF00018	0.531
LIG_SH3_3	151	157	PF00018	0.663
LIG_SH3_3	166	172	PF00018	0.495
LIG_SH3_3	395	401	PF00018	0.354
LIG_SH3_3	66	72	PF00018	0.646
LIG_SUMO_SIM_anti_2	359	366	PF11976	0.390
LIG_SUMO_SIM_par_1	245	252	PF11976	0.388
LIG_TRAF2_1	85	88	PF00917	0.615
LIG_UBA3_1	7	16	PF00899	0.469
MOD_CDK_SPxxK_3	9	16	PF00069	0.378
MOD_CK1_1	134	140	PF00069	0.607
MOD_CK1_1	300	306	PF00069	0.402
MOD_CK1_1	53	59	PF00069	0.696
MOD_CK1_1	6	12	PF00069	0.528
MOD_CK1_1	61	67	PF00069	0.781
MOD_CK1_1	70	76	PF00069	0.566
MOD_CK2_1	372	378	PF00069	0.349
MOD_CK2_1	436	442	PF00069	0.395
MOD_CK2_1	489	495	PF00069	0.629
MOD_CK2_1	82	88	PF00069	0.701
MOD_DYRK1A_RPxSP_1	144	148	PF00069	0.693
MOD_GlcNHglycan	148	151	PF01048	0.586
MOD_GlcNHglycan	154	157	PF01048	0.514
MOD_GlcNHglycan	163	166	PF01048	0.405
MOD_GlcNHglycan	359	362	PF01048	0.434
MOD_GlcNHglycan	374	377	PF01048	0.378
MOD_GlcNHglycan	392	395	PF01048	0.550
MOD_GlcNHglycan	52	55	PF01048	0.760
MOD_GlcNHglycan	66	69	PF01048	0.613
MOD_GlcNHglycan	8	11	PF01048	0.556
MOD_GSK3_1	132	139	PF00069	0.647
MOD_GSK3_1	152	159	PF00069	0.682
MOD_GSK3_1	208	215	PF00069	0.347
MOD_GSK3_1	238	245	PF00069	0.487
MOD_GSK3_1	443	450	PF00069	0.438
MOD_GSK3_1	46	53	PF00069	0.679
MOD_GSK3_1	54	61	PF00069	0.703
MOD_GSK3_1	63	70	PF00069	0.679
MOD_NEK2_1	224	229	PF00069	0.370
MOD_NEK2_1	292	297	PF00069	0.486
MOD_NEK2_1	357	362	PF00069	0.434
MOD_NEK2_1	372	377	PF00069	0.491
MOD_NEK2_1	403	408	PF00069	0.334
MOD_NEK2_1	489	494	PF00069	0.486
MOD_PIKK_1	216	222	PF00454	0.316
MOD_PIKK_1	297	303	PF00454	0.401
MOD_PK_1	246	252	PF00069	0.385
MOD_PKA_2	152	158	PF00069	0.482
MOD_PKA_2	208	214	PF00069	0.414
MOD_PKB_1	144	152	PF00069	0.640
MOD_Plk_1	292	298	PF00069	0.396
MOD_Plk_1	403	409	PF00069	0.362
MOD_Plk_2-3	82	88	PF00069	0.528
MOD_Plk_4	246	252	PF00069	0.424
MOD_Plk_4	292	298	PF00069	0.544
MOD_Plk_4	3	9	PF00069	0.630
MOD_Plk_4	30	36	PF00069	0.378
MOD_Plk_4	436	442	PF00069	0.384
MOD_ProDKin_1	144	150	PF00069	0.668
MOD_ProDKin_1	397	403	PF00069	0.390
MOD_ProDKin_1	429	435	PF00069	0.621
MOD_ProDKin_1	61	67	PF00069	0.663
MOD_ProDKin_1	9	15	PF00069	0.376
MOD_SUMO_rev_2	185	195	PF00179	0.400
TRG_ER_diArg_1	110	112	PF00400	0.554
TRG_ER_diArg_1	304	306	PF00400	0.488
TRG_ER_diArg_1	310	313	PF00400	0.587
TRG_NLS_MonoExtC_3	108	113	PF00514	0.411
TRG_NLS_MonoExtC_3	141	146	PF00514	0.613
TRG_NLS_MonoExtN_4	142	147	PF00514	0.610
TRG_Pf-PMV_PEXEL_1	332	336	PF00026	0.329
TRG_Pf-PMV_PEXEL_1	457	462	PF00026	0.543

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I161	Leptomonas seymouri	44%	99%
A0A0S4IWK0	Bodo saltans	31%	100%
A0A1X0P685	Trypanosomatidae	34%	98%
A0A3R7KFJ2	Trypanosoma rangeli	32%	100%
A0A3S5H760	Leishmania donovani	74%	99%
A4HY95	Leishmania infantum	75%	99%
D0A0M9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E9AS27	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	99%
Q4QDE6	Leishmania major	73%	99%
V5B315	Trypanosoma cruzi	31%	100%