Malate dehydrogenase

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

glycosomal malate dehydrogenase

Species:

Leishmania braziliensis

UniProt:

A4HA28_LEIBR

TriTrypDb:

LbrM.19.1020 , LBRM2903_190016100

Length:

322

Annotations

LeishMANIAdb annotations

A group of metabolic enzymes without any likely TM segment. Very conserved in Eukaryota.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 7

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 7

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005777	peroxisome	6	1
GO:0020015	glycosome	7	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0042579	microbody	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0097014	ciliary plasm	5	1

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Expansion

Sequence features

A4HA28

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HA28

Function

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Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	11
GO:0006099	tricarboxylic acid cycle	3	11
GO:0008152	metabolic process	1	11
GO:0009987	cellular process	1	11
GO:0019752	carboxylic acid metabolic process	5	11
GO:0043436	oxoacid metabolic process	4	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0044281	small molecule metabolic process	2	11
GO:0071704	organic substance metabolic process	2	11

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0016491	oxidoreductase activity	2	11
GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	3	11
GO:0016615	malate dehydrogenase activity	4	11
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	4	11
GO:0030060	L-malate dehydrogenase activity	5	11

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	155	159	PF00656	0.381
CLV_C14_Caspase3-7	47	51	PF00656	0.473
CLV_NRD_NRD_1	169	171	PF00675	0.473
CLV_NRD_NRD_1	88	90	PF00675	0.381
CLV_PCSK_KEX2_1	211	213	PF00082	0.381
CLV_PCSK_KEX2_1	285	287	PF00082	0.381
CLV_PCSK_PC1ET2_1	211	213	PF00082	0.381
CLV_PCSK_PC1ET2_1	285	287	PF00082	0.381
CLV_PCSK_SKI1_1	119	123	PF00082	0.473
CLV_PCSK_SKI1_1	208	212	PF00082	0.473

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6H7	Leptomonas seymouri	37%	100%
A0A0N0P6W7	Leptomonas seymouri	43%	100%
A0A0N1HYD1	Leptomonas seymouri	83%	100%
A0A0N1I818	Leptomonas seymouri	32%	94%
A0A0N1ILF3	Leptomonas seymouri	44%	99%
A0A0S3QTC6	Thermosulfidibacter takaii (strain DSM 17441 / JCM 13301 / NBRC 103674 / ABI70S6)	31%	100%
A0A0S4IRB3	Bodo saltans	29%	98%
A0A0S4IRQ1	Bodo saltans	43%	79%
A0A0S4ITJ4	Bodo saltans	62%	98%
A0A1X0NQI1	Trypanosomatidae	30%	98%

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