Putative extracellular receptor

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

extracellular receptor, putative

Species:

Leishmania braziliensis

UniProt:

A4HA22_LEIBR

TriTrypDb:

LbrM.19.0960 , LBRM2903_190015300

Length:

941

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 2, no: 8
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

A4HA22

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HA22

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0004888	transmembrane signaling receptor activity	3	4
GO:0004930	G protein-coupled receptor activity	4	4
GO:0004965	G protein-coupled GABA receptor activity	5	2
GO:0016917	GABA receptor activity	4	2
GO:0038023	signaling receptor activity	2	4
GO:0060089	molecular transducer activity	1	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	489	493	PF00656	0.248
CLV_C14_Caspase3-7	578	582	PF00656	0.177
CLV_C14_Caspase3-7	60	64	PF00656	0.334
CLV_C14_Caspase3-7	802	806	PF00656	0.237
CLV_C14_Caspase3-7	869	873	PF00656	0.355
CLV_NRD_NRD_1	284	286	PF00675	0.533
CLV_NRD_NRD_1	740	742	PF00675	0.395
CLV_NRD_NRD_1	913	915	PF00675	0.380
CLV_NRD_NRD_1	932	934	PF00675	0.288
CLV_PCSK_KEX2_1	284	286	PF00082	0.468
CLV_PCSK_KEX2_1	913	915	PF00082	0.380
CLV_PCSK_KEX2_1	932	934	PF00082	0.288
CLV_PCSK_SKI1_1	199	203	PF00082	0.388
CLV_PCSK_SKI1_1	229	233	PF00082	0.424
CLV_PCSK_SKI1_1	396	400	PF00082	0.430
CLV_PCSK_SKI1_1	40	44	PF00082	0.551
CLV_PCSK_SKI1_1	456	460	PF00082	0.431
CLV_PCSK_SKI1_1	793	797	PF00082	0.392
CLV_PCSK_SKI1_1	935	939	PF00082	0.415
DEG_APCC_DBOX_1	198	206	PF00400	0.196
DEG_APCC_DBOX_1	305	313	PF00400	0.228
DEG_APCC_DBOX_1	792	800	PF00400	0.160
DEG_Nend_UBRbox_1	1	4	PF02207	0.615
DEG_SPOP_SBC_1	253	257	PF00917	0.355
DOC_CDC14_PxL_1	309	317	PF14671	0.195
DOC_CYCLIN_yCln2_LP_2	106	112	PF00134	0.257
DOC_CYCLIN_yCln2_LP_2	131	137	PF00134	0.195
DOC_MAPK_gen_1	292	302	PF00069	0.213
DOC_MAPK_gen_1	703	712	PF00069	0.208
DOC_MAPK_gen_1	8	16	PF00069	0.387
DOC_MAPK_HePTP_8	645	657	PF00069	0.228
DOC_MAPK_MEF2A_6	648	657	PF00069	0.200
DOC_MAPK_MEF2A_6	844	851	PF00069	0.254
DOC_PP1_RVXF_1	394	400	PF00149	0.193
DOC_PP4_FxxP_1	546	549	PF00568	0.226
DOC_USP7_MATH_1	147	151	PF00917	0.228
DOC_USP7_MATH_1	171	175	PF00917	0.208
DOC_USP7_MATH_1	230	234	PF00917	0.203
DOC_USP7_MATH_1	38	42	PF00917	0.434
DOC_USP7_MATH_1	398	402	PF00917	0.329
DOC_USP7_MATH_1	54	58	PF00917	0.402
DOC_USP7_MATH_1	554	558	PF00917	0.160
DOC_USP7_MATH_1	693	697	PF00917	0.266
DOC_USP7_MATH_1	785	789	PF00917	0.194
DOC_USP7_MATH_1	9	13	PF00917	0.551
DOC_USP7_MATH_1	918	922	PF00917	0.535
DOC_USP7_MATH_2	337	343	PF00917	0.195
DOC_USP7_UBL2_3	644	648	PF12436	0.195
DOC_WW_Pin1_4	3	8	PF00397	0.540
DOC_WW_Pin1_4	332	337	PF00397	0.250
DOC_WW_Pin1_4	450	455	PF00397	0.250
DOC_WW_Pin1_4	461	466	PF00397	0.223
DOC_WW_Pin1_4	52	57	PF00397	0.452
DOC_WW_Pin1_4	537	542	PF00397	0.188
DOC_WW_Pin1_4	759	764	PF00397	0.269
DOC_WW_Pin1_4	843	848	PF00397	0.275
DOC_WW_Pin1_4	881	886	PF00397	0.332
LIG_14-3-3_CanoR_1	292	302	PF00244	0.234
LIG_14-3-3_CanoR_1	522	527	PF00244	0.188
LIG_14-3-3_CanoR_1	609	614	PF00244	0.228
LIG_14-3-3_CanoR_1	670	678	PF00244	0.195
LIG_14-3-3_CanoR_1	741	750	PF00244	0.230
LIG_14-3-3_CanoR_1	77	85	PF00244	0.267
LIG_14-3-3_CanoR_1	8	17	PF00244	0.384
LIG_14-3-3_CanoR_1	800	807	PF00244	0.196
LIG_14-3-3_CanoR_1	923	931	PF00244	0.516
LIG_Actin_WH2_2	442	458	PF00022	0.251
LIG_BIR_III_2	53	57	PF00653	0.368
LIG_BIR_III_4	507	511	PF00653	0.243
LIG_BRCT_BRCA1_1	138	142	PF00533	0.261
LIG_BRCT_BRCA1_1	214	218	PF00533	0.160
LIG_BRCT_BRCA1_1	297	301	PF00533	0.194
LIG_BRCT_BRCA1_1	341	345	PF00533	0.195
LIG_BRCT_BRCA1_1	475	479	PF00533	0.207
LIG_BRCT_BRCA1_1	556	560	PF00533	0.194
LIG_BRCT_BRCA1_1	920	924	PF00533	0.514
LIG_Clathr_ClatBox_1	369	373	PF01394	0.269
LIG_DLG_GKlike_1	609	617	PF00625	0.174
LIG_EH_1	657	661	PF12763	0.195
LIG_FHA_1	102	108	PF00498	0.335
LIG_FHA_1	126	132	PF00498	0.258
LIG_FHA_1	144	150	PF00498	0.159
LIG_FHA_1	161	167	PF00498	0.171
LIG_FHA_1	230	236	PF00498	0.268
LIG_FHA_1	239	245	PF00498	0.217
LIG_FHA_1	28	34	PF00498	0.214
LIG_FHA_1	297	303	PF00498	0.218
LIG_FHA_1	314	320	PF00498	0.270
LIG_FHA_1	392	398	PF00498	0.191
LIG_FHA_1	41	47	PF00498	0.417
LIG_FHA_1	424	430	PF00498	0.258
LIG_FHA_1	444	450	PF00498	0.209
LIG_FHA_1	455	461	PF00498	0.227
LIG_FHA_1	469	475	PF00498	0.227
LIG_FHA_1	521	527	PF00498	0.191
LIG_FHA_1	538	544	PF00498	0.187
LIG_FHA_1	625	631	PF00498	0.237
LIG_FHA_1	756	762	PF00498	0.184
LIG_FHA_1	88	94	PF00498	0.322
LIG_FHA_1	885	891	PF00498	0.183
LIG_FHA_1	896	902	PF00498	0.241
LIG_FHA_2	254	260	PF00498	0.210
LIG_FHA_2	576	582	PF00498	0.233
LIG_FHA_2	58	64	PF00498	0.345
LIG_FHA_2	598	604	PF00498	0.195
LIG_FHA_2	635	641	PF00498	0.195
LIG_FHA_2	734	740	PF00498	0.178
LIG_FHA_2	800	806	PF00498	0.208
LIG_FHA_2	867	873	PF00498	0.329
LIG_FHA_2	925	931	PF00498	0.531
LIG_GBD_Chelix_1	67	75	PF00786	0.478
LIG_IRF3_LxIS_1	893	900	PF10401	0.165
LIG_LIR_Apic_2	332	337	PF02991	0.269
LIG_LIR_Gen_1	355	365	PF02991	0.176
LIG_LIR_Gen_1	401	411	PF02991	0.272
LIG_LIR_Gen_1	643	654	PF02991	0.269
LIG_LIR_Gen_1	770	779	PF02991	0.199
LIG_LIR_Gen_1	853	864	PF02991	0.250
LIG_LIR_Nem_3	136	140	PF02991	0.275
LIG_LIR_Nem_3	355	360	PF02991	0.237
LIG_LIR_Nem_3	401	407	PF02991	0.282
LIG_LIR_Nem_3	408	414	PF02991	0.215
LIG_LIR_Nem_3	494	500	PF02991	0.257
LIG_LIR_Nem_3	536	542	PF02991	0.160
LIG_LIR_Nem_3	643	649	PF02991	0.261
LIG_LIR_Nem_3	666	671	PF02991	0.228
LIG_LIR_Nem_3	762	767	PF02991	0.209
LIG_LIR_Nem_3	770	776	PF02991	0.185
LIG_LIR_Nem_3	853	859	PF02991	0.273
LIG_LIR_Nem_3	900	906	PF02991	0.171
LIG_LYPXL_S_1	566	570	PF13949	0.374
LIG_LYPXL_S_1	712	716	PF13949	0.395
LIG_LYPXL_yS_3	713	716	PF13949	0.195
LIG_NRBOX	102	108	PF00104	0.227
LIG_NRBOX	361	367	PF00104	0.269
LIG_PDZ_Class_3	936	941	PF00595	0.624
LIG_Pex14_1	326	330	PF04695	0.196
LIG_Pex14_2	837	841	PF04695	0.226
LIG_REV1ctd_RIR_1	567	574	PF16727	0.160
LIG_REV1ctd_RIR_1	666	674	PF16727	0.375
LIG_SH2_CRK	334	338	PF00017	0.260
LIG_SH2_CRK	646	650	PF00017	0.261
LIG_SH2_NCK_1	334	338	PF00017	0.228
LIG_SH2_PTP2	773	776	PF00017	0.269
LIG_SH2_SRC	623	626	PF00017	0.190
LIG_SH2_STAP1	357	361	PF00017	0.194
LIG_SH2_STAP1	432	436	PF00017	0.345
LIG_SH2_STAP1	646	650	PF00017	0.225
LIG_SH2_STAP1	824	828	PF00017	0.269
LIG_SH2_STAT3	677	680	PF00017	0.195
LIG_SH2_STAT3	909	912	PF00017	0.468
LIG_SH2_STAT5	102	105	PF00017	0.305
LIG_SH2_STAT5	22	25	PF00017	0.165
LIG_SH2_STAT5	334	337	PF00017	0.209
LIG_SH2_STAT5	393	396	PF00017	0.261
LIG_SH2_STAT5	623	626	PF00017	0.195
LIG_SH2_STAT5	629	632	PF00017	0.181
LIG_SH2_STAT5	681	684	PF00017	0.175
LIG_SH2_STAT5	728	731	PF00017	0.237
LIG_SH2_STAT5	773	776	PF00017	0.206
LIG_SH2_STAT5	798	801	PF00017	0.269
LIG_SH2_STAT5	903	906	PF00017	0.410
LIG_SH3_3	417	423	PF00018	0.226
LIG_SH3_3	653	659	PF00018	0.174
LIG_SH3_5	549	553	PF00018	0.228
LIG_Sin3_3	13	20	PF02671	0.183
LIG_SUMO_SIM_anti_2	12	18	PF11976	0.202
LIG_SUMO_SIM_anti_2	152	158	PF11976	0.213
LIG_SUMO_SIM_anti_2	163	170	PF11976	0.196
LIG_SUMO_SIM_anti_2	594	601	PF11976	0.188
LIG_SUMO_SIM_anti_2	651	657	PF11976	0.208
LIG_SUMO_SIM_par_1	110	116	PF11976	0.270
LIG_SUMO_SIM_par_1	163	170	PF11976	0.264
LIG_SUMO_SIM_par_1	200	206	PF11976	0.269
LIG_SUMO_SIM_par_1	367	373	PF11976	0.269
LIG_SUMO_SIM_par_1	500	507	PF11976	0.244
LIG_SUMO_SIM_par_1	594	601	PF11976	0.228
LIG_SUMO_SIM_par_1	69	74	PF11976	0.176
LIG_SUMO_SIM_par_1	886	891	PF11976	0.167
LIG_SUMO_SIM_par_1	895	900	PF11976	0.175
LIG_SxIP_EBH_1	511	522	PF03271	0.226
LIG_TRAF2_1	736	739	PF00917	0.337
LIG_TRAF2_1	927	930	PF00917	0.540
LIG_TYR_ITIM	402	407	PF00017	0.265
LIG_WRC_WIRS_1	867	872	PF05994	0.337
MOD_CDC14_SPxK_1	453	456	PF00782	0.245
MOD_CDK_SPK_2	3	8	PF00069	0.540
MOD_CDK_SPxK_1	450	456	PF00069	0.249
MOD_CDK_SPxxK_3	3	10	PF00069	0.537
MOD_CK1_1	119	125	PF00069	0.164
MOD_CK1_1	170	176	PF00069	0.197
MOD_CK1_1	305	311	PF00069	0.258
MOD_CK1_1	332	338	PF00069	0.228
MOD_CK1_1	412	418	PF00069	0.229
MOD_CK1_1	464	470	PF00069	0.208
MOD_CK1_1	509	515	PF00069	0.297
MOD_CK1_1	52	58	PF00069	0.413
MOD_CK1_1	612	618	PF00069	0.387
MOD_CK1_1	752	758	PF00069	0.235
MOD_CK1_1	759	765	PF00069	0.196
MOD_CK1_1	843	849	PF00069	0.266
MOD_CK1_1	879	885	PF00069	0.291
MOD_CK1_1	96	102	PF00069	0.341
MOD_CK2_1	276	282	PF00069	0.166
MOD_CK2_1	38	44	PF00069	0.349
MOD_CK2_1	628	634	PF00069	0.190
MOD_CK2_1	733	739	PF00069	0.186
MOD_CK2_1	748	754	PF00069	0.161
MOD_CK2_1	81	87	PF00069	0.283
MOD_CK2_1	924	930	PF00069	0.537
MOD_GlcNHglycan	11	14	PF01048	0.181
MOD_GlcNHglycan	148	152	PF01048	0.421
MOD_GlcNHglycan	169	172	PF01048	0.405
MOD_GlcNHglycan	250	253	PF01048	0.500
MOD_GlcNHglycan	331	334	PF01048	0.508
MOD_GlcNHglycan	351	354	PF01048	0.546
MOD_GlcNHglycan	355	360	PF01048	0.551
MOD_GlcNHglycan	488	491	PF01048	0.442
MOD_GlcNHglycan	507	511	PF01048	0.463
MOD_GlcNHglycan	686	689	PF01048	0.395
MOD_GlcNHglycan	695	698	PF01048	0.375
MOD_GlcNHglycan	730	733	PF01048	0.361
MOD_GlcNHglycan	831	834	PF01048	0.498
MOD_GlcNHglycan	878	881	PF01048	0.554
MOD_GlcNHglycan	96	99	PF01048	0.542
MOD_GSK3_1	143	150	PF00069	0.182
MOD_GSK3_1	167	174	PF00069	0.214
MOD_GSK3_1	212	219	PF00069	0.200
MOD_GSK3_1	225	232	PF00069	0.198
MOD_GSK3_1	234	241	PF00069	0.283
MOD_GSK3_1	248	255	PF00069	0.301
MOD_GSK3_1	345	352	PF00069	0.306
MOD_GSK3_1	36	43	PF00069	0.431
MOD_GSK3_1	412	419	PF00069	0.218
MOD_GSK3_1	450	457	PF00069	0.281
MOD_GSK3_1	460	467	PF00069	0.235
MOD_GSK3_1	502	509	PF00069	0.233
MOD_GSK3_1	525	532	PF00069	0.235
MOD_GSK3_1	533	540	PF00069	0.218
MOD_GSK3_1	554	561	PF00069	0.194
MOD_GSK3_1	57	64	PF00069	0.432
MOD_GSK3_1	570	577	PF00069	0.187
MOD_GSK3_1	605	612	PF00069	0.194
MOD_GSK3_1	624	631	PF00069	0.160
MOD_GSK3_1	669	676	PF00069	0.256
MOD_GSK3_1	728	735	PF00069	0.310
MOD_GSK3_1	748	755	PF00069	0.190
MOD_GSK3_1	805	812	PF00069	0.210
MOD_GSK3_1	83	90	PF00069	0.308
MOD_GSK3_1	884	891	PF00069	0.186
MOD_N-GLC_1	293	298	PF02516	0.360
MOD_N-GLC_1	319	324	PF02516	0.489
MOD_N-GLC_1	380	385	PF02516	0.413
MOD_N-GLC_1	486	491	PF02516	0.551
MOD_N-GLC_1	57	62	PF02516	0.659
MOD_N-GLC_1	634	639	PF02516	0.432
MOD_N-GLC_1	714	719	PF02516	0.472
MOD_N-GLC_1	785	790	PF02516	0.401
MOD_N-GLC_1	805	810	PF02516	0.350
MOD_N-GLC_1	860	865	PF02516	0.549
MOD_N-GLC_1	94	99	PF02516	0.561
MOD_NEK2_1	167	172	PF00069	0.244
MOD_NEK2_1	28	33	PF00069	0.320
MOD_NEK2_1	360	365	PF00069	0.281
MOD_NEK2_1	449	454	PF00069	0.283
MOD_NEK2_1	473	478	PF00069	0.325
MOD_NEK2_1	479	484	PF00069	0.405
MOD_NEK2_1	570	575	PF00069	0.195
MOD_NEK2_1	605	610	PF00069	0.258
MOD_NEK2_1	684	689	PF00069	0.355
MOD_NEK2_1	727	732	PF00069	0.176
MOD_NEK2_1	75	80	PF00069	0.244
MOD_NEK2_1	837	842	PF00069	0.236
MOD_NEK2_1	857	862	PF00069	0.295
MOD_NEK2_1	895	900	PF00069	0.179
MOD_NEK2_1	93	98	PF00069	0.356
MOD_NEK2_2	398	403	PF00069	0.393
MOD_NEK2_2	416	421	PF00069	0.212
MOD_NEK2_2	866	871	PF00069	0.245
MOD_OFUCOSY	461	468	PF10250	0.404
MOD_PIKK_1	122	128	PF00454	0.337
MOD_PIKK_1	230	236	PF00454	0.180
MOD_PIKK_1	339	345	PF00454	0.206
MOD_PIKK_1	468	474	PF00454	0.225
MOD_PIKK_1	714	720	PF00454	0.296
MOD_PK_1	800	806	PF00069	0.204
MOD_PKA_2	305	311	PF00069	0.191
MOD_PKA_2	669	675	PF00069	0.195
MOD_PKA_2	799	805	PF00069	0.188
MOD_PKA_2	9	15	PF00069	0.387
MOD_Plk_1	355	361	PF00069	0.160
MOD_Plk_1	380	386	PF00069	0.230
MOD_Plk_1	624	630	PF00069	0.201
MOD_Plk_1	634	640	PF00069	0.198
MOD_Plk_1	756	762	PF00069	0.190
MOD_Plk_1	785	791	PF00069	0.213
MOD_Plk_1	809	815	PF00069	0.306
MOD_Plk_1	81	87	PF00069	0.281
MOD_Plk_1	852	858	PF00069	0.357
MOD_Plk_1	860	866	PF00069	0.398
MOD_Plk_1	871	877	PF00069	0.274
MOD_Plk_2-3	634	640	PF00069	0.165
MOD_Plk_4	102	108	PF00069	0.285
MOD_Plk_4	116	122	PF00069	0.220
MOD_Plk_4	136	142	PF00069	0.181
MOD_Plk_4	149	155	PF00069	0.231
MOD_Plk_4	212	218	PF00069	0.222
MOD_Plk_4	240	246	PF00069	0.223
MOD_Plk_4	296	302	PF00069	0.290
MOD_Plk_4	398	404	PF00069	0.278
MOD_Plk_4	406	412	PF00069	0.207
MOD_Plk_4	42	48	PF00069	0.380
MOD_Plk_4	473	479	PF00069	0.222
MOD_Plk_4	513	519	PF00069	0.242
MOD_Plk_4	522	528	PF00069	0.183
MOD_Plk_4	624	630	PF00069	0.248
MOD_Plk_4	664	670	PF00069	0.242
MOD_Plk_4	673	679	PF00069	0.211
MOD_Plk_4	852	858	PF00069	0.231
MOD_Plk_4	860	866	PF00069	0.275
MOD_Plk_4	871	877	PF00069	0.361
MOD_Plk_4	884	890	PF00069	0.166
MOD_ProDKin_1	3	9	PF00069	0.535
MOD_ProDKin_1	332	338	PF00069	0.250
MOD_ProDKin_1	450	456	PF00069	0.248
MOD_ProDKin_1	461	467	PF00069	0.227
MOD_ProDKin_1	52	58	PF00069	0.452
MOD_ProDKin_1	537	543	PF00069	0.188
MOD_ProDKin_1	759	765	PF00069	0.269
MOD_ProDKin_1	843	849	PF00069	0.269
MOD_ProDKin_1	881	887	PF00069	0.329
TRG_DiLeu_BaEn_2	355	361	PF01217	0.261
TRG_DiLeu_BaEn_4	929	935	PF01217	0.540
TRG_ENDOCYTIC_2	22	25	PF00928	0.165
TRG_ENDOCYTIC_2	357	360	PF00928	0.220
TRG_ENDOCYTIC_2	404	407	PF00928	0.248
TRG_ENDOCYTIC_2	567	570	PF00928	0.188
TRG_ENDOCYTIC_2	646	649	PF00928	0.269
TRG_ENDOCYTIC_2	681	684	PF00928	0.188
TRG_ENDOCYTIC_2	713	716	PF00928	0.195
TRG_ENDOCYTIC_2	764	767	PF00928	0.205
TRG_ENDOCYTIC_2	773	776	PF00928	0.180
TRG_ER_diArg_1	269	272	PF00400	0.351
TRG_ER_diArg_1	283	285	PF00400	0.213
TRG_ER_diArg_1	7	10	PF00400	0.551
TRG_ER_diArg_1	913	915	PF00400	0.538
TRG_ER_diArg_1	931	933	PF00400	0.481
TRG_NES_CRM1_1	194	208	PF08389	0.228
TRG_Pf-PMV_PEXEL_1	199	203	PF00026	0.469
TRG_Pf-PMV_PEXEL_1	913	917	PF00026	0.458
TRG_Pf-PMV_PEXEL_1	935	939	PF00026	0.358

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMK8	Leptomonas seymouri	67%	95%
A0A0S4ITA9	Bodo saltans	36%	100%
A0A1X0P7Q8	Trypanosomatidae	42%	100%
A0A3S7WVK2	Leishmania donovani	83%	100%
A0A422NN34	Trypanosoma rangeli	40%	100%
A4HY85	Leishmania infantum	80%	100%
E9AS16	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
Q4QDF7	Leishmania major	83%	100%
V5C1V3	Trypanosoma cruzi	43%	100%