CYTH domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HA20_LEIBR

TriTrypDb:

LbrM.19.0940 , LBRM2903_190015100

Length:

741

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HA20

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HA20

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	3
GO:0016462	pyrophosphatase activity	5	3
GO:0016787	hydrolase activity	2	3
GO:0016817	hydrolase activity, acting on acid anhydrides	3	3
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	295	299	PF00656	0.556
CLV_NRD_NRD_1	320	322	PF00675	0.413
CLV_NRD_NRD_1	461	463	PF00675	0.751
CLV_NRD_NRD_1	509	511	PF00675	0.572
CLV_NRD_NRD_1	517	519	PF00675	0.482
CLV_PCSK_KEX2_1	461	463	PF00082	0.674
CLV_PCSK_KEX2_1	509	511	PF00082	0.572
CLV_PCSK_SKI1_1	145	149	PF00082	0.500
CLV_PCSK_SKI1_1	321	325	PF00082	0.536
CLV_PCSK_SKI1_1	512	516	PF00082	0.592
CLV_PCSK_SKI1_1	525	529	PF00082	0.355
CLV_PCSK_SKI1_1	590	594	PF00082	0.462
DEG_COP1_1	165	172	PF00400	0.373
DEG_Nend_UBRbox_3	1	3	PF02207	0.376
DEG_SCF_FBW7_1	67	72	PF00400	0.531
DOC_CYCLIN_yCln2_LP_2	446	452	PF00134	0.459
DOC_CYCLIN_yCln2_LP_2	599	605	PF00134	0.552
DOC_MAPK_DCC_7	650	659	PF00069	0.590
DOC_MAPK_FxFP_2	37	40	PF00069	0.430
DOC_MAPK_gen_1	347	357	PF00069	0.481
DOC_MAPK_gen_1	509	517	PF00069	0.533
DOC_MAPK_HePTP_8	647	659	PF00069	0.471
DOC_MAPK_MEF2A_6	350	357	PF00069	0.465
DOC_MAPK_MEF2A_6	47	55	PF00069	0.378
DOC_MAPK_MEF2A_6	650	659	PF00069	0.658
DOC_PP2B_LxvP_1	133	136	PF13499	0.648
DOC_PP2B_LxvP_1	371	374	PF13499	0.409
DOC_PP2B_LxvP_1	446	449	PF13499	0.571
DOC_PP2B_LxvP_1	53	56	PF13499	0.436
DOC_PP2B_LxvP_1	599	602	PF13499	0.487
DOC_PP4_FxxP_1	37	40	PF00568	0.430
DOC_PP4_FxxP_1	501	504	PF00568	0.528
DOC_USP7_MATH_1	105	109	PF00917	0.779
DOC_USP7_MATH_1	222	226	PF00917	0.528
DOC_USP7_MATH_1	254	258	PF00917	0.791
DOC_USP7_MATH_1	455	459	PF00917	0.680
DOC_USP7_MATH_1	626	630	PF00917	0.656
DOC_USP7_MATH_1	69	73	PF00917	0.718
DOC_USP7_UBL2_3	145	149	PF12436	0.455
DOC_USP7_UBL2_3	289	293	PF12436	0.826
DOC_USP7_UBL2_3	577	581	PF12436	0.612
DOC_WW_Pin1_4	136	141	PF00397	0.376
DOC_WW_Pin1_4	500	505	PF00397	0.531
DOC_WW_Pin1_4	632	637	PF00397	0.588
DOC_WW_Pin1_4	65	70	PF00397	0.513
DOC_WW_Pin1_4	97	102	PF00397	0.500
LIG_14-3-3_CanoR_1	17	23	PF00244	0.430
LIG_14-3-3_CanoR_1	229	237	PF00244	0.471
LIG_14-3-3_CanoR_1	47	51	PF00244	0.501
LIG_14-3-3_CanoR_1	509	515	PF00244	0.525
LIG_14-3-3_CanoR_1	590	595	PF00244	0.471
LIG_14-3-3_CanoR_1	598	602	PF00244	0.426
LIG_14-3-3_CanoR_1	676	685	PF00244	0.633
LIG_Actin_WH2_2	307	323	PF00022	0.501
LIG_APCC_ABBA_1	657	662	PF00400	0.489
LIG_BRCT_BRCA1_1	201	205	PF00533	0.629
LIG_Clathr_ClatBox_1	658	662	PF01394	0.367
LIG_DLG_GKlike_1	510	517	PF00625	0.605
LIG_FHA_1	185	191	PF00498	0.558
LIG_FHA_1	408	414	PF00498	0.558
LIG_FHA_1	561	567	PF00498	0.517
LIG_FHA_1	594	600	PF00498	0.452
LIG_FHA_1	633	639	PF00498	0.587
LIG_FHA_1	690	696	PF00498	0.503
LIG_FHA_1	712	718	PF00498	0.475
LIG_FHA_1	723	729	PF00498	0.466
LIG_FHA_2	341	347	PF00498	0.601
LIG_FHA_2	365	371	PF00498	0.590
LIG_FHA_2	493	499	PF00498	0.497
LIG_FXI_DFP_1	36	40	PF00024	0.430
LIG_GBD_Chelix_1	709	717	PF00786	0.582
LIG_HP1_1	328	332	PF01393	0.374
LIG_LIR_Apic_2	34	40	PF02991	0.430
LIG_LIR_Apic_2	358	364	PF02991	0.502
LIG_LIR_Apic_2	498	504	PF02991	0.515
LIG_LIR_Apic_2	664	669	PF02991	0.517
LIG_LIR_Gen_1	202	212	PF02991	0.592
LIG_LIR_Gen_1	259	269	PF02991	0.693
LIG_LIR_Gen_1	30	40	PF02991	0.420
LIG_LIR_Gen_1	513	521	PF02991	0.570
LIG_LIR_Gen_1	523	532	PF02991	0.417
LIG_LIR_Gen_1	571	579	PF02991	0.560
LIG_LIR_Gen_1	733	741	PF02991	0.495
LIG_LIR_Gen_1	84	93	PF02991	0.592
LIG_LIR_Nem_3	202	208	PF02991	0.595
LIG_LIR_Nem_3	259	264	PF02991	0.696
LIG_LIR_Nem_3	29	35	PF02991	0.423
LIG_LIR_Nem_3	403	409	PF02991	0.462
LIG_LIR_Nem_3	513	517	PF02991	0.496
LIG_LIR_Nem_3	523	529	PF02991	0.512
LIG_LIR_Nem_3	571	576	PF02991	0.567
LIG_LIR_Nem_3	578	583	PF02991	0.558
LIG_LIR_Nem_3	733	738	PF02991	0.467
LIG_LIR_Nem_3	84	90	PF02991	0.590
LIG_MYND_2	655	659	PF01753	0.400
LIG_MYND_3	308	312	PF01753	0.615
LIG_PAM2_1	232	244	PF00658	0.615
LIG_PCNA_TLS_4	729	736	PF02747	0.492
LIG_SH2_CRK	326	330	PF00017	0.499
LIG_SH2_CRK	666	670	PF00017	0.551
LIG_SH2_NCK_1	436	440	PF00017	0.339
LIG_SH2_SRC	436	439	PF00017	0.521
LIG_SH2_SRC	569	572	PF00017	0.520
LIG_SH2_SRC	63	66	PF00017	0.473
LIG_SH2_STAP1	33	37	PF00017	0.509
LIG_SH2_STAP1	369	373	PF00017	0.412
LIG_SH2_STAP1	409	413	PF00017	0.576
LIG_SH2_STAP1	451	455	PF00017	0.679
LIG_SH2_STAP1	569	573	PF00017	0.632
LIG_SH2_STAP1	63	67	PF00017	0.735
LIG_SH2_STAP1	693	697	PF00017	0.445
LIG_SH2_STAP1	87	91	PF00017	0.576
LIG_SH2_STAT3	211	214	PF00017	0.612
LIG_SH2_STAT3	275	278	PF00017	0.689
LIG_SH2_STAT5	361	364	PF00017	0.578
LIG_SH2_STAT5	409	412	PF00017	0.561
LIG_SH2_STAT5	463	466	PF00017	0.550
LIG_SH2_STAT5	491	494	PF00017	0.585
LIG_SH2_STAT5	526	529	PF00017	0.490
LIG_SH2_STAT5	735	738	PF00017	0.496
LIG_SH3_1	650	656	PF00018	0.627
LIG_SH3_3	53	59	PF00018	0.574
LIG_SH3_3	650	656	PF00018	0.608
LIG_SH3_3	672	678	PF00018	0.686
LIG_SH3_3	700	706	PF00018	0.648
LIG_TRAF2_1	43	46	PF00917	0.430
LIG_TRAF2_1	457	460	PF00917	0.557
LIG_UBA3_1	527	531	PF00899	0.567
LIG_WRC_WIRS_1	135	140	PF05994	0.384
MOD_CK1_1	108	114	PF00069	0.686
MOD_CK1_1	184	190	PF00069	0.558
MOD_CK1_1	232	238	PF00069	0.514
MOD_CK1_1	244	250	PF00069	0.633
MOD_CK1_1	256	262	PF00069	0.490
MOD_CK1_1	283	289	PF00069	0.771
MOD_CK1_1	404	410	PF00069	0.495
MOD_CK1_1	543	549	PF00069	0.590
MOD_CK1_1	616	622	PF00069	0.576
MOD_CK1_1	631	637	PF00069	0.664
MOD_CK1_1	74	80	PF00069	0.574
MOD_CK2_1	249	255	PF00069	0.560
MOD_CK2_1	340	346	PF00069	0.608
MOD_CK2_1	364	370	PF00069	0.609
MOD_CK2_1	454	460	PF00069	0.606
MOD_CK2_1	462	468	PF00069	0.642
MOD_CK2_1	727	733	PF00069	0.500
MOD_CK2_1	734	740	PF00069	0.517
MOD_GlcNHglycan	110	113	PF01048	0.682
MOD_GlcNHglycan	128	131	PF01048	0.640
MOD_GlcNHglycan	170	173	PF01048	0.417
MOD_GlcNHglycan	208	211	PF01048	0.576
MOD_GlcNHglycan	224	227	PF01048	0.518
MOD_GlcNHglycan	234	237	PF01048	0.476
MOD_GlcNHglycan	290	293	PF01048	0.594
MOD_GlcNHglycan	41	44	PF01048	0.249
MOD_GlcNHglycan	488	491	PF01048	0.494
MOD_GlcNHglycan	536	539	PF01048	0.642
MOD_GlcNHglycan	618	621	PF01048	0.733
MOD_GlcNHglycan	71	74	PF01048	0.730
MOD_GSK3_1	11	18	PF00069	0.462
MOD_GSK3_1	244	251	PF00069	0.676
MOD_GSK3_1	279	286	PF00069	0.780
MOD_GSK3_1	479	486	PF00069	0.643
MOD_GSK3_1	500	507	PF00069	0.537
MOD_GSK3_1	593	600	PF00069	0.468
MOD_GSK3_1	609	616	PF00069	0.590
MOD_GSK3_1	628	635	PF00069	0.668
MOD_GSK3_1	65	72	PF00069	0.537
MOD_GSK3_1	677	684	PF00069	0.696
MOD_N-GLC_1	108	113	PF02516	0.591
MOD_N-GLC_1	244	249	PF02516	0.524
MOD_NEK2_1	280	285	PF00069	0.778
MOD_NEK2_1	357	362	PF00069	0.342
MOD_NEK2_1	428	433	PF00069	0.535
MOD_NEK2_1	613	618	PF00069	0.669
MOD_NEK2_1	661	666	PF00069	0.485
MOD_NEK2_1	695	700	PF00069	0.345
MOD_NEK2_2	15	20	PF00069	0.249
MOD_NEK2_2	316	321	PF00069	0.460
MOD_NEK2_2	364	369	PF00069	0.622
MOD_NEK2_2	504	509	PF00069	0.553
MOD_PIKK_1	229	235	PF00454	0.354
MOD_PIKK_1	280	286	PF00454	0.725
MOD_PIKK_1	407	413	PF00454	0.562
MOD_PIKK_1	455	461	PF00454	0.662
MOD_PIKK_1	560	566	PF00454	0.477
MOD_PIKK_1	626	632	PF00454	0.685
MOD_PIKK_1	677	683	PF00454	0.740
MOD_PKA_2	407	413	PF00069	0.593
MOD_PKA_2	428	434	PF00069	0.549
MOD_PKA_2	46	52	PF00069	0.376
MOD_PKA_2	548	554	PF00069	0.489
MOD_PKA_2	597	603	PF00069	0.514
MOD_Plk_1	357	363	PF00069	0.430
MOD_Plk_1	45	51	PF00069	0.460
MOD_Plk_1	467	473	PF00069	0.730
MOD_Plk_1	479	485	PF00069	0.643
MOD_Plk_1	504	510	PF00069	0.561
MOD_Plk_1	661	667	PF00069	0.441
MOD_Plk_1	711	717	PF00069	0.539
MOD_Plk_1	722	728	PF00069	0.453
MOD_Plk_4	181	187	PF00069	0.584
MOD_Plk_4	271	277	PF00069	0.503
MOD_Plk_4	357	363	PF00069	0.407
MOD_Plk_4	364	370	PF00069	0.436
MOD_Plk_4	46	52	PF00069	0.395
MOD_Plk_4	510	516	PF00069	0.502
MOD_Plk_4	575	581	PF00069	0.529
MOD_ProDKin_1	136	142	PF00069	0.371
MOD_ProDKin_1	500	506	PF00069	0.533
MOD_ProDKin_1	632	638	PF00069	0.589
MOD_ProDKin_1	65	71	PF00069	0.517
MOD_ProDKin_1	97	103	PF00069	0.505
MOD_SUMO_rev_2	283	291	PF00179	0.557
MOD_SUMO_rev_2	402	407	PF00179	0.469
MOD_SUMO_rev_2	420	428	PF00179	0.530
TRG_DiLeu_BaEn_1	86	91	PF01217	0.651
TRG_DiLeu_BaEn_2	385	391	PF01217	0.563
TRG_DiLeu_BaLyEn_6	653	658	PF01217	0.557
TRG_ENDOCYTIC_2	32	35	PF00928	0.420
TRG_ENDOCYTIC_2	326	329	PF00928	0.490
TRG_ENDOCYTIC_2	436	439	PF00928	0.521
TRG_ENDOCYTIC_2	526	529	PF00928	0.309
TRG_ENDOCYTIC_2	735	738	PF00928	0.443
TRG_ENDOCYTIC_2	87	90	PF00928	0.583
TRG_ER_diArg_1	353	356	PF00400	0.443
TRG_ER_diArg_1	461	463	PF00400	0.497
TRG_ER_diArg_1	508	510	PF00400	0.510
TRG_ER_diArg_1	51	54	PF00400	0.376
TRG_ER_diArg_1	515	518	PF00400	0.409
TRG_NES_CRM1_1	712	723	PF08389	0.536
TRG_Pf-PMV_PEXEL_1	229	233	PF00026	0.458
TRG_Pf-PMV_PEXEL_1	441	445	PF00026	0.618
TRG_Pf-PMV_PEXEL_1	556	560	PF00026	0.537

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMD6	Leptomonas seymouri	52%	92%
A0A1X0P6B2	Trypanosomatidae	27%	100%
A0A3S7WVE7	Leishmania donovani	79%	100%
A4HY83	Leishmania infantum	79%	100%
E9AS14	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
Q4QDF9	Leishmania major	79%	100%