Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4HA18_LEIBR

TriTrypDb:

LbrM.19.0920 , LBRM2903_190014900

Length:

755

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HA18

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HA18

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	175	179	PF00656	0.535
CLV_C14_Caspase3-7	299	303	PF00656	0.559
CLV_C14_Caspase3-7	437	441	PF00656	0.539
CLV_NRD_NRD_1	132	134	PF00675	0.544
CLV_NRD_NRD_1	267	269	PF00675	0.659
CLV_NRD_NRD_1	417	419	PF00675	0.670
CLV_NRD_NRD_1	506	508	PF00675	0.498
CLV_PCSK_FUR_1	490	494	PF00082	0.463
CLV_PCSK_KEX2_1	132	134	PF00082	0.544
CLV_PCSK_KEX2_1	492	494	PF00082	0.517
CLV_PCSK_KEX2_1	506	508	PF00082	0.498
CLV_PCSK_PC1ET2_1	492	494	PF00082	0.517
CLV_PCSK_SKI1_1	251	255	PF00082	0.537
CLV_PCSK_SKI1_1	359	363	PF00082	0.535
CLV_PCSK_SKI1_1	411	415	PF00082	0.621
CLV_PCSK_SKI1_1	508	512	PF00082	0.396
CLV_PCSK_SKI1_1	516	520	PF00082	0.467
CLV_PCSK_SKI1_1	618	622	PF00082	0.495
DEG_COP1_1	270	277	PF00400	0.530
DEG_SCF_FBW7_1	594	600	PF00400	0.531
DEG_SCF_TRCP1_1	742	748	PF00400	0.562
DEG_SPOP_SBC_1	750	754	PF00917	0.564
DOC_CKS1_1	317	322	PF01111	0.544
DOC_CKS1_1	594	599	PF01111	0.530
DOC_CKS1_1	602	607	PF01111	0.501
DOC_CYCLIN_yCln2_LP_2	177	183	PF00134	0.533
DOC_CYCLIN_yCln2_LP_2	621	627	PF00134	0.506
DOC_MAPK_gen_1	406	415	PF00069	0.580
DOC_MAPK_MEF2A_6	359	367	PF00069	0.530
DOC_PP1_RVXF_1	505	512	PF00149	0.356
DOC_PP1_RVXF_1	711	718	PF00149	0.594
DOC_USP7_MATH_1	163	167	PF00917	0.656
DOC_USP7_MATH_1	236	240	PF00917	0.673
DOC_USP7_MATH_1	294	298	PF00917	0.581
DOC_USP7_MATH_1	32	36	PF00917	0.637
DOC_USP7_MATH_1	342	346	PF00917	0.560
DOC_USP7_MATH_1	404	408	PF00917	0.704
DOC_USP7_MATH_1	544	548	PF00917	0.546
DOC_USP7_MATH_1	696	700	PF00917	0.573
DOC_USP7_UBL2_3	8	12	PF12436	0.546
DOC_WW_Pin1_4	103	108	PF00397	0.682
DOC_WW_Pin1_4	176	181	PF00397	0.593
DOC_WW_Pin1_4	273	278	PF00397	0.564
DOC_WW_Pin1_4	316	321	PF00397	0.536
DOC_WW_Pin1_4	338	343	PF00397	0.563
DOC_WW_Pin1_4	348	353	PF00397	0.536
DOC_WW_Pin1_4	378	383	PF00397	0.667
DOC_WW_Pin1_4	447	452	PF00397	0.609
DOC_WW_Pin1_4	566	571	PF00397	0.528
DOC_WW_Pin1_4	593	598	PF00397	0.524
DOC_WW_Pin1_4	601	606	PF00397	0.509
DOC_WW_Pin1_4	626	631	PF00397	0.533
DOC_WW_Pin1_4	745	750	PF00397	0.730
DOC_WW_Pin1_4	82	87	PF00397	0.673
LIG_14-3-3_CanoR_1	102	107	PF00244	0.555
LIG_14-3-3_CanoR_1	132	138	PF00244	0.666
LIG_14-3-3_CanoR_1	199	205	PF00244	0.648
LIG_14-3-3_CanoR_1	251	257	PF00244	0.672
LIG_14-3-3_CanoR_1	268	277	PF00244	0.515
LIG_14-3-3_CanoR_1	359	364	PF00244	0.533
LIG_14-3-3_CanoR_1	411	416	PF00244	0.588
LIG_14-3-3_CanoR_1	580	588	PF00244	0.466
LIG_14-3-3_CanoR_1	70	74	PF00244	0.687
LIG_14-3-3_CanoR_1	723	732	PF00244	0.560
LIG_EVH1_1	146	150	PF00568	0.554
LIG_EVH1_2	50	54	PF00568	0.546
LIG_FHA_1	132	138	PF00498	0.549
LIG_FHA_1	172	178	PF00498	0.569
LIG_FHA_1	360	366	PF00498	0.603
LIG_FHA_1	475	481	PF00498	0.348
LIG_FHA_1	594	600	PF00498	0.531
LIG_FHA_2	173	179	PF00498	0.537
LIG_FHA_2	297	303	PF00498	0.559
LIG_FHA_2	457	463	PF00498	0.425
LIG_FHA_2	677	683	PF00498	0.586
LIG_LIR_Apic_2	217	222	PF02991	0.676
LIG_LIR_Nem_3	464	470	PF02991	0.539
LIG_LIR_Nem_3	563	568	PF02991	0.608
LIG_LIR_Nem_3	682	688	PF02991	0.530
LIG_LIR_Nem_3	709	715	PF02991	0.648
LIG_MYND_1	82	86	PF01753	0.566
LIG_NRBOX	532	538	PF00104	0.352
LIG_NRBOX	654	660	PF00104	0.456
LIG_PTAP_UEV_1	375	380	PF05743	0.525
LIG_SH2_CRK	219	223	PF00017	0.672
LIG_SH2_CRK	467	471	PF00017	0.497
LIG_SH2_CRK	712	716	PF00017	0.645
LIG_SH2_STAP1	471	475	PF00017	0.339
LIG_SH2_STAT3	139	142	PF00017	0.695
LIG_SH2_STAT5	469	472	PF00017	0.622
LIG_SH2_STAT5	95	98	PF00017	0.574
LIG_SH3_2	394	399	PF14604	0.568
LIG_SH3_3	104	110	PF00018	0.676
LIG_SH3_3	144	150	PF00018	0.560
LIG_SH3_3	202	208	PF00018	0.704
LIG_SH3_3	22	28	PF00018	0.540
LIG_SH3_3	271	277	PF00018	0.544
LIG_SH3_3	290	296	PF00018	0.621
LIG_SH3_3	314	320	PF00018	0.557
LIG_SH3_3	373	379	PF00018	0.636
LIG_SH3_3	391	397	PF00018	0.563
LIG_SH3_3	452	458	PF00018	0.646
LIG_SH3_3	591	597	PF00018	0.653
LIG_SH3_3	600	606	PF00018	0.562
LIG_SH3_3	624	630	PF00018	0.659
LIG_SH3_3	633	639	PF00018	0.580
LIG_SH3_3	689	695	PF00018	0.555
LIG_SH3_3	716	722	PF00018	0.646
LIG_SH3_3	729	735	PF00018	0.516
LIG_TRAF2_1	459	462	PF00917	0.413
LIG_TRAF2_1	512	515	PF00917	0.430
LIG_TRAF2_2	570	575	PF00917	0.449
LIG_WW_1	222	225	PF00397	0.530
MOD_CDK_SPxxK_3	447	454	PF00069	0.537
MOD_CK1_1	103	109	PF00069	0.673
MOD_CK1_1	167	173	PF00069	0.672
MOD_CK1_1	195	201	PF00069	0.695
MOD_CK1_1	245	251	PF00069	0.671
MOD_CK1_1	297	303	PF00069	0.559
MOD_CK1_1	332	338	PF00069	0.572
MOD_CK1_1	341	347	PF00069	0.547
MOD_CK1_1	385	391	PF00069	0.578
MOD_CK1_1	407	413	PF00069	0.589
MOD_CK1_1	41	47	PF00069	0.676
MOD_CK1_1	421	427	PF00069	0.604
MOD_CK1_1	456	462	PF00069	0.497
MOD_CK1_1	547	553	PF00069	0.492
MOD_CK1_1	57	63	PF00069	0.541
MOD_CK1_1	587	593	PF00069	0.553
MOD_CK1_1	64	70	PF00069	0.615
MOD_CK1_1	72	78	PF00069	0.567
MOD_CK1_1	730	736	PF00069	0.720
MOD_CK2_1	456	462	PF00069	0.445
MOD_CK2_1	551	557	PF00069	0.533
MOD_CK2_1	604	610	PF00069	0.499
MOD_CK2_1	740	746	PF00069	0.564
MOD_GlcNHglycan	100	105	PF01048	0.637
MOD_GlcNHglycan	122	125	PF01048	0.652
MOD_GlcNHglycan	154	157	PF01048	0.572
MOD_GlcNHglycan	299	302	PF01048	0.562
MOD_GlcNHglycan	330	334	PF01048	0.559
MOD_GlcNHglycan	344	347	PF01048	0.548
MOD_GlcNHglycan	353	356	PF01048	0.525
MOD_GlcNHglycan	367	370	PF01048	0.563
MOD_GlcNHglycan	371	374	PF01048	0.591
MOD_GlcNHglycan	376	379	PF01048	0.638
MOD_GlcNHglycan	402	405	PF01048	0.706
MOD_GlcNHglycan	428	432	PF01048	0.591
MOD_GlcNHglycan	437	440	PF01048	0.541
MOD_GlcNHglycan	528	531	PF01048	0.430
MOD_GlcNHglycan	549	552	PF01048	0.654
MOD_GlcNHglycan	581	584	PF01048	0.508
MOD_GlcNHglycan	66	69	PF01048	0.649
MOD_GlcNHglycan	729	732	PF01048	0.642
MOD_GlcNHglycan	741	745	PF01048	0.603
MOD_GSK3_1	116	123	PF00069	0.639
MOD_GSK3_1	131	138	PF00069	0.590
MOD_GSK3_1	163	170	PF00069	0.671
MOD_GSK3_1	172	179	PF00069	0.593
MOD_GSK3_1	186	193	PF00069	0.614
MOD_GSK3_1	195	202	PF00069	0.600
MOD_GSK3_1	238	245	PF00069	0.659
MOD_GSK3_1	252	259	PF00069	0.534
MOD_GSK3_1	278	285	PF00069	0.551
MOD_GSK3_1	32	39	PF00069	0.647
MOD_GSK3_1	329	336	PF00069	0.562
MOD_GSK3_1	338	345	PF00069	0.548
MOD_GSK3_1	365	372	PF00069	0.622
MOD_GSK3_1	374	381	PF00069	0.557
MOD_GSK3_1	400	407	PF00069	0.700
MOD_GSK3_1	41	48	PF00069	0.638
MOD_GSK3_1	547	554	PF00069	0.527
MOD_GSK3_1	566	573	PF00069	0.548
MOD_GSK3_1	57	64	PF00069	0.610
MOD_GSK3_1	593	600	PF00069	0.636
MOD_GSK3_1	672	679	PF00069	0.538
MOD_GSK3_1	686	693	PF00069	0.547
MOD_GSK3_1	69	76	PF00069	0.561
MOD_GSK3_1	723	730	PF00069	0.557
MOD_GSK3_1	740	747	PF00069	0.669
MOD_LATS_1	131	137	PF00433	0.547
MOD_LATS_1	197	203	PF00433	0.710
MOD_N-GLC_1	241	246	PF02516	0.652
MOD_N-GLC_1	249	254	PF02516	0.626
MOD_N-GLC_1	256	261	PF02516	0.556
MOD_N-GLC_1	297	302	PF02516	0.561
MOD_N-GLC_1	342	347	PF02516	0.565
MOD_N-GLC_1	41	46	PF02516	0.552
MOD_N-GLC_1	426	431	PF02516	0.667
MOD_N-GLC_1	552	557	PF02516	0.558
MOD_N-GLC_1	584	589	PF02516	0.553
MOD_NEK2_1	125	130	PF00069	0.673
MOD_NEK2_1	152	157	PF00069	0.558
MOD_NEK2_1	171	176	PF00069	0.524
MOD_NEK2_1	185	190	PF00069	0.515
MOD_NEK2_1	249	254	PF00069	0.548
MOD_NEK2_1	256	261	PF00069	0.627
MOD_NEK2_1	288	293	PF00069	0.591
MOD_NEK2_1	38	43	PF00069	0.568
MOD_NEK2_1	474	479	PF00069	0.440
MOD_NEK2_1	54	59	PF00069	0.598
MOD_PIKK_1	192	198	PF00454	0.553
MOD_PIKK_1	36	42	PF00454	0.552
MOD_PIKK_1	696	702	PF00454	0.683
MOD_PIKK_1	73	79	PF00454	0.710
MOD_PKA_1	268	274	PF00069	0.615
MOD_PKA_1	418	424	PF00069	0.560
MOD_PKA_2	131	137	PF00069	0.664
MOD_PKA_2	198	204	PF00069	0.578
MOD_PKA_2	267	273	PF00069	0.562
MOD_PKA_2	453	459	PF00069	0.511
MOD_PKA_2	547	553	PF00069	0.492
MOD_PKA_2	579	585	PF00069	0.451
MOD_PKA_2	69	75	PF00069	0.708
MOD_PKB_1	409	417	PF00069	0.560
MOD_Plk_1	241	247	PF00069	0.645
MOD_Plk_1	249	255	PF00069	0.616
MOD_Plk_1	41	47	PF00069	0.553
MOD_Plk_1	493	499	PF00069	0.430
MOD_Plk_1	552	558	PF00069	0.548
MOD_Plk_1	584	590	PF00069	0.561
MOD_Plk_4	256	262	PF00069	0.667
MOD_Plk_4	359	365	PF00069	0.598
MOD_Plk_4	493	499	PF00069	0.379
MOD_Plk_4	673	679	PF00069	0.535
MOD_ProDKin_1	103	109	PF00069	0.678
MOD_ProDKin_1	176	182	PF00069	0.595
MOD_ProDKin_1	273	279	PF00069	0.562
MOD_ProDKin_1	316	322	PF00069	0.538
MOD_ProDKin_1	338	344	PF00069	0.565
MOD_ProDKin_1	348	354	PF00069	0.533
MOD_ProDKin_1	378	384	PF00069	0.667
MOD_ProDKin_1	447	453	PF00069	0.609
MOD_ProDKin_1	566	572	PF00069	0.521
MOD_ProDKin_1	593	599	PF00069	0.527
MOD_ProDKin_1	601	607	PF00069	0.503
MOD_ProDKin_1	626	632	PF00069	0.533
MOD_ProDKin_1	745	751	PF00069	0.731
MOD_ProDKin_1	82	88	PF00069	0.672
MOD_SUMO_for_1	491	494	PF00179	0.609
TRG_DiLeu_BaEn_1	515	520	PF01217	0.495
TRG_DiLeu_BaLyEn_6	379	384	PF01217	0.590
TRG_ENDOCYTIC_2	225	228	PF00928	0.674
TRG_ENDOCYTIC_2	467	470	PF00928	0.605
TRG_ENDOCYTIC_2	471	474	PF00928	0.576
TRG_ENDOCYTIC_2	712	715	PF00928	0.644
TRG_ER_diArg_1	3	6	PF00400	0.665
TRG_ER_diArg_1	409	412	PF00400	0.568
TRG_ER_diArg_1	505	507	PF00400	0.498
TRG_Pf-PMV_PEXEL_1	468	472	PF00026	0.491

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IEG9	Leishmania donovani	54%	97%
A4HY81	Leishmania infantum	55%	97%
E9AS12	Leishmania mexicana (strain MHOM/GT/2001/U1103)	52%	100%
Q4QDG1	Leishmania major	53%	97%