Transmembrane protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HA16_LEIBR

TriTrypDb:

LbrM.19.0900 , LBRM2903_190014500

Length:

528

Annotations

LeishMANIAdb annotations

Belongs to a poorly known protein family found in basal Eukaryota (also containing A0A0A1U905_ENTIV, A0A0A1U245_ENTIV). Very distantly related to animal prominins.. The first TM segment can equally be a signal peptide, with no change in overall topology. If related to prominins, this massively expanded family could play a role in vesicular processes.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 9

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 18, no: 1
NetGPI	no	yes: 0, no: 19

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	18
GO:0110165	cellular anatomical entity	1	18

Expansion

Sequence features

A4HA16

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HA16

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	275	277	PF00082	0.523
CLV_PCSK_KEX2_1	510	512	PF00082	0.419
CLV_PCSK_PC1ET2_1	275	277	PF00082	0.523
CLV_PCSK_PC1ET2_1	510	512	PF00082	0.419
CLV_PCSK_SKI1_1	3	7	PF00082	0.659
CLV_PCSK_SKI1_1	364	368	PF00082	0.646
DOC_CKS1_1	168	173	PF01111	0.371
DOC_MAPK_MEF2A_6	103	112	PF00069	0.587
DOC_USP7_MATH_1	178	182	PF00917	0.465
DOC_USP7_MATH_1	25	29	PF00917	0.512
DOC_USP7_MATH_1	418	422	PF00917	0.474
DOC_WW_Pin1_4	164	169	PF00397	0.531
DOC_WW_Pin1_4	89	94	PF00397	0.689
LIG_14-3-3_CanoR_1	154	164	PF00244	0.399
LIG_14-3-3_CanoR_1	467	472	PF00244	0.385
LIG_14-3-3_CanoR_1	511	521	PF00244	0.725
LIG_14-3-3_CanoR_1	53	62	PF00244	0.464
LIG_APCC_ABBA_1	317	322	PF00400	0.360
LIG_BIR_II_1	1	5	PF00653	0.568
LIG_BIR_III_3	1	5	PF00653	0.383
LIG_EH1_1	200	208	PF00400	0.396
LIG_EH1_1	216	224	PF00400	0.427
LIG_EH1_1	476	484	PF00400	0.380
LIG_eIF4E_1	242	248	PF01652	0.270
LIG_FHA_1	156	162	PF00498	0.465
LIG_FHA_1	171	177	PF00498	0.474
LIG_FHA_1	255	261	PF00498	0.496
LIG_FHA_1	354	360	PF00498	0.346
LIG_FHA_1	366	372	PF00498	0.423
LIG_FHA_1	406	412	PF00498	0.396
LIG_FHA_1	466	472	PF00498	0.374
LIG_FHA_1	515	521	PF00498	0.802
LIG_FHA_1	72	78	PF00498	0.372
LIG_FHA_2	341	347	PF00498	0.345
LIG_FHA_2	377	383	PF00498	0.478
LIG_FHA_2	90	96	PF00498	0.657
LIG_LIR_Apic_2	360	365	PF02991	0.400
LIG_LIR_Apic_2	395	399	PF02991	0.466
LIG_LIR_Apic_2	425	429	PF02991	0.393
LIG_LIR_Gen_1	187	197	PF02991	0.397
LIG_LIR_Gen_1	259	265	PF02991	0.234
LIG_LIR_Gen_1	292	302	PF02991	0.434
LIG_LIR_Nem_3	195	200	PF02991	0.366
LIG_LIR_Nem_3	239	245	PF02991	0.345
LIG_LIR_Nem_3	259	264	PF02991	0.197
LIG_LIR_Nem_3	292	298	PF02991	0.456
LIG_LIR_Nem_3	425	431	PF02991	0.493
LIG_LIR_Nem_3	56	61	PF02991	0.396
LIG_LYPXL_S_1	427	431	PF13949	0.473
LIG_LYPXL_S_1	62	66	PF13949	0.562
LIG_LYPXL_yS_3	428	431	PF13949	0.277
LIG_Pex14_1	238	242	PF04695	0.614
LIG_Pex14_2	245	249	PF04695	0.400
LIG_SH2_CRK	126	130	PF00017	0.462
LIG_SH2_GRB2like	149	152	PF00017	0.403
LIG_SH2_PTP2	362	365	PF00017	0.401
LIG_SH2_PTP2	426	429	PF00017	0.450
LIG_SH2_SRC	396	399	PF00017	0.420
LIG_SH2_SRC	426	429	PF00017	0.387
LIG_SH2_SRC	61	64	PF00017	0.443
LIG_SH2_STAP1	189	193	PF00017	0.412
LIG_SH2_STAP1	406	410	PF00017	0.466
LIG_SH2_STAP1	449	453	PF00017	0.395
LIG_SH2_STAT3	406	409	PF00017	0.367
LIG_SH2_STAT5	105	108	PF00017	0.288
LIG_SH2_STAT5	149	152	PF00017	0.382
LIG_SH2_STAT5	197	200	PF00017	0.371
LIG_SH2_STAT5	242	245	PF00017	0.370
LIG_SH2_STAT5	261	264	PF00017	0.315
LIG_SH2_STAT5	284	287	PF00017	0.342
LIG_SH2_STAT5	362	365	PF00017	0.451
LIG_SH2_STAT5	426	429	PF00017	0.438
LIG_SH2_STAT5	484	487	PF00017	0.275
LIG_SH2_STAT5	489	492	PF00017	0.323
LIG_SH2_STAT5	61	64	PF00017	0.384
LIG_SH3_1	396	402	PF00018	0.424
LIG_SH3_2	399	404	PF14604	0.381
LIG_SH3_3	165	171	PF00018	0.493
LIG_SH3_3	322	328	PF00018	0.405
LIG_SH3_3	396	402	PF00018	0.424
LIG_SUMO_SIM_anti_2	352	361	PF11976	0.467
LIG_SUMO_SIM_anti_2	74	79	PF11976	0.234
LIG_SUMO_SIM_par_1	355	361	PF11976	0.341
LIG_TRAF2_1	92	95	PF00917	0.561
LIG_TRFH_1	60	64	PF08558	0.479
LIG_TYR_ITIM	124	129	PF00017	0.512
LIG_TYR_ITIM	198	203	PF00017	0.301
LIG_UBA3_1	44	51	PF00899	0.392
LIG_Vh1_VBS_1	1	19	PF01044	0.415
MOD_CK1_1	156	162	PF00069	0.295
MOD_CK1_1	167	173	PF00069	0.386
MOD_CK1_1	312	318	PF00069	0.386
MOD_CK1_1	40	46	PF00069	0.429
MOD_CK1_1	451	457	PF00069	0.592
MOD_CK1_1	512	518	PF00069	0.716
MOD_CK2_1	137	143	PF00069	0.278
MOD_CK2_1	340	346	PF00069	0.357
MOD_CK2_1	376	382	PF00069	0.465
MOD_CK2_1	512	518	PF00069	0.710
MOD_CK2_1	89	95	PF00069	0.742
MOD_Cter_Amidation	508	511	PF01082	0.422
MOD_GlcNHglycan	164	167	PF01048	0.671
MOD_GlcNHglycan	23	26	PF01048	0.644
MOD_GlcNHglycan	230	233	PF01048	0.495
MOD_GlcNHglycan	311	314	PF01048	0.638
MOD_GlcNHglycan	463	466	PF01048	0.675
MOD_GlcNHglycan	506	510	PF01048	0.517
MOD_GlcNHglycan	511	514	PF01048	0.519
MOD_GlcNHglycan	89	92	PF01048	0.364
MOD_GSK3_1	155	162	PF00069	0.370
MOD_GSK3_1	21	28	PF00069	0.522
MOD_GSK3_1	33	40	PF00069	0.366
MOD_GSK3_1	353	360	PF00069	0.398
MOD_GSK3_1	418	425	PF00069	0.396
MOD_GSK3_1	461	468	PF00069	0.453
MOD_GSK3_1	505	512	PF00069	0.744
MOD_N-GLC_1	143	148	PF02516	0.576
MOD_N-GLC_1	150	155	PF02516	0.568
MOD_N-GLC_1	162	167	PF02516	0.588
MOD_N-GLC_1	184	189	PF02516	0.625
MOD_N-GLC_1	340	345	PF02516	0.595
MOD_N-GLC_1	373	378	PF02516	0.740
MOD_N-GLC_1	40	45	PF02516	0.672
MOD_N-GLC_1	418	423	PF02516	0.582
MOD_NEK2_1	131	136	PF00069	0.352
MOD_NEK2_1	150	155	PF00069	0.463
MOD_NEK2_1	18	23	PF00069	0.576
MOD_NEK2_1	256	261	PF00069	0.290
MOD_NEK2_1	33	38	PF00069	0.474
MOD_NEK2_1	367	372	PF00069	0.434
MOD_NEK2_1	472	477	PF00069	0.394
MOD_NEK2_1	478	483	PF00069	0.394
MOD_NEK2_1	71	76	PF00069	0.439
MOD_OFUCOSY	233	240	PF10250	0.427
MOD_PIKK_1	307	313	PF00454	0.426
MOD_PIKK_1	376	382	PF00454	0.471
MOD_PIKK_1	405	411	PF00454	0.378
MOD_PIKK_1	53	59	PF00454	0.455
MOD_PK_1	467	473	PF00069	0.365
MOD_PKA_2	153	159	PF00069	0.351
MOD_PKA_2	193	199	PF00069	0.427
MOD_PKA_2	228	234	PF00069	0.621
MOD_PKA_2	466	472	PF00069	0.429
MOD_Plk_1	143	149	PF00069	0.401
MOD_Plk_1	150	156	PF00069	0.428
MOD_Plk_1	184	190	PF00069	0.423
MOD_Plk_1	376	382	PF00069	0.457
MOD_Plk_1	40	46	PF00069	0.468
MOD_Plk_1	449	455	PF00069	0.531
MOD_Plk_2-3	143	149	PF00069	0.502
MOD_Plk_2-3	382	388	PF00069	0.387
MOD_Plk_4	156	162	PF00069	0.329
MOD_Plk_4	193	199	PF00069	0.361
MOD_Plk_4	256	262	PF00069	0.309
MOD_Plk_4	353	359	PF00069	0.366
MOD_Plk_4	40	46	PF00069	0.403
MOD_Plk_4	422	428	PF00069	0.428
MOD_Plk_4	467	473	PF00069	0.329
MOD_Plk_4	478	484	PF00069	0.342
MOD_ProDKin_1	164	170	PF00069	0.528
MOD_ProDKin_1	89	95	PF00069	0.691
MOD_SUMO_rev_2	90	99	PF00179	0.549
TRG_DiLeu_BaEn_2	331	337	PF01217	0.388
TRG_DiLeu_BaLyEn_6	426	431	PF01217	0.382
TRG_ENDOCYTIC_2	105	108	PF00928	0.298
TRG_ENDOCYTIC_2	126	129	PF00928	0.433
TRG_ENDOCYTIC_2	189	192	PF00928	0.461
TRG_ENDOCYTIC_2	200	203	PF00928	0.424
TRG_ENDOCYTIC_2	242	245	PF00928	0.335
TRG_ENDOCYTIC_2	261	264	PF00928	0.411
TRG_ENDOCYTIC_2	428	431	PF00928	0.277
TRG_ENDOCYTIC_2	63	66	PF00928	0.327

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8Y8	Leptomonas seymouri	54%	100%
A0A0S4IXB1	Bodo saltans	25%	100%
A0A0S4IXU4	Bodo saltans	26%	100%
A0A1X0NVP9	Trypanosomatidae	40%	100%
A0A1X0NWC8	Trypanosomatidae	36%	100%
A0A1X0P6A6	Trypanosomatidae	29%	100%
A0A3Q8IB78	Leishmania donovani	73%	100%
A0A3S7WVB2	Leishmania donovani	74%	100%
A0A422N059	Trypanosoma rangeli	37%	100%
A4HY78	Leishmania infantum	73%	100%
A4HY79	Leishmania infantum	74%	100%
C9ZWF5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	97%
D0A5X9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	93%
E9AS08	Leishmania mexicana (strain MHOM/GT/2001/U1103)	70%	100%
E9AS09	Leishmania mexicana (strain MHOM/GT/2001/U1103)	71%	100%
Q4QDG4	Leishmania major	71%	100%
Q4QDG5	Leishmania major	71%	100%
V5C1U9	Trypanosoma cruzi	30%	100%