Methionine aminopeptidase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

metallo- peptidase, Clan MG, Family M24

Species:

Leishmania braziliensis

UniProt:

A4HA12_LEIBR

TriTrypDb:

LbrM.19.0860 , LBRM2903_190013300

Length:

401

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	1
GO:0005737	cytoplasm	2	1
GO:0005829	cytosol	2	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HA12

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HA12

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0019538	protein metabolic process	3	12
GO:0036211	protein modification process	4	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043412	macromolecule modification	4	12
GO:0044238	primary metabolic process	2	12
GO:0070084	protein initiator methionine removal	5	12
GO:0071704	organic substance metabolic process	2	12
GO:1901564	organonitrogen compound metabolic process	3	12
GO:0016485	protein processing	5	1
GO:0035551	protein initiator methionine removal involved in protein maturation	6	1
GO:0051604	protein maturation	4	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0004177	aminopeptidase activity	5	12
GO:0005488	binding	1	12
GO:0008233	peptidase activity	3	12
GO:0008235	metalloexopeptidase activity	5	12
GO:0008237	metallopeptidase activity	4	12
GO:0008238	exopeptidase activity	4	12
GO:0016787	hydrolase activity	2	12
GO:0043167	ion binding	2	12
GO:0043169	cation binding	3	12
GO:0046872	metal ion binding	4	12
GO:0070006	metalloaminopeptidase activity	6	12
GO:0140096	catalytic activity, acting on a protein	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	103	107	PF00656	0.408
CLV_C14_Caspase3-7	338	342	PF00656	0.242
CLV_C14_Caspase3-7	372	376	PF00656	0.344
CLV_C14_Caspase3-7	94	98	PF00656	0.414
CLV_NRD_NRD_1	130	132	PF00675	0.434
CLV_NRD_NRD_1	80	82	PF00675	0.378
CLV_PCSK_KEX2_1	130	132	PF00082	0.531
CLV_PCSK_KEX2_1	139	141	PF00082	0.338
CLV_PCSK_KEX2_1	351	353	PF00082	0.236
CLV_PCSK_KEX2_1	80	82	PF00082	0.378
CLV_PCSK_PC1ET2_1	139	141	PF00082	0.379
CLV_PCSK_PC1ET2_1	351	353	PF00082	0.251
CLV_PCSK_PC7_1	76	82	PF00082	0.340
CLV_PCSK_SKI1_1	146	150	PF00082	0.236
CLV_PCSK_SKI1_1	382	386	PF00082	0.295
DOC_CKS1_1	361	366	PF01111	0.379
DOC_CYCLIN_RxL_1	16	26	PF00134	0.410
DOC_MAPK_gen_1	130	138	PF00069	0.455
DOC_MAPK_gen_1	382	391	PF00069	0.396
DOC_PP2B_LxvP_1	21	24	PF13499	0.425
DOC_PP4_FxxP_1	68	71	PF00568	0.397
DOC_USP7_MATH_1	279	283	PF00917	0.359
DOC_WW_Pin1_4	178	183	PF00397	0.236
DOC_WW_Pin1_4	360	365	PF00397	0.379
DOC_WW_Pin1_4	75	80	PF00397	0.387
LIG_Actin_WH2_2	58	75	PF00022	0.506
LIG_deltaCOP1_diTrp_1	336	343	PF00928	0.236
LIG_deltaCOP1_diTrp_1	372	379	PF00928	0.440
LIG_EVH1_2	24	28	PF00568	0.399
LIG_FHA_1	160	166	PF00498	0.250
LIG_FHA_1	232	238	PF00498	0.251
LIG_FHA_1	38	44	PF00498	0.497
LIG_FHA_1	46	52	PF00498	0.529
LIG_FHA_1	67	73	PF00498	0.375
LIG_FHA_2	159	165	PF00498	0.270
LIG_FHA_2	331	337	PF00498	0.244
LIG_FHA_2	55	61	PF00498	0.417
LIG_LIR_Apic_2	386	390	PF02991	0.451
LIG_LIR_Gen_1	250	259	PF02991	0.299
LIG_LIR_Gen_1	333	340	PF02991	0.270
LIG_LIR_Nem_3	250	255	PF02991	0.212
LIG_LIR_Nem_3	265	271	PF02991	0.254
LIG_LIR_Nem_3	333	337	PF02991	0.289
LIG_PDZ_Class_2	396	401	PF00595	0.534
LIG_Pex14_2	34	38	PF04695	0.399
LIG_REV1ctd_RIR_1	25	34	PF16727	0.341
LIG_SH2_CRK	186	190	PF00017	0.236
LIG_SH2_CRK	252	256	PF00017	0.350
LIG_SH2_CRK	268	272	PF00017	0.277
LIG_SH2_GRB2like	185	188	PF00017	0.251
LIG_SH2_SRC	223	226	PF00017	0.270
LIG_SH2_STAP1	252	256	PF00017	0.296
LIG_SH2_STAT3	380	383	PF00017	0.288
LIG_SH2_STAT5	223	226	PF00017	0.251
LIG_SH2_STAT5	270	273	PF00017	0.379
LIG_SH2_STAT5	290	293	PF00017	0.226
LIG_SH3_2	71	76	PF14604	0.408
LIG_SH3_3	234	240	PF00018	0.270
LIG_SH3_3	258	264	PF00018	0.251
LIG_SH3_3	334	340	PF00018	0.236
LIG_SH3_3	358	364	PF00018	0.330
LIG_SH3_3	68	74	PF00018	0.392
LIG_SUMO_SIM_anti_2	365	372	PF11976	0.448
LIG_TRAF2_1	209	212	PF00917	0.330
LIG_UBA3_1	135	139	PF00899	0.379
LIG_UBA3_1	255	263	PF00899	0.330
MOD_CDK_SPK_2	75	80	PF00069	0.362
MOD_CDK_SPxK_1	75	81	PF00069	0.356
MOD_CK1_1	191	197	PF00069	0.236
MOD_CK1_1	282	288	PF00069	0.330
MOD_CK2_1	158	164	PF00069	0.270
MOD_CK2_1	192	198	PF00069	0.236
MOD_CK2_1	54	60	PF00069	0.503
MOD_CK2_1	97	103	PF00069	0.349
MOD_Cter_Amidation	349	352	PF01082	0.236
MOD_GlcNHglycan	106	109	PF01048	0.449
MOD_GlcNHglycan	280	284	PF01048	0.342
MOD_GlcNHglycan	313	316	PF01048	0.270
MOD_GlcNHglycan	344	347	PF01048	0.270
MOD_GSK3_1	155	162	PF00069	0.376
MOD_GSK3_1	188	195	PF00069	0.260
MOD_GSK3_1	19	26	PF00069	0.413
MOD_GSK3_1	282	289	PF00069	0.251
MOD_GSK3_1	356	363	PF00069	0.251
MOD_N-GLC_1	124	129	PF02516	0.277
MOD_N-GLC_1	231	236	PF02516	0.251
MOD_N-GLC_1	310	315	PF02516	0.236
MOD_N-GLC_1	341	346	PF02516	0.251
MOD_N-GLC_1	66	71	PF02516	0.400
MOD_N-GLC_2	304	306	PF02516	0.312
MOD_NEK2_1	231	236	PF00069	0.263
MOD_NEK2_1	356	361	PF00069	0.236
MOD_NEK2_1	66	71	PF00069	0.346
MOD_PK_1	385	391	PF00069	0.275
MOD_PKA_1	130	136	PF00069	0.398
MOD_PKA_1	19	25	PF00069	0.454
MOD_PKA_2	130	136	PF00069	0.435
MOD_Plk_1	170	176	PF00069	0.226
MOD_Plk_1	218	224	PF00069	0.251
MOD_Plk_1	231	237	PF00069	0.251
MOD_Plk_1	241	247	PF00069	0.251
MOD_Plk_1	335	341	PF00069	0.236
MOD_Plk_1	356	362	PF00069	0.236
MOD_Plk_1	385	391	PF00069	0.275
MOD_Plk_2-3	97	103	PF00069	0.492
MOD_Plk_4	23	29	PF00069	0.420
MOD_Plk_4	231	237	PF00069	0.308
MOD_Plk_4	282	288	PF00069	0.236
MOD_Plk_4	356	362	PF00069	0.236
MOD_ProDKin_1	178	184	PF00069	0.236
MOD_ProDKin_1	360	366	PF00069	0.379
MOD_ProDKin_1	75	81	PF00069	0.385
MOD_SUMO_rev_2	345	353	PF00179	0.251
MOD_SUMO_rev_2	394	401	PF00179	0.521
MOD_SUMO_rev_2	97	107	PF00179	0.279
TRG_DiLeu_BaEn_1	365	370	PF01217	0.382
TRG_ENDOCYTIC_2	185	188	PF00928	0.236
TRG_ENDOCYTIC_2	252	255	PF00928	0.236
TRG_ENDOCYTIC_2	268	271	PF00928	0.236
TRG_ER_diArg_1	129	131	PF00400	0.420
TRG_ER_diArg_1	79	81	PF00400	0.370
TRG_Pf-PMV_PEXEL_1	118	122	PF00026	0.541
TRG_Pf-PMV_PEXEL_1	208	212	PF00026	0.236
TRG_Pf-PMV_PEXEL_1	382	386	PF00026	0.465

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEB6	Leptomonas seymouri	84%	97%
A0A0S4IW90	Bodo saltans	65%	100%
A0A0S4IXB9	Bodo saltans	53%	100%
A0A1X0P6I6	Trypanosomatidae	72%	100%
A0A3R7P3I2	Trypanosoma rangeli	72%	100%
A0A3S7WVI9	Leishmania donovani	93%	100%
A4HY76	Leishmania infantum	93%	100%
A6QLA4	Bos taurus	52%	100%
D0A0J6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	69%	100%
E9AS06	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
O59730	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	47%	100%
P0A5J3	Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)	43%	100%
P53582	Homo sapiens	52%	100%
P9WK18	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	43%	100%
P9WK19	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	43%	100%
Q01662	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	47%	100%
Q4QDG7	Leishmania major	93%	100%
Q4QRK0	Danio rerio	53%	100%
Q4VBS4	Danio rerio	41%	100%
Q54VU7	Dictyostelium discoideum	41%	99%
Q54WU3	Dictyostelium discoideum	52%	100%
Q5I0A0	Xenopus tropicalis	54%	100%
Q5RBF3	Pongo abelii	53%	100%
Q5ZIM5	Gallus gallus	53%	100%
Q6UB28	Homo sapiens	38%	100%
Q7ZWV9	Xenopus laevis	54%	100%
Q8BP48	Mus musculus	52%	100%
Q8IJP2	Plasmodium falciparum (isolate 3D7)	46%	78%
Q9CPW9	Mus musculus	39%	100%
Q9FV50	Arabidopsis thaliana	45%	100%
Q9FV51	Arabidopsis thaliana	42%	100%
Q9FV52	Arabidopsis thaliana	45%	100%
Q9SLN5	Arabidopsis thaliana	47%	100%
V5DTM6	Trypanosoma cruzi	72%	100%