Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HA11_LEIBR

TriTrypDb:

LbrM.19.0850 , LBRM2903_190013200

Length:

713

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	9
GO:0042995	cell projection	2	9
GO:0043226	organelle	2	9
GO:0043227	membrane-bounded organelle	3	9
GO:0110165	cellular anatomical entity	1	10
GO:0120025	plasma membrane bounded cell projection	3	9
GO:0016020	membrane	2	1
GO:0031090	organelle membrane	3	1
GO:0031253	cell projection membrane	4	1
GO:0060170	ciliary membrane	5	1
GO:0098588	bounding membrane of organelle	4	1
GO:0098590	plasma membrane region	3	1

Expansion

Sequence features

A4HA11

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HA11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	539	543	PF00656	0.780
CLV_C14_Caspase3-7	83	87	PF00656	0.538
CLV_NRD_NRD_1	447	449	PF00675	0.730
CLV_NRD_NRD_1	508	510	PF00675	0.621
CLV_NRD_NRD_1	562	564	PF00675	0.675
CLV_PCSK_FUR_1	38	42	PF00082	0.758
CLV_PCSK_KEX2_1	40	42	PF00082	0.700
CLV_PCSK_KEX2_1	447	449	PF00082	0.692
CLV_PCSK_KEX2_1	508	510	PF00082	0.621
CLV_PCSK_KEX2_1	561	563	PF00082	0.674
CLV_PCSK_PC1ET2_1	40	42	PF00082	0.735
CLV_PCSK_SKI1_1	206	210	PF00082	0.554
CLV_PCSK_SKI1_1	224	228	PF00082	0.335
CLV_PCSK_SKI1_1	368	372	PF00082	0.577
CLV_PCSK_SKI1_1	520	524	PF00082	0.742
CLV_PCSK_SKI1_1	563	567	PF00082	0.688
CLV_PCSK_SKI1_1	705	709	PF00082	0.586
DEG_APCC_DBOX_1	695	703	PF00400	0.635
DEG_SCF_FBW7_1	199	205	PF00400	0.434
DOC_CKS1_1	142	147	PF01111	0.737
DOC_CKS1_1	173	178	PF01111	0.601
DOC_CKS1_1	199	204	PF01111	0.441
DOC_CKS1_1	564	569	PF01111	0.653
DOC_CYCLIN_yCln2_LP_2	299	305	PF00134	0.254
DOC_MAPK_gen_1	375	383	PF00069	0.391
DOC_PIKK_1	461	468	PF02985	0.628
DOC_PP2B_LxvP_1	299	302	PF13499	0.466
DOC_PP2B_LxvP_1	411	414	PF13499	0.543
DOC_PP2B_LxvP_1	449	452	PF13499	0.765
DOC_PP4_MxPP_1	392	395	PF00568	0.411
DOC_USP7_MATH_1	28	32	PF00917	0.694
DOC_USP7_MATH_1	427	431	PF00917	0.596
DOC_USP7_MATH_1	499	503	PF00917	0.618
DOC_USP7_MATH_1	521	525	PF00917	0.679
DOC_USP7_MATH_1	571	575	PF00917	0.753
DOC_USP7_MATH_1	580	584	PF00917	0.538
DOC_USP7_MATH_1	627	631	PF00917	0.676
DOC_USP7_MATH_1	664	668	PF00917	0.739
DOC_USP7_MATH_1	707	711	PF00917	0.606
DOC_WW_Pin1_4	141	146	PF00397	0.733
DOC_WW_Pin1_4	172	177	PF00397	0.624
DOC_WW_Pin1_4	198	203	PF00397	0.511
DOC_WW_Pin1_4	307	312	PF00397	0.430
DOC_WW_Pin1_4	508	513	PF00397	0.609
DOC_WW_Pin1_4	563	568	PF00397	0.712
DOC_WW_Pin1_4	604	609	PF00397	0.641
LIG_14-3-3_CanoR_1	10	17	PF00244	0.635
LIG_14-3-3_CanoR_1	206	213	PF00244	0.582
LIG_14-3-3_CanoR_1	224	232	PF00244	0.344
LIG_14-3-3_CanoR_1	346	351	PF00244	0.408
LIG_14-3-3_CanoR_1	498	506	PF00244	0.622
LIG_14-3-3_CanoR_1	520	526	PF00244	0.501
LIG_14-3-3_CanoR_1	537	546	PF00244	0.511
LIG_14-3-3_CanoR_1	644	653	PF00244	0.717
LIG_BIR_II_1	1	5	PF00653	0.730
LIG_deltaCOP1_diTrp_1	215	219	PF00928	0.502
LIG_deltaCOP1_diTrp_1	631	638	PF00928	0.713
LIG_DLG_GKlike_1	81	89	PF00625	0.534
LIG_FHA_1	12	18	PF00498	0.655
LIG_FHA_1	168	174	PF00498	0.732
LIG_FHA_1	203	209	PF00498	0.520
LIG_FHA_1	225	231	PF00498	0.392
LIG_FHA_1	25	31	PF00498	0.663
LIG_FHA_1	316	322	PF00498	0.428
LIG_FHA_1	546	552	PF00498	0.642
LIG_FHA_1	555	561	PF00498	0.649
LIG_FHA_1	88	94	PF00498	0.673
LIG_FHA_2	215	221	PF00498	0.438
LIG_FHA_2	416	422	PF00498	0.495
LIG_FHA_2	453	459	PF00498	0.660
LIG_FHA_2	672	678	PF00498	0.742
LIG_FHA_2	81	87	PF00498	0.672
LIG_LIR_Apic_2	96	102	PF02991	0.522
LIG_LIR_Gen_1	18	29	PF02991	0.497
LIG_LIR_Gen_1	217	226	PF02991	0.467
LIG_LIR_Gen_1	268	278	PF02991	0.361
LIG_LIR_Gen_1	400	409	PF02991	0.394
LIG_LIR_Gen_1	430	437	PF02991	0.457
LIG_LIR_Gen_1	632	643	PF02991	0.706
LIG_LIR_Gen_1	667	672	PF02991	0.720
LIG_LIR_Nem_3	18	24	PF02991	0.656
LIG_LIR_Nem_3	217	222	PF02991	0.513
LIG_LIR_Nem_3	268	273	PF02991	0.350
LIG_LIR_Nem_3	298	303	PF02991	0.382
LIG_LIR_Nem_3	365	370	PF02991	0.507
LIG_LIR_Nem_3	387	393	PF02991	0.613
LIG_LIR_Nem_3	400	404	PF02991	0.363
LIG_LIR_Nem_3	406	411	PF02991	0.277
LIG_LIR_Nem_3	430	435	PF02991	0.450
LIG_LIR_Nem_3	478	484	PF02991	0.583
LIG_LIR_Nem_3	632	638	PF02991	0.571
LIG_LIR_Nem_3	667	671	PF02991	0.726
LIG_MYND_1	391	395	PF01753	0.520
LIG_Pex14_2	522	526	PF04695	0.757
LIG_SH2_CRK	496	500	PF00017	0.606
LIG_SH2_CRK	668	672	PF00017	0.718
LIG_SH2_CRK	99	103	PF00017	0.525
LIG_SH2_STAT5	275	278	PF00017	0.455
LIG_SH2_STAT5	300	303	PF00017	0.482
LIG_SH3_3	170	176	PF00018	0.659
LIG_SH3_3	385	391	PF00018	0.716
LIG_SH3_3	477	483	PF00018	0.507
LIG_SH3_3	515	521	PF00018	0.639
LIG_SUMO_SIM_anti_2	316	323	PF11976	0.399
LIG_SUMO_SIM_par_1	316	323	PF11976	0.427
LIG_TRAF2_1	441	444	PF00917	0.723
LIG_TRAF2_1	630	633	PF00917	0.709
LIG_TRAF2_1	72	75	PF00917	0.524
LIG_TYR_ITIM	273	278	PF00017	0.479
LIG_UBA3_1	32	40	PF00899	0.767
MOD_CDK_SPK_2	508	513	PF00069	0.507
MOD_CK1_1	125	131	PF00069	0.615
MOD_CK1_1	167	173	PF00069	0.726
MOD_CK1_1	249	255	PF00069	0.502
MOD_CK1_1	258	264	PF00069	0.510
MOD_CK1_1	431	437	PF00069	0.648
MOD_CK1_1	47	53	PF00069	0.712
MOD_CK1_1	511	517	PF00069	0.618
MOD_CK1_1	524	530	PF00069	0.642
MOD_CK1_1	535	541	PF00069	0.631
MOD_CK1_1	544	550	PF00069	0.643
MOD_CK1_1	576	582	PF00069	0.594
MOD_CK1_1	649	655	PF00069	0.719
MOD_CK1_1	658	664	PF00069	0.685
MOD_CK2_1	152	158	PF00069	0.525
MOD_CK2_1	19	25	PF00069	0.623
MOD_CK2_1	214	220	PF00069	0.423
MOD_CK2_1	292	298	PF00069	0.521
MOD_CK2_1	43	49	PF00069	0.585
MOD_CK2_1	437	443	PF00069	0.735
MOD_CK2_1	460	466	PF00069	0.660
MOD_CK2_1	627	633	PF00069	0.679
MOD_CK2_1	671	677	PF00069	0.698
MOD_CK2_1	69	75	PF00069	0.594
MOD_CMANNOS	216	219	PF00535	0.467
MOD_GlcNHglycan	118	121	PF01048	0.618
MOD_GlcNHglycan	124	127	PF01048	0.599
MOD_GlcNHglycan	154	157	PF01048	0.740
MOD_GlcNHglycan	21	24	PF01048	0.754
MOD_GlcNHglycan	405	408	PF01048	0.270
MOD_GlcNHglycan	440	443	PF01048	0.461
MOD_GlcNHglycan	542	546	PF01048	0.608
MOD_GlcNHglycan	575	578	PF01048	0.736
MOD_GlcNHglycan	611	614	PF01048	0.630
MOD_GlcNHglycan	646	649	PF01048	0.692
MOD_GlcNHglycan	74	79	PF01048	0.700
MOD_GSK3_1	11	18	PF00069	0.717
MOD_GSK3_1	116	123	PF00069	0.599
MOD_GSK3_1	124	131	PF00069	0.573
MOD_GSK3_1	198	205	PF00069	0.709
MOD_GSK3_1	24	31	PF00069	0.748
MOD_GSK3_1	393	400	PF00069	0.523
MOD_GSK3_1	427	434	PF00069	0.630
MOD_GSK3_1	43	50	PF00069	0.648
MOD_GSK3_1	520	527	PF00069	0.702
MOD_GSK3_1	528	535	PF00069	0.672
MOD_GSK3_1	537	544	PF00069	0.723
MOD_GSK3_1	55	62	PF00069	0.627
MOD_GSK3_1	571	578	PF00069	0.635
MOD_GSK3_1	604	611	PF00069	0.769
MOD_GSK3_1	638	645	PF00069	0.641
MOD_GSK3_1	655	662	PF00069	0.614
MOD_GSK3_1	81	88	PF00069	0.693
MOD_N-GLC_1	255	260	PF02516	0.413
MOD_N-GLC_1	554	559	PF02516	0.770
MOD_N-GLC_1	599	604	PF02516	0.581
MOD_N-GLC_1	627	632	PF02516	0.450
MOD_N-GLC_2	279	281	PF02516	0.497
MOD_NEK2_1	129	134	PF00069	0.575
MOD_NEK2_1	152	157	PF00069	0.722
MOD_NEK2_1	255	260	PF00069	0.420
MOD_NEK2_1	437	442	PF00069	0.715
MOD_NEK2_1	460	465	PF00069	0.443
MOD_NEK2_1	533	538	PF00069	0.706
MOD_NEK2_1	54	59	PF00069	0.750
MOD_NEK2_1	575	580	PF00069	0.704
MOD_NEK2_1	638	643	PF00069	0.642
MOD_NEK2_1	656	661	PF00069	0.558
MOD_NEK2_1	671	676	PF00069	0.739
MOD_NEK2_1	85	90	PF00069	0.795
MOD_PIKK_1	15	21	PF00454	0.588
MOD_PIKK_1	225	231	PF00454	0.396
MOD_PIKK_1	47	53	PF00454	0.753
MOD_PIKK_1	589	595	PF00454	0.716
MOD_PIKK_1	599	605	PF00454	0.470
MOD_PIKK_1	642	648	PF00454	0.648
MOD_PIKK_1	671	677	PF00454	0.718
MOD_PKA_2	258	264	PF00069	0.390
MOD_PKA_2	475	481	PF00069	0.502
MOD_PKA_2	497	503	PF00069	0.676
MOD_PKA_2	536	542	PF00069	0.516
MOD_PKA_2	80	86	PF00069	0.700
MOD_PKB_1	41	49	PF00069	0.792
MOD_PKB_1	586	594	PF00069	0.509
MOD_Plk_1	164	170	PF00069	0.688
MOD_Plk_1	460	466	PF00069	0.470
MOD_Plk_1	541	547	PF00069	0.732
MOD_Plk_1	599	605	PF00069	0.613
MOD_Plk_1	656	662	PF00069	0.637
MOD_Plk_1	81	87	PF00069	0.653
MOD_Plk_4	28	34	PF00069	0.495
MOD_Plk_4	292	298	PF00069	0.521
MOD_Plk_4	346	352	PF00069	0.512
MOD_Plk_4	521	527	PF00069	0.488
MOD_Plk_4	580	586	PF00069	0.515
MOD_Plk_4	638	644	PF00069	0.617
MOD_ProDKin_1	141	147	PF00069	0.733
MOD_ProDKin_1	172	178	PF00069	0.622
MOD_ProDKin_1	198	204	PF00069	0.510
MOD_ProDKin_1	307	313	PF00069	0.434
MOD_ProDKin_1	508	514	PF00069	0.607
MOD_ProDKin_1	563	569	PF00069	0.710
MOD_ProDKin_1	604	610	PF00069	0.641
TRG_DiLeu_BaEn_1	158	163	PF01217	0.485
TRG_DiLeu_BaEn_1	466	471	PF01217	0.621
TRG_DiLeu_BaLyEn_6	480	485	PF01217	0.506
TRG_ENDOCYTIC_2	275	278	PF00928	0.440
TRG_ENDOCYTIC_2	300	303	PF00928	0.383
TRG_ENDOCYTIC_2	367	370	PF00928	0.533
TRG_ENDOCYTIC_2	668	671	PF00928	0.763
TRG_ER_diArg_1	41	44	PF00400	0.744
TRG_ER_diArg_1	447	449	PF00400	0.758
TRG_ER_diArg_1	508	510	PF00400	0.563
TRG_ER_diArg_1	560	563	PF00400	0.650
TRG_ER_diArg_1	585	588	PF00400	0.516
TRG_ER_diArg_1	701	704	PF00400	0.533
TRG_NES_CRM1_1	220	235	PF08389	0.485
TRG_NES_CRM1_1	415	425	PF08389	0.311
TRG_NES_CRM1_1	458	473	PF08389	0.630
TRG_NLS_MonoExtN_4	38	44	PF00514	0.781
TRG_Pf-PMV_PEXEL_1	224	229	PF00026	0.472
TRG_Pf-PMV_PEXEL_1	368	373	PF00026	0.580

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I334	Leptomonas seymouri	48%	80%
A0A1X0P7D2	Trypanosomatidae	30%	82%
A0A3Q8IBC8	Leishmania donovani	72%	96%
A0A422P3D4	Trypanosoma rangeli	31%	90%
A4HY75	Leishmania infantum	71%	96%
E9AS05	Leishmania mexicana (strain MHOM/GT/2001/U1103)	71%	79%
Q4QDG8	Leishmania major	71%	100%
V5BBW9	Trypanosoma cruzi	33%	90%