Calmodulin

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Calmodulin

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HA10_LEIBR

TriTrypDb:

LbrM.19.0840 , LBRM2903_190013100

Length:

600

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HA10

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HA10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	501	505	PF00656	0.537
CLV_C14_Caspase3-7	81	85	PF00656	0.582
CLV_NRD_NRD_1	170	172	PF00675	0.613
CLV_NRD_NRD_1	207	209	PF00675	0.437
CLV_NRD_NRD_1	224	226	PF00675	0.430
CLV_NRD_NRD_1	245	247	PF00675	0.461
CLV_NRD_NRD_1	296	298	PF00675	0.385
CLV_NRD_NRD_1	328	330	PF00675	0.552
CLV_NRD_NRD_1	412	414	PF00675	0.511
CLV_NRD_NRD_1	469	471	PF00675	0.426
CLV_NRD_NRD_1	483	485	PF00675	0.341
CLV_PCSK_FUR_1	167	171	PF00082	0.685
CLV_PCSK_FUR_1	222	226	PF00082	0.331
CLV_PCSK_FUR_1	467	471	PF00082	0.502
CLV_PCSK_KEX2_1	169	171	PF00082	0.679
CLV_PCSK_KEX2_1	206	208	PF00082	0.445
CLV_PCSK_KEX2_1	224	226	PF00082	0.430
CLV_PCSK_KEX2_1	296	298	PF00082	0.385
CLV_PCSK_KEX2_1	328	330	PF00082	0.567
CLV_PCSK_KEX2_1	464	466	PF00082	0.471
CLV_PCSK_KEX2_1	469	471	PF00082	0.435
CLV_PCSK_KEX2_1	483	485	PF00082	0.329
CLV_PCSK_KEX2_1	549	551	PF00082	0.356
CLV_PCSK_KEX2_1	571	573	PF00082	0.401
CLV_PCSK_PC1ET2_1	169	171	PF00082	0.623
CLV_PCSK_PC1ET2_1	464	466	PF00082	0.321
CLV_PCSK_PC1ET2_1	549	551	PF00082	0.356
CLV_PCSK_PC1ET2_1	571	573	PF00082	0.408
CLV_PCSK_PC7_1	292	298	PF00082	0.307
CLV_PCSK_PC7_1	465	471	PF00082	0.331
CLV_PCSK_SKI1_1	201	205	PF00082	0.409
CLV_PCSK_SKI1_1	256	260	PF00082	0.479
CLV_PCSK_SKI1_1	357	361	PF00082	0.660
CLV_PCSK_SKI1_1	430	434	PF00082	0.481
CLV_PCSK_SKI1_1	439	443	PF00082	0.456
CLV_PCSK_SKI1_1	469	473	PF00082	0.404
CLV_PCSK_SKI1_1	591	595	PF00082	0.677
DEG_APCC_DBOX_1	235	243	PF00400	0.394
DOC_CDC14_PxL_1	1	9	PF14671	0.448
DOC_CKS1_1	395	400	PF01111	0.493
DOC_CKS1_1	535	540	PF01111	0.478
DOC_CYCLIN_RxL_1	354	364	PF00134	0.543
DOC_MAPK_gen_1	124	133	PF00069	0.463
DOC_MAPK_gen_1	428	436	PF00069	0.468
DOC_MAPK_gen_1	552	561	PF00069	0.647
DOC_MAPK_gen_1	569	576	PF00069	0.614
DOC_MAPK_MEF2A_6	455	463	PF00069	0.500
DOC_PP1_RVXF_1	283	290	PF00149	0.374
DOC_PP1_RVXF_1	412	419	PF00149	0.557
DOC_PP4_FxxP_1	155	158	PF00568	0.656
DOC_USP7_MATH_1	23	27	PF00917	0.455
DOC_USP7_MATH_1	30	34	PF00917	0.444
DOC_USP7_MATH_1	482	486	PF00917	0.511
DOC_USP7_MATH_1	61	65	PF00917	0.580
DOC_USP7_UBL2_3	247	251	PF12436	0.472
DOC_USP7_UBL2_3	435	439	PF12436	0.384
DOC_USP7_UBL2_3	440	444	PF12436	0.374
DOC_WW_Pin1_4	394	399	PF00397	0.500
DOC_WW_Pin1_4	41	46	PF00397	0.707
DOC_WW_Pin1_4	534	539	PF00397	0.527
LIG_14-3-3_CanoR_1	21	31	PF00244	0.459
LIG_14-3-3_CanoR_1	483	489	PF00244	0.453
LIG_14-3-3_CanoR_1	555	560	PF00244	0.534
LIG_14-3-3_CanoR_1	591	596	PF00244	0.567
LIG_BIR_II_1	1	5	PF00653	0.445
LIG_BRCT_BRCA1_1	32	36	PF00533	0.672
LIG_BRCT_BRCA1_1	321	325	PF00533	0.419
LIG_BRCT_BRCA1_1	453	457	PF00533	0.394
LIG_BRCT_BRCA1_1	8	12	PF00533	0.456
LIG_CaM_IQ_9	223	238	PF13499	0.502
LIG_CaM_IQ_9	280	296	PF13499	0.402
LIG_FHA_1	103	109	PF00498	0.488
LIG_FHA_1	257	263	PF00498	0.532
LIG_FHA_1	406	412	PF00498	0.614
LIG_FHA_1	431	437	PF00498	0.425
LIG_FHA_1	58	64	PF00498	0.627
LIG_FHA_1	592	598	PF00498	0.507
LIG_FHA_2	212	218	PF00498	0.479
LIG_FHA_2	340	346	PF00498	0.710
LIG_FHA_2	371	377	PF00498	0.497
LIG_FHA_2	394	400	PF00498	0.460
LIG_FHA_2	57	63	PF00498	0.544
LIG_FHA_2	79	85	PF00498	0.496
LIG_Integrin_isoDGR_2	16	18	PF01839	0.454
LIG_LIR_Apic_2	153	158	PF02991	0.531
LIG_LIR_Gen_1	528	536	PF02991	0.527
LIG_LIR_Gen_1	553	562	PF02991	0.431
LIG_LIR_Nem_3	115	121	PF02991	0.494
LIG_LIR_Nem_3	139	143	PF02991	0.578
LIG_LIR_Nem_3	146	152	PF02991	0.567
LIG_LIR_Nem_3	197	203	PF02991	0.479
LIG_LIR_Nem_3	454	460	PF02991	0.347
LIG_MLH1_MIPbox_1	321	325	PF16413	0.419
LIG_PCNA_yPIPBox_3	188	200	PF02747	0.457
LIG_PDZ_Class_1	595	600	PF00595	0.486
LIG_Pex14_1	327	331	PF04695	0.439
LIG_SH2_CRK	118	122	PF00017	0.495
LIG_SH2_CRK	278	282	PF00017	0.311
LIG_SH2_NCK_1	144	148	PF00017	0.440
LIG_SH2_SRC	144	147	PF00017	0.618
LIG_SH2_SRC	578	581	PF00017	0.659
LIG_SH2_STAP1	152	156	PF00017	0.595
LIG_SH2_STAP1	278	282	PF00017	0.495
LIG_SH2_STAT5	152	155	PF00017	0.570
LIG_SH2_STAT5	257	260	PF00017	0.475
LIG_SH2_STAT5	290	293	PF00017	0.370
LIG_SH2_STAT5	324	327	PF00017	0.434
LIG_SH2_STAT5	445	448	PF00017	0.423
LIG_SH2_STAT5	460	463	PF00017	0.386
LIG_SH2_STAT5	575	578	PF00017	0.545
LIG_SH3_3	144	150	PF00018	0.514
LIG_SH3_3	151	157	PF00018	0.581
LIG_SH3_3	362	368	PF00018	0.596
LIG_SH3_3	532	538	PF00018	0.522
LIG_SH3_3	590	596	PF00018	0.498
LIG_SUMO_SIM_anti_2	67	73	PF11976	0.474
LIG_TRAF2_1	372	375	PF00917	0.395
LIG_TYR_ITIM	116	121	PF00017	0.471
LIG_UBA3_1	31	37	PF00899	0.473
LIG_WW_1	538	541	PF00397	0.396
LIG_WW_3	164	168	PF00397	0.590
MOD_CK1_1	26	32	PF00069	0.408
MOD_CK1_1	44	50	PF00069	0.505
MOD_CK1_1	6	12	PF00069	0.454
MOD_CK1_1	64	70	PF00069	0.478
MOD_CK2_1	211	217	PF00069	0.456
MOD_CK2_1	339	345	PF00069	0.473
MOD_CK2_1	370	376	PF00069	0.488
MOD_CK2_1	393	399	PF00069	0.501
MOD_GlcNHglycan	25	28	PF01048	0.454
MOD_GlcNHglycan	386	390	PF01048	0.400
MOD_GlcNHglycan	504	508	PF01048	0.548
MOD_GlcNHglycan	72	75	PF01048	0.508
MOD_GSK3_1	22	29	PF00069	0.459
MOD_GSK3_1	31	38	PF00069	0.713
MOD_GSK3_1	315	322	PF00069	0.393
MOD_GSK3_1	426	433	PF00069	0.446
MOD_GSK3_1	435	442	PF00069	0.387
MOD_GSK3_1	57	64	PF00069	0.710
MOD_GSK3_1	591	598	PF00069	0.506
MOD_GSK3_1	84	91	PF00069	0.494
MOD_N-GLC_1	355	360	PF02516	0.446
MOD_N-GLC_1	56	61	PF02516	0.582
MOD_NEK2_1	12	17	PF00069	0.448
MOD_NEK2_1	120	125	PF00069	0.633
MOD_NEK2_1	31	36	PF00069	0.474
MOD_NEK2_1	393	398	PF00069	0.552
MOD_NEK2_1	426	431	PF00069	0.539
MOD_NEK2_1	503	508	PF00069	0.539
MOD_NEK2_2	150	155	PF00069	0.447
MOD_PIKK_1	370	376	PF00454	0.599
MOD_PIKK_1	44	50	PF00454	0.518
MOD_PIKK_1	472	478	PF00454	0.369
MOD_PKA_1	439	445	PF00069	0.369
MOD_PKA_1	469	475	PF00069	0.336
MOD_PKA_2	469	475	PF00069	0.513
MOD_PKA_2	482	488	PF00069	0.411
MOD_PKB_1	467	475	PF00069	0.518
MOD_Plk_1	194	200	PF00069	0.514
MOD_Plk_1	355	361	PF00069	0.447
MOD_Plk_1	503	509	PF00069	0.322
MOD_Plk_2-3	78	84	PF00069	0.494
MOD_Plk_4	150	156	PF00069	0.467
MOD_Plk_4	31	37	PF00069	0.473
MOD_Plk_4	319	325	PF00069	0.420
MOD_ProDKin_1	394	400	PF00069	0.493
MOD_ProDKin_1	41	47	PF00069	0.708
MOD_ProDKin_1	534	540	PF00069	0.531
MOD_SUMO_for_1	548	551	PF00179	0.359
MOD_SUMO_rev_2	399	408	PF00179	0.588
MOD_SUMO_rev_2	485	489	PF00179	0.400
TRG_ENDOCYTIC_2	118	121	PF00928	0.498
TRG_ENDOCYTIC_2	144	147	PF00928	0.613
TRG_ENDOCYTIC_2	152	155	PF00928	0.648
TRG_ENDOCYTIC_2	278	281	PF00928	0.406
TRG_ENDOCYTIC_2	460	463	PF00928	0.347
TRG_ENDOCYTIC_2	529	532	PF00928	0.542
TRG_ENDOCYTIC_2	541	544	PF00928	0.480
TRG_ER_diArg_1	170	173	PF00400	0.667
TRG_ER_diArg_1	206	208	PF00400	0.445
TRG_ER_diArg_1	222	225	PF00400	0.426
TRG_ER_diArg_1	237	240	PF00400	0.427
TRG_ER_diArg_1	327	329	PF00400	0.506
TRG_ER_diArg_1	465	468	PF00400	0.469
TRG_ER_diArg_1	478	481	PF00400	0.417
TRG_NLS_MonoExtC_3	168	173	PF00514	0.599
TRG_NLS_MonoExtN_4	166	173	PF00514	0.595
TRG_Pf-PMV_PEXEL_1	207	211	PF00026	0.398
TRG_Pf-PMV_PEXEL_1	213	217	PF00026	0.407
TRG_Pf-PMV_PEXEL_1	357	361	PF00026	0.660
TRG_Pf-PMV_PEXEL_1	439	443	PF00026	0.521
TRG_Pf-PMV_PEXEL_1	500	504	PF00026	0.485

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I9S0	Leptomonas seymouri	47%	100%
A0A1X0P7R9	Trypanosomatidae	31%	100%
A0A3S7WVD7	Leishmania donovani	67%	100%
A0A422P367	Trypanosoma rangeli	35%	100%
A4HY74	Leishmania infantum	69%	100%
D0A0J3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9AS04	Leishmania mexicana (strain MHOM/GT/2001/U1103)	63%	100%
Q4QDG9	Leishmania major	65%	100%
V5BSD1	Trypanosoma cruzi	34%	100%