Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HA08_LEIBR

TriTrypDb:

LbrM.19.0820 , LBRM2903_190012900

Length:

299

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HA08

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HA08

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	217	221	PF00656	0.734
CLV_NRD_NRD_1	106	108	PF00675	0.622
CLV_NRD_NRD_1	215	217	PF00675	0.755
CLV_NRD_NRD_1	42	44	PF00675	0.540
CLV_NRD_NRD_1	75	77	PF00675	0.525
CLV_NRD_NRD_1	93	95	PF00675	0.531
CLV_PCSK_KEX2_1	106	108	PF00082	0.605
CLV_PCSK_KEX2_1	215	217	PF00082	0.758
CLV_PCSK_KEX2_1	41	43	PF00082	0.544
CLV_PCSK_KEX2_1	74	76	PF00082	0.575
CLV_PCSK_KEX2_1	93	95	PF00082	0.459
CLV_PCSK_PC7_1	211	217	PF00082	0.797
CLV_PCSK_PC7_1	70	76	PF00082	0.466
CLV_PCSK_SKI1_1	144	148	PF00082	0.555
DEG_APCC_DBOX_1	150	158	PF00400	0.590
DEG_APCC_DBOX_1	83	91	PF00400	0.557
DEG_Nend_UBRbox_2	1	3	PF02207	0.720
DOC_ANK_TNKS_1	215	222	PF00023	0.560
DOC_MIT_MIM_1	162	171	PF04212	0.557
DOC_PP4_FxxP_1	117	120	PF00568	0.606
DOC_USP7_MATH_1	241	245	PF00917	0.719
DOC_USP7_UBL2_3	57	61	PF12436	0.563
DOC_WW_Pin1_4	192	197	PF00397	0.631
DOC_WW_Pin1_4	225	230	PF00397	0.763
DOC_WW_Pin1_4	234	239	PF00397	0.719
DOC_WW_Pin1_4	9	14	PF00397	0.615
LIG_14-3-3_CterR_2	294	299	PF00244	0.583
LIG_Actin_WH2_2	170	187	PF00022	0.365
LIG_FHA_1	2	8	PF00498	0.692
LIG_FHA_1	241	247	PF00498	0.519
LIG_FHA_2	121	127	PF00498	0.551
LIG_FHA_2	76	82	PF00498	0.538
LIG_Integrin_RGD_1	218	220	PF01839	0.561
LIG_IRF3_LxIS_1	292	298	PF10401	0.550
LIG_LIR_Apic_2	115	120	PF02991	0.637
LIG_LIR_Gen_1	164	174	PF02991	0.492
LIG_LIR_Nem_3	16	22	PF02991	0.534
LIG_LIR_Nem_3	164	170	PF02991	0.481
LIG_NRBOX	34	40	PF00104	0.587
LIG_SH2_PTP2	22	25	PF00017	0.629
LIG_SH2_STAT5	22	25	PF00017	0.629
LIG_SH3_1	22	28	PF00018	0.629
LIG_SH3_3	22	28	PF00018	0.629
LIG_SH3_3	63	69	PF00018	0.652
LIG_SH3_4	57	64	PF00018	0.594
LIG_TRAF2_1	101	104	PF00917	0.667
LIG_TRAF2_1	77	80	PF00917	0.502
MOD_CK1_1	194	200	PF00069	0.717
MOD_CK1_1	26	32	PF00069	0.618
MOD_CK1_1	88	94	PF00069	0.547
MOD_CK2_1	120	126	PF00069	0.562
MOD_CK2_1	260	266	PF00069	0.617
MOD_CK2_1	75	81	PF00069	0.512
MOD_GlcNHglycan	196	199	PF01048	0.629
MOD_GSK3_1	210	217	PF00069	0.793
MOD_GSK3_1	221	228	PF00069	0.706
MOD_GSK3_1	23	30	PF00069	0.624
MOD_GSK3_1	273	280	PF00069	0.524
MOD_GSK3_1	88	95	PF00069	0.421
MOD_N-GLC_1	221	226	PF02516	0.560
MOD_N-GLC_1	88	93	PF02516	0.423
MOD_NEK2_1	1	6	PF00069	0.700
MOD_PKA_1	75	81	PF00069	0.546
MOD_PKA_2	115	121	PF00069	0.598
MOD_PKA_2	210	216	PF00069	0.741
MOD_PKA_2	260	266	PF00069	0.510
MOD_PKA_2	75	81	PF00069	0.512
MOD_PKA_2	85	91	PF00069	0.528
MOD_PKA_2	92	98	PF00069	0.540
MOD_Plk_1	1	7	PF00069	0.698
MOD_Plk_1	221	227	PF00069	0.559
MOD_Plk_1	290	296	PF00069	0.433
MOD_Plk_4	277	283	PF00069	0.537
MOD_ProDKin_1	192	198	PF00069	0.632
MOD_ProDKin_1	225	231	PF00069	0.761
MOD_ProDKin_1	234	240	PF00069	0.716
MOD_ProDKin_1	9	15	PF00069	0.603
TRG_DiLeu_BaEn_1	34	39	PF01217	0.477
TRG_ER_diArg_1	151	154	PF00400	0.553
TRG_ER_diArg_1	215	218	PF00400	0.556
TRG_ER_diArg_1	41	43	PF00400	0.591
TRG_ER_diArg_1	68	71	PF00400	0.581
TRG_ER_diArg_1	73	76	PF00400	0.555
TRG_Pf-PMV_PEXEL_1	107	111	PF00026	0.473
TRG_Pf-PMV_PEXEL_1	171	175	PF00026	0.507

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMK6	Leptomonas seymouri	61%	98%
A0A3S5H756	Leishmania donovani	80%	100%
A4HY72	Leishmania infantum	80%	100%
D0A0J1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E9AS02	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
Q4QDH1	Leishmania major	80%	100%
V5DTM1	Trypanosoma cruzi	38%	100%