Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HA07_LEIBR

TriTrypDb:

LbrM.19.0810 , LBRM2903_190012800

Length:

214

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11
GO:0005635	nuclear envelope	4	1
GO:0005783	endoplasmic reticulum	5	1
GO:0020016	ciliary pocket	2	1
GO:0031967	organelle envelope	3	1
GO:0031975	envelope	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A4HA07

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HA07

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	181	183	PF00675	0.265
CLV_NRD_NRD_1	203	205	PF00675	0.434
CLV_NRD_NRD_1	39	41	PF00675	0.429
CLV_NRD_NRD_1	80	82	PF00675	0.440
CLV_PCSK_KEX2_1	181	183	PF00082	0.265
CLV_PCSK_KEX2_1	203	205	PF00082	0.352
CLV_PCSK_KEX2_1	39	41	PF00082	0.470
CLV_PCSK_PC7_1	199	205	PF00082	0.422
CLV_PCSK_PC7_1	35	41	PF00082	0.492
CLV_PCSK_SKI1_1	195	199	PF00082	0.267
CLV_PCSK_SKI1_1	23	27	PF00082	0.458
CLV_PCSK_SKI1_1	40	44	PF00082	0.495
DEG_APCC_DBOX_1	3	11	PF00400	0.719
DEG_Nend_Nbox_1	1	3	PF02207	0.665
DOC_CYCLIN_RxL_1	20	29	PF00134	0.567
DOC_MAPK_gen_1	203	211	PF00069	0.534
DOC_MAPK_gen_1	85	93	PF00069	0.596
DOC_MAPK_MEF2A_6	21	28	PF00069	0.611
DOC_PP1_RVXF_1	179	186	PF00149	0.280
DOC_PP4_FxxP_1	103	106	PF00568	0.558
DOC_USP7_MATH_1	15	19	PF00917	0.711
DOC_USP7_MATH_1	47	51	PF00917	0.652
DOC_USP7_MATH_1	98	102	PF00917	0.643
DOC_USP7_UBL2_3	44	48	PF12436	0.694
LIG_14-3-3_CanoR_1	182	188	PF00244	0.441
LIG_14-3-3_CanoR_1	23	29	PF00244	0.740
LIG_14-3-3_CanoR_1	4	8	PF00244	0.678
LIG_Actin_WH2_2	21	37	PF00022	0.712
LIG_deltaCOP1_diTrp_1	145	154	PF00928	0.252
LIG_FHA_1	20	26	PF00498	0.599
LIG_FHA_2	41	47	PF00498	0.731
LIG_FHA_2	84	90	PF00498	0.607
LIG_LIR_Apic_2	101	106	PF02991	0.561
LIG_LIR_Gen_1	167	175	PF02991	0.340
LIG_LIR_Nem_3	167	171	PF02991	0.359
LIG_NRBOX	204	210	PF00104	0.626
LIG_SH2_CRK	160	164	PF00017	0.299
LIG_SH2_CRK	168	172	PF00017	0.410
LIG_SH2_STAP1	168	172	PF00017	0.280
LIG_SH2_STAT5	126	129	PF00017	0.357
LIG_SH2_STAT5	134	137	PF00017	0.281
LIG_SH2_STAT5	160	163	PF00017	0.280
LIG_SH2_STAT5	92	95	PF00017	0.584
LIG_TYR_ITIM	158	163	PF00017	0.399
MOD_CK1_1	14	20	PF00069	0.695
MOD_CK2_1	40	46	PF00069	0.695
MOD_CK2_1	83	89	PF00069	0.631
MOD_Cter_Amidation	179	182	PF01082	0.313
MOD_GlcNHglycan	121	124	PF01048	0.316
MOD_GlcNHglycan	13	16	PF01048	0.466
MOD_GlcNHglycan	28	31	PF01048	0.401
MOD_GlcNHglycan	58	61	PF01048	0.580
MOD_GSK3_1	11	18	PF00069	0.740
MOD_GSK3_1	115	122	PF00069	0.295
MOD_GSK3_1	191	198	PF00069	0.466
MOD_GSK3_1	64	71	PF00069	0.630
MOD_N-GLC_1	15	20	PF02516	0.367
MOD_N-GLC_1	199	204	PF02516	0.376
MOD_NEK2_1	115	120	PF00069	0.349
MOD_NEK2_1	19	24	PF00069	0.643
MOD_NEK2_1	26	31	PF00069	0.759
MOD_NEK2_2	98	103	PF00069	0.646
MOD_PIKK_1	68	74	PF00454	0.712
MOD_PKA_2	3	9	PF00069	0.640
MOD_Plk_1	15	21	PF00069	0.569
MOD_Plk_4	166	172	PF00069	0.295
MOD_Plk_4	98	104	PF00069	0.589
TRG_DiLeu_BaLyEn_6	21	26	PF01217	0.567
TRG_ENDOCYTIC_2	156	159	PF00928	0.247
TRG_ENDOCYTIC_2	160	163	PF00928	0.280
TRG_ENDOCYTIC_2	168	171	PF00928	0.280
TRG_ER_diArg_1	181	183	PF00400	0.445
TRG_ER_diArg_1	203	205	PF00400	0.633

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PE20	Leptomonas seymouri	77%	100%
A0A0S4IUQ3	Bodo saltans	47%	100%
A0A1X0P6B8	Trypanosomatidae	61%	100%
A0A3R7KYF8	Trypanosoma rangeli	62%	100%
A0A3S7WVB3	Leishmania donovani	88%	100%
A4HY71	Leishmania infantum	87%	100%
D0A0J0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	58%	100%
E9AS01	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	75%
Q4QDH2	Leishmania major	88%	100%
V5DTP2	Trypanosoma cruzi	58%	100%