Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4HA06_LEIBR

TriTrypDb:

LbrM.19.0800 , LBRM2903_190012700

Length:

262

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	4
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

A4HA06

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HA06

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	20	22	PF00675	0.491
CLV_NRD_NRD_1	232	234	PF00675	0.462
CLV_NRD_NRD_1	250	252	PF00675	0.472
CLV_NRD_NRD_1	259	261	PF00675	0.504
CLV_NRD_NRD_1	35	37	PF00675	0.621
CLV_PCSK_KEX2_1	20	22	PF00082	0.491
CLV_PCSK_KEX2_1	200	202	PF00082	0.618
CLV_PCSK_KEX2_1	232	234	PF00082	0.462
CLV_PCSK_KEX2_1	250	252	PF00082	0.472
CLV_PCSK_KEX2_1	259	261	PF00082	0.504
CLV_PCSK_KEX2_1	35	37	PF00082	0.621
CLV_PCSK_PC1ET2_1	200	202	PF00082	0.618
CLV_PCSK_PC7_1	255	261	PF00082	0.403
CLV_PCSK_SKI1_1	172	176	PF00082	0.377
CLV_PCSK_SKI1_1	200	204	PF00082	0.620
CLV_Separin_Metazoa	54	58	PF03568	0.631
DEG_APCC_DBOX_1	121	129	PF00400	0.579
DEG_APCC_DBOX_1	249	257	PF00400	0.744
DEG_Nend_Nbox_1	1	3	PF02207	0.719
DEG_SPOP_SBC_1	25	29	PF00917	0.637
DOC_CYCLIN_RxL_1	197	207	PF00134	0.498
DOC_MAPK_DCC_7	9	18	PF00069	0.629
DOC_MAPK_gen_1	119	128	PF00069	0.579
DOC_MAPK_RevD_3	245	260	PF00069	0.668
DOC_PP2B_LxvP_1	150	153	PF13499	0.722
DOC_PP2B_LxvP_1	56	59	PF13499	0.638
DOC_USP7_MATH_1	25	29	PF00917	0.693
DOC_USP7_MATH_1	34	38	PF00917	0.644
DOC_WW_Pin1_4	117	122	PF00397	0.753
DOC_WW_Pin1_4	86	91	PF00397	0.751
LIG_14-3-3_CanoR_1	159	168	PF00244	0.499
LIG_14-3-3_CanoR_1	250	254	PF00244	0.675
LIG_14-3-3_CanoR_1	35	39	PF00244	0.715
LIG_14-3-3_CanoR_1	43	51	PF00244	0.756
LIG_BRCT_BRCA1_1	219	223	PF00533	0.338
LIG_EH1_1	60	68	PF00400	0.630
LIG_FHA_1	110	116	PF00498	0.666
LIG_FHA_1	160	166	PF00498	0.499
LIG_FHA_1	206	212	PF00498	0.499
LIG_FHA_1	25	31	PF00498	0.695
LIG_FHA_1	51	57	PF00498	0.731
LIG_FHA_2	171	177	PF00498	0.274
LIG_FHA_2	43	49	PF00498	0.810
LIG_LIR_Gen_1	173	183	PF02991	0.404
LIG_LIR_Nem_3	171	177	PF02991	0.456
LIG_LIR_Nem_3	181	187	PF02991	0.417
LIG_Pex14_1	188	192	PF04695	0.457
LIG_Pex14_2	219	223	PF04695	0.402
LIG_SH2_PTP2	246	249	PF00017	0.740
LIG_SH2_SRC	246	249	PF00017	0.579
LIG_SH2_STAT5	169	172	PF00017	0.424
LIG_SH2_STAT5	246	249	PF00017	0.740
LIG_SH2_STAT5	52	55	PF00017	0.730
LIG_SH3_3	102	108	PF00018	0.783
LIG_SUMO_SIM_anti_2	148	153	PF11976	0.729
LIG_TRAF2_1	153	156	PF00917	0.597
LIG_TRAF2_1	45	48	PF00917	0.648
LIG_TYR_ITIM	182	187	PF00017	0.540
LIG_UBA3_1	164	172	PF00899	0.274
LIG_WRC_WIRS_1	216	221	PF05994	0.402
MOD_CDK_SPK_2	117	122	PF00069	0.705
MOD_CK1_1	37	43	PF00069	0.596
MOD_CK2_1	117	123	PF00069	0.476
MOD_CK2_1	42	48	PF00069	0.784
MOD_Cter_Amidation	230	233	PF01082	0.567
MOD_GlcNHglycan	225	228	PF01048	0.469
MOD_GlcNHglycan	83	86	PF01048	0.676
MOD_GSK3_1	37	44	PF00069	0.707
MOD_N-GLC_1	117	122	PF02516	0.480
MOD_NEK2_1	128	133	PF00069	0.664
MOD_NEK2_1	168	173	PF00069	0.402
MOD_NEK2_1	215	220	PF00069	0.450
MOD_NEK2_1	223	228	PF00069	0.495
MOD_PKA_2	249	255	PF00069	0.491
MOD_PKA_2	34	40	PF00069	0.703
MOD_PKA_2	42	48	PF00069	0.744
MOD_Plk_1	194	200	PF00069	0.453
MOD_Plk_4	145	151	PF00069	0.592
MOD_Plk_4	170	176	PF00069	0.274
MOD_Plk_4	194	200	PF00069	0.522
MOD_Plk_4	62	68	PF00069	0.756
MOD_ProDKin_1	117	123	PF00069	0.701
MOD_ProDKin_1	86	92	PF00069	0.699
TRG_DiLeu_BaLyEn_6	198	203	PF01217	0.635
TRG_ENDOCYTIC_2	184	187	PF00928	0.537
TRG_ER_diArg_1	20	22	PF00400	0.637
TRG_ER_diArg_1	249	251	PF00400	0.598
TRG_ER_diArg_1	34	36	PF00400	0.571

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8L3	Leptomonas seymouri	51%	99%
A0A3Q8IJZ2	Leishmania donovani	68%	100%
A4HY70	Leishmania infantum	68%	100%