Putative nuclear cap binding complex subunit CBP30

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

nuclear cap binding complex subunit CBP30, putative

Species:

Leishmania braziliensis

UniProt:

A4HA05_LEIBR

TriTrypDb:

LbrM.19.0790 , LBRM2903_190012600

Length:

357

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005846	nuclear cap binding complex	3	11
GO:0032991	protein-containing complex	1	11
GO:0034518	RNA cap binding complex	2	11
GO:0140535	intracellular protein-containing complex	2	11
GO:0005634	nucleus	5	1
GO:0005654	nucleoplasm	2	1
GO:0005730	nucleolus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HA05

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HA05

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	104	106	PF00675	0.410
CLV_NRD_NRD_1	316	318	PF00675	0.393
CLV_NRD_NRD_1	43	45	PF00675	0.276
CLV_PCSK_KEX2_1	104	106	PF00082	0.295
CLV_PCSK_KEX2_1	303	305	PF00082	0.399
CLV_PCSK_KEX2_1	316	318	PF00082	0.267
CLV_PCSK_PC1ET2_1	303	305	PF00082	0.268
CLV_PCSK_SKI1_1	296	300	PF00082	0.317
CLV_PCSK_SKI1_1	61	65	PF00082	0.279
DOC_CKS1_1	22	27	PF01111	0.279
DOC_CYCLIN_RxL_1	31	39	PF00134	0.347
DOC_CYCLIN_yCln2_LP_2	22	28	PF00134	0.297
DOC_MAPK_DCC_7	236	245	PF00069	0.355
DOC_MAPK_FxFP_2	205	208	PF00069	0.279
DOC_MAPK_gen_1	293	301	PF00069	0.197
DOC_MAPK_gen_1	44	53	PF00069	0.255
DOC_PP2B_LxvP_1	159	162	PF13499	0.197
DOC_PP2B_LxvP_1	299	302	PF13499	0.307
DOC_PP2B_PxIxI_1	219	225	PF00149	0.355
DOC_PP4_FxxP_1	205	208	PF00568	0.279
DOC_USP7_MATH_1	162	166	PF00917	0.351
DOC_USP7_MATH_1	192	196	PF00917	0.442
DOC_USP7_MATH_1	284	288	PF00917	0.355
DOC_USP7_UBL2_3	296	300	PF12436	0.197
DOC_WW_Pin1_4	118	123	PF00397	0.456
DOC_WW_Pin1_4	21	26	PF00397	0.279
DOC_WW_Pin1_4	238	243	PF00397	0.297
LIG_14-3-3_CanoR_1	263	270	PF00244	0.410
LIG_14-3-3_CanoR_1	34	39	PF00244	0.197
LIG_14-3-3_CanoR_1	66	70	PF00244	0.317
LIG_Actin_WH2_2	340	357	PF00022	0.410
LIG_BIR_II_1	1	5	PF00653	0.749
LIG_BRCT_BRCA1_1	265	269	PF00533	0.410
LIG_CtBP_PxDLS_1	54	58	PF00389	0.410
LIG_DLG_GKlike_1	265	273	PF00625	0.410
LIG_DLG_GKlike_1	34	41	PF00625	0.197
LIG_FHA_1	147	153	PF00498	0.215
LIG_FHA_1	178	184	PF00498	0.297
LIG_FHA_1	33	39	PF00498	0.412
LIG_FHA_2	22	28	PF00498	0.382
LIG_FHA_2	223	229	PF00498	0.369
LIG_FHA_2	242	248	PF00498	0.366
LIG_FHA_2	330	336	PF00498	0.368
LIG_HCF-1_HBM_1	323	326	PF13415	0.197
LIG_Integrin_RGD_1	317	319	PF01839	0.197
LIG_LIR_Apic_2	135	141	PF02991	0.197
LIG_LIR_Gen_1	17	26	PF02991	0.322
LIG_LIR_Nem_3	17	22	PF02991	0.322
LIG_LIR_Nem_3	62	67	PF02991	0.335
LIG_LIR_Nem_3	70	76	PF02991	0.305
LIG_LYPXL_L_2	282	291	PF13949	0.197
LIG_MYND_1	89	93	PF01753	0.297
LIG_Pex14_1	60	64	PF04695	0.279
LIG_SH2_CRK	138	142	PF00017	0.197
LIG_SH2_NCK_1	326	330	PF00017	0.355
LIG_SH2_PTP2	239	242	PF00017	0.322
LIG_SH2_SRC	326	329	PF00017	0.355
LIG_SH2_STAP1	73	77	PF00017	0.378
LIG_SH2_STAT5	239	242	PF00017	0.318
LIG_SH2_STAT5	30	33	PF00017	0.410
LIG_SH3_2	93	98	PF14604	0.355
LIG_SH3_3	137	143	PF00018	0.197
LIG_SH3_3	48	54	PF00018	0.252
LIG_SH3_3	86	92	PF00018	0.279
LIG_SUMO_SIM_anti_2	285	292	PF11976	0.332
LIG_SUMO_SIM_par_1	34	39	PF11976	0.410
LIG_TRAF2_1	225	228	PF00917	0.279
LIG_TRAF2_1	246	249	PF00917	0.287
LIG_TRAF2_1	252	255	PF00917	0.292
LIG_TRAF2_1	332	335	PF00917	0.475
LIG_TRAF2_1	68	71	PF00917	0.355
LIG_WW_2	140	143	PF00397	0.197
MOD_CK1_1	125	131	PF00069	0.366
MOD_CK1_1	165	171	PF00069	0.327
MOD_CK1_1	2	8	PF00069	0.668
MOD_CK1_1	241	247	PF00069	0.396
MOD_CK1_1	312	318	PF00069	0.483
MOD_CK2_1	222	228	PF00069	0.279
MOD_CK2_1	241	247	PF00069	0.335
MOD_CK2_1	329	335	PF00069	0.408
MOD_CK2_1	43	49	PF00069	0.338
MOD_CK2_1	65	71	PF00069	0.355
MOD_GlcNHglycan	128	131	PF01048	0.488
MOD_GlcNHglycan	159	162	PF01048	0.376
MOD_GlcNHglycan	16	19	PF01048	0.280
MOD_GlcNHglycan	170	173	PF01048	0.249
MOD_GlcNHglycan	180	183	PF01048	0.259
MOD_GlcNHglycan	214	217	PF01048	0.311
MOD_GlcNHglycan	38	41	PF01048	0.414
MOD_GSK3_1	118	125	PF00069	0.424
MOD_GSK3_1	143	150	PF00069	0.272
MOD_GSK3_1	164	171	PF00069	0.304
MOD_GSK3_1	178	185	PF00069	0.321
MOD_GSK3_1	259	266	PF00069	0.306
MOD_GSK3_1	28	35	PF00069	0.372
MOD_GSK3_1	308	315	PF00069	0.313
MOD_N-GLC_1	165	170	PF02516	0.441
MOD_NEK2_1	1	6	PF00069	0.770
MOD_NEK2_1	116	121	PF00069	0.487
MOD_NEK2_1	126	131	PF00069	0.460
MOD_NEK2_1	259	264	PF00069	0.279
MOD_NEK2_1	308	313	PF00069	0.197
MOD_NEK2_1	36	41	PF00069	0.410
MOD_PIKK_1	182	188	PF00454	0.344
MOD_PKA_2	14	20	PF00069	0.322
MOD_PKA_2	177	183	PF00069	0.346
MOD_PKA_2	43	49	PF00069	0.408
MOD_PKA_2	65	71	PF00069	0.355
MOD_PKB_1	263	271	PF00069	0.325
MOD_Plk_1	329	335	PF00069	0.301
MOD_Plk_2-3	335	341	PF00069	0.329
MOD_Plk_4	265	271	PF00069	0.357
MOD_Plk_4	55	61	PF00069	0.357
MOD_ProDKin_1	118	124	PF00069	0.456
MOD_ProDKin_1	21	27	PF00069	0.279
MOD_ProDKin_1	238	244	PF00069	0.297
MOD_SUMO_for_1	302	305	PF00179	0.197
TRG_DiLeu_BaEn_4	254	260	PF01217	0.319
TRG_DiLeu_BaEn_4	334	340	PF01217	0.355
TRG_ER_diArg_1	41	44	PF00400	0.277
TRG_NLS_MonoExtC_3	43	49	PF00514	0.385
TRG_NLS_MonoExtN_4	42	48	PF00514	0.385
TRG_Pf-PMV_PEXEL_1	341	345	PF00026	0.436

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMD4	Leptomonas seymouri	57%	100%
A0A1X0P6J9	Trypanosomatidae	42%	100%
A0A3R7N3C2	Trypanosoma rangeli	43%	100%
A0A3S5H755	Leishmania donovani	76%	99%
A4HY69	Leishmania infantum	76%	99%
D0A0I9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9ARZ9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	99%
Q4QDH4	Leishmania major	74%	100%
V5BBW3	Trypanosoma cruzi	39%	100%