WASH_WAHD domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Predicted coiled-coil domain-containing protein (DUF2360), putative

Species:

Leishmania braziliensis

UniProt:

A4HA04_LEIBR

TriTrypDb:

LbrM.19.0780 , LBRM2903_190012500

Length:

286

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0032991	protein-containing complex	1	7
GO:0071203	WASH complex	2	7
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HA04

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HA04

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0006887	exocytosis	4	1
GO:0007015	actin filament organization	5	1
GO:0008154	actin polymerization or depolymerization	6	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0016192	vesicle-mediated transport	4	1
GO:0022607	cellular component assembly	4	1
GO:0030041	actin filament polymerization	7	1
GO:0032940	secretion by cell	3	1
GO:0043933	protein-containing complex organization	4	1
GO:0046903	secretion	4	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051258	protein polymerization	6	1
GO:0065003	protein-containing complex assembly	5	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0097435	supramolecular fiber organization	4	1
GO:0140352	export from cell	2	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	264	268	PF00656	0.497
CLV_NRD_NRD_1	154	156	PF00675	0.400
CLV_NRD_NRD_1	166	168	PF00675	0.255
CLV_PCSK_KEX2_1	154	156	PF00082	0.412
CLV_PCSK_SKI1_1	191	195	PF00082	0.312
DOC_CDC14_PxL_1	197	205	PF14671	0.312
DOC_CKS1_1	263	268	PF01111	0.489
DOC_CYCLIN_yCln2_LP_2	144	150	PF00134	0.303
DOC_CYCLIN_yCln2_LP_2	203	206	PF00134	0.315
DOC_MAPK_JIP1_4	221	227	PF00069	0.312
DOC_PP2B_LxvP_1	144	147	PF13499	0.380
DOC_PP2B_LxvP_1	203	206	PF13499	0.315
DOC_PP2B_LxvP_1	242	245	PF13499	0.312
DOC_SPAK_OSR1_1	27	31	PF12202	0.312
DOC_USP7_MATH_1	148	152	PF00917	0.317
DOC_USP7_MATH_1	175	179	PF00917	0.277
DOC_USP7_UBL2_3	246	250	PF12436	0.231
DOC_WW_Pin1_4	146	151	PF00397	0.340
DOC_WW_Pin1_4	262	267	PF00397	0.513
LIG_14-3-3_CanoR_1	191	196	PF00244	0.321
LIG_14-3-3_CanoR_1	27	36	PF00244	0.338
LIG_14-3-3_CanoR_1	46	54	PF00244	0.415
LIG_CtBP_PxDLS_1	217	221	PF00389	0.312
LIG_FHA_1	192	198	PF00498	0.243
LIG_FHA_1	59	65	PF00498	0.312
LIG_MYND_1	201	205	PF01753	0.312
LIG_Pex14_2	258	262	PF04695	0.388
LIG_Pex14_2	35	39	PF04695	0.312
LIG_SH2_STAP1	17	21	PF00017	0.333
LIG_SH2_STAT5	236	239	PF00017	0.388
LIG_SH3_1	167	173	PF00018	0.311
LIG_SH3_3	144	150	PF00018	0.496
LIG_SH3_3	156	162	PF00018	0.322
LIG_SH3_3	167	173	PF00018	0.334
LIG_SH3_3	195	201	PF00018	0.312
LIG_SH3_3	209	215	PF00018	0.312
LIG_SH3_3	263	269	PF00018	0.509
LIG_SH3_3	279	285	PF00018	0.615
LIG_SH3_5	162	166	PF00018	0.231
LIG_SUMO_SIM_anti_2	194	199	PF11976	0.243
LIG_TRAF2_1	183	186	PF00917	0.312
LIG_TRAF2_1	78	81	PF00917	0.292
LIG_UBA3_1	239	246	PF00899	0.231
LIG_WW_3	169	173	PF00397	0.388
MOD_CK1_1	113	119	PF00069	0.505
MOD_CK1_1	135	141	PF00069	0.237
MOD_CK1_1	4	10	PF00069	0.453
MOD_CK2_1	135	141	PF00069	0.276
MOD_CK2_1	94	100	PF00069	0.231
MOD_GlcNHglycan	155	158	PF01048	0.406
MOD_GlcNHglycan	207	210	PF01048	0.393
MOD_GlcNHglycan	274	277	PF01048	0.601
MOD_GlcNHglycan	70	73	PF01048	0.311
MOD_GSK3_1	135	142	PF00069	0.258
MOD_N-GLC_1	110	115	PF02516	0.248
MOD_N-GLC_1	2	7	PF02516	0.556
MOD_NEK2_1	1	6	PF00069	0.492
MOD_NEK2_1	28	33	PF00069	0.333
MOD_NEK2_1	67	72	PF00069	0.312
MOD_PIKK_1	58	64	PF00454	0.312
MOD_PKA_2	123	129	PF00069	0.331
MOD_PKA_2	153	159	PF00069	0.321
MOD_PKA_2	37	43	PF00069	0.394
MOD_Plk_1	50	56	PF00069	0.388
MOD_Plk_4	139	145	PF00069	0.364
MOD_Plk_4	17	23	PF00069	0.328
MOD_Plk_4	193	199	PF00069	0.231
MOD_ProDKin_1	146	152	PF00069	0.340
MOD_ProDKin_1	262	268	PF00069	0.509
TRG_DiLeu_BaLyEn_6	221	226	PF01217	0.388
TRG_ENDOCYTIC_2	236	239	PF00928	0.312
TRG_ER_diArg_1	121	124	PF00400	0.330
TRG_ER_diArg_1	231	234	PF00400	0.265

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8Y5	Leptomonas seymouri	56%	93%
A0A3Q8ID87	Leishmania donovani	80%	97%
A4HY68	Leishmania infantum	80%	97%
E9ARZ8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	97%
Q4QDH5	Leishmania major	78%	100%