Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HA03_LEIBR

TriTrypDb:

LbrM.19.0770 , LBRM2903_190012300

Length:

950

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005815	microtubule organizing center	2	1
GO:0036064	ciliary basal body	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HA03

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HA03

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	139	143	PF00656	0.777
CLV_C14_Caspase3-7	738	742	PF00656	0.564
CLV_C14_Caspase3-7	783	787	PF00656	0.555
CLV_C14_Caspase3-7	811	815	PF00656	0.500
CLV_C14_Caspase3-7	939	943	PF00656	0.617
CLV_NRD_NRD_1	145	147	PF00675	0.763
CLV_NRD_NRD_1	169	171	PF00675	0.818
CLV_NRD_NRD_1	175	177	PF00675	0.726
CLV_NRD_NRD_1	178	180	PF00675	0.713
CLV_NRD_NRD_1	223	225	PF00675	0.718
CLV_NRD_NRD_1	259	261	PF00675	0.647
CLV_NRD_NRD_1	275	277	PF00675	0.789
CLV_NRD_NRD_1	306	308	PF00675	0.782
CLV_NRD_NRD_1	452	454	PF00675	0.606
CLV_NRD_NRD_1	48	50	PF00675	0.574
CLV_PCSK_FUR_1	176	180	PF00082	0.568
CLV_PCSK_KEX2_1	145	147	PF00082	0.732
CLV_PCSK_KEX2_1	169	171	PF00082	0.818
CLV_PCSK_KEX2_1	175	177	PF00082	0.723
CLV_PCSK_KEX2_1	178	180	PF00082	0.709
CLV_PCSK_KEX2_1	223	225	PF00082	0.718
CLV_PCSK_KEX2_1	259	261	PF00082	0.647
CLV_PCSK_KEX2_1	275	277	PF00082	0.789
CLV_PCSK_KEX2_1	306	308	PF00082	0.782
CLV_PCSK_KEX2_1	451	453	PF00082	0.601
CLV_PCSK_SKI1_1	105	109	PF00082	0.554
CLV_PCSK_SKI1_1	178	182	PF00082	0.645
CLV_PCSK_SKI1_1	188	192	PF00082	0.450
DEG_APCC_DBOX_1	19	27	PF00400	0.534
DEG_SCF_FBW7_1	416	422	PF00400	0.567
DEG_SCF_FBW7_1	597	602	PF00400	0.563
DEG_SCF_FBW7_1	666	672	PF00400	0.531
DEG_SPOP_SBC_1	299	303	PF00917	0.591
DEG_SPOP_SBC_1	367	371	PF00917	0.616
DEG_SPOP_SBC_1	591	595	PF00917	0.651
DEG_SPOP_SBC_1	599	603	PF00917	0.642
DEG_SPOP_SBC_1	854	858	PF00917	0.728
DOC_CKS1_1	106	111	PF01111	0.551
DOC_CKS1_1	416	421	PF01111	0.569
DOC_CKS1_1	666	671	PF01111	0.533
DOC_CKS1_1	866	871	PF01111	0.549
DOC_MAPK_gen_1	612	621	PF00069	0.806
DOC_MAPK_gen_1	679	685	PF00069	0.405
DOC_MIT_MIM_1	14	24	PF04212	0.637
DOC_PP2B_LxvP_1	270	273	PF13499	0.559
DOC_PP2B_LxvP_1	365	368	PF13499	0.612
DOC_PP2B_LxvP_1	597	600	PF13499	0.598
DOC_PP4_FxxP_1	114	117	PF00568	0.700
DOC_PP4_FxxP_1	355	358	PF00568	0.711
DOC_USP7_MATH_1	140	144	PF00917	0.821
DOC_USP7_MATH_1	162	166	PF00917	0.584
DOC_USP7_MATH_1	277	281	PF00917	0.731
DOC_USP7_MATH_1	299	303	PF00917	0.719
DOC_USP7_MATH_1	368	372	PF00917	0.626
DOC_USP7_MATH_1	408	412	PF00917	0.566
DOC_USP7_MATH_1	540	544	PF00917	0.563
DOC_USP7_MATH_1	591	595	PF00917	0.801
DOC_USP7_MATH_1	600	604	PF00917	0.746
DOC_USP7_MATH_1	669	673	PF00917	0.529
DOC_USP7_MATH_1	678	682	PF00917	0.584
DOC_USP7_MATH_1	722	726	PF00917	0.752
DOC_USP7_MATH_1	739	743	PF00917	0.584
DOC_USP7_MATH_1	854	858	PF00917	0.791
DOC_USP7_UBL2_3	534	538	PF12436	0.716
DOC_WW_Pin1_4	105	110	PF00397	0.509
DOC_WW_Pin1_4	275	280	PF00397	0.668
DOC_WW_Pin1_4	300	305	PF00397	0.765
DOC_WW_Pin1_4	379	384	PF00397	0.717
DOC_WW_Pin1_4	392	397	PF00397	0.787
DOC_WW_Pin1_4	415	420	PF00397	0.773
DOC_WW_Pin1_4	428	433	PF00397	0.734
DOC_WW_Pin1_4	521	526	PF00397	0.689
DOC_WW_Pin1_4	582	587	PF00397	0.748
DOC_WW_Pin1_4	595	600	PF00397	0.656
DOC_WW_Pin1_4	610	615	PF00397	0.704
DOC_WW_Pin1_4	639	644	PF00397	0.766
DOC_WW_Pin1_4	649	654	PF00397	0.637
DOC_WW_Pin1_4	665	670	PF00397	0.652
DOC_WW_Pin1_4	865	870	PF00397	0.662
DOC_WW_Pin1_4	89	94	PF00397	0.790
LIG_14-3-3_CanoR_1	152	159	PF00244	0.730
LIG_14-3-3_CanoR_1	183	192	PF00244	0.549
LIG_14-3-3_CanoR_1	260	266	PF00244	0.742
LIG_14-3-3_CanoR_1	290	295	PF00244	0.572
LIG_14-3-3_CanoR_1	337	345	PF00244	0.709
LIG_14-3-3_CanoR_1	377	382	PF00244	0.780
LIG_14-3-3_CanoR_1	560	565	PF00244	0.553
LIG_14-3-3_CanoR_1	590	600	PF00244	0.572
LIG_14-3-3_CanoR_1	848	853	PF00244	0.540
LIG_14-3-3_CanoR_1	901	911	PF00244	0.547
LIG_14-3-3_CanoR_1	97	101	PF00244	0.721
LIG_Actin_WH2_2	685	703	PF00022	0.645
LIG_APCC_ABBA_1	209	214	PF00400	0.535
LIG_BIR_II_1	1	5	PF00653	0.687
LIG_BIR_III_2	640	644	PF00653	0.563
LIG_BIR_III_4	840	844	PF00653	0.556
LIG_BRCT_BRCA1_1	10	14	PF00533	0.577
LIG_BRCT_BRCA1_1	523	527	PF00533	0.568
LIG_BRCT_BRCA1_1	544	548	PF00533	0.577
LIG_FHA_1	139	145	PF00498	0.634
LIG_FHA_1	264	270	PF00498	0.557
LIG_FHA_1	333	339	PF00498	0.827
LIG_FHA_1	39	45	PF00498	0.584
LIG_FHA_1	392	398	PF00498	0.588
LIG_FHA_1	513	519	PF00498	0.771
LIG_FHA_1	616	622	PF00498	0.701
LIG_FHA_1	769	775	PF00498	0.769
LIG_FHA_1	780	786	PF00498	0.701
LIG_FHA_1	916	922	PF00498	0.458
LIG_FHA_1	93	99	PF00498	0.729
LIG_FHA_2	153	159	PF00498	0.575
LIG_FHA_2	420	426	PF00498	0.648
LIG_FHA_2	432	438	PF00498	0.776
LIG_FHA_2	499	505	PF00498	0.709
LIG_FHA_2	60	66	PF00498	0.531
LIG_FHA_2	763	769	PF00498	0.541
LIG_FHA_2	809	815	PF00498	0.597
LIG_Integrin_RGD_1	224	226	PF01839	0.800
LIG_LIR_Apic_2	352	358	PF02991	0.682
LIG_LIR_Apic_2	632	638	PF02991	0.811
LIG_LIR_Gen_1	11	21	PF02991	0.646
LIG_LIR_Gen_1	189	198	PF02991	0.643
LIG_LIR_Gen_1	360	368	PF02991	0.576
LIG_LIR_Gen_1	545	556	PF02991	0.494
LIG_LIR_Gen_1	681	689	PF02991	0.605
LIG_LIR_Gen_1	891	898	PF02991	0.417
LIG_LIR_Gen_1	923	933	PF02991	0.462
LIG_LIR_Nem_3	11	17	PF02991	0.652
LIG_LIR_Nem_3	189	195	PF02991	0.630
LIG_LIR_Nem_3	291	297	PF02991	0.620
LIG_LIR_Nem_3	360	365	PF02991	0.576
LIG_LIR_Nem_3	545	551	PF02991	0.499
LIG_LIR_Nem_3	681	685	PF02991	0.616
LIG_LIR_Nem_3	891	896	PF02991	0.416
LIG_LIR_Nem_3	923	929	PF02991	0.522
LIG_PCNA_yPIPBox_3	697	705	PF02747	0.562
LIG_PTB_Apo_2	889	896	PF02174	0.605
LIG_PTB_Phospho_1	889	895	PF10480	0.606
LIG_REV1ctd_RIR_1	189	197	PF16727	0.638
LIG_SH2_CRK	294	298	PF00017	0.738
LIG_SH2_CRK	635	639	PF00017	0.819
LIG_SH2_CRK	803	807	PF00017	0.557
LIG_SH2_NCK_1	635	639	PF00017	0.566
LIG_SH2_NCK_1	660	664	PF00017	0.537
LIG_SH2_SRC	660	663	PF00017	0.538
LIG_SH2_SRC	940	943	PF00017	0.514
LIG_SH2_STAP1	212	216	PF00017	0.538
LIG_SH2_STAP1	617	621	PF00017	0.560
LIG_SH2_STAP1	660	664	PF00017	0.537
LIG_SH2_STAT5	505	508	PF00017	0.568
LIG_SH2_STAT5	581	584	PF00017	0.618
LIG_SH2_STAT5	617	620	PF00017	0.560
LIG_SH2_STAT5	764	767	PF00017	0.573
LIG_SH2_STAT5	803	806	PF00017	0.517
LIG_SH2_STAT5	895	898	PF00017	0.604
LIG_SH2_STAT5	940	943	PF00017	0.514
LIG_SH3_3	104	110	PF00018	0.681
LIG_SH3_3	171	177	PF00018	0.571
LIG_SH3_3	293	299	PF00018	0.782
LIG_SH3_3	462	468	PF00018	0.625
LIG_SH3_3	519	525	PF00018	0.593
LIG_SH3_3	562	568	PF00018	0.559
LIG_SH3_3	583	589	PF00018	0.578
LIG_SH3_3	663	669	PF00018	0.534
LIG_SH3_3	861	867	PF00018	0.725
LIG_SH3_3	95	101	PF00018	0.730
LIG_SUMO_SIM_par_1	617	623	PF11976	0.559
LIG_SUMO_SIM_par_1	768	775	PF11976	0.557
LIG_TRAF2_1	715	718	PF00917	0.550
LIG_TYR_ITIM	801	806	PF00017	0.566
LIG_WW_3	108	112	PF00397	0.703
LIG_WW_3	73	77	PF00397	0.567
MOD_CDC14_SPxK_1	303	306	PF00782	0.595
MOD_CDC14_SPxK_1	585	588	PF00782	0.579
MOD_CDK_SPK_2	521	526	PF00069	0.689
MOD_CDK_SPK_2	610	615	PF00069	0.704
MOD_CDK_SPxK_1	105	111	PF00069	0.709
MOD_CDK_SPxK_1	300	306	PF00069	0.593
MOD_CDK_SPxK_1	415	421	PF00069	0.567
MOD_CDK_SPxK_1	582	588	PF00069	0.583
MOD_CDK_SPxxK_3	300	307	PF00069	0.596
MOD_CDK_SPxxK_3	865	872	PF00069	0.549
MOD_CK1_1	138	144	PF00069	0.637
MOD_CK1_1	147	153	PF00069	0.732
MOD_CK1_1	165	171	PF00069	0.527
MOD_CK1_1	263	269	PF00069	0.615
MOD_CK1_1	300	306	PF00069	0.593
MOD_CK1_1	369	375	PF00069	0.642
MOD_CK1_1	415	421	PF00069	0.592
MOD_CK1_1	431	437	PF00069	0.762
MOD_CK1_1	440	446	PF00069	0.628
MOD_CK1_1	476	482	PF00069	0.643
MOD_CK1_1	513	519	PF00069	0.714
MOD_CK1_1	559	565	PF00069	0.608
MOD_CK1_1	595	601	PF00069	0.565
MOD_CK1_1	603	609	PF00069	0.538
MOD_CK1_1	636	642	PF00069	0.731
MOD_CK1_1	672	678	PF00069	0.687
MOD_CK1_1	742	748	PF00069	0.659
MOD_CK1_1	906	912	PF00069	0.541
MOD_CK1_1	92	98	PF00069	0.816
MOD_CK2_1	129	135	PF00069	0.756
MOD_CK2_1	152	158	PF00069	0.576
MOD_CK2_1	181	187	PF00069	0.741
MOD_CK2_1	367	373	PF00069	0.714
MOD_CK2_1	498	504	PF00069	0.710
MOD_CK2_1	678	684	PF00069	0.661
MOD_CK2_1	7	13	PF00069	0.588
MOD_CK2_1	742	748	PF00069	0.722
MOD_CK2_1	762	768	PF00069	0.461
MOD_Cter_Amidation	257	260	PF01082	0.566
MOD_DYRK1A_RPxSP_1	379	383	PF00069	0.578
MOD_GlcNHglycan	10	13	PF01048	0.578
MOD_GlcNHglycan	102	105	PF01048	0.687
MOD_GlcNHglycan	118	121	PF01048	0.690
MOD_GlcNHglycan	131	134	PF01048	0.601
MOD_GlcNHglycan	138	141	PF01048	0.476
MOD_GlcNHglycan	160	163	PF01048	0.583
MOD_GlcNHglycan	266	269	PF01048	0.812
MOD_GlcNHglycan	455	458	PF01048	0.714
MOD_GlcNHglycan	475	478	PF01048	0.550
MOD_GlcNHglycan	492	495	PF01048	0.805
MOD_GlcNHglycan	508	511	PF01048	0.746
MOD_GlcNHglycan	542	545	PF01048	0.797
MOD_GlcNHglycan	594	597	PF01048	0.732
MOD_GlcNHglycan	602	605	PF01048	0.735
MOD_GlcNHglycan	674	677	PF01048	0.586
MOD_GlcNHglycan	684	688	PF01048	0.594
MOD_GlcNHglycan	720	723	PF01048	0.763
MOD_GlcNHglycan	823	826	PF01048	0.502
MOD_GlcNHglycan	827	831	PF01048	0.531
MOD_GlcNHglycan	844	847	PF01048	0.506
MOD_GSK3_1	136	143	PF00069	0.786
MOD_GSK3_1	144	151	PF00069	0.652
MOD_GSK3_1	158	165	PF00069	0.642
MOD_GSK3_1	260	267	PF00069	0.548
MOD_GSK3_1	286	293	PF00069	0.565
MOD_GSK3_1	353	360	PF00069	0.644
MOD_GSK3_1	4	11	PF00069	0.473
MOD_GSK3_1	408	415	PF00069	0.592
MOD_GSK3_1	419	426	PF00069	0.552
MOD_GSK3_1	431	438	PF00069	0.608
MOD_GSK3_1	440	447	PF00069	0.748
MOD_GSK3_1	45	52	PF00069	0.458
MOD_GSK3_1	506	513	PF00069	0.665
MOD_GSK3_1	552	559	PF00069	0.667
MOD_GSK3_1	577	584	PF00069	0.713
MOD_GSK3_1	591	598	PF00069	0.713
MOD_GSK3_1	599	606	PF00069	0.712
MOD_GSK3_1	629	636	PF00069	0.641
MOD_GSK3_1	665	672	PF00069	0.691
MOD_GSK3_1	674	681	PF00069	0.619
MOD_GSK3_1	718	725	PF00069	0.775
MOD_GSK3_1	739	746	PF00069	0.707
MOD_GSK3_1	775	782	PF00069	0.752
MOD_GSK3_1	902	909	PF00069	0.544
MOD_GSK3_1	915	922	PF00069	0.520
MOD_GSK3_1	92	99	PF00069	0.797
MOD_N-GLC_1	392	397	PF02516	0.585
MOD_N-GLC_1	412	417	PF02516	0.486
MOD_N-GLC_1	780	785	PF02516	0.550
MOD_N-GLC_1	903	908	PF02516	0.545
MOD_NEK2_1	144	149	PF00069	0.578
MOD_NEK2_1	181	186	PF00069	0.707
MOD_NEK2_1	219	224	PF00069	0.554
MOD_NEK2_1	38	43	PF00069	0.571
MOD_NEK2_1	498	503	PF00069	0.564
MOD_NEK2_1	506	511	PF00069	0.535
MOD_NEK2_1	558	563	PF00069	0.792
MOD_NEK2_1	605	610	PF00069	0.598
MOD_NEK2_1	654	659	PF00069	0.559
MOD_NEK2_1	674	679	PF00069	0.500
MOD_NEK2_1	801	806	PF00069	0.517
MOD_NEK2_1	847	852	PF00069	0.642
MOD_NEK2_1	902	907	PF00069	0.548
MOD_NEK2_2	140	145	PF00069	0.825
MOD_NEK2_2	617	622	PF00069	0.560
MOD_NEK2_2	655	660	PF00069	0.539
MOD_PIKK_1	337	343	PF00454	0.742
MOD_PIKK_1	385	391	PF00454	0.574
MOD_PIKK_1	516	522	PF00454	0.790
MOD_PIKK_1	669	675	PF00454	0.509
MOD_PIKK_1	801	807	PF00454	0.562
MOD_PIKK_1	808	814	PF00454	0.543
MOD_PIKK_1	906	912	PF00454	0.541
MOD_PK_1	560	566	PF00069	0.555
MOD_PKA_1	49	55	PF00069	0.511
MOD_PKA_2	115	121	PF00069	0.528
MOD_PKA_2	128	134	PF00069	0.697
MOD_PKA_2	144	150	PF00069	0.714
MOD_PKA_2	182	188	PF00069	0.560
MOD_PKA_2	232	238	PF00069	0.658
MOD_PKA_2	311	317	PF00069	0.573
MOD_PKA_2	506	512	PF00069	0.774
MOD_PKA_2	559	565	PF00069	0.549
MOD_PKA_2	591	597	PF00069	0.581
MOD_PKA_2	636	642	PF00069	0.567
MOD_PKA_2	762	768	PF00069	0.577
MOD_PKA_2	847	853	PF00069	0.573
MOD_PKA_2	915	921	PF00069	0.518
MOD_PKA_2	96	102	PF00069	0.758
MOD_PKB_1	451	459	PF00069	0.601
MOD_PKB_1	588	596	PF00069	0.580
MOD_Plk_1	351	357	PF00069	0.638
MOD_Plk_1	408	414	PF00069	0.672
MOD_Plk_1	436	442	PF00069	0.818
MOD_Plk_1	513	519	PF00069	0.556
MOD_Plk_1	65	71	PF00069	0.794
MOD_Plk_1	743	749	PF00069	0.564
MOD_Plk_1	768	774	PF00069	0.808
MOD_Plk_2-3	768	774	PF00069	0.559
MOD_Plk_2-3	932	938	PF00069	0.608
MOD_Plk_4	277	283	PF00069	0.562
MOD_Plk_4	560	566	PF00069	0.739
MOD_Plk_4	655	661	PF00069	0.615
MOD_Plk_4	678	684	PF00069	0.408
MOD_Plk_4	848	854	PF00069	0.532
MOD_Plk_4	932	938	PF00069	0.608
MOD_ProDKin_1	105	111	PF00069	0.511
MOD_ProDKin_1	275	281	PF00069	0.670
MOD_ProDKin_1	300	306	PF00069	0.768
MOD_ProDKin_1	379	385	PF00069	0.716
MOD_ProDKin_1	392	398	PF00069	0.790
MOD_ProDKin_1	415	421	PF00069	0.777
MOD_ProDKin_1	428	434	PF00069	0.734
MOD_ProDKin_1	521	527	PF00069	0.690
MOD_ProDKin_1	582	588	PF00069	0.694
MOD_ProDKin_1	595	601	PF00069	0.657
MOD_ProDKin_1	610	616	PF00069	0.703
MOD_ProDKin_1	639	645	PF00069	0.766
MOD_ProDKin_1	649	655	PF00069	0.638
MOD_ProDKin_1	665	671	PF00069	0.650
MOD_ProDKin_1	865	871	PF00069	0.678
MOD_ProDKin_1	89	95	PF00069	0.788
TRG_DiLeu_BaEn_1	13	18	PF01217	0.539
TRG_DiLeu_BaEn_1	784	789	PF01217	0.734
TRG_DiLeu_BaEn_1	797	802	PF01217	0.579
TRG_ENDOCYTIC_2	294	297	PF00928	0.738
TRG_ENDOCYTIC_2	362	365	PF00928	0.579
TRG_ENDOCYTIC_2	803	806	PF00928	0.562
TRG_ER_diArg_1	144	146	PF00400	0.741
TRG_ER_diArg_1	169	171	PF00400	0.828
TRG_ER_diArg_1	174	176	PF00400	0.725
TRG_ER_diArg_1	177	179	PF00400	0.726
TRG_ER_diArg_1	198	201	PF00400	0.785
TRG_ER_diArg_1	275	277	PF00400	0.681
TRG_ER_diArg_1	451	453	PF00400	0.601
TRG_ER_diArg_1	588	591	PF00400	0.578
TRG_ER_diArg_1	80	83	PF00400	0.704
TRG_ER_diArg_1	88	91	PF00400	0.649
TRG_NES_CRM1_1	684	695	PF08389	0.625
TRG_NES_CRM1_1	812	823	PF08389	0.678

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8K8	Leptomonas seymouri	32%	95%
A0A3S7WVC5	Leishmania donovani	58%	100%
A4HY67	Leishmania infantum	58%	100%
E9ARZ7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	58%	100%
Q4QDH6	Leishmania major	57%	100%