Putative nucleosome assembly protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

nucleosome assembly protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HA02_LEIBR

TriTrypDb:

LbrM.19.0760 , LBRM2903_190012200

Length:

354

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 4
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 18

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 12

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 15
NetGPI	no	yes: 0, no: 15

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	16
GO:0043226	organelle	2	16
GO:0043227	membrane-bounded organelle	3	16
GO:0043229	intracellular organelle	3	16
GO:0043231	intracellular membrane-bounded organelle	4	16
GO:0110165	cellular anatomical entity	1	16
GO:0000785	chromatin	2	2
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

A4HA02

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HA02

Function

Biological processes
Term	Name	Level	Count
GO:0006325	chromatin organization	4	16
GO:0006334	nucleosome assembly	7	16
GO:0006338	chromatin remodeling	5	16
GO:0009987	cellular process	1	16
GO:0016043	cellular component organization	3	16
GO:0022607	cellular component assembly	4	16
GO:0034728	nucleosome organization	6	16
GO:0043933	protein-containing complex organization	4	16
GO:0065003	protein-containing complex assembly	5	16
GO:0065004	protein-DNA complex assembly	6	16
GO:0071824	protein-DNA complex subunit organization	5	16
GO:0071840	cellular component organization or biogenesis	2	16

Molecular functions
Term	Name	Level	Count
GO:0003682	chromatin binding	2	2
GO:0005488	binding	1	2
GO:0005515	protein binding	2	2
GO:0042393	histone binding	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	80	82	PF00675	0.282
CLV_NRD_NRD_1	93	95	PF00675	0.266
CLV_PCSK_FUR_1	235	239	PF00082	0.353
CLV_PCSK_KEX2_1	237	239	PF00082	0.277
CLV_PCSK_KEX2_1	80	82	PF00082	0.264
CLV_PCSK_KEX2_1	92	94	PF00082	0.263
CLV_PCSK_PC1ET2_1	237	239	PF00082	0.258
CLV_PCSK_SKI1_1	209	213	PF00082	0.295
DOC_MAPK_gen_1	206	214	PF00069	0.482
DOC_MAPK_gen_1	69	78	PF00069	0.638
DOC_MAPK_gen_1	80	87	PF00069	0.433
DOC_MAPK_MEF2A_6	80	89	PF00069	0.466
DOC_PP2B_LxvP_1	85	88	PF13499	0.423
DOC_USP7_MATH_1	100	104	PF00917	0.482
DOC_USP7_MATH_1	201	205	PF00917	0.490
DOC_USP7_MATH_1	250	254	PF00917	0.503
DOC_USP7_UBL2_3	233	237	PF12436	0.474
DOC_WW_Pin1_4	186	191	PF00397	0.573
DOC_WW_Pin1_4	212	217	PF00397	0.490
LIG_14-3-3_CanoR_1	243	252	PF00244	0.598
LIG_14-3-3_CanoR_1	279	284	PF00244	0.553
LIG_14-3-3_CterR_2	349	354	PF00244	0.515
LIG_APCC_ABBA_1	156	161	PF00400	0.482
LIG_BIR_III_4	134	138	PF00653	0.482
LIG_BRCT_BRCA1_1	38	42	PF00533	0.447
LIG_FHA_1	114	120	PF00498	0.413
LIG_FHA_1	198	204	PF00498	0.528
LIG_FHA_1	280	286	PF00498	0.494
LIG_FHA_2	99	105	PF00498	0.476
LIG_LIR_Gen_1	181	190	PF02991	0.486
LIG_LIR_Nem_3	176	182	PF02991	0.470
LIG_LIR_Nem_3	253	258	PF02991	0.511
LIG_LIR_Nem_3	29	33	PF02991	0.515
LIG_LIR_Nem_3	83	89	PF02991	0.474
LIG_Pex14_2	182	186	PF04695	0.470
LIG_Pex14_2	254	258	PF04695	0.497
LIG_Pex14_2	38	42	PF04695	0.471
LIG_SH2_CRK	82	86	PF00017	0.494
LIG_SH2_SRC	33	36	PF00017	0.596
LIG_SH2_STAP1	60	64	PF00017	0.482
LIG_SH2_STAP1	82	86	PF00017	0.458
LIG_SH2_STAT5	298	301	PF00017	0.497
LIG_SH2_STAT5	33	36	PF00017	0.499
LIG_SUMO_SIM_anti_2	281	288	PF11976	0.553
LIG_SUMO_SIM_par_1	166	172	PF11976	0.510
LIG_SUMO_SIM_par_1	200	208	PF11976	0.511
LIG_SUMO_SIM_par_1	210	215	PF11976	0.405
LIG_TRAF2_1	103	106	PF00917	0.497
LIG_WRC_WIRS_1	179	184	PF05994	0.467
LIG_WRC_WIRS_1	185	190	PF05994	0.473
MOD_CK1_1	210	216	PF00069	0.515
MOD_CK2_1	100	106	PF00069	0.497
MOD_CK2_1	151	157	PF00069	0.481
MOD_CK2_1	278	284	PF00069	0.553
MOD_CK2_1	42	48	PF00069	0.515
MOD_GlcNHglycan	171	174	PF01048	0.236
MOD_GlcNHglycan	57	60	PF01048	0.361
MOD_GlcNHglycan	61	67	PF01048	0.280
MOD_GSK3_1	113	120	PF00069	0.444
MOD_GSK3_1	195	202	PF00069	0.494
MOD_N-GLC_1	36	41	PF02516	0.378
MOD_NEK2_1	226	231	PF00069	0.625
MOD_NEK2_1	42	47	PF00069	0.454
MOD_NEK2_2	201	206	PF00069	0.490
MOD_NEK2_2	250	255	PF00069	0.553
MOD_PKA_2	278	284	PF00069	0.553
MOD_PKA_2	339	345	PF00069	0.657
MOD_Plk_1	152	158	PF00069	0.482
MOD_Plk_1	195	201	PF00069	0.497
MOD_Plk_1	207	213	PF00069	0.497
MOD_Plk_4	207	213	PF00069	0.466
MOD_Plk_4	250	256	PF00069	0.497
MOD_ProDKin_1	186	192	PF00069	0.573
MOD_ProDKin_1	212	218	PF00069	0.490
MOD_SUMO_rev_2	204	211	PF00179	0.629
TRG_DiLeu_BaEn_3	322	328	PF01217	0.736
TRG_DiLeu_BaLyEn_6	85	90	PF01217	0.539
TRG_ENDOCYTIC_2	179	182	PF00928	0.464
TRG_ENDOCYTIC_2	82	85	PF00928	0.458
TRG_ER_diArg_1	329	332	PF00400	0.737
TRG_ER_diArg_1	50	53	PF00400	0.557
TRG_ER_diArg_1	79	81	PF00400	0.483
TRG_ER_diArg_1	92	94	PF00400	0.553

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1J2	Leptomonas seymouri	68%	100%
A0A0N1IJI7	Leptomonas seymouri	29%	87%
A0A0S4J1L1	Bodo saltans	25%	86%
A0A1X0P6J1	Trypanosomatidae	46%	84%
A0A3Q8IA70	Leishmania donovani	81%	100%
A0A3R7KRI5	Trypanosoma rangeli	49%	100%
A0A3S7X4M4	Leishmania donovani	34%	88%
A2ZX50	Oryza sativa subsp. japonica	26%	100%
A4HJF7	Leishmania braziliensis	32%	87%
A4HY66	Leishmania infantum	81%	100%
A4I6V2	Leishmania infantum	34%	88%
A6H767	Bos taurus	30%	91%
B8AW64	Oryza sativa subsp. indica	29%	97%
B8B2R4	Oryza sativa subsp. indica	30%	94%
B8B4K9	Oryza sativa subsp. indica	24%	100%
B9FU45	Oryza sativa subsp. japonica	26%	100%
D0A0I6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	97%
E9ARZ6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
E9B1X5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	87%
F4JEI8	Arabidopsis thaliana	28%	100%
O59797	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	28%	90%
P25293	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	24%	85%
P28656	Mus musculus	30%	91%
P55209	Homo sapiens	29%	91%
P78920	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	29%	93%
Q28EB4	Xenopus tropicalis	30%	90%
Q2TA40	Bos taurus	30%	92%
Q4Q687	Leishmania major	33%	87%
Q4QDH7	Leishmania major	82%	100%
Q4U0Y4	Xenopus laevis	29%	90%
Q53WK4	Oryza sativa subsp. japonica	29%	97%
Q55ED1	Dictyostelium discoideum	31%	100%
Q5AAI8	Candida albicans (strain SC5314 / ATCC MYA-2876)	26%	81%
Q5MGA9	Oryza sativa subsp. indica	27%	100%
Q5R4D4	Pongo abelii	29%	91%
Q5U2Z3	Rattus norvegicus	30%	92%
Q5VND6	Oryza sativa subsp. japonica	30%	94%
Q70Z16	Nicotiana tabacum	25%	99%
Q70Z17	Nicotiana tabacum	26%	94%
Q70Z18	Nicotiana tabacum	26%	94%
Q70Z19	Nicotiana tabacum	28%	95%
Q78ZA7	Mus musculus	31%	94%
Q7ZY81	Xenopus laevis	29%	90%
Q94K07	Arabidopsis thaliana	29%	95%
Q99733	Homo sapiens	30%	94%
Q9SZI2	Arabidopsis thaliana	30%	95%
Q9ULW6	Homo sapiens	25%	77%
Q9Z2G8	Rattus norvegicus	30%	91%
Q9ZUP3	Arabidopsis thaliana	26%	93%
V5BX23	Trypanosoma cruzi	48%	99%