DNA-directed RNA polymerase subunit

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DNA-directed RNA polymerase III subunit C11, putative

Species:

Leishmania braziliensis

UniProt:

A4HA00_LEIBR

TriTrypDb:

LbrM.19.0740 , LBRM2903_190012000

Length:

162

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0000428	DNA-directed RNA polymerase complex	4	12
GO:0005730	nucleolus	5	11
GO:0030880	RNA polymerase complex	3	12
GO:0032991	protein-containing complex	1	12
GO:0043226	organelle	2	11
GO:0043228	non-membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11
GO:0043232	intracellular non-membrane-bounded organelle	4	11
GO:0061695	transferase complex, transferring phosphorus-containing groups	4	12
GO:0110165	cellular anatomical entity	1	11
GO:0140535	intracellular protein-containing complex	2	12
GO:1902494	catalytic complex	2	12
GO:1990234	transferase complex	3	12
GO:0005666	RNA polymerase III complex	4	1
GO:0055029	nuclear DNA-directed RNA polymerase complex	3	1
GO:0140513	nuclear protein-containing complex	2	1

Expansion

Sequence features

A4HA00

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HA00

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006351	DNA-templated transcription	7	11
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009058	biosynthetic process	2	12
GO:0009059	macromolecule biosynthetic process	4	12
GO:0009987	cellular process	1	12
GO:0016070	RNA metabolic process	5	12
GO:0018130	heterocycle biosynthetic process	4	12
GO:0019438	aromatic compound biosynthetic process	4	12
GO:0032774	RNA biosynthetic process	5	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0034654	nucleobase-containing compound biosynthetic process	4	12
GO:0043170	macromolecule metabolic process	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044249	cellular biosynthetic process	3	12
GO:0044271	cellular nitrogen compound biosynthetic process	4	12
GO:0046483	heterocycle metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:0097659	nucleic acid-templated transcription	6	11
GO:1901360	organic cyclic compound metabolic process	3	12
GO:1901362	organic cyclic compound biosynthetic process	4	12
GO:1901576	organic substance biosynthetic process	3	12
GO:0006353	DNA-templated transcription termination	6	1
GO:0006354	DNA-templated transcription elongation	6	1
GO:0006355	regulation of DNA-templated transcription	6	1
GO:0006386	termination of RNA polymerase III transcription	7	1
GO:0009889	regulation of biosynthetic process	4	1
GO:0010468	regulation of gene expression	5	1
GO:0010556	regulation of macromolecule biosynthetic process	5	1
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	1
GO:0019222	regulation of metabolic process	3	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0031326	regulation of cellular biosynthetic process	5	1
GO:0042779	tRNA 3'-trailer cleavage	7	9
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051171	regulation of nitrogen compound metabolic process	4	1
GO:0051252	regulation of RNA metabolic process	5	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1
GO:0080090	regulation of primary metabolic process	4	1
GO:0090305	nucleic acid phosphodiester bond hydrolysis	5	9
GO:0090501	RNA phosphodiester bond hydrolysis	6	9
GO:1903506	regulation of nucleic acid-templated transcription	7	1
GO:2001141	regulation of RNA biosynthetic process	6	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0005488	binding	1	12
GO:0008270	zinc ion binding	6	12
GO:0043167	ion binding	2	12
GO:0043169	cation binding	3	12
GO:0046872	metal ion binding	4	12
GO:0046914	transition metal ion binding	5	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12
GO:0003677	DNA binding	4	1
GO:0003700	DNA-binding transcription factor activity	2	1
GO:0003824	catalytic activity	1	2
GO:0003899	DNA-directed 5'-3' RNA polymerase activity	6	1
GO:0016740	transferase activity	2	2
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	2
GO:0016779	nucleotidyltransferase activity	4	2
GO:0034062	5'-3' RNA polymerase activity	5	1
GO:0097747	RNA polymerase activity	4	1
GO:0140098	catalytic activity, acting on RNA	3	1
GO:0140110	transcription regulator activity	1	1
GO:0140640	catalytic activity, acting on a nucleic acid	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	39	43	PF00082	0.601
DEG_Nend_Nbox_1	1	3	PF02207	0.424
DEG_SPOP_SBC_1	75	79	PF00917	0.677
DOC_MAPK_gen_1	128	137	PF00069	0.417
DOC_MAPK_MEF2A_6	131	139	PF00069	0.302
DOC_PP2B_LxvP_1	12	15	PF13499	0.538
DOC_PP4_FxxP_1	2	5	PF00568	0.387
DOC_USP7_MATH_1	126	130	PF00917	0.316
DOC_USP7_MATH_1	34	38	PF00917	0.417
DOC_USP7_MATH_1	5	9	PF00917	0.499
DOC_USP7_MATH_1	74	78	PF00917	0.709
DOC_USP7_MATH_1	86	90	PF00917	0.654
DOC_WW_Pin1_4	87	92	PF00397	0.568
DOC_WW_Pin1_4	94	99	PF00397	0.529
LIG_14-3-3_CanoR_1	28	34	PF00244	0.469
LIG_FHA_1	40	46	PF00498	0.387
LIG_FHA_1	7	13	PF00498	0.385
LIG_FHA_2	95	101	PF00498	0.666
LIG_LIR_LC3C_4	9	14	PF02991	0.475
LIG_LIR_Nem_3	147	153	PF02991	0.318
LIG_Pex14_2	2	6	PF04695	0.392
LIG_REV1ctd_RIR_1	147	155	PF16727	0.302
LIG_SH2_STAT3	133	136	PF00017	0.422
LIG_SH2_STAT5	133	136	PF00017	0.322
LIG_SH2_STAT5	29	32	PF00017	0.393
LIG_SUMO_SIM_anti_2	8	15	PF11976	0.381
LIG_TRAF2_2	119	124	PF00917	0.449
MOD_CDK_SPxxK_3	87	94	PF00069	0.575
MOD_CK2_1	138	144	PF00069	0.302
MOD_CK2_1	52	58	PF00069	0.601
MOD_CK2_1	94	100	PF00069	0.698
MOD_GlcNHglycan	107	111	PF01048	0.662
MOD_GlcNHglycan	140	143	PF01048	0.301
MOD_GSK3_1	29	36	PF00069	0.353
MOD_GSK3_1	48	55	PF00069	0.544
MOD_GSK3_1	76	83	PF00069	0.665
MOD_NEK2_1	23	28	PF00069	0.275
MOD_NEK2_1	6	11	PF00069	0.368
MOD_PIKK_1	34	40	PF00454	0.440
MOD_PKA_2	127	133	PF00069	0.235
MOD_Plk_4	144	150	PF00069	0.305
MOD_Plk_4	52	58	PF00069	0.522
MOD_Plk_4	6	12	PF00069	0.371
MOD_ProDKin_1	87	93	PF00069	0.571
MOD_ProDKin_1	94	100	PF00069	0.529
MOD_SUMO_for_1	93	96	PF00179	0.707
TRG_DiLeu_BaEn_2	17	23	PF01217	0.285
TRG_Pf-PMV_PEXEL_1	61	65	PF00026	0.683

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I894	Leptomonas seymouri	65%	100%
A0A0S4IUU6	Bodo saltans	41%	100%
A0A1X0P6N2	Trypanosomatidae	40%	100%
A0A3Q8IEF7	Leishmania donovani	75%	100%
A0A422P380	Trypanosoma rangeli	36%	100%
A4HY64	Leishmania infantum	75%	100%
D0A0I3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
E9ARZ4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	73%	100%
O13896	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	28%	100%
Q4QDH9	Leishmania major	76%	93%
Q9CQZ7	Mus musculus	28%	100%
Q9Y2Y1	Homo sapiens	27%	100%
V5C1W2	Trypanosoma cruzi	36%	100%