Proteasome maturation protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

proteasome maturation factor UMP1, putative

Species:

Leishmania braziliensis

UniProt:

A4H9Z9_LEIBR

TriTrypDb:

LbrM.19.0730 , LBRM2903_190011900

Length:

124

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1
GO:0000502	proteasome complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0140535	intracellular protein-containing complex	2	1
GO:1902494	catalytic complex	2	1
GO:1905368	peptidase complex	3	1
GO:1905369	endopeptidase complex	4	1

Expansion

Sequence features

A4H9Z9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H9Z9

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	2
GO:0016043	cellular component organization	3	2
GO:0022607	cellular component assembly	4	2
GO:0043248	proteasome assembly	6	2
GO:0043933	protein-containing complex organization	4	2
GO:0065003	protein-containing complex assembly	5	2
GO:0071840	cellular component organization or biogenesis	2	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	63	65	PF00675	0.560
CLV_PCSK_KEX2_1	63	65	PF00082	0.560
CLV_Separin_Metazoa	33	37	PF03568	0.412
DOC_CYCLIN_yCln2_LP_2	17	23	PF00134	0.662
DOC_MAPK_gen_1	13	23	PF00069	0.675
DOC_USP7_MATH_1	67	71	PF00917	0.414
DOC_WW_Pin1_4	83	88	PF00397	0.445
LIG_14-3-3_CanoR_1	79	87	PF00244	0.506
LIG_BIR_II_1	1	5	PF00653	0.521
LIG_FHA_1	41	47	PF00498	0.594
LIG_FHA_2	84	90	PF00498	0.441
LIG_LIR_Apic_2	89	94	PF02991	0.544
LIG_LIR_Nem_3	73	78	PF02991	0.476
LIG_LRP6_Inhibitor_1	35	41	PF00058	0.558
LIG_PDZ_Class_2	119	124	PF00595	0.693
LIG_SUMO_SIM_anti_2	55	62	PF11976	0.640
LIG_TRAF2_1	12	15	PF00917	0.703
LIG_TRAF2_1	29	32	PF00917	0.648
MOD_CK1_1	70	76	PF00069	0.444
MOD_GSK3_1	55	62	PF00069	0.511
MOD_N-GLC_1	80	85	PF02516	0.546
MOD_NEK2_1	59	64	PF00069	0.572
MOD_NEK2_1	68	73	PF00069	0.526
MOD_PKA_2	40	46	PF00069	0.524
MOD_Plk_1	115	121	PF00069	0.523
MOD_Plk_1	55	61	PF00069	0.502
MOD_Plk_4	55	61	PF00069	0.497
MOD_Plk_4	70	76	PF00069	0.507
MOD_ProDKin_1	83	89	PF00069	0.443
TRG_ER_diArg_1	63	65	PF00400	0.548

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDC2	Leptomonas seymouri	89%	100%
A0A0S4ISS2	Bodo saltans	37%	100%
A0A3S5H754	Leishmania donovani	90%	100%
A0A422P399	Trypanosoma rangeli	57%	100%
A4HY63	Leishmania infantum	90%	100%
D0A0I2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	57%	100%
E9ARZ3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4QDI0	Leishmania major	90%	100%
V5BBY6	Trypanosoma cruzi	55%	100%