EF-hand domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H9Z2_LEIBR

TriTrypDb:

LbrM.19.0660 , LBRM2903_190011200

Length:

444

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	11
GO:0043226	organelle	2	11
GO:0043227	membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11
GO:0043231	intracellular membrane-bounded organelle	4	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

A4H9Z2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H9Z2

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005509	calcium ion binding	5	1
GO:0043167	ion binding	2	1
GO:0043169	cation binding	3	1
GO:0046872	metal ion binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	188	192	PF00656	0.607
CLV_NRD_NRD_1	152	154	PF00675	0.602
CLV_NRD_NRD_1	180	182	PF00675	0.536
CLV_NRD_NRD_1	211	213	PF00675	0.484
CLV_NRD_NRD_1	278	280	PF00675	0.394
CLV_NRD_NRD_1	337	339	PF00675	0.370
CLV_NRD_NRD_1	388	390	PF00675	0.430
CLV_PCSK_FUR_1	178	182	PF00082	0.546
CLV_PCSK_KEX2_1	152	154	PF00082	0.577
CLV_PCSK_KEX2_1	180	182	PF00082	0.536
CLV_PCSK_KEX2_1	278	280	PF00082	0.397
CLV_PCSK_KEX2_1	337	339	PF00082	0.370
CLV_PCSK_KEX2_1	388	390	PF00082	0.423
CLV_PCSK_SKI1_1	212	216	PF00082	0.514
CLV_PCSK_SKI1_1	229	233	PF00082	0.522
CLV_PCSK_SKI1_1	327	331	PF00082	0.507
CLV_PCSK_SKI1_1	433	437	PF00082	0.565
DEG_Nend_Nbox_1	1	3	PF02207	0.657
DEG_SCF_FBW7_1	67	73	PF00400	0.451
DEG_SPOP_SBC_1	70	74	PF00917	0.645
DOC_CKS1_1	67	72	PF01111	0.452
DOC_CKS1_1	82	87	PF01111	0.402
DOC_CYCLIN_RxL_1	178	189	PF00134	0.517
DOC_MAPK_gen_1	178	185	PF00069	0.494
DOC_MAPK_gen_1	300	310	PF00069	0.447
DOC_PP1_RVXF_1	301	308	PF00149	0.528
DOC_PP4_FxxP_1	357	360	PF00568	0.536
DOC_USP7_MATH_1	198	202	PF00917	0.485
DOC_USP7_MATH_1	315	319	PF00917	0.593
DOC_USP7_MATH_1	353	357	PF00917	0.517
DOC_USP7_MATH_1	90	94	PF00917	0.715
DOC_USP7_UBL2_3	401	405	PF12436	0.576
DOC_USP7_UBL2_3	429	433	PF12436	0.509
DOC_WW_Pin1_4	186	191	PF00397	0.418
DOC_WW_Pin1_4	291	296	PF00397	0.542
DOC_WW_Pin1_4	439	444	PF00397	0.579
DOC_WW_Pin1_4	66	71	PF00397	0.453
DOC_WW_Pin1_4	81	86	PF00397	0.401
LIG_14-3-3_CanoR_1	10	17	PF00244	0.753
LIG_14-3-3_CanoR_1	100	109	PF00244	0.691
LIG_14-3-3_CanoR_1	68	78	PF00244	0.657
LIG_AP2alpha_1	348	352	PF02296	0.518
LIG_CaM_NSCaTE_8	130	137	PF13499	0.423
LIG_eIF4E_1	38	44	PF01652	0.711
LIG_eIF4E_1	57	63	PF01652	0.460
LIG_FHA_1	142	148	PF00498	0.556
LIG_FHA_1	171	177	PF00498	0.506
LIG_FHA_1	194	200	PF00498	0.712
LIG_FHA_1	338	344	PF00498	0.569
LIG_FHA_1	362	368	PF00498	0.499
LIG_FHA_1	38	44	PF00498	0.636
LIG_FHA_2	398	404	PF00498	0.488
LIG_FHA_2	411	417	PF00498	0.479
LIG_FHA_2	72	78	PF00498	0.655
LIG_Integrin_isoDGR_2	396	398	PF01839	0.491
LIG_LIR_Apic_2	144	149	PF02991	0.537
LIG_LIR_Apic_2	354	360	PF02991	0.521
LIG_LIR_Gen_1	106	113	PF02991	0.696
LIG_LIR_Gen_1	261	271	PF02991	0.518
LIG_LIR_Gen_1	306	315	PF02991	0.545
LIG_LIR_Gen_1	350	360	PF02991	0.288
LIG_LIR_Gen_1	362	372	PF02991	0.262
LIG_LIR_Nem_3	106	111	PF02991	0.699
LIG_LIR_Nem_3	261	267	PF02991	0.520
LIG_LIR_Nem_3	284	290	PF02991	0.391
LIG_LIR_Nem_3	306	310	PF02991	0.508
LIG_LIR_Nem_3	350	355	PF02991	0.273
LIG_LIR_Nem_3	362	368	PF02991	0.289
LIG_MYND_1	124	128	PF01753	0.678
LIG_NRBOX	418	424	PF00104	0.573
LIG_PDZ_Class_1	439	444	PF00595	0.579
LIG_Pex14_1	71	75	PF04695	0.571
LIG_Pex14_2	330	334	PF04695	0.406
LIG_Pex14_2	348	352	PF04695	0.369
LIG_SH2_CRK	287	291	PF00017	0.530
LIG_SH2_GRB2like	225	228	PF00017	0.292
LIG_SH2_PTP2	146	149	PF00017	0.597
LIG_SH2_PTP2	159	162	PF00017	0.522
LIG_SH2_PTP2	264	267	PF00017	0.453
LIG_SH2_SRC	146	149	PF00017	0.543
LIG_SH2_SRC	159	162	PF00017	0.604
LIG_SH2_SRC	225	228	PF00017	0.292
LIG_SH2_SRC	27	30	PF00017	0.628
LIG_SH2_STAT5	146	149	PF00017	0.560
LIG_SH2_STAT5	159	162	PF00017	0.485
LIG_SH2_STAT5	225	228	PF00017	0.292
LIG_SH2_STAT5	253	256	PF00017	0.566
LIG_SH2_STAT5	264	267	PF00017	0.220
LIG_SH2_STAT5	27	30	PF00017	0.628
LIG_SH3_3	437	443	PF00018	0.614
LIG_SH3_3	79	85	PF00018	0.681
LIG_SH3_4	167	174	PF00018	0.608
LIG_SUMO_SIM_anti_2	246	252	PF11976	0.451
LIG_TRAF2_1	129	132	PF00917	0.676
MOD_CK1_1	104	110	PF00069	0.664
MOD_CK1_1	169	175	PF00069	0.570
MOD_CK1_1	66	72	PF00069	0.549
MOD_CK2_1	397	403	PF00069	0.461
MOD_CK2_1	410	416	PF00069	0.448
MOD_CK2_1	71	77	PF00069	0.580
MOD_DYRK1A_RPxSP_1	291	295	PF00069	0.561
MOD_DYRK1A_RPxSP_1	439	443	PF00069	0.558
MOD_GlcNHglycan	200	203	PF01048	0.462
MOD_GlcNHglycan	284	287	PF01048	0.286
MOD_GlcNHglycan	317	320	PF01048	0.502
MOD_GlcNHglycan	321	324	PF01048	0.455
MOD_GlcNHglycan	375	378	PF01048	0.402
MOD_GlcNHglycan	88	91	PF01048	0.665
MOD_GlcNHglycan	92	95	PF01048	0.702
MOD_GSK3_1	130	137	PF00069	0.571
MOD_GSK3_1	138	145	PF00069	0.522
MOD_GSK3_1	166	173	PF00069	0.608
MOD_GSK3_1	186	193	PF00069	0.474
MOD_GSK3_1	28	35	PF00069	0.622
MOD_GSK3_1	315	322	PF00069	0.445
MOD_GSK3_1	337	344	PF00069	0.530
MOD_GSK3_1	378	385	PF00069	0.358
MOD_GSK3_1	62	69	PF00069	0.500
MOD_GSK3_1	86	93	PF00069	0.684
MOD_GSK3_1	9	16	PF00069	0.742
MOD_N-GLC_1	383	388	PF02516	0.430
MOD_N-GLC_1	45	50	PF02516	0.633
MOD_NEK2_1	134	139	PF00069	0.539
MOD_NEK2_1	142	147	PF00069	0.600
MOD_NEK2_1	282	287	PF00069	0.511
MOD_NEK2_1	289	294	PF00069	0.488
MOD_NEK2_1	62	67	PF00069	0.443
MOD_NEK2_1	88	93	PF00069	0.691
MOD_OFUCOSY	382	387	PF10250	0.549
MOD_PIKK_1	167	173	PF00454	0.588
MOD_PIKK_1	256	262	PF00454	0.321
MOD_PIKK_1	341	347	PF00454	0.556
MOD_PIKK_1	98	104	PF00454	0.662
MOD_PKA_1	337	343	PF00069	0.331
MOD_PKA_2	337	343	PF00069	0.584
MOD_PKA_2	378	384	PF00069	0.337
MOD_PKA_2	397	403	PF00069	0.450
MOD_PKA_2	9	15	PF00069	0.642
MOD_Plk_1	115	121	PF00069	0.440
MOD_Plk_1	353	359	PF00069	0.359
MOD_Plk_1	361	367	PF00069	0.521
MOD_Plk_1	415	421	PF00069	0.591
MOD_Plk_1	98	104	PF00069	0.706
MOD_Plk_2-3	415	421	PF00069	0.337
MOD_Plk_4	104	110	PF00069	0.601
MOD_Plk_4	142	148	PF00069	0.638
MOD_Plk_4	39	45	PF00069	0.706
MOD_Plk_4	418	424	PF00069	0.573
MOD_ProDKin_1	186	192	PF00069	0.427
MOD_ProDKin_1	291	297	PF00069	0.538
MOD_ProDKin_1	66	72	PF00069	0.453
MOD_ProDKin_1	81	87	PF00069	0.403
MOD_SUMO_rev_2	53	62	PF00179	0.628
TRG_DiLeu_BaEn_1	246	251	PF01217	0.409
TRG_ENDOCYTIC_2	264	267	PF00928	0.502
TRG_ENDOCYTIC_2	287	290	PF00928	0.427
TRG_ENDOCYTIC_2	75	78	PF00928	0.567
TRG_ER_diArg_1	151	153	PF00400	0.643
TRG_ER_diArg_1	177	180	PF00400	0.476
TRG_ER_diArg_1	337	339	PF00400	0.370
TRG_ER_diArg_1	388	390	PF00400	0.430
TRG_Pf-PMV_PEXEL_1	229	233	PF00026	0.512
TRG_Pf-PMV_PEXEL_1	291	296	PF00026	0.311

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8K5	Leptomonas seymouri	59%	98%
A0A0S4J8I1	Bodo saltans	37%	100%
A0A0S4J9L9	Bodo saltans	37%	100%
A0A1X0P6D5	Trypanosomatidae	45%	100%
A0A3R7KYH1	Trypanosoma rangeli	45%	100%
A0A3S5H753	Leishmania donovani	82%	97%
A4HY56	Leishmania infantum	82%	97%
D0A0G4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
E9ARY6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	97%
Q4QDI7	Leishmania major	82%	100%
V5C1T2	Trypanosoma cruzi	46%	100%