WD_REPEATS_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

intraflagellar transport protein 80, putative

Species:

Leishmania braziliensis

UniProt:

A4H9Z1_LEIBR

TriTrypDb:

LbrM.19.0650 , LBRM2903_190011100

Length:

784

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005813	centrosome	3	1
GO:0005815	microtubule organizing center	2	1
GO:0005929	cilium	4	4
GO:0030990	intraciliary transport particle	2	1
GO:0030992	intraciliary transport particle B	2	1
GO:0032991	protein-containing complex	1	1
GO:0042995	cell projection	2	4
GO:0043226	organelle	2	4
GO:0043227	membrane-bounded organelle	3	4
GO:0110165	cellular anatomical entity	1	4
GO:0120025	plasma membrane bounded cell projection	3	4
GO:0031514	motile cilium	5	3

Expansion

Sequence features

A4H9Z1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H9Z1

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0006996	organelle organization	4	1
GO:0007017	microtubule-based process	2	1
GO:0007018	microtubule-based movement	3	1
GO:0009987	cellular process	1	1
GO:0010970	transport along microtubule	4	1
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0030030	cell projection organization	4	1
GO:0030031	cell projection assembly	5	1
GO:0030705	cytoskeleton-dependent intracellular transport	4	1
GO:0031503	protein-containing complex localization	2	1
GO:0035735	intraciliary transport involved in cilium assembly	4	1
GO:0042073	intraciliary transport	3	1
GO:0044782	cilium organization	5	1
GO:0046907	intracellular transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0060271	cilium assembly	6	1
GO:0070925	organelle assembly	5	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0099111	microtubule-based transport	4	1
GO:0120031	plasma membrane bounded cell projection assembly	6	1
GO:0120036	plasma membrane bounded cell projection organization	5	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	324	328	PF00656	0.373
CLV_C14_Caspase3-7	81	85	PF00656	0.457
CLV_NRD_NRD_1	313	315	PF00675	0.376
CLV_NRD_NRD_1	329	331	PF00675	0.361
CLV_NRD_NRD_1	37	39	PF00675	0.321
CLV_NRD_NRD_1	489	491	PF00675	0.357
CLV_NRD_NRD_1	586	588	PF00675	0.383
CLV_NRD_NRD_1	721	723	PF00675	0.435
CLV_NRD_NRD_1	732	734	PF00675	0.401
CLV_PCSK_KEX2_1	329	331	PF00082	0.518
CLV_PCSK_KEX2_1	37	39	PF00082	0.339
CLV_PCSK_KEX2_1	586	588	PF00082	0.383
CLV_PCSK_KEX2_1	732	734	PF00082	0.420
CLV_PCSK_PC7_1	582	588	PF00082	0.399
CLV_PCSK_SKI1_1	164	168	PF00082	0.551
CLV_PCSK_SKI1_1	193	197	PF00082	0.237
CLV_PCSK_SKI1_1	329	333	PF00082	0.504
CLV_PCSK_SKI1_1	349	353	PF00082	0.143
CLV_PCSK_SKI1_1	396	400	PF00082	0.328
CLV_PCSK_SKI1_1	491	495	PF00082	0.322
CLV_PCSK_SKI1_1	552	556	PF00082	0.378
CLV_PCSK_SKI1_1	623	627	PF00082	0.496
CLV_PCSK_SKI1_1	691	695	PF00082	0.392
DEG_APCC_DBOX_1	146	154	PF00400	0.353
DEG_Nend_UBRbox_1	1	4	PF02207	0.350
DEG_ODPH_VHL_1	746	758	PF01847	0.559
DEG_SPOP_SBC_1	362	366	PF00917	0.389
DOC_ANK_TNKS_1	248	255	PF00023	0.484
DOC_ANK_TNKS_1	585	592	PF00023	0.430
DOC_CKS1_1	669	674	PF01111	0.386
DOC_CYCLIN_yCln2_LP_2	376	382	PF00134	0.389
DOC_CYCLIN_yCln2_LP_2	594	600	PF00134	0.482
DOC_MAPK_gen_1	196	205	PF00069	0.437
DOC_MAPK_gen_1	559	569	PF00069	0.325
DOC_MAPK_gen_1	708	718	PF00069	0.466
DOC_MAPK_HePTP_8	583	598	PF00069	0.487
DOC_MAPK_MEF2A_6	385	393	PF00069	0.358
DOC_MAPK_MEF2A_6	415	424	PF00069	0.489
DOC_MAPK_MEF2A_6	427	435	PF00069	0.440
DOC_MAPK_RevD_3	477	491	PF00069	0.418
DOC_PP1_RVXF_1	191	198	PF00149	0.306
DOC_PP1_RVXF_1	312	319	PF00149	0.382
DOC_PP1_RVXF_1	488	495	PF00149	0.346
DOC_PP1_RVXF_1	507	513	PF00149	0.408
DOC_PP1_RVXF_1	755	761	PF00149	0.468
DOC_PP2B_LxvP_1	376	379	PF13499	0.397
DOC_PP2B_LxvP_1	594	597	PF13499	0.489
DOC_PP2B_PxIxI_1	386	392	PF00149	0.472
DOC_USP7_MATH_1	123	127	PF00917	0.409
DOC_USP7_MATH_1	177	181	PF00917	0.419
DOC_USP7_MATH_1	244	248	PF00917	0.384
DOC_USP7_MATH_1	258	262	PF00917	0.264
DOC_USP7_MATH_1	401	405	PF00917	0.499
DOC_USP7_MATH_1	449	453	PF00917	0.270
DOC_USP7_MATH_1	91	95	PF00917	0.426
DOC_USP7_UBL2_3	192	196	PF12436	0.278
DOC_WW_Pin1_4	436	441	PF00397	0.361
DOC_WW_Pin1_4	596	601	PF00397	0.360
DOC_WW_Pin1_4	668	673	PF00397	0.398
LIG_14-3-3_CanoR_1	11	19	PF00244	0.367
LIG_14-3-3_CanoR_1	147	151	PF00244	0.323
LIG_14-3-3_CanoR_1	279	286	PF00244	0.479
LIG_14-3-3_CanoR_1	314	319	PF00244	0.475
LIG_14-3-3_CanoR_1	329	334	PF00244	0.389
LIG_14-3-3_CanoR_1	415	420	PF00244	0.370
LIG_14-3-3_CanoR_1	722	730	PF00244	0.398
LIG_Actin_WH2_2	626	642	PF00022	0.344
LIG_APCC_ABBA_1	746	751	PF00400	0.436
LIG_BRCT_BRCA1_1	246	250	PF00533	0.388
LIG_BRCT_BRCA1_1	30	34	PF00533	0.447
LIG_BRCT_BRCA1_1	545	549	PF00533	0.444
LIG_BRCT_BRCA1_1	93	97	PF00533	0.407
LIG_CSL_BTD_1	60	63	PF09270	0.312
LIG_FHA_1	115	121	PF00498	0.412
LIG_FHA_1	16	22	PF00498	0.461
LIG_FHA_1	293	299	PF00498	0.341
LIG_FHA_1	301	307	PF00498	0.324
LIG_FHA_1	430	436	PF00498	0.453
LIG_FHA_1	517	523	PF00498	0.362
LIG_FHA_1	556	562	PF00498	0.380
LIG_FHA_1	579	585	PF00498	0.463
LIG_FHA_1	593	599	PF00498	0.325
LIG_FHA_2	128	134	PF00498	0.496
LIG_FHA_2	216	222	PF00498	0.437
LIG_FHA_2	322	328	PF00498	0.363
LIG_FHA_2	330	336	PF00498	0.370
LIG_FHA_2	338	344	PF00498	0.405
LIG_FHA_2	548	554	PF00498	0.425
LIG_FHA_2	558	564	PF00498	0.345
LIG_FHA_2	568	574	PF00498	0.226
LIG_FHA_2	722	728	PF00498	0.425
LIG_GBD_Chelix_1	621	629	PF00786	0.254
LIG_LIR_Apic_2	500	505	PF02991	0.440
LIG_LIR_Apic_2	541	545	PF02991	0.314
LIG_LIR_Gen_1	208	217	PF02991	0.438
LIG_LIR_Gen_1	261	267	PF02991	0.355
LIG_LIR_Gen_1	759	767	PF02991	0.413
LIG_LIR_Gen_1	92	101	PF02991	0.305
LIG_LIR_Nem_3	261	265	PF02991	0.331
LIG_LIR_Nem_3	317	321	PF02991	0.491
LIG_LIR_Nem_3	500	506	PF02991	0.323
LIG_LIR_Nem_3	648	654	PF02991	0.344
LIG_LIR_Nem_3	759	763	PF02991	0.409
LIG_LIR_Nem_3	92	98	PF02991	0.291
LIG_LYPXL_yS_3	601	604	PF13949	0.250
LIG_Pex14_1	273	277	PF04695	0.404
LIG_SH2_CRK	651	655	PF00017	0.356
LIG_SH2_STAP1	321	325	PF00017	0.478
LIG_SH2_STAT5	359	362	PF00017	0.332
LIG_SH2_STAT5	502	505	PF00017	0.321
LIG_SH2_STAT5	662	665	PF00017	0.361
LIG_SH2_STAT5	736	739	PF00017	0.412
LIG_SH3_3	180	186	PF00018	0.283
LIG_SH3_3	224	230	PF00018	0.462
LIG_SH3_3	594	600	PF00018	0.451
LIG_SUMO_SIM_anti_2	322	328	PF11976	0.494
LIG_SUMO_SIM_anti_2	678	683	PF11976	0.262
LIG_SUMO_SIM_par_1	17	22	PF11976	0.347
LIG_SUMO_SIM_par_1	434	439	PF11976	0.353
LIG_SUMO_SIM_par_1	529	536	PF11976	0.308
LIG_SUMO_SIM_par_1	553	558	PF11976	0.487
LIG_TRAF2_1	340	343	PF00917	0.391
LIG_TYR_ITIM	649	654	PF00017	0.343
LIG_TYR_ITIM	698	703	PF00017	0.340
LIG_UBA3_1	554	559	PF00899	0.447
LIG_UBA3_1	604	612	PF00899	0.460
LIG_WRC_WIRS_1	259	264	PF05994	0.337
MOD_CDK_SPxxK_3	668	675	PF00069	0.394
MOD_CK1_1	127	133	PF00069	0.412
MOD_CK1_1	210	216	PF00069	0.437
MOD_CK1_1	439	445	PF00069	0.337
MOD_CK1_1	516	522	PF00069	0.375
MOD_CK1_1	54	60	PF00069	0.291
MOD_CK2_1	127	133	PF00069	0.396
MOD_CK2_1	215	221	PF00069	0.437
MOD_CK2_1	337	343	PF00069	0.453
MOD_CK2_1	4	10	PF00069	0.426
MOD_CK2_1	738	744	PF00069	0.567
MOD_Cter_Amidation	730	733	PF01082	0.484
MOD_GlcNHglycan	101	104	PF01048	0.371
MOD_GlcNHglycan	212	215	PF01048	0.323
MOD_GlcNHglycan	237	240	PF01048	0.355
MOD_GlcNHglycan	28	31	PF01048	0.280
MOD_GlcNHglycan	282	286	PF01048	0.380
MOD_GlcNHglycan	460	463	PF01048	0.486
MOD_GlcNHglycan	483	486	PF01048	0.495
MOD_GlcNHglycan	6	9	PF01048	0.505
MOD_GlcNHglycan	751	755	PF01048	0.578
MOD_GSK3_1	10	17	PF00069	0.455
MOD_GSK3_1	112	119	PF00069	0.318
MOD_GSK3_1	123	130	PF00069	0.407
MOD_GSK3_1	231	238	PF00069	0.374
MOD_GSK3_1	273	280	PF00069	0.448
MOD_GSK3_1	28	35	PF00069	0.395
MOD_GSK3_1	300	307	PF00069	0.420
MOD_GSK3_1	321	328	PF00069	0.435
MOD_GSK3_1	475	482	PF00069	0.345
MOD_GSK3_1	513	520	PF00069	0.372
MOD_GSK3_1	543	550	PF00069	0.315
MOD_GSK3_1	553	560	PF00069	0.344
MOD_GSK3_1	57	64	PF00069	0.444
MOD_GSK3_1	592	599	PF00069	0.381
MOD_GSK3_1	721	728	PF00069	0.415
MOD_GSK3_1	738	745	PF00069	0.479
MOD_GSK3_1	93	100	PF00069	0.407
MOD_N-GLC_1	3	8	PF02516	0.363
MOD_N-GLC_1	300	305	PF02516	0.468
MOD_NEK2_1	215	220	PF00069	0.446
MOD_NEK2_1	3	8	PF00069	0.349
MOD_NEK2_1	325	330	PF00069	0.453
MOD_NEK2_1	457	462	PF00069	0.324
MOD_NEK2_1	481	486	PF00069	0.365
MOD_NEK2_1	518	523	PF00069	0.365
MOD_NEK2_1	555	560	PF00069	0.409
MOD_NEK2_1	578	583	PF00069	0.400
MOD_NEK2_1	97	102	PF00069	0.404
MOD_NEK2_2	244	249	PF00069	0.363
MOD_PIKK_1	138	144	PF00454	0.398
MOD_PIKK_1	292	298	PF00454	0.363
MOD_PIKK_1	363	369	PF00454	0.330
MOD_PIKK_1	401	407	PF00454	0.484
MOD_PIKK_1	479	485	PF00454	0.346
MOD_PIKK_1	607	613	PF00454	0.510
MOD_PIKK_1	738	744	PF00454	0.567
MOD_PK_1	415	421	PF00069	0.486
MOD_PKA_1	314	320	PF00069	0.494
MOD_PKA_1	329	335	PF00069	0.472
MOD_PKA_2	10	16	PF00069	0.472
MOD_PKA_2	146	152	PF00069	0.332
MOD_PKA_2	210	216	PF00069	0.498
MOD_PKA_2	278	284	PF00069	0.484
MOD_PKA_2	329	335	PF00069	0.485
MOD_PKA_2	573	579	PF00069	0.434
MOD_PKA_2	721	727	PF00069	0.414
MOD_Plk_1	105	111	PF00069	0.239
MOD_Plk_1	207	213	PF00069	0.431
MOD_Plk_1	32	38	PF00069	0.370
MOD_Plk_1	449	455	PF00069	0.414
MOD_Plk_1	466	472	PF00069	0.227
MOD_Plk_4	116	122	PF00069	0.411
MOD_Plk_4	124	130	PF00069	0.394
MOD_Plk_4	231	237	PF00069	0.518
MOD_Plk_4	258	264	PF00069	0.345
MOD_Plk_4	321	327	PF00069	0.362
MOD_Plk_4	527	533	PF00069	0.357
MOD_Plk_4	538	544	PF00069	0.299
MOD_Plk_4	54	60	PF00069	0.434
MOD_Plk_4	725	731	PF00069	0.397
MOD_ProDKin_1	436	442	PF00069	0.360
MOD_ProDKin_1	596	602	PF00069	0.354
MOD_ProDKin_1	668	674	PF00069	0.394
MOD_SUMO_for_1	351	354	PF00179	0.347
MOD_SUMO_for_1	767	770	PF00179	0.492
MOD_SUMO_rev_2	307	317	PF00179	0.459
MOD_SUMO_rev_2	484	493	PF00179	0.407
MOD_SUMO_rev_2	717	724	PF00179	0.403
MOD_SUMO_rev_2	759	767	PF00179	0.468
TRG_ENDOCYTIC_2	359	362	PF00928	0.369
TRG_ENDOCYTIC_2	601	604	PF00928	0.350
TRG_ENDOCYTIC_2	651	654	PF00928	0.346
TRG_ENDOCYTIC_2	700	703	PF00928	0.337
TRG_ER_diArg_1	329	331	PF00400	0.518
TRG_ER_diArg_1	36	38	PF00400	0.338
TRG_ER_diArg_1	585	587	PF00400	0.376
TRG_NES_CRM1_1	416	429	PF08389	0.503
TRG_NES_CRM1_1	627	643	PF08389	0.416
TRG_Pf-PMV_PEXEL_1	329	334	PF00026	0.476
TRG_Pf-PMV_PEXEL_1	623	627	PF00026	0.376
TRG_Pf-PMV_PEXEL_1	691	695	PF00026	0.392
TRG_Pf-PMV_PEXEL_1	735	739	PF00026	0.521

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMK4	Leptomonas seymouri	86%	100%
A0A0S4KKI7	Bodo saltans	57%	100%
A0A1X0P6J7	Trypanosomatidae	68%	100%
A0A3Q8IJX2	Leishmania donovani	94%	100%
A0A3R7N3D3	Trypanosoma rangeli	67%	100%
A4HY55	Leishmania infantum	94%	100%
D0A0G3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	64%	100%
E9ARY5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q4QDI8	Leishmania major	94%	100%
Q66HB3	Rattus norvegicus	39%	100%
Q8K057	Mus musculus	39%	100%
Q9P2H3	Homo sapiens	38%	100%
V5BWZ3	Trypanosoma cruzi	68%	100%