Putative intraflagellar transport protein component

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

intraflagellar transport protein 52

Species:

Leishmania braziliensis

UniProt:

A4H9Z0_LEIBR

TriTrypDb:

LbrM.19.0640 , LBRM2903_190011000

Length:

672

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 12

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 6

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	12
GO:0031514	motile cilium	5	12
GO:0042995	cell projection	2	12
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	12
GO:0110165	cellular anatomical entity	1	12
GO:0120025	plasma membrane bounded cell projection	3	12
GO:0005814	centriole	5	1
GO:0005815	microtubule organizing center	2	1
GO:0030990	intraciliary transport particle	2	1
GO:0030992	intraciliary transport particle B	2	1
GO:0032991	protein-containing complex	1	1
GO:0035869	ciliary transition zone	2	1
GO:0036064	ciliary basal body	3	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1

Expansion

Sequence features

A4H9Z0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H9Z0

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0006996	organelle organization	4	1
GO:0007017	microtubule-based process	2	1
GO:0007018	microtubule-based movement	3	1
GO:0009987	cellular process	1	1
GO:0010970	transport along microtubule	4	1
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0030030	cell projection organization	4	1
GO:0030031	cell projection assembly	5	1
GO:0030705	cytoskeleton-dependent intracellular transport	4	1
GO:0031503	protein-containing complex localization	2	1
GO:0035735	intraciliary transport involved in cilium assembly	4	1
GO:0042073	intraciliary transport	3	1
GO:0044782	cilium organization	5	1
GO:0046907	intracellular transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0060271	cilium assembly	6	1
GO:0070925	organelle assembly	5	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0099111	microtubule-based transport	4	1
GO:0120031	plasma membrane bounded cell projection assembly	6	1
GO:0120036	plasma membrane bounded cell projection organization	5	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	59	61	PF00675	0.537
CLV_PCSK_SKI1_1	147	151	PF00082	0.544
CLV_PCSK_SKI1_1	176	180	PF00082	0.560
CLV_PCSK_SKI1_1	187	191	PF00082	0.660
CLV_PCSK_SKI1_1	307	311	PF00082	0.274
CLV_PCSK_SKI1_1	382	386	PF00082	0.489
CLV_PCSK_SKI1_1	502	506	PF00082	0.448
CLV_PCSK_SKI1_1	663	667	PF00082	0.530
CLV_Separin_Metazoa	379	383	PF03568	0.501
DEG_APCC_DBOX_1	340	348	PF00400	0.398
DEG_APCC_DBOX_1	460	468	PF00400	0.515
DEG_APCC_DBOX_1	501	509	PF00400	0.439
DEG_APCC_DBOX_1	662	670	PF00400	0.538
DEG_SCF_FBW7_2	91	97	PF00400	0.510
DOC_ANK_TNKS_1	103	110	PF00023	0.478
DOC_CKS1_1	424	429	PF01111	0.576
DOC_CKS1_1	91	96	PF01111	0.503
DOC_CYCLIN_RxL_1	302	313	PF00134	0.299
DOC_CYCLIN_yCln2_LP_2	283	289	PF00134	0.385
DOC_CYCLIN_yCln2_LP_2	419	422	PF00134	0.527
DOC_MAPK_DCC_7	409	419	PF00069	0.630
DOC_MAPK_FxFP_2	256	259	PF00069	0.348
DOC_MAPK_gen_1	302	311	PF00069	0.401
DOC_MAPK_gen_1	9	17	PF00069	0.546
DOC_MAPK_MEF2A_6	441	450	PF00069	0.543
DOC_MAPK_RevD_3	503	517	PF00069	0.463
DOC_PP1_RVXF_1	36	42	PF00149	0.448
DOC_PP2B_LxvP_1	419	422	PF13499	0.527
DOC_PP4_FxxP_1	256	259	PF00568	0.348
DOC_PP4_FxxP_1	424	427	PF00568	0.544
DOC_PP4_FxxP_1	88	91	PF00568	0.444
DOC_USP7_MATH_1	329	333	PF00917	0.292
DOC_USP7_MATH_1	522	526	PF00917	0.738
DOC_USP7_UBL2_3	172	176	PF12436	0.475
DOC_USP7_UBL2_3	409	413	PF12436	0.466
DOC_WW_Pin1_4	423	428	PF00397	0.580
DOC_WW_Pin1_4	492	497	PF00397	0.541
DOC_WW_Pin1_4	563	568	PF00397	0.486
DOC_WW_Pin1_4	90	95	PF00397	0.566
LIG_14-3-3_CanoR_1	573	577	PF00244	0.330
LIG_14-3-3_CanoR_1	79	87	PF00244	0.587
LIG_Actin_WH2_2	633	651	PF00022	0.424
LIG_APCC_ABBAyCdc20_2	573	579	PF00400	0.440
LIG_BIR_III_2	564	568	PF00653	0.542
LIG_BRCT_BRCA1_1	252	256	PF00533	0.413
LIG_BRCT_BRCA1_1	274	278	PF00533	0.377
LIG_BRCT_BRCA1_1	331	335	PF00533	0.449
LIG_BRCT_BRCA1_1	596	600	PF00533	0.485
LIG_Clathr_ClatBox_1	387	391	PF01394	0.558
LIG_Clathr_ClatBox_1	450	454	PF01394	0.534
LIG_FHA_1	160	166	PF00498	0.505
LIG_FHA_1	203	209	PF00498	0.799
LIG_FHA_1	250	256	PF00498	0.427
LIG_FHA_1	261	267	PF00498	0.382
LIG_FHA_1	311	317	PF00498	0.329
LIG_FHA_1	361	367	PF00498	0.525
LIG_FHA_1	395	401	PF00498	0.487
LIG_FHA_1	488	494	PF00498	0.492
LIG_FHA_2	137	143	PF00498	0.403
LIG_FHA_2	531	537	PF00498	0.560
LIG_FHA_2	564	570	PF00498	0.510
LIG_FHA_2	666	672	PF00498	0.596
LIG_GBD_Chelix_1	330	338	PF00786	0.509
LIG_LIR_Apic_2	14	19	PF02991	0.708
LIG_LIR_Apic_2	253	259	PF02991	0.373
LIG_LIR_Apic_2	423	427	PF02991	0.546
LIG_LIR_Gen_1	332	342	PF02991	0.390
LIG_LIR_Gen_1	355	364	PF02991	0.496
LIG_LIR_Gen_1	383	390	PF02991	0.505
LIG_LIR_Gen_1	405	414	PF02991	0.479
LIG_LIR_Nem_3	133	138	PF02991	0.392
LIG_LIR_Nem_3	275	281	PF02991	0.384
LIG_LIR_Nem_3	332	338	PF02991	0.471
LIG_LIR_Nem_3	355	360	PF02991	0.511
LIG_LIR_Nem_3	383	387	PF02991	0.497
LIG_LIR_Nem_3	405	410	PF02991	0.471
LIG_LIR_Nem_3	475	481	PF02991	0.450
LIG_LIR_Nem_3	506	512	PF02991	0.442
LIG_LIR_Nem_3	514	518	PF02991	0.488
LIG_LIR_Nem_3	622	626	PF02991	0.429
LIG_PCNA_yPIPBox_3	324	334	PF02747	0.294
LIG_PDZ_Class_3	667	672	PF00595	0.469
LIG_Pex14_2	317	321	PF04695	0.531
LIG_Pex14_2	384	388	PF04695	0.480
LIG_SH2_CRK	125	129	PF00017	0.419
LIG_SH2_CRK	407	411	PF00017	0.495
LIG_SH2_CRK	515	519	PF00017	0.541
LIG_SH2_GRB2like	127	130	PF00017	0.421
LIG_SH2_GRB2like	337	340	PF00017	0.312
LIG_SH2_PTP2	637	640	PF00017	0.519
LIG_SH2_SRC	106	109	PF00017	0.448
LIG_SH2_SRC	153	156	PF00017	0.457
LIG_SH2_SRC	337	340	PF00017	0.509
LIG_SH2_SRC	577	580	PF00017	0.544
LIG_SH2_STAT3	479	482	PF00017	0.468
LIG_SH2_STAT5	106	109	PF00017	0.388
LIG_SH2_STAT5	127	130	PF00017	0.432
LIG_SH2_STAT5	153	156	PF00017	0.442
LIG_SH2_STAT5	337	340	PF00017	0.460
LIG_SH2_STAT5	479	482	PF00017	0.432
LIG_SH2_STAT5	507	510	PF00017	0.474
LIG_SH2_STAT5	577	580	PF00017	0.544
LIG_SH2_STAT5	637	640	PF00017	0.519
LIG_SH2_STAT5	667	670	PF00017	0.525
LIG_SH3_2	427	432	PF14604	0.559
LIG_SH3_3	263	269	PF00018	0.425
LIG_SH3_3	424	430	PF00018	0.552
LIG_SH3_3	440	446	PF00018	0.640
LIG_SH3_3	83	89	PF00018	0.525
LIG_SUMO_SIM_anti_2	112	117	PF11976	0.396
LIG_SUMO_SIM_anti_2	415	421	PF11976	0.514
LIG_SUMO_SIM_par_1	112	119	PF11976	0.472
LIG_SUMO_SIM_par_1	307	313	PF11976	0.369
LIG_TRAF2_1	243	246	PF00917	0.702
LIG_TRAF2_1	524	527	PF00917	0.765
LIG_TRAF2_1	668	671	PF00917	0.552
LIG_TYR_ITIM	476	481	PF00017	0.578
LIG_TYR_ITIM	513	518	PF00017	0.515
LIG_TYR_ITIM	635	640	PF00017	0.526
LIG_UBA3_1	334	343	PF00899	0.386
LIG_UBA3_1	387	394	PF00899	0.532
LIG_WRC_WIRS_1	390	395	PF05994	0.505
MOD_CDK_SPK_2	492	497	PF00069	0.541
MOD_CDK_SPxxK_3	492	499	PF00069	0.534
MOD_CK1_1	210	216	PF00069	0.688
MOD_CK1_1	408	414	PF00069	0.548
MOD_CK1_1	465	471	PF00069	0.460
MOD_CK2_1	136	142	PF00069	0.399
MOD_CK2_1	362	368	PF00069	0.512
MOD_CK2_1	530	536	PF00069	0.699
MOD_CK2_1	665	671	PF00069	0.601
MOD_GlcNHglycan	187	190	PF01048	0.745
MOD_GlcNHglycan	195	198	PF01048	0.766
MOD_GlcNHglycan	275	278	PF01048	0.391
MOD_GlcNHglycan	325	330	PF01048	0.448
MOD_GlcNHglycan	656	659	PF01048	0.586
MOD_GlcNHglycan	80	83	PF01048	0.469
MOD_GSK3_1	159	166	PF00069	0.502
MOD_GSK3_1	207	214	PF00069	0.662
MOD_GSK3_1	325	332	PF00069	0.524
MOD_GSK3_1	360	367	PF00069	0.530
MOD_GSK3_1	555	562	PF00069	0.630
MOD_N-GLC_1	215	220	PF02516	0.630
MOD_N-GLC_1	225	230	PF02516	0.635
MOD_N-GLC_2	42	44	PF02516	0.439
MOD_N-GLC_2	469	471	PF02516	0.452
MOD_NEK2_1	208	213	PF00069	0.639
MOD_NEK2_1	215	220	PF00069	0.655
MOD_NEK2_1	249	254	PF00069	0.593
MOD_NEK2_1	273	278	PF00069	0.488
MOD_NEK2_1	310	315	PF00069	0.322
MOD_NEK2_1	487	492	PF00069	0.487
MOD_NEK2_1	530	535	PF00069	0.699
MOD_NEK2_1	594	599	PF00069	0.530
MOD_NEK2_2	40	45	PF00069	0.336
MOD_NEK2_2	572	577	PF00069	0.608
MOD_PIKK_1	31	37	PF00454	0.693
MOD_PIKK_1	382	388	PF00454	0.628
MOD_PIKK_1	462	468	PF00454	0.457
MOD_PIKK_1	522	528	PF00454	0.738
MOD_PKA_2	159	165	PF00069	0.326
MOD_PKA_2	462	468	PF00069	0.447
MOD_PKA_2	555	561	PF00069	0.529
MOD_PKA_2	572	578	PF00069	0.494
MOD_PKA_2	594	600	PF00069	0.478
MOD_PKA_2	78	84	PF00069	0.596
MOD_Plk_1	215	221	PF00069	0.658
MOD_Plk_1	225	231	PF00069	0.672
MOD_Plk_1	249	255	PF00069	0.585
MOD_Plk_1	325	331	PF00069	0.481
MOD_Plk_1	382	388	PF00069	0.592
MOD_Plk_1	595	601	PF00069	0.588
MOD_Plk_1	73	79	PF00069	0.469
MOD_Plk_2-3	362	368	PF00069	0.492
MOD_Plk_2-3	73	79	PF00069	0.469
MOD_Plk_4	109	115	PF00069	0.349
MOD_Plk_4	123	129	PF00069	0.496
MOD_Plk_4	225	231	PF00069	0.805
MOD_Plk_4	250	256	PF00069	0.429
MOD_Plk_4	329	335	PF00069	0.400
MOD_Plk_4	415	421	PF00069	0.526
MOD_ProDKin_1	423	429	PF00069	0.577
MOD_ProDKin_1	492	498	PF00069	0.537
MOD_ProDKin_1	563	569	PF00069	0.489
MOD_ProDKin_1	90	96	PF00069	0.569
MOD_SUMO_for_1	412	415	PF00179	0.473
MOD_SUMO_rev_2	604	614	PF00179	0.624
MOD_SUMO_rev_2	96	103	PF00179	0.470
TRG_DiLeu_BaEn_1	250	255	PF01217	0.564
TRG_DiLeu_BaEn_1	415	420	PF01217	0.512
TRG_DiLeu_BaEn_4	325	331	PF01217	0.394
TRG_DiLeu_BaLyEn_6	269	274	PF01217	0.516
TRG_ENDOCYTIC_2	125	128	PF00928	0.419
TRG_ENDOCYTIC_2	357	360	PF00928	0.518
TRG_ENDOCYTIC_2	407	410	PF00928	0.475
TRG_ENDOCYTIC_2	478	481	PF00928	0.566
TRG_ENDOCYTIC_2	515	518	PF00928	0.533
TRG_ENDOCYTIC_2	55	58	PF00928	0.466
TRG_ENDOCYTIC_2	637	640	PF00928	0.519
TRG_ER_diArg_1	369	372	PF00400	0.584
TRG_ER_diArg_1	461	464	PF00400	0.517
TRG_ER_diArg_1	496	499	PF00400	0.591
TRG_NES_CRM1_1	378	391	PF08389	0.630
TRG_Pf-PMV_PEXEL_1	502	506	PF00026	0.476
TRG_Pf-PMV_PEXEL_1	60	64	PF00026	0.479

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDM4	Leptomonas seymouri	79%	99%
A0A0S4KG78	Bodo saltans	55%	100%
A0A1X0P7F0	Trypanosomatidae	66%	100%
A0A3R7NUY6	Trypanosoma rangeli	65%	100%
A0A3S5H752	Leishmania donovani	86%	100%
A4HY54	Leishmania infantum	87%	100%
D0A0G1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	63%	100%
E9ARY4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4QDI9	Leishmania major	89%	100%
V5DTK4	Trypanosoma cruzi	65%	100%