RNA binding protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

RNA binding protein

Gene product:

RNA binding protein

Species:

Leishmania braziliensis

UniProt:

A4H9Y8_LEIBR

TriTrypDb:

LbrM.19.0620 , LBRM2903_190010300

Length:

392

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 19
NetGPI	no	yes: 0, no: 19

Cellular components
Term	Name	Level	Count
GO:0020022	acidocalcisome	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	2
GO:0016020	membrane	2	1

Expansion

Sequence features

A4H9Y8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H9Y8

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	14
GO:0043167	ion binding	2	13
GO:0043169	cation binding	3	13
GO:0046872	metal ion binding	4	13
GO:0003824	catalytic activity	1	1
GO:0004842	ubiquitin-protein transferase activity	4	1
GO:0016740	transferase activity	2	1
GO:0019787	ubiquitin-like protein transferase activity	3	1
GO:0140096	catalytic activity, acting on a protein	2	1
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	170	174	PF00656	0.446
CLV_C14_Caspase3-7	64	68	PF00656	0.528
CLV_NRD_NRD_1	117	119	PF00675	0.315
CLV_NRD_NRD_1	144	146	PF00675	0.452
CLV_NRD_NRD_1	376	378	PF00675	0.485
CLV_NRD_NRD_1	71	73	PF00675	0.564
CLV_NRD_NRD_1	88	90	PF00675	0.582
CLV_PCSK_KEX2_1	144	146	PF00082	0.404
CLV_PCSK_KEX2_1	71	73	PF00082	0.533
CLV_PCSK_KEX2_1	88	90	PF00082	0.534
CLV_PCSK_SKI1_1	49	53	PF00082	0.492
DEG_Nend_UBRbox_3	1	3	PF02207	0.673
DEG_SCF_FBW7_1	217	222	PF00400	0.488
DOC_MAPK_MEF2A_6	246	253	PF00069	0.425
DOC_USP7_MATH_1	333	337	PF00917	0.716
DOC_USP7_MATH_1	343	347	PF00917	0.656
DOC_USP7_MATH_2	353	359	PF00917	0.488
DOC_USP7_UBL2_3	119	123	PF12436	0.567
DOC_WW_Pin1_4	13	18	PF00397	0.551
DOC_WW_Pin1_4	215	220	PF00397	0.483
LIG_14-3-3_CanoR_1	282	292	PF00244	0.530
LIG_14-3-3_CanoR_1	40	48	PF00244	0.595
LIG_14-3-3_CanoR_1	71	80	PF00244	0.553
LIG_DLG_GKlike_1	377	385	PF00625	0.485
LIG_FHA_1	1	7	PF00498	0.432
LIG_FHA_1	109	115	PF00498	0.474
LIG_FHA_1	132	138	PF00498	0.480
LIG_FHA_1	14	20	PF00498	0.536
LIG_FHA_1	153	159	PF00498	0.462
LIG_FHA_1	22	28	PF00498	0.470
LIG_FHA_1	242	248	PF00498	0.402
LIG_FHA_1	366	372	PF00498	0.484
LIG_FHA_2	127	133	PF00498	0.439
LIG_FHA_2	284	290	PF00498	0.576
LIG_GBD_Chelix_1	44	52	PF00786	0.452
LIG_LIR_Apic_2	218	224	PF02991	0.487
LIG_LIR_Gen_1	57	63	PF02991	0.544
LIG_LIR_Nem_3	262	268	PF02991	0.393
LIG_LIR_Nem_3	57	62	PF02991	0.547
LIG_LIR_Nem_3	67	73	PF02991	0.543
LIG_LRP6_Inhibitor_1	272	278	PF00058	0.380
LIG_NRBOX	145	151	PF00104	0.505
LIG_NRBOX	26	32	PF00104	0.530
LIG_PTB_Apo_2	264	271	PF02174	0.411
LIG_PTB_Phospho_1	264	270	PF10480	0.429
LIG_SH2_CRK	221	225	PF00017	0.504
LIG_SH2_CRK	234	238	PF00017	0.544
LIG_SH2_CRK	299	303	PF00017	0.534
LIG_SH2_CRK	59	63	PF00017	0.443
LIG_SH2_CRK	70	74	PF00017	0.461
LIG_SH2_GRB2like	299	302	PF00017	0.555
LIG_SH2_NCK_1	234	238	PF00017	0.497
LIG_SH2_SRC	299	302	PF00017	0.546
LIG_SH2_SRC	90	93	PF00017	0.502
LIG_SH2_STAP1	270	274	PF00017	0.420
LIG_SH2_STAP1	381	385	PF00017	0.490
LIG_SH2_STAT3	12	15	PF00017	0.499
LIG_SH2_STAT3	125	128	PF00017	0.539
LIG_SH2_STAT5	103	106	PF00017	0.450
LIG_SH2_STAT5	113	116	PF00017	0.407
LIG_SH2_STAT5	221	224	PF00017	0.490
LIG_SH2_STAT5	356	359	PF00017	0.485
LIG_SH3_3	153	159	PF00018	0.666
LIG_SH3_3	291	297	PF00018	0.587
LIG_SH3_3	90	96	PF00018	0.390
LIG_TRAF2_1	129	132	PF00917	0.464
LIG_WW_1	353	356	PF00397	0.494
MOD_CK1_1	126	132	PF00069	0.483
MOD_CK1_1	235	241	PF00069	0.543
MOD_CK1_1	346	352	PF00069	0.670
MOD_CK1_1	380	386	PF00069	0.727
MOD_CK2_1	126	132	PF00069	0.461
MOD_CK2_1	283	289	PF00069	0.577
MOD_CK2_1	355	361	PF00069	0.668
MOD_CK2_1	44	50	PF00069	0.519
MOD_GlcNHglycan	197	200	PF01048	0.641
MOD_GlcNHglycan	207	210	PF01048	0.498
MOD_GlcNHglycan	227	231	PF01048	0.668
MOD_GlcNHglycan	348	351	PF01048	0.674
MOD_GlcNHglycan	382	385	PF01048	0.736
MOD_GlcNHglycan	74	77	PF01048	0.316
MOD_GSK3_1	108	115	PF00069	0.428
MOD_GSK3_1	119	126	PF00069	0.477
MOD_GSK3_1	167	174	PF00069	0.716
MOD_GSK3_1	191	198	PF00069	0.547
MOD_GSK3_1	213	220	PF00069	0.601
MOD_GSK3_1	72	79	PF00069	0.482
MOD_GSK3_1	97	104	PF00069	0.430
MOD_N-GLC_1	139	144	PF02516	0.440
MOD_N-GLC_1	333	338	PF02516	0.772
MOD_NEK2_1	167	172	PF00069	0.625
MOD_NEK2_1	283	288	PF00069	0.481
MOD_NEK2_1	44	49	PF00069	0.418
MOD_OFUCOSY	281	287	PF10250	0.564
MOD_PIKK_1	11	17	PF00454	0.666
MOD_PIKK_1	123	129	PF00454	0.406
MOD_PIKK_1	21	27	PF00454	0.591
MOD_PIKK_1	333	339	PF00454	0.594
MOD_PKA_1	377	383	PF00069	0.484
MOD_PKA_2	117	123	PF00069	0.600
MOD_PKA_2	346	352	PF00069	0.664
MOD_PKA_2	39	45	PF00069	0.592
MOD_Plk_1	108	114	PF00069	0.431
MOD_Plk_1	139	145	PF00069	0.457
MOD_Plk_1	213	219	PF00069	0.479
MOD_Plk_1	261	267	PF00069	0.436
MOD_Plk_2-3	101	107	PF00069	0.431
MOD_Plk_2-3	355	361	PF00069	0.488
MOD_ProDKin_1	13	19	PF00069	0.546
MOD_ProDKin_1	215	221	PF00069	0.485
TRG_ENDOCYTIC_2	59	62	PF00928	0.426
TRG_ENDOCYTIC_2	70	73	PF00928	0.437
TRG_ENDOCYTIC_2	90	93	PF00928	0.403
TRG_ER_diArg_1	143	145	PF00400	0.444
TRG_ER_diArg_1	70	72	PF00400	0.531
TRG_ER_diArg_1	87	89	PF00400	0.512
TRG_NES_CRM1_1	148	160	PF08389	0.635
TRG_Pf-PMV_PEXEL_1	112	116	PF00026	0.500
TRG_Pf-PMV_PEXEL_1	144	148	PF00026	0.432

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1I4	Leptomonas seymouri	63%	99%
A0A0N1PG85	Leptomonas seymouri	31%	100%
A0A0S4KEK3	Bodo saltans	35%	100%
A0A1X0P6E1	Trypanosomatidae	37%	100%
A0A1X0P6N8	Trypanosomatidae	33%	78%
A0A3Q8IA61	Leishmania donovani	32%	100%
A0A3R7RSV6	Trypanosoma rangeli	36%	100%
A0A3S7WVD2	Leishmania donovani	74%	100%
A0A422P3A2	Trypanosoma rangeli	39%	96%
A4H9Y7	Leishmania braziliensis	32%	100%
A4HY39	Leishmania infantum	74%	100%
A4HY52	Leishmania infantum	32%	100%
D0A0F7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	91%
E9ARY1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	100%
E9ARY2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	71%	100%
Q4QDJ1	Leishmania major	34%	100%
V5BSB1	Trypanosoma cruzi	36%	82%
V5BWY8	Trypanosoma cruzi	36%	100%