Putative RNA binding protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA binding protein, putative

Species:

Leishmania braziliensis

UniProt:

A4H9Y7_LEIBR

TriTrypDb:

LbrM.19.0610 , LBRM2903_190010800

Length:

313

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 18
NetGPI	no	yes: 0, no: 18

Cellular components
Term	Name	Level	Count
GO:0020022	acidocalcisome	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H9Y7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H9Y7

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	13
GO:0043167	ion binding	2	12
GO:0043169	cation binding	3	12
GO:0046872	metal ion binding	4	12
GO:0003824	catalytic activity	1	1
GO:0004842	ubiquitin-protein transferase activity	4	1
GO:0016740	transferase activity	2	1
GO:0019787	ubiquitin-like protein transferase activity	3	1
GO:0140096	catalytic activity, acting on a protein	2	1
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	211	213	PF00675	0.658
CLV_PCSK_KEX2_1	211	213	PF00082	0.658
CLV_PCSK_KEX2_1	40	42	PF00082	0.441
CLV_PCSK_KEX2_1	96	98	PF00082	0.539
CLV_PCSK_PC1ET2_1	40	42	PF00082	0.441
CLV_PCSK_PC1ET2_1	96	98	PF00082	0.535
CLV_PCSK_SKI1_1	149	153	PF00082	0.496
CLV_PCSK_SKI1_1	159	163	PF00082	0.410
CLV_PCSK_SKI1_1	167	171	PF00082	0.429
DEG_Nend_UBRbox_1	1	4	PF02207	0.638
DOC_MAPK_DCC_7	219	227	PF00069	0.433
DOC_MAPK_gen_1	230	240	PF00069	0.489
DOC_MAPK_MEF2A_6	2	9	PF00069	0.427
DOC_MAPK_MEF2A_6	233	240	PF00069	0.414
DOC_PP1_RVXF_1	275	282	PF00149	0.452
DOC_PP2B_LxvP_1	154	157	PF13499	0.559
DOC_PP2B_PxIxI_1	235	241	PF00149	0.448
DOC_PP4_FxxP_1	281	284	PF00568	0.474
DOC_USP7_MATH_1	150	154	PF00917	0.467
DOC_USP7_MATH_1	157	161	PF00917	0.382
DOC_USP7_MATH_1	23	27	PF00917	0.650
DOC_USP7_MATH_1	304	308	PF00917	0.712
DOC_USP7_UBL2_3	173	177	PF12436	0.409
DOC_USP7_UBL2_3	267	271	PF12436	0.559
DOC_WW_Pin1_4	138	143	PF00397	0.538
DOC_WW_Pin1_4	220	225	PF00397	0.446
LIG_14-3-3_CanoR_1	159	165	PF00244	0.549
LIG_14-3-3_CanoR_1	167	172	PF00244	0.482
LIG_14-3-3_CanoR_1	46	50	PF00244	0.509
LIG_BRCT_BRCA1_1	117	121	PF00533	0.388
LIG_FHA_1	150	156	PF00498	0.464
LIG_FHA_1	194	200	PF00498	0.740
LIG_FHA_1	58	64	PF00498	0.567
LIG_FHA_2	161	167	PF00498	0.550
LIG_KLC1_Yacidic_2	83	88	PF13176	0.436
LIG_LIR_Apic_2	280	284	PF02991	0.475
LIG_LIR_Nem_3	106	111	PF02991	0.544
LIG_NRP_CendR_1	312	313	PF00754	0.448
LIG_PCNA_yPIPBox_3	158	167	PF02747	0.454
LIG_SH2_CRK	190	194	PF00017	0.470
LIG_SH2_CRK	35	39	PF00017	0.477
LIG_SH2_NCK_1	35	39	PF00017	0.389
LIG_SH2_PTP2	108	111	PF00017	0.545
LIG_SH2_SRC	131	134	PF00017	0.516
LIG_SH2_SRC	77	80	PF00017	0.542
LIG_SH2_STAP1	257	261	PF00017	0.403
LIG_SH2_STAP1	77	81	PF00017	0.423
LIG_SH2_STAT5	108	111	PF00017	0.485
LIG_SH2_STAT5	131	134	PF00017	0.416
LIG_SH2_STAT5	243	246	PF00017	0.399
LIG_SH2_STAT5	86	89	PF00017	0.514
LIG_SH3_1	173	179	PF00018	0.534
LIG_SH3_3	173	179	PF00018	0.648
LIG_SH3_5	284	288	PF00018	0.620
LIG_TRAF2_1	298	301	PF00917	0.611
LIG_TRAF2_1	307	310	PF00917	0.500
LIG_TRAF2_1	80	83	PF00917	0.545
LIG_TYR_ITIM	33	38	PF00017	0.526
MOD_CK1_1	144	150	PF00069	0.481
MOD_CK1_1	160	166	PF00069	0.422
MOD_CK2_1	127	133	PF00069	0.508
MOD_CK2_1	220	226	PF00069	0.614
MOD_CK2_1	23	29	PF00069	0.643
MOD_CK2_1	288	294	PF00069	0.694
MOD_CK2_1	304	310	PF00069	0.496
MOD_GlcNHglycan	202	205	PF01048	0.544
MOD_GSK3_1	115	122	PF00069	0.410
MOD_GSK3_1	140	147	PF00069	0.501
MOD_GSK3_1	167	174	PF00069	0.449
MOD_N-GLC_1	157	162	PF02516	0.434
MOD_N-GLC_1	200	205	PF02516	0.709
MOD_N-GLC_1	220	225	PF02516	0.539
MOD_N-GLC_2	266	268	PF02516	0.546
MOD_N-GLC_2	272	274	PF02516	0.570
MOD_NEK2_1	202	207	PF00069	0.716
MOD_NEK2_1	45	50	PF00069	0.519
MOD_NEK2_2	157	162	PF00069	0.414
MOD_PIKK_1	202	208	PF00454	0.593
MOD_PKA_2	124	130	PF00069	0.537
MOD_PKA_2	210	216	PF00069	0.490
MOD_PKA_2	45	51	PF00069	0.582
MOD_Plk_1	157	163	PF00069	0.452
MOD_Plk_2-3	119	125	PF00069	0.420
MOD_Plk_4	127	133	PF00069	0.496
MOD_Plk_4	150	156	PF00069	0.433
MOD_Plk_4	160	166	PF00069	0.418
MOD_Plk_4	45	51	PF00069	0.575
MOD_ProDKin_1	138	144	PF00069	0.530
MOD_ProDKin_1	220	226	PF00069	0.440
MOD_SUMO_for_1	229	232	PF00179	0.630
TRG_DiLeu_BaEn_1	62	67	PF01217	0.459
TRG_ENDOCYTIC_2	108	111	PF00928	0.432
TRG_ENDOCYTIC_2	35	38	PF00928	0.370
TRG_ER_diArg_1	311	313	PF00400	0.451
TRG_Pf-PMV_PEXEL_1	64	69	PF00026	0.509

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1I4	Leptomonas seymouri	32%	79%
A0A0N1PG85	Leptomonas seymouri	63%	99%
A0A0S4KMM7	Bodo saltans	37%	82%
A0A1X0P6E1	Trypanosomatidae	37%	95%
A0A3Q8IA61	Leishmania donovani	80%	100%
A0A3R7RSV6	Trypanosoma rangeli	39%	100%
A0A3S7WVD2	Leishmania donovani	32%	80%
A0A422P3A2	Trypanosoma rangeli	30%	77%
A4H9Y8	Leishmania braziliensis	32%	80%
A4HY39	Leishmania infantum	32%	80%
A4HY52	Leishmania infantum	80%	100%
D0A0F3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
D0A0F7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	72%
E9ARY1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
E9ARY2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	80%
Q4QDJ1	Leishmania major	78%	100%
V5BWY8	Trypanosoma cruzi	41%	100%