Putative sarcoplasmic reticulum glycoprotein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Sarcalumenin, putative

Species:

Leishmania braziliensis

UniProt:

A4H9Y5_LEIBR

TriTrypDb:

LbrM.19.0590 , LBRM2903_190010600

Length:

626

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 4
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 9

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 6

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 17
NetGPI	no	yes: 0, no: 17

Cellular components
Term	Name	Level	Count
GO:0005886	plasma membrane	3	18
GO:0016020	membrane	2	18
GO:0110165	cellular anatomical entity	1	18
GO:0005737	cytoplasm	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2

Expansion

Sequence features

A4H9Y5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H9Y5

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	2
GO:0006897	endocytosis	5	2
GO:0009987	cellular process	1	2
GO:0016192	vesicle-mediated transport	4	2
GO:0016197	endosomal transport	4	2
GO:0046907	intracellular transport	3	2
GO:0051179	localization	1	2
GO:0051234	establishment of localization	2	2
GO:0051641	cellular localization	2	2
GO:0051649	establishment of localization in cell	3	2

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	18
GO:0005488	binding	1	18
GO:0005525	GTP binding	5	18
GO:0017076	purine nucleotide binding	4	18
GO:0019001	guanyl nucleotide binding	5	18
GO:0032553	ribonucleotide binding	3	18
GO:0032555	purine ribonucleotide binding	4	18
GO:0032561	guanyl ribonucleotide binding	5	18
GO:0035639	purine ribonucleoside triphosphate binding	4	18
GO:0036094	small molecule binding	2	18
GO:0043167	ion binding	2	18
GO:0043168	anion binding	3	18
GO:0097159	organic cyclic compound binding	2	18
GO:0097367	carbohydrate derivative binding	2	18
GO:1901265	nucleoside phosphate binding	3	18
GO:1901363	heterocyclic compound binding	2	18

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	155	159	PF00656	0.188
CLV_C14_Caspase3-7	197	201	PF00656	0.318
CLV_C14_Caspase3-7	448	452	PF00656	0.664
CLV_NRD_NRD_1	171	173	PF00675	0.336
CLV_NRD_NRD_1	306	308	PF00675	0.308
CLV_NRD_NRD_1	335	337	PF00675	0.261
CLV_NRD_NRD_1	344	346	PF00675	0.336
CLV_NRD_NRD_1	440	442	PF00675	0.740
CLV_NRD_NRD_1	455	457	PF00675	0.461
CLV_PCSK_KEX2_1	306	308	PF00082	0.311
CLV_PCSK_KEX2_1	335	337	PF00082	0.261
CLV_PCSK_KEX2_1	344	346	PF00082	0.336
CLV_PCSK_KEX2_1	440	442	PF00082	0.459
CLV_PCSK_KEX2_1	454	456	PF00082	0.434
CLV_PCSK_PC1ET2_1	335	337	PF00082	0.203
CLV_PCSK_PC1ET2_1	454	456	PF00082	0.461
CLV_PCSK_SKI1_1	128	132	PF00082	0.294
CLV_PCSK_SKI1_1	206	210	PF00082	0.327
CLV_PCSK_SKI1_1	221	225	PF00082	0.329
CLV_PCSK_SKI1_1	306	310	PF00082	0.303
CLV_PCSK_SKI1_1	367	371	PF00082	0.343
CLV_Separin_Metazoa	234	238	PF03568	0.376
CLV_Separin_Metazoa	254	258	PF03568	0.387
DEG_APCC_DBOX_1	185	193	PF00400	0.276
DEG_APCC_DBOX_1	321	329	PF00400	0.330
DEG_APCC_DBOX_1	421	429	PF00400	0.348
DEG_SPOP_SBC_1	506	510	PF00917	0.622
DEG_SPOP_SBC_1	565	569	PF00917	0.521
DOC_CYCLIN_RxL_1	123	135	PF00134	0.409
DOC_CYCLIN_yCln2_LP_2	70	76	PF00134	0.285
DOC_MAPK_gen_1	172	179	PF00069	0.339
DOC_MAPK_gen_1	306	313	PF00069	0.314
DOC_MAPK_MEF2A_6	186	194	PF00069	0.251
DOC_MAPK_NFAT4_5	186	194	PF00069	0.188
DOC_PP2B_LxvP_1	594	597	PF13499	0.567
DOC_PP2B_LxvP_1	603	606	PF13499	0.541
DOC_PP4_FxxP_1	144	147	PF00568	0.354
DOC_PP4_FxxP_1	193	196	PF00568	0.285
DOC_PP4_FxxP_1	497	500	PF00568	0.784
DOC_USP7_MATH_1	14	18	PF00917	0.551
DOC_USP7_MATH_1	184	188	PF00917	0.276
DOC_USP7_MATH_1	267	271	PF00917	0.361
DOC_USP7_MATH_1	466	470	PF00917	0.700
DOC_USP7_MATH_1	493	497	PF00917	0.688
DOC_USP7_MATH_1	506	510	PF00917	0.794
DOC_USP7_MATH_1	518	522	PF00917	0.636
DOC_USP7_MATH_1	565	569	PF00917	0.787
DOC_USP7_MATH_1	576	580	PF00917	0.722
DOC_USP7_MATH_1	585	589	PF00917	0.681
DOC_USP7_UBL2_3	331	335	PF12436	0.317
DOC_USP7_UBL2_3	382	386	PF12436	0.404
DOC_WW_Pin1_4	156	161	PF00397	0.305
DOC_WW_Pin1_4	443	448	PF00397	0.535
DOC_WW_Pin1_4	464	469	PF00397	0.721
DOC_WW_Pin1_4	491	496	PF00397	0.757
DOC_WW_Pin1_4	566	571	PF00397	0.720
DOC_WW_Pin1_4	581	586	PF00397	0.606
DOC_WW_Pin1_4	598	603	PF00397	0.502
LIG_14-3-3_CanoR_1	153	157	PF00244	0.376
LIG_14-3-3_CanoR_1	564	570	PF00244	0.534
LIG_14-3-3_CanoR_1	65	71	PF00244	0.371
LIG_Actin_WH2_2	209	227	PF00022	0.250
LIG_Actin_WH2_2	390	408	PF00022	0.371
LIG_APCC_ABBA_1	190	195	PF00400	0.285
LIG_APCC_ABBA_1	426	431	PF00400	0.552
LIG_BRCT_BRCA1_1	269	273	PF00533	0.376
LIG_BRCT_BRCA1_1	478	482	PF00533	0.505
LIG_BRCT_BRCA1_1	493	497	PF00533	0.562
LIG_Clathr_ClatBox_1	191	195	PF01394	0.188
LIG_CtBP_PxDLS_1	500	504	PF00389	0.504
LIG_EH_1	414	418	PF12763	0.630
LIG_FHA_1	230	236	PF00498	0.358
LIG_FHA_1	35	41	PF00498	0.458
LIG_FHA_1	77	83	PF00498	0.435
LIG_FHA_2	153	159	PF00498	0.276
LIG_FHA_2	615	621	PF00498	0.540
LIG_FHA_2	96	102	PF00498	0.262
LIG_FXI_DFP_1	357	361	PF00024	0.276
LIG_LIR_Apic_2	262	267	PF02991	0.401
LIG_LIR_Apic_2	494	500	PF02991	0.490
LIG_LIR_Gen_1	175	184	PF02991	0.315
LIG_LIR_Gen_1	270	278	PF02991	0.415
LIG_LIR_Gen_1	64	73	PF02991	0.461
LIG_LIR_Gen_1	99	107	PF02991	0.305
LIG_LIR_Nem_3	122	127	PF02991	0.251
LIG_LIR_Nem_3	175	179	PF02991	0.311
LIG_LIR_Nem_3	211	216	PF02991	0.409
LIG_LIR_Nem_3	241	246	PF02991	0.380
LIG_LIR_Nem_3	270	276	PF02991	0.406
LIG_LIR_Nem_3	359	363	PF02991	0.325
LIG_LIR_Nem_3	376	381	PF02991	0.406
LIG_LIR_Nem_3	64	70	PF02991	0.376
LIG_LIR_Nem_3	79	84	PF02991	0.298
LIG_Pex14_1	264	268	PF04695	0.411
LIG_Pex14_2	133	137	PF04695	0.305
LIG_Pex14_2	209	213	PF04695	0.262
LIG_Pex14_2	273	277	PF04695	0.368
LIG_Pex14_2	369	373	PF04695	0.266
LIG_Pex14_2	52	56	PF04695	0.318
LIG_Pex14_2	67	71	PF04695	0.288
LIG_PTB_Apo_2	118	125	PF02174	0.188
LIG_PTB_Phospho_1	118	124	PF10480	0.188
LIG_SH2_CRK	174	178	PF00017	0.318
LIG_SH2_CRK	239	243	PF00017	0.364
LIG_SH2_NCK_1	346	350	PF00017	0.347
LIG_SH2_PTP2	176	179	PF00017	0.334
LIG_SH2_SRC	174	177	PF00017	0.409
LIG_SH2_STAP1	36	40	PF00017	0.480
LIG_SH2_STAP1	57	61	PF00017	0.365
LIG_SH2_STAT3	84	87	PF00017	0.354
LIG_SH2_STAT5	124	127	PF00017	0.197
LIG_SH2_STAT5	176	179	PF00017	0.318
LIG_SH2_STAT5	259	262	PF00017	0.354
LIG_SH2_STAT5	36	39	PF00017	0.331
LIG_SH2_STAT5	457	460	PF00017	0.475
LIG_SH2_STAT5	84	87	PF00017	0.317
LIG_SH3_3	567	573	PF00018	0.689
LIG_SH3_3	579	585	PF00018	0.693
LIG_SH3_3	596	602	PF00018	0.658
LIG_SUMO_SIM_anti_2	152	159	PF11976	0.321
LIG_SUMO_SIM_anti_2	187	193	PF11976	0.188
LIG_SUMO_SIM_anti_2	279	287	PF11976	0.431
LIG_TRAF2_1	231	234	PF00917	0.509
LIG_TRAF2_1	42	45	PF00917	0.409
LIG_TRAF2_1	584	587	PF00917	0.607
LIG_TRAF2_2	293	298	PF00917	0.378
LIG_WRC_WIRS_1	260	265	PF05994	0.374
LIG_WW_3	254	258	PF00397	0.387
MOD_CK1_1	24	30	PF00069	0.538
MOD_CK1_1	476	482	PF00069	0.610
MOD_CK1_1	521	527	PF00069	0.580
MOD_CK1_1	533	539	PF00069	0.454
MOD_CK2_1	146	152	PF00069	0.384
MOD_CK2_1	228	234	PF00069	0.494
MOD_CK2_1	52	58	PF00069	0.287
MOD_CK2_1	581	587	PF00069	0.734
MOD_CK2_1	95	101	PF00069	0.262
MOD_Cter_Amidation	438	441	PF01082	0.431
MOD_GlcNHglycan	16	19	PF01048	0.653
MOD_GlcNHglycan	164	167	PF01048	0.383
MOD_GlcNHglycan	460	463	PF01048	0.593
MOD_GlcNHglycan	491	494	PF01048	0.751
MOD_GlcNHglycan	520	523	PF01048	0.727
MOD_GlcNHglycan	553	556	PF01048	0.576
MOD_GlcNHglycan	587	590	PF01048	0.636
MOD_GlcNHglycan	74	77	PF01048	0.305
MOD_GSK3_1	152	159	PF00069	0.336
MOD_GSK3_1	267	274	PF00069	0.377
MOD_GSK3_1	464	471	PF00069	0.717
MOD_GSK3_1	473	480	PF00069	0.552
MOD_GSK3_1	482	489	PF00069	0.602
MOD_GSK3_1	491	498	PF00069	0.494
MOD_GSK3_1	501	508	PF00069	0.655
MOD_GSK3_1	517	524	PF00069	0.723
MOD_GSK3_1	551	558	PF00069	0.736
MOD_GSK3_1	577	584	PF00069	0.661
MOD_GSK3_1	72	79	PF00069	0.319
MOD_GSK3_1	96	103	PF00069	0.319
MOD_LATS_1	562	568	PF00433	0.519
MOD_N-GLC_1	244	249	PF02516	0.386
MOD_N-GLC_1	250	255	PF02516	0.407
MOD_NEK2_1	119	124	PF00069	0.388
MOD_NEK2_1	133	138	PF00069	0.307
MOD_NEK2_1	208	213	PF00069	0.356
MOD_NEK2_1	329	334	PF00069	0.337
MOD_NEK2_1	396	401	PF00069	0.482
MOD_NEK2_1	458	463	PF00069	0.623
MOD_NEK2_1	505	510	PF00069	0.795
MOD_NEK2_1	551	556	PF00069	0.490
MOD_NEK2_1	85	90	PF00069	0.417
MOD_NEK2_2	66	71	PF00069	0.276
MOD_PIKK_1	229	235	PF00454	0.360
MOD_PIKK_1	34	40	PF00454	0.285
MOD_PIKK_1	432	438	PF00454	0.382
MOD_PKA_2	14	20	PF00069	0.716
MOD_PKA_2	152	158	PF00069	0.318
MOD_PKA_2	52	58	PF00069	0.318
MOD_PKB_1	430	438	PF00069	0.354
MOD_Plk_1	100	106	PF00069	0.263
MOD_Plk_1	57	63	PF00069	0.358
MOD_Plk_1	577	583	PF00069	0.747
MOD_Plk_2-3	146	152	PF00069	0.406
MOD_Plk_4	133	139	PF00069	0.296
MOD_Plk_4	146	152	PF00069	0.338
MOD_Plk_4	238	244	PF00069	0.381
MOD_Plk_4	24	30	PF00069	0.375
MOD_Plk_4	259	265	PF00069	0.380
MOD_Plk_4	300	306	PF00069	0.318
MOD_Plk_4	396	402	PF00069	0.324
MOD_Plk_4	477	483	PF00069	0.591
MOD_Plk_4	52	58	PF00069	0.327
MOD_Plk_4	530	536	PF00069	0.499
MOD_Plk_4	595	601	PF00069	0.698
MOD_Plk_4	66	72	PF00069	0.281
MOD_Plk_4	77	83	PF00069	0.340
MOD_ProDKin_1	156	162	PF00069	0.305
MOD_ProDKin_1	443	449	PF00069	0.535
MOD_ProDKin_1	464	470	PF00069	0.723
MOD_ProDKin_1	491	497	PF00069	0.758
MOD_ProDKin_1	566	572	PF00069	0.718
MOD_ProDKin_1	581	587	PF00069	0.608
MOD_ProDKin_1	598	604	PF00069	0.502
MOD_SUMO_rev_2	274	282	PF00179	0.480
TRG_DiLeu_BaEn_1	146	151	PF01217	0.425
TRG_DiLeu_BaEn_1	152	157	PF01217	0.423
TRG_DiLeu_BaEn_1	185	190	PF01217	0.318
TRG_DiLeu_BaEn_1	280	285	PF01217	0.354
TRG_DiLeu_BaEn_1	385	390	PF01217	0.383
TRG_DiLeu_BaEn_1	421	426	PF01217	0.438
TRG_ENDOCYTIC_2	124	127	PF00928	0.270
TRG_ENDOCYTIC_2	174	177	PF00928	0.310
TRG_ENDOCYTIC_2	239	242	PF00928	0.366
TRG_ENDOCYTIC_2	346	349	PF00928	0.299
TRG_ENDOCYTIC_2	366	369	PF00928	0.158
TRG_ER_diArg_1	219	222	PF00400	0.409
TRG_ER_diArg_1	305	307	PF00400	0.333
TRG_ER_diArg_1	343	345	PF00400	0.466
TRG_ER_diArg_1	455	457	PF00400	0.480
TRG_NLS_Bipartite_1	440	458	PF00514	0.466
TRG_NLS_MonoExtC_3	334	340	PF00514	0.294
TRG_NLS_MonoExtN_4	333	339	PF00514	0.276
TRG_Pf-PMV_PEXEL_1	206	210	PF00026	0.285
TRG_Pf-PMV_PEXEL_1	391	395	PF00026	0.361
TRG_Pf-PMV_PEXEL_1	432	436	PF00026	0.336

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8K7	Leptomonas seymouri	74%	100%
A0A0S4KGM0	Bodo saltans	64%	100%
A0A1X0P6D7	Trypanosomatidae	61%	100%
A0A3R7LDF3	Trypanosoma rangeli	60%	100%
A0A3S7WV81	Leishmania donovani	75%	99%
A0A3S7X801	Leishmania donovani	46%	100%
A0A422P0G8	Trypanosoma rangeli	46%	100%
A4HAT9	Leishmania braziliensis	44%	100%
A4HY50	Leishmania infantum	75%	99%
A4IA07	Leishmania infantum	46%	100%
D0A0F1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	100%
E9ARX9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	100%
E9B513	Leishmania mexicana (strain MHOM/GT/2001/U1103)	47%	100%
Q4Q2X3	Leishmania major	47%	100%
Q4QDJ3	Leishmania major	75%	100%
V5BSA9	Trypanosoma cruzi	59%	100%