Kinesin-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

C-terminal motor kinesin, putative

Species:

Leishmania braziliensis

UniProt:

A4H9Y3_LEIBR

TriTrypDb:

LbrM.19.0570 , LBRM2903_190010400

Length:

839

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 12

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 5

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 5

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005874	microtubule	6	12
GO:0099080	supramolecular complex	2	12
GO:0099081	supramolecular polymer	3	12
GO:0099512	supramolecular fiber	4	12
GO:0099513	polymeric cytoskeletal fiber	5	12
GO:0110165	cellular anatomical entity	1	12
GO:0005871	kinesin complex	3	1
GO:0005875	microtubule associated complex	2	1
GO:0032991	protein-containing complex	1	1

Expansion

Sequence features

A4H9Y3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H9Y3

Function

Biological processes
Term	Name	Level	Count
GO:0007017	microtubule-based process	2	12
GO:0007018	microtubule-based movement	3	12
GO:0009987	cellular process	1	12
GO:0006810	transport	3	1
GO:0030705	cytoskeleton-dependent intracellular transport	4	1
GO:0046907	intracellular transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003774	cytoskeletal motor activity	1	12
GO:0003777	microtubule motor activity	2	12
GO:0005488	binding	1	12
GO:0005515	protein binding	2	12
GO:0005524	ATP binding	5	12
GO:0005543	phospholipid binding	3	12
GO:0008017	microtubule binding	5	12
GO:0008092	cytoskeletal protein binding	3	12
GO:0008289	lipid binding	2	12
GO:0015631	tubulin binding	4	12
GO:0017076	purine nucleotide binding	4	12
GO:0030554	adenyl nucleotide binding	5	12
GO:0032182	ubiquitin-like protein binding	3	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032559	adenyl ribonucleotide binding	5	12
GO:0035091	phosphatidylinositol binding	4	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0043130	ubiquitin binding	4	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:0140657	ATP-dependent activity	1	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12
GO:0003824	catalytic activity	1	1
GO:0016462	pyrophosphatase activity	5	1
GO:0016787	hydrolase activity	2	1
GO:0016817	hydrolase activity, acting on acid anhydrides	3	1
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	1
GO:0016887	ATP hydrolysis activity	7	1
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	186	190	PF00656	0.714
CLV_C14_Caspase3-7	268	272	PF00656	0.500
CLV_C14_Caspase3-7	570	574	PF00656	0.345
CLV_NRD_NRD_1	277	279	PF00675	0.744
CLV_NRD_NRD_1	302	304	PF00675	0.666
CLV_NRD_NRD_1	307	309	PF00675	0.667
CLV_NRD_NRD_1	315	317	PF00675	0.679
CLV_NRD_NRD_1	427	429	PF00675	0.540
CLV_NRD_NRD_1	467	469	PF00675	0.645
CLV_NRD_NRD_1	488	490	PF00675	0.484
CLV_NRD_NRD_1	617	619	PF00675	0.362
CLV_PCSK_FUR_1	300	304	PF00082	0.771
CLV_PCSK_KEX2_1	276	278	PF00082	0.746
CLV_PCSK_KEX2_1	302	304	PF00082	0.671
CLV_PCSK_KEX2_1	307	309	PF00082	0.670
CLV_PCSK_KEX2_1	483	485	PF00082	0.600
CLV_PCSK_PC1ET2_1	276	278	PF00082	0.739
CLV_PCSK_PC1ET2_1	483	485	PF00082	0.562
CLV_PCSK_PC7_1	303	309	PF00082	0.752
CLV_PCSK_SKI1_1	103	107	PF00082	0.452
CLV_PCSK_SKI1_1	159	163	PF00082	0.586
CLV_PCSK_SKI1_1	355	359	PF00082	0.568
CLV_PCSK_SKI1_1	432	436	PF00082	0.586
CLV_PCSK_SKI1_1	484	488	PF00082	0.503
CLV_PCSK_SKI1_1	510	514	PF00082	0.380
CLV_PCSK_SKI1_1	589	593	PF00082	0.409
CLV_PCSK_SKI1_1	639	643	PF00082	0.345
CLV_PCSK_SKI1_1	832	836	PF00082	0.656
CLV_Separin_Metazoa	313	317	PF03568	0.494
DEG_APCC_DBOX_1	336	344	PF00400	0.608
DEG_Nend_UBRbox_3	1	3	PF02207	0.556
DEG_SPOP_SBC_1	108	112	PF00917	0.552
DOC_CDC14_PxL_1	389	397	PF14671	0.723
DOC_CYCLIN_RxL_1	792	803	PF00134	0.361
DOC_MAPK_gen_1	468	475	PF00069	0.436
DOC_MAPK_MEF2A_6	703	712	PF00069	0.345
DOC_MAPK_MEF2A_6	795	802	PF00069	0.380
DOC_MAPK_NFAT4_5	703	711	PF00069	0.345
DOC_PP1_RVXF_1	793	800	PF00149	0.345
DOC_PP1_RVXF_1	821	828	PF00149	0.486
DOC_USP7_MATH_1	12	16	PF00917	0.643
DOC_USP7_MATH_1	152	156	PF00917	0.474
DOC_USP7_MATH_1	451	455	PF00917	0.450
DOC_USP7_MATH_1	809	813	PF00917	0.359
DOC_USP7_UBL2_3	358	362	PF12436	0.600
DOC_USP7_UBL2_3	483	487	PF12436	0.480
DOC_WW_Pin1_4	31	36	PF00397	0.596
DOC_WW_Pin1_4	395	400	PF00397	0.643
DOC_WW_Pin1_4	672	677	PF00397	0.245
DOC_WW_Pin1_4	800	805	PF00397	0.361
LIG_14-3-3_CanoR_1	253	261	PF00244	0.511
LIG_14-3-3_CanoR_1	277	281	PF00244	0.668
LIG_14-3-3_CanoR_1	28	35	PF00244	0.540
LIG_14-3-3_CanoR_1	489	493	PF00244	0.402
LIG_14-3-3_CanoR_1	778	786	PF00244	0.361
LIG_APCC_ABBA_1	631	636	PF00400	0.345
LIG_BRCT_BRCA1_1	557	561	PF00533	0.315
LIG_BRCT_BRCA1_1	814	818	PF00533	0.345
LIG_CaM_IQ_9	475	491	PF13499	0.543
LIG_Clathr_ClatBox_1	544	548	PF01394	0.403
LIG_deltaCOP1_diTrp_1	98	105	PF00928	0.500
LIG_eIF4E_1	724	730	PF01652	0.403
LIG_FHA_1	21	27	PF00498	0.617
LIG_FHA_1	253	259	PF00498	0.411
LIG_FHA_1	320	326	PF00498	0.615
LIG_FHA_1	331	337	PF00498	0.592
LIG_FHA_1	40	46	PF00498	0.593
LIG_FHA_1	476	482	PF00498	0.552
LIG_FHA_1	562	568	PF00498	0.345
LIG_FHA_1	603	609	PF00498	0.370
LIG_FHA_1	621	627	PF00498	0.223
LIG_FHA_1	650	656	PF00498	0.417
LIG_FHA_1	781	787	PF00498	0.345
LIG_FHA_1	99	105	PF00498	0.509
LIG_FHA_2	110	116	PF00498	0.548
LIG_FHA_2	286	292	PF00498	0.796
LIG_FHA_2	493	499	PF00498	0.519
LIG_FHA_2	642	648	PF00498	0.421
LIG_FHA_2	76	82	PF00498	0.467
LIG_LIR_Gen_1	151	161	PF02991	0.489
LIG_LIR_Gen_1	259	269	PF02991	0.583
LIG_LIR_Gen_1	491	499	PF02991	0.386
LIG_LIR_Gen_1	546	555	PF02991	0.345
LIG_LIR_Gen_1	609	617	PF02991	0.331
LIG_LIR_Nem_3	151	156	PF02991	0.487
LIG_LIR_Nem_3	491	496	PF02991	0.573
LIG_LIR_Nem_3	546	550	PF02991	0.345
LIG_LIR_Nem_3	609	615	PF02991	0.361
LIG_LIR_Nem_3	723	727	PF02991	0.245
LIG_NRBOX	781	787	PF00104	0.345
LIG_PCNA_yPIPBox_3	428	438	PF02747	0.385
LIG_PCNA_yPIPBox_3	66	80	PF02747	0.565
LIG_Pex14_1	127	131	PF04695	0.455
LIG_Pex14_2	153	157	PF04695	0.575
LIG_PTAP_UEV_1	552	557	PF05743	0.492
LIG_SH2_CRK	493	497	PF00017	0.478
LIG_SH2_CRK	506	510	PF00017	0.345
LIG_SH2_CRK	67	71	PF00017	0.607
LIG_SH2_CRK	724	728	PF00017	0.403
LIG_SH2_GRB2like	492	495	PF00017	0.493
LIG_SH2_NCK_1	493	497	PF00017	0.478
LIG_SH2_NCK_1	67	71	PF00017	0.607
LIG_SH2_PTP2	709	712	PF00017	0.345
LIG_SH2_SRC	709	712	PF00017	0.403
LIG_SH2_STAP1	261	265	PF00017	0.716
LIG_SH2_STAP1	371	375	PF00017	0.582
LIG_SH2_STAT3	527	530	PF00017	0.492
LIG_SH2_STAT3	634	637	PF00017	0.431
LIG_SH2_STAT5	207	210	PF00017	0.421
LIG_SH2_STAT5	506	509	PF00017	0.387
LIG_SH2_STAT5	634	637	PF00017	0.333
LIG_SH2_STAT5	664	667	PF00017	0.345
LIG_SH2_STAT5	709	712	PF00017	0.345
LIG_SH3_3	547	553	PF00018	0.357
LIG_SH3_3	670	676	PF00018	0.245
LIG_SUMO_SIM_anti_2	373	379	PF11976	0.592
LIG_SUMO_SIM_par_1	620	629	PF11976	0.335
LIG_SUMO_SIM_par_1	75	81	PF11976	0.464
LIG_TRAF2_1	318	321	PF00917	0.717
LIG_TRAF2_1	495	498	PF00917	0.513
LIG_TYR_ITIM	707	712	PF00017	0.345
LIG_UBA3_1	156	164	PF00899	0.662
LIG_UBA3_1	611	619	PF00899	0.370
MOD_CDK_SPK_2	672	677	PF00069	0.315
MOD_CK1_1	213	219	PF00069	0.418
MOD_CK1_1	31	37	PF00069	0.616
MOD_CK1_1	440	446	PF00069	0.452
MOD_CK1_1	526	532	PF00069	0.466
MOD_CK1_1	587	593	PF00069	0.345
MOD_CK1_1	691	697	PF00069	0.370
MOD_CK1_1	701	707	PF00069	0.357
MOD_CK1_1	780	786	PF00069	0.357
MOD_CK1_1	803	809	PF00069	0.352
MOD_CK1_1	810	816	PF00069	0.340
MOD_CK2_1	109	115	PF00069	0.596
MOD_CK2_1	13	19	PF00069	0.670
MOD_CK2_1	213	219	PF00069	0.438
MOD_CK2_1	246	252	PF00069	0.667
MOD_CK2_1	256	262	PF00069	0.515
MOD_CK2_1	363	369	PF00069	0.462
MOD_CK2_1	492	498	PF00069	0.517
MOD_CK2_1	526	532	PF00069	0.378
MOD_CK2_1	626	632	PF00069	0.345
MOD_CK2_1	641	647	PF00069	0.345
MOD_CK2_1	738	744	PF00069	0.361
MOD_Cter_Amidation	305	308	PF01082	0.629
MOD_GlcNHglycan	112	115	PF01048	0.375
MOD_GlcNHglycan	15	18	PF01048	0.598
MOD_GlcNHglycan	236	239	PF01048	0.600
MOD_GlcNHglycan	403	406	PF01048	0.742
MOD_GlcNHglycan	449	452	PF01048	0.538
MOD_GlcNHglycan	537	541	PF01048	0.409
MOD_GlcNHglycan	553	556	PF01048	0.431
MOD_GlcNHglycan	586	589	PF01048	0.345
MOD_GlcNHglycan	739	743	PF01048	0.361
MOD_GlcNHglycan	758	761	PF01048	0.223
MOD_GlcNHglycan	779	782	PF01048	0.442
MOD_GlcNHglycan	86	89	PF01048	0.566
MOD_GlcNHglycan	95	98	PF01048	0.522
MOD_GSK3_1	175	182	PF00069	0.707
MOD_GSK3_1	234	241	PF00069	0.713
MOD_GSK3_1	252	259	PF00069	0.540
MOD_GSK3_1	272	279	PF00069	0.432
MOD_GSK3_1	380	387	PF00069	0.704
MOD_GSK3_1	401	408	PF00069	0.733
MOD_GSK3_1	447	454	PF00069	0.537
MOD_GSK3_1	488	495	PF00069	0.396
MOD_GSK3_1	551	558	PF00069	0.290
MOD_GSK3_1	678	685	PF00069	0.356
MOD_GSK3_1	688	695	PF00069	0.343
MOD_GSK3_1	712	719	PF00069	0.351
MOD_GSK3_1	803	810	PF00069	0.361
MOD_N-GLC_1	179	184	PF02516	0.520
MOD_N-GLC_1	754	759	PF02516	0.345
MOD_N-GLC_1	807	812	PF02516	0.347
MOD_N-GLC_1	832	837	PF02516	0.663
MOD_N-GLC_2	576	578	PF02516	0.345
MOD_NEK2_1	130	135	PF00069	0.490
MOD_NEK2_1	143	148	PF00069	0.456
MOD_NEK2_1	179	184	PF00069	0.632
MOD_NEK2_1	384	389	PF00069	0.692
MOD_NEK2_1	488	493	PF00069	0.551
MOD_NEK2_1	535	540	PF00069	0.379
MOD_NEK2_1	561	566	PF00069	0.345
MOD_NEK2_1	567	572	PF00069	0.345
MOD_NEK2_1	641	646	PF00069	0.406
MOD_NEK2_1	777	782	PF00069	0.361
MOD_NEK2_1	786	791	PF00069	0.376
MOD_NEK2_1	817	822	PF00069	0.466
MOD_NEK2_2	152	157	PF00069	0.503
MOD_PIKK_1	330	336	PF00454	0.555
MOD_PIKK_1	475	481	PF00454	0.572
MOD_PIKK_1	526	532	PF00454	0.492
MOD_PIKK_1	69	75	PF00454	0.573
MOD_PIKK_1	766	772	PF00454	0.375
MOD_PKA_1	276	282	PF00069	0.532
MOD_PKA_1	618	624	PF00069	0.361
MOD_PKA_2	252	258	PF00069	0.533
MOD_PKA_2	276	282	PF00069	0.532
MOD_PKA_2	488	494	PF00069	0.396
MOD_PKA_2	712	718	PF00069	0.361
MOD_PKA_2	777	783	PF00069	0.332
MOD_PKB_1	328	336	PF00069	0.611
MOD_Plk_1	238	244	PF00069	0.451
MOD_Plk_1	621	627	PF00069	0.345
MOD_Plk_1	754	760	PF00069	0.345
MOD_Plk_2-3	201	207	PF00069	0.529
MOD_Plk_2-3	246	252	PF00069	0.669
MOD_Plk_2-3	256	262	PF00069	0.515
MOD_Plk_2-3	287	293	PF00069	0.768
MOD_Plk_2-3	363	369	PF00069	0.462
MOD_Plk_4	120	126	PF00069	0.451
MOD_Plk_4	152	158	PF00069	0.350
MOD_Plk_4	210	216	PF00069	0.418
MOD_Plk_4	246	252	PF00069	0.677
MOD_Plk_4	256	262	PF00069	0.515
MOD_Plk_4	363	369	PF00069	0.613
MOD_Plk_4	488	494	PF00069	0.396
MOD_Plk_4	567	573	PF00069	0.345
MOD_Plk_4	621	627	PF00069	0.359
MOD_Plk_4	660	666	PF00069	0.354
MOD_Plk_4	678	684	PF00069	0.233
MOD_Plk_4	725	731	PF00069	0.332
MOD_Plk_4	780	786	PF00069	0.359
MOD_Plk_4	812	818	PF00069	0.462
MOD_ProDKin_1	31	37	PF00069	0.585
MOD_ProDKin_1	395	401	PF00069	0.643
MOD_ProDKin_1	672	678	PF00069	0.245
MOD_ProDKin_1	800	806	PF00069	0.361
MOD_SUMO_rev_2	464	470	PF00179	0.555
MOD_SUMO_rev_2	480	488	PF00179	0.467
MOD_SUMO_rev_2	526	536	PF00179	0.294
MOD_SUMO_rev_2	597	603	PF00179	0.397
MOD_SUMO_rev_2	613	621	PF00179	0.285
TRG_DiLeu_BaEn_1	191	196	PF01217	0.679
TRG_DiLeu_BaEn_1	21	26	PF01217	0.596
TRG_DiLeu_BaEn_1	246	251	PF01217	0.553
TRG_DiLeu_BaEn_1	321	326	PF01217	0.723
TRG_DiLeu_BaEn_1	373	378	PF01217	0.454
TRG_DiLeu_BaEn_4	191	197	PF01217	0.665
TRG_DiLeu_BaLyEn_6	135	140	PF01217	0.465
TRG_DiLeu_BaLyEn_6	563	568	PF01217	0.345
TRG_ENDOCYTIC_2	261	264	PF00928	0.468
TRG_ENDOCYTIC_2	493	496	PF00928	0.487
TRG_ENDOCYTIC_2	506	509	PF00928	0.385
TRG_ENDOCYTIC_2	709	712	PF00928	0.345
TRG_ENDOCYTIC_2	724	727	PF00928	0.345
TRG_ER_diArg_1	299	302	PF00400	0.645
TRG_ER_diArg_1	508	511	PF00400	0.345
TRG_Pf-PMV_PEXEL_1	147	151	PF00026	0.581
TRG_Pf-PMV_PEXEL_1	278	282	PF00026	0.713
TRG_Pf-PMV_PEXEL_1	297	301	PF00026	0.700
TRG_Pf-PMV_PEXEL_1	432	436	PF00026	0.505

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8X9	Leptomonas seymouri	74%	99%
A0A0S4KHP9	Bodo saltans	52%	92%
A0A1X0P6D6	Trypanosomatidae	60%	100%
A0A3S5H751	Leishmania donovani	80%	100%
A0A422P3A3	Trypanosoma rangeli	58%	100%
A4HY48	Leishmania infantum	80%	100%
D0A0E6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	100%
E9ARX7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
P28739	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	33%	100%
Q4QDJ5	Leishmania major	79%	100%
V5BWY3	Trypanosoma cruzi	59%	100%