UVR domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

centrosomal protein of 104 kDa

Species:

Leishmania braziliensis

UniProt:

A4H9Y2_LEIBR

TriTrypDb:

LbrM.19.0560 , LBRM2903_190010200

Length:

876

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	1
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0097542	ciliary tip	2	1
GO:0110165	cellular anatomical entity	1	1
GO:0120025	plasma membrane bounded cell projection	3	1

Expansion

Sequence features

A4H9Y2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H9Y2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	462	466	PF00656	0.268
CLV_C14_Caspase3-7	712	716	PF00656	0.497
CLV_MEL_PAP_1	213	219	PF00089	0.385
CLV_NRD_NRD_1	132	134	PF00675	0.379
CLV_NRD_NRD_1	438	440	PF00675	0.487
CLV_NRD_NRD_1	554	556	PF00675	0.438
CLV_NRD_NRD_1	689	691	PF00675	0.765
CLV_PCSK_KEX2_1	105	107	PF00082	0.380
CLV_PCSK_KEX2_1	132	134	PF00082	0.432
CLV_PCSK_KEX2_1	554	556	PF00082	0.435
CLV_PCSK_KEX2_1	689	691	PF00082	0.751
CLV_PCSK_KEX2_1	800	802	PF00082	0.433
CLV_PCSK_PC1ET2_1	105	107	PF00082	0.470
CLV_PCSK_PC1ET2_1	800	802	PF00082	0.485
CLV_PCSK_SKI1_1	101	105	PF00082	0.403
CLV_PCSK_SKI1_1	123	127	PF00082	0.337
CLV_PCSK_SKI1_1	138	142	PF00082	0.391
CLV_PCSK_SKI1_1	262	266	PF00082	0.427
CLV_PCSK_SKI1_1	270	274	PF00082	0.392
CLV_PCSK_SKI1_1	288	292	PF00082	0.488
CLV_PCSK_SKI1_1	541	545	PF00082	0.436
CLV_PCSK_SKI1_1	827	831	PF00082	0.303
DEG_Nend_Nbox_1	1	3	PF02207	0.471
DEG_SCF_FBW7_1	721	726	PF00400	0.487
DEG_SPOP_SBC_1	451	455	PF00917	0.300
DEG_SPOP_SBC_1	638	642	PF00917	0.477
DOC_CDC14_PxL_1	609	617	PF14671	0.391
DOC_CKS1_1	174	179	PF01111	0.496
DOC_CYCLIN_RxL_1	629	640	PF00134	0.310
DOC_CYCLIN_yCln2_LP_2	407	413	PF00134	0.332
DOC_MAPK_gen_1	105	112	PF00069	0.379
DOC_MAPK_gen_1	132	139	PF00069	0.281
DOC_MAPK_gen_1	270	279	PF00069	0.516
DOC_MAPK_gen_1	554	562	PF00069	0.473
DOC_MAPK_MEF2A_6	132	141	PF00069	0.305
DOC_MAPK_MEF2A_6	270	279	PF00069	0.429
DOC_MAPK_MEF2A_6	554	561	PF00069	0.413
DOC_MAPK_MEF2A_6	7	16	PF00069	0.315
DOC_MAPK_MEF2A_6	74	83	PF00069	0.325
DOC_PP2B_LxvP_1	732	735	PF13499	0.488
DOC_PP4_FxxP_1	702	705	PF00568	0.485
DOC_PP4_MxPP_1	193	196	PF00568	0.393
DOC_USP7_MATH_1	296	300	PF00917	0.518
DOC_USP7_MATH_1	306	310	PF00917	0.493
DOC_USP7_MATH_1	451	455	PF00917	0.464
DOC_USP7_MATH_1	459	463	PF00917	0.356
DOC_USP7_MATH_1	492	496	PF00917	0.377
DOC_USP7_MATH_1	506	510	PF00917	0.415
DOC_USP7_MATH_1	576	580	PF00917	0.429
DOC_USP7_MATH_1	675	679	PF00917	0.636
DOC_USP7_MATH_1	695	699	PF00917	0.685
DOC_USP7_MATH_1	723	727	PF00917	0.627
DOC_USP7_MATH_1	833	837	PF00917	0.271
DOC_USP7_MATH_2	198	204	PF00917	0.468
DOC_USP7_UBL2_3	101	105	PF12436	0.471
DOC_USP7_UBL2_3	270	274	PF12436	0.305
DOC_USP7_UBL2_3	422	426	PF12436	0.467
DOC_USP7_UBL2_3	519	523	PF12436	0.255
DOC_USP7_UBL2_3	566	570	PF12436	0.575
DOC_USP7_UBL2_3	826	830	PF12436	0.366
DOC_WW_Pin1_4	173	178	PF00397	0.515
DOC_WW_Pin1_4	304	309	PF00397	0.618
DOC_WW_Pin1_4	314	319	PF00397	0.734
DOC_WW_Pin1_4	333	338	PF00397	0.480
DOC_WW_Pin1_4	546	551	PF00397	0.455
DOC_WW_Pin1_4	719	724	PF00397	0.492
DOC_WW_Pin1_4	856	861	PF00397	0.370
LIG_14-3-3_CanoR_1	132	137	PF00244	0.375
LIG_14-3-3_CanoR_1	216	223	PF00244	0.510
LIG_14-3-3_CanoR_1	262	267	PF00244	0.345
LIG_14-3-3_CanoR_1	36	42	PF00244	0.390
LIG_14-3-3_CanoR_1	604	610	PF00244	0.376
LIG_14-3-3_CanoR_1	67	75	PF00244	0.215
LIG_14-3-3_CanoR_1	815	823	PF00244	0.406
LIG_ActinCP_TwfCPI_2	702	709	PF01115	0.488
LIG_AP2alpha_1	587	591	PF02296	0.435
LIG_APCC_ABBA_1	160	165	PF00400	0.197
LIG_Clathr_ClatBox_1	559	563	PF01394	0.469
LIG_Clathr_ClatBox_1	633	637	PF01394	0.433
LIG_CtBP_PxDLS_1	729	733	PF00389	0.460
LIG_eIF4E_1	431	437	PF01652	0.288
LIG_eIF4E_1	663	669	PF01652	0.384
LIG_FHA_1	125	131	PF00498	0.312
LIG_FHA_1	185	191	PF00498	0.454
LIG_FHA_1	212	218	PF00498	0.502
LIG_FHA_1	362	368	PF00498	0.659
LIG_FHA_1	423	429	PF00498	0.390
LIG_FHA_1	496	502	PF00498	0.412
LIG_FHA_1	523	529	PF00498	0.528
LIG_FHA_1	601	607	PF00498	0.495
LIG_FHA_1	63	69	PF00498	0.477
LIG_FHA_1	680	686	PF00498	0.753
LIG_FHA_1	720	726	PF00498	0.786
LIG_FHA_1	832	838	PF00498	0.323
LIG_FHA_2	242	248	PF00498	0.369
LIG_FHA_2	263	269	PF00498	0.307
LIG_FHA_2	584	590	PF00498	0.409
LIG_FHA_2	715	721	PF00498	0.735
LIG_FHA_2	794	800	PF00498	0.407
LIG_FHA_2	85	91	PF00498	0.377
LIG_GBD_Chelix_1	625	633	PF00786	0.210
LIG_LIR_Gen_1	135	144	PF02991	0.351
LIG_LIR_Gen_1	148	157	PF02991	0.268
LIG_LIR_Gen_1	465	475	PF02991	0.284
LIG_LIR_Gen_1	740	751	PF02991	0.292
LIG_LIR_Nem_3	13	18	PF02991	0.214
LIG_LIR_Nem_3	135	139	PF02991	0.333
LIG_LIR_Nem_3	148	152	PF02991	0.301
LIG_LIR_Nem_3	465	471	PF02991	0.301
LIG_LIR_Nem_3	740	746	PF02991	0.539
LIG_MYND_1	773	777	PF01753	0.289
LIG_NRBOX	629	635	PF00104	0.365
LIG_Pex14_2	587	591	PF04695	0.435
LIG_PTAP_UEV_1	704	709	PF05743	0.489
LIG_SH2_CRK	474	478	PF00017	0.345
LIG_SH2_CRK	743	747	PF00017	0.508
LIG_SH2_GRB2like	328	331	PF00017	0.482
LIG_SH2_SRC	635	638	PF00017	0.386
LIG_SH2_STAP1	424	428	PF00017	0.418
LIG_SH2_STAP1	99	103	PF00017	0.408
LIG_SH2_STAT5	136	139	PF00017	0.343
LIG_SH2_STAT5	15	18	PF00017	0.361
LIG_SH2_STAT5	339	342	PF00017	0.475
LIG_SH2_STAT5	424	427	PF00017	0.347
LIG_SH2_STAT5	431	434	PF00017	0.260
LIG_SH2_STAT5	635	638	PF00017	0.414
LIG_SH2_STAT5	644	647	PF00017	0.441
LIG_SH2_STAT5	743	746	PF00017	0.312
LIG_SH2_STAT5	768	771	PF00017	0.429
LIG_SH2_STAT5	82	85	PF00017	0.415
LIG_SH3_3	192	198	PF00018	0.470
LIG_SH3_3	42	48	PF00018	0.251
LIG_SH3_3	479	485	PF00018	0.279
LIG_SH3_3	607	613	PF00018	0.407
LIG_SH3_3	702	708	PF00018	0.556
LIG_SH3_3	80	86	PF00018	0.405
LIG_SH3_3	857	863	PF00018	0.355
LIG_SH3_3	92	98	PF00018	0.369
LIG_SH3_4	422	429	PF00018	0.351
LIG_SUMO_SIM_anti_2	558	563	PF11976	0.440
LIG_SUMO_SIM_par_1	558	563	PF11976	0.422
LIG_SUMO_SIM_par_1	608	614	PF11976	0.393
LIG_TRAF2_1	227	230	PF00917	0.452
LIG_TRAF2_1	717	720	PF00917	0.655
LIG_TRAF2_1	87	90	PF00917	0.376
LIG_TYR_ITIM	472	477	PF00017	0.324
LIG_WRC_WIRS_1	584	589	PF05994	0.422
MOD_CDK_SPK_2	333	338	PF00069	0.605
MOD_CK1_1	203	209	PF00069	0.589
MOD_CK1_1	211	217	PF00069	0.484
MOD_CK1_1	307	313	PF00069	0.590
MOD_CK1_1	361	367	PF00069	0.755
MOD_CK1_1	373	379	PF00069	0.532
MOD_CK1_1	454	460	PF00069	0.401
MOD_CK1_1	495	501	PF00069	0.487
MOD_CK1_1	605	611	PF00069	0.383
MOD_CK1_1	639	645	PF00069	0.453
MOD_CK1_1	691	697	PF00069	0.615
MOD_CK1_1	70	76	PF00069	0.296
MOD_CK2_1	18	24	PF00069	0.447
MOD_CK2_1	241	247	PF00069	0.274
MOD_CK2_1	714	720	PF00069	0.735
MOD_CK2_1	755	761	PF00069	0.442
MOD_CK2_1	793	799	PF00069	0.363
MOD_CK2_1	84	90	PF00069	0.403
MOD_CK2_1	844	850	PF00069	0.461
MOD_GlcNHglycan	205	208	PF01048	0.507
MOD_GlcNHglycan	26	29	PF01048	0.391
MOD_GlcNHglycan	298	301	PF01048	0.646
MOD_GlcNHglycan	323	326	PF01048	0.769
MOD_GlcNHglycan	375	378	PF01048	0.650
MOD_GlcNHglycan	494	497	PF01048	0.359
MOD_GlcNHglycan	508	511	PF01048	0.446
MOD_GlcNHglycan	641	644	PF01048	0.429
MOD_GlcNHglycan	677	680	PF01048	0.525
MOD_GlcNHglycan	691	694	PF01048	0.549
MOD_GlcNHglycan	705	708	PF01048	0.721
MOD_GlcNHglycan	737	740	PF01048	0.420
MOD_GlcNHglycan	846	849	PF01048	0.276
MOD_GSK3_1	199	206	PF00069	0.560
MOD_GSK3_1	208	215	PF00069	0.422
MOD_GSK3_1	304	311	PF00069	0.638
MOD_GSK3_1	361	368	PF00069	0.628
MOD_GSK3_1	450	457	PF00069	0.327
MOD_GSK3_1	611	618	PF00069	0.338
MOD_GSK3_1	675	682	PF00069	0.599
MOD_GSK3_1	691	698	PF00069	0.495
MOD_GSK3_1	70	77	PF00069	0.331
MOD_GSK3_1	719	726	PF00069	0.604
MOD_LATS_1	568	574	PF00433	0.348
MOD_LATS_1	842	848	PF00433	0.272
MOD_N-GLC_1	211	216	PF02516	0.433
MOD_N-GLC_1	304	309	PF02516	0.543
MOD_N-GLC_1	373	378	PF02516	0.553
MOD_N-GLC_1	755	760	PF02516	0.443
MOD_NEK2_1	313	318	PF00069	0.569
MOD_NEK2_1	360	365	PF00069	0.567
MOD_NEK2_1	473	478	PF00069	0.442
MOD_NEK2_1	528	533	PF00069	0.427
MOD_NEK2_1	615	620	PF00069	0.264
MOD_NEK2_2	62	67	PF00069	0.294
MOD_OFUCOSY	744	749	PF10250	0.269
MOD_PIKK_1	308	314	PF00454	0.650
MOD_PIKK_1	454	460	PF00454	0.522
MOD_PIKK_1	695	701	PF00454	0.499
MOD_PIKK_1	831	837	PF00454	0.252
MOD_PK_1	570	576	PF00069	0.460
MOD_PKA_1	132	138	PF00069	0.210
MOD_PKA_1	689	695	PF00069	0.614
MOD_PKA_2	110	116	PF00069	0.341
MOD_PKA_2	132	138	PF00069	0.309
MOD_PKA_2	215	221	PF00069	0.465
MOD_PKA_2	35	41	PF00069	0.282
MOD_PKA_2	688	694	PF00069	0.569
MOD_PKA_2	703	709	PF00069	0.721
MOD_PKA_2	814	820	PF00069	0.400
MOD_Plk_1	755	761	PF00069	0.453
MOD_Plk_4	132	138	PF00069	0.420
MOD_Plk_4	402	408	PF00069	0.315
MOD_Plk_4	583	589	PF00069	0.305
MOD_Plk_4	605	611	PF00069	0.405
MOD_ProDKin_1	173	179	PF00069	0.512
MOD_ProDKin_1	304	310	PF00069	0.618
MOD_ProDKin_1	314	320	PF00069	0.733
MOD_ProDKin_1	333	339	PF00069	0.488
MOD_ProDKin_1	546	552	PF00069	0.453
MOD_ProDKin_1	719	725	PF00069	0.492
MOD_ProDKin_1	856	862	PF00069	0.363
MOD_SUMO_rev_2	118	128	PF00179	0.383
MOD_SUMO_rev_2	267	272	PF00179	0.516
MOD_SUMO_rev_2	70	76	PF00179	0.234
TRG_DiLeu_BaEn_1	799	804	PF01217	0.364
TRG_ENDOCYTIC_2	136	139	PF00928	0.294
TRG_ENDOCYTIC_2	149	152	PF00928	0.375
TRG_ENDOCYTIC_2	357	360	PF00928	0.552
TRG_ENDOCYTIC_2	474	477	PF00928	0.301
TRG_ENDOCYTIC_2	743	746	PF00928	0.522
TRG_ER_diArg_1	554	556	PF00400	0.477
TRG_NLS_MonoExtN_4	270	277	PF00514	0.289
TRG_Pf-PMV_PEXEL_1	67	72	PF00026	0.267
TRG_Pf-PMV_PEXEL_1	801	806	PF00026	0.358

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8K1	Leptomonas seymouri	62%	100%
A0A0S4ILQ6	Bodo saltans	26%	88%
A0A1X0P6E5	Trypanosomatidae	39%	100%
A0A3R7MW28	Trypanosoma rangeli	37%	100%
A0A3S7WVF9	Leishmania donovani	76%	100%
A4HY47	Leishmania infantum	77%	100%
D0A0E4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	98%
D3Z8X7	Rattus norvegicus	27%	95%
E9ARX6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	100%
O60308	Homo sapiens	26%	95%
Q4Q4L6	Leishmania major	25%	100%
Q4QDJ6	Leishmania major	76%	100%
Q80V31	Mus musculus	26%	95%
V5DTJ3	Trypanosoma cruzi	39%	100%