Complex1_LYR_dom domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Complex 1 protein (LYR family), putative

Species:

Leishmania braziliensis

UniProt:

A4H9Y0_LEIBR

TriTrypDb:

LbrM.19.0540 , LBRM2903_190010000

Length:

664

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005747	mitochondrial respiratory chain complex I	4	11
GO:0030964	NADH dehydrogenase complex	3	11
GO:0032991	protein-containing complex	1	11
GO:0045271	respiratory chain complex I	4	11
GO:0098796	membrane protein complex	2	11
GO:0098798	mitochondrial protein-containing complex	2	11
GO:0098800	inner mitochondrial membrane protein complex	3	11
GO:0098803	respiratory chain complex	3	11
GO:1902494	catalytic complex	2	11
GO:1902495	transmembrane transporter complex	3	11
GO:1990204	oxidoreductase complex	3	11
GO:1990351	transporter complex	2	11
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H9Y0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H9Y0

Function

Biological processes
Term	Name	Level	Count
GO:0006950	response to stress	2	1
GO:0006979	response to oxidative stress	3	1
GO:0050896	response to stimulus	1	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	13	17	PF00656	0.512
CLV_C14_Caspase3-7	55	59	PF00656	0.530
CLV_NRD_NRD_1	125	127	PF00675	0.674
CLV_NRD_NRD_1	211	213	PF00675	0.427
CLV_NRD_NRD_1	253	255	PF00675	0.546
CLV_NRD_NRD_1	324	326	PF00675	0.543
CLV_NRD_NRD_1	346	348	PF00675	0.520
CLV_NRD_NRD_1	350	352	PF00675	0.497
CLV_NRD_NRD_1	523	525	PF00675	0.580
CLV_NRD_NRD_1	575	577	PF00675	0.500
CLV_PCSK_FUR_1	533	537	PF00082	0.490
CLV_PCSK_KEX2_1	125	127	PF00082	0.561
CLV_PCSK_KEX2_1	211	213	PF00082	0.427
CLV_PCSK_KEX2_1	253	255	PF00082	0.546
CLV_PCSK_KEX2_1	324	326	PF00082	0.561
CLV_PCSK_KEX2_1	346	348	PF00082	0.520
CLV_PCSK_KEX2_1	350	352	PF00082	0.497
CLV_PCSK_KEX2_1	523	525	PF00082	0.560
CLV_PCSK_KEX2_1	535	537	PF00082	0.529
CLV_PCSK_KEX2_1	575	577	PF00082	0.500
CLV_PCSK_KEX2_1	91	93	PF00082	0.660
CLV_PCSK_PC1ET2_1	535	537	PF00082	0.496
CLV_PCSK_PC1ET2_1	91	93	PF00082	0.660
CLV_PCSK_PC7_1	320	326	PF00082	0.549
CLV_PCSK_PC7_1	346	352	PF00082	0.506
CLV_PCSK_SKI1_1	151	155	PF00082	0.410
CLV_PCSK_SKI1_1	194	198	PF00082	0.324
CLV_PCSK_SKI1_1	351	355	PF00082	0.489
CLV_PCSK_SKI1_1	413	417	PF00082	0.526
CLV_PCSK_SKI1_1	438	442	PF00082	0.504
DEG_APCC_DBOX_1	150	158	PF00400	0.297
DEG_APCC_DBOX_1	437	445	PF00400	0.527
DEG_ODPH_VHL_1	441	453	PF01847	0.497
DOC_CDC14_PxL_1	154	162	PF14671	0.197
DOC_CKS1_1	106	111	PF01111	0.615
DOC_CKS1_1	60	65	PF01111	0.635
DOC_CYCLIN_RxL_1	435	445	PF00134	0.533
DOC_CYCLIN_yCln2_LP_2	440	446	PF00134	0.443
DOC_CYCLIN_yCln2_LP_2	45	48	PF00134	0.495
DOC_MAPK_gen_1	174	181	PF00069	0.383
DOC_MAPK_MEF2A_6	161	170	PF00069	0.472
DOC_MAPK_MEF2A_6	174	181	PF00069	0.344
DOC_MAPK_MEF2A_6	632	639	PF00069	0.534
DOC_MAPK_NFAT4_5	174	182	PF00069	0.410
DOC_PP1_RVXF_1	176	182	PF00149	0.410
DOC_PP2B_LxvP_1	166	169	PF13499	0.410
DOC_PP2B_LxvP_1	440	443	PF13499	0.457
DOC_PP2B_LxvP_1	45	48	PF13499	0.746
DOC_PP4_FxxP_1	210	213	PF00568	0.480
DOC_PP4_FxxP_1	567	570	PF00568	0.647
DOC_PP4_FxxP_1	633	636	PF00568	0.382
DOC_SPAK_OSR1_1	632	636	PF12202	0.503
DOC_USP7_MATH_1	145	149	PF00917	0.297
DOC_USP7_MATH_1	656	660	PF00917	0.541
DOC_USP7_UBL2_3	231	235	PF12436	0.583
DOC_USP7_UBL2_3	34	38	PF12436	0.573
DOC_WW_Pin1_4	105	110	PF00397	0.609
DOC_WW_Pin1_4	59	64	PF00397	0.637
LIG_14-3-3_CanoR_1	279	285	PF00244	0.510
LIG_14-3-3_CanoR_1	426	435	PF00244	0.492
LIG_APCC_ABBA_1	637	642	PF00400	0.486
LIG_BIR_II_1	1	5	PF00653	0.507
LIG_BRCT_BRCA1_1	27	31	PF00533	0.685
LIG_BRCT_BRCA1_1	404	408	PF00533	0.465
LIG_BRCT_BRCA1_1	475	479	PF00533	0.374
LIG_FHA_1	128	134	PF00498	0.588
LIG_FHA_1	47	53	PF00498	0.647
LIG_FHA_1	473	479	PF00498	0.425
LIG_FHA_1	507	513	PF00498	0.446
LIG_FHA_2	106	112	PF00498	0.613
LIG_FHA_2	11	17	PF00498	0.523
LIG_FHA_2	232	238	PF00498	0.505
LIG_FHA_2	27	33	PF00498	0.639
LIG_FHA_2	356	362	PF00498	0.522
LIG_FHA_2	381	387	PF00498	0.425
LIG_FHA_2	404	410	PF00498	0.489
LIG_FHA_2	492	498	PF00498	0.460
LIG_FXI_DFP_1	516	520	PF00024	0.489
LIG_LIR_Apic_2	332	338	PF02991	0.531
LIG_LIR_Apic_2	49	53	PF02991	0.719
LIG_LIR_Apic_2	565	570	PF02991	0.566
LIG_LIR_Apic_2	574	580	PF02991	0.476
LIG_LIR_Gen_1	222	229	PF02991	0.446
LIG_LIR_Gen_1	270	281	PF02991	0.597
LIG_LIR_Gen_1	373	380	PF02991	0.461
LIG_LIR_Gen_1	445	455	PF02991	0.456
LIG_LIR_Gen_1	476	484	PF02991	0.399
LIG_LIR_Gen_1	494	502	PF02991	0.484
LIG_LIR_Nem_3	100	104	PF02991	0.557
LIG_LIR_Nem_3	118	122	PF02991	0.659
LIG_LIR_Nem_3	148	153	PF02991	0.366
LIG_LIR_Nem_3	218	223	PF02991	0.464
LIG_LIR_Nem_3	270	276	PF02991	0.584
LIG_LIR_Nem_3	373	379	PF02991	0.459
LIG_LIR_Nem_3	405	411	PF02991	0.474
LIG_LIR_Nem_3	431	437	PF02991	0.466
LIG_LIR_Nem_3	445	451	PF02991	0.463
LIG_LIR_Nem_3	476	482	PF02991	0.416
LIG_LIR_Nem_3	494	498	PF02991	0.456
LIG_LIR_Nem_3	556	560	PF02991	0.454
LIG_MLH1_MIPbox_1	27	31	PF16413	0.446
LIG_NRBOX	436	442	PF00104	0.538
LIG_PCNA_TLS_4	214	221	PF02747	0.430
LIG_Pex14_1	495	499	PF04695	0.474
LIG_Pex14_2	498	502	PF04695	0.507
LIG_PTB_Apo_2	627	634	PF02174	0.512
LIG_RPA_C_Fungi	121	133	PF08784	0.656
LIG_SH2_CRK	150	154	PF00017	0.410
LIG_SH2_CRK	335	339	PF00017	0.536
LIG_SH2_CRK	50	54	PF00017	0.646
LIG_SH2_CRK	577	581	PF00017	0.474
LIG_SH2_CRK	586	590	PF00017	0.400
LIG_SH2_GRB2like	560	563	PF00017	0.467
LIG_SH2_STAP1	404	408	PF00017	0.465
LIG_SH2_STAP1	411	415	PF00017	0.471
LIG_SH2_STAP1	474	478	PF00017	0.494
LIG_SH2_STAT3	414	417	PF00017	0.458
LIG_SH2_STAT5	220	223	PF00017	0.544
LIG_SH2_STAT5	233	236	PF00017	0.462
LIG_SH2_STAT5	290	293	PF00017	0.518
LIG_SH2_STAT5	30	33	PF00017	0.530
LIG_SH2_STAT5	312	315	PF00017	0.548
LIG_SH2_STAT5	368	371	PF00017	0.458
LIG_SH2_STAT5	378	381	PF00017	0.480
LIG_SH2_STAT5	414	417	PF00017	0.458
LIG_SH2_STAT5	434	437	PF00017	0.582
LIG_SH2_STAT5	439	442	PF00017	0.496
LIG_SH2_STAT5	474	477	PF00017	0.497
LIG_SH2_STAT5	549	552	PF00017	0.470
LIG_SH2_STAT5	560	563	PF00017	0.480
LIG_SH2_STAT5	77	80	PF00017	0.558
LIG_SH3_3	103	109	PF00018	0.609
LIG_SH3_3	501	507	PF00018	0.464
LIG_SH3_3	558	564	PF00018	0.479
LIG_TRAF2_1	234	237	PF00917	0.529
LIG_TRAF2_1	455	458	PF00917	0.461
LIG_TRFH_1	439	443	PF08558	0.527
LIG_TYR_ITIM	99	104	PF00017	0.522
LIG_UBA3_1	153	161	PF00899	0.389
LIG_UBA3_1	166	174	PF00899	0.241
LIG_UBA3_1	478	486	PF00899	0.424
LIG_ULM_U2AF65_1	523	528	PF00076	0.490
LIG_WW_1	47	50	PF00397	0.654
MOD_CK1_1	612	618	PF00069	0.410
MOD_CK2_1	105	111	PF00069	0.610
MOD_CK2_1	222	228	PF00069	0.480
MOD_CK2_1	231	237	PF00069	0.493
MOD_CK2_1	26	32	PF00069	0.547
MOD_CK2_1	355	361	PF00069	0.489
MOD_CK2_1	380	386	PF00069	0.518
MOD_CK2_1	403	409	PF00069	0.542
MOD_Cter_Amidation	123	126	PF01082	0.541
MOD_GlcNHglycan	332	335	PF01048	0.537
MOD_GlcNHglycan	539	542	PF01048	0.587
MOD_GlcNHglycan	571	574	PF01048	0.506
MOD_GlcNHglycan	606	610	PF01048	0.503
MOD_GlcNHglycan	654	657	PF01048	0.549
MOD_GlcNHglycan	658	661	PF01048	0.606
MOD_GSK3_1	145	152	PF00069	0.286
MOD_GSK3_1	280	287	PF00069	0.517
MOD_GSK3_1	355	362	PF00069	0.489
MOD_GSK3_1	380	387	PF00069	0.510
MOD_GSK3_1	601	608	PF00069	0.544
MOD_GSK3_1	652	659	PF00069	0.607
MOD_N-GLC_1	10	15	PF02516	0.543
MOD_N-GLC_1	609	614	PF02516	0.603
MOD_N-GLC_1	65	70	PF02516	0.612
MOD_N-GLC_2	652	654	PF02516	0.493
MOD_NEK2_1	120	125	PF00069	0.654
MOD_NEK2_1	149	154	PF00069	0.449
MOD_NEK2_1	271	276	PF00069	0.658
MOD_NEK2_1	359	364	PF00069	0.543
MOD_NEK2_1	403	408	PF00069	0.478
MOD_NEK2_1	491	496	PF00069	0.429
MOD_NEK2_1	65	70	PF00069	0.614
MOD_NEK2_2	145	150	PF00069	0.279
MOD_PIKK_1	453	459	PF00454	0.457
MOD_PIKK_1	642	648	PF00454	0.391
MOD_PKA_2	213	219	PF00069	0.395
MOD_PKA_2	380	386	PF00069	0.518
MOD_PKA_2	601	607	PF00069	0.533
MOD_Plk_1	360	366	PF00069	0.526
MOD_Plk_1	65	71	PF00069	0.551
MOD_Plk_2-3	222	228	PF00069	0.547
MOD_Plk_2-3	355	361	PF00069	0.504
MOD_Plk_4	127	133	PF00069	0.607
MOD_Plk_4	145	151	PF00069	0.224
MOD_Plk_4	26	32	PF00069	0.451
MOD_Plk_4	355	361	PF00069	0.504
MOD_Plk_4	41	47	PF00069	0.480
MOD_Plk_4	549	555	PF00069	0.405
MOD_ProDKin_1	105	111	PF00069	0.610
MOD_ProDKin_1	59	65	PF00069	0.635
MOD_SUMO_rev_2	27	36	PF00179	0.721
MOD_SUMO_rev_2	540	548	PF00179	0.536
TRG_DiLeu_BaEn_1	41	46	PF01217	0.474
TRG_DiLeu_BaEn_2	126	132	PF01217	0.650
TRG_ENDOCYTIC_2	101	104	PF00928	0.535
TRG_ENDOCYTIC_2	150	153	PF00928	0.360
TRG_ENDOCYTIC_2	163	166	PF00928	0.201
TRG_ENDOCYTIC_2	223	226	PF00928	0.493
TRG_ENDOCYTIC_2	349	352	PF00928	0.496
TRG_ENDOCYTIC_2	434	437	PF00928	0.458
TRG_ENDOCYTIC_2	499	502	PF00928	0.521
TRG_ENDOCYTIC_2	586	589	PF00928	0.452
TRG_ER_diArg_1	177	180	PF00400	0.357
TRG_ER_diArg_1	210	212	PF00400	0.399
TRG_ER_diArg_1	349	351	PF00400	0.505
TRG_ER_diArg_1	435	438	PF00400	0.472
TRG_ER_diArg_1	575	577	PF00400	0.500
TRG_NES_CRM1_1	584	599	PF08389	0.453
TRG_Pf-PMV_PEXEL_1	180	185	PF00026	0.297
TRG_Pf-PMV_PEXEL_1	394	399	PF00026	0.486

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I9Q5	Leptomonas seymouri	80%	95%
A0A0S4KEU9	Bodo saltans	62%	82%
A0A1X0P7G4	Trypanosomatidae	75%	94%
A0A3S7WVA4	Leishmania donovani	93%	100%
A4HY45	Leishmania infantum	93%	100%
D0A0E2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	74%	93%
E9ARX4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	96%
Q4QDJ8	Leishmania major	93%	100%
V5BSA4	Trypanosoma cruzi	74%	97%