Putative polyprenyl synthase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

polyprenyl synthase, putative

Species:

Leishmania braziliensis

UniProt:

A4H9X9_LEIBR

TriTrypDb:

LbrM.19.0530

Length:

742

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H9X9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H9X9

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	10
GO:0006720	isoprenoid metabolic process	4	10
GO:0008152	metabolic process	1	10
GO:0008299	isoprenoid biosynthetic process	4	10
GO:0008610	lipid biosynthetic process	4	10
GO:0009058	biosynthetic process	2	10
GO:0009987	cellular process	1	10
GO:0044237	cellular metabolic process	2	10
GO:0044238	primary metabolic process	2	10
GO:0044249	cellular biosynthetic process	3	10
GO:0044255	cellular lipid metabolic process	3	10
GO:0071704	organic substance metabolic process	2	10
GO:1901576	organic substance biosynthetic process	3	10

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0004659	prenyltransferase activity	4	1
GO:0016740	transferase activity	2	1
GO:0016765	transferase activity, transferring alkyl or aryl (other than methyl) groups	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	285	289	PF00656	0.380
CLV_C14_Caspase3-7	406	410	PF00656	0.588
CLV_C14_Caspase3-7	488	492	PF00656	0.391
CLV_C14_Caspase3-7	579	583	PF00656	0.276
CLV_C14_Caspase3-7	647	651	PF00656	0.274
CLV_C14_Caspase3-7	685	689	PF00656	0.201
CLV_NRD_NRD_1	110	112	PF00675	0.380
CLV_NRD_NRD_1	277	279	PF00675	0.264
CLV_NRD_NRD_1	470	472	PF00675	0.313
CLV_NRD_NRD_1	496	498	PF00675	0.274
CLV_NRD_NRD_1	57	59	PF00675	0.352
CLV_NRD_NRD_1	676	678	PF00675	0.313
CLV_PCSK_KEX2_1	470	472	PF00082	0.313
CLV_PCSK_KEX2_1	496	498	PF00082	0.274
CLV_PCSK_KEX2_1	57	59	PF00082	0.189
CLV_PCSK_SKI1_1	134	138	PF00082	0.319
CLV_PCSK_SKI1_1	220	224	PF00082	0.497
CLV_PCSK_SKI1_1	245	249	PF00082	0.286
CLV_PCSK_SKI1_1	369	373	PF00082	0.410
CLV_Separin_Metazoa	242	246	PF03568	0.361
DEG_APCC_DBOX_1	668	676	PF00400	0.336
DEG_APCC_DBOX_1	706	714	PF00400	0.384
DEG_Nend_UBRbox_3	1	3	PF02207	0.450
DEG_SPOP_SBC_1	380	384	PF00917	0.284
DOC_MAPK_gen_1	445	455	PF00069	0.310
DOC_MAPK_gen_1	496	504	PF00069	0.298
DOC_MAPK_gen_1	535	544	PF00069	0.298
DOC_MAPK_gen_1	649	659	PF00069	0.279
DOC_MAPK_HePTP_8	39	51	PF00069	0.189
DOC_MAPK_MEF2A_6	42	51	PF00069	0.189
DOC_MAPK_MEF2A_6	616	625	PF00069	0.482
DOC_MAPK_MEF2A_6	652	661	PF00069	0.471
DOC_MAPK_MEF2A_6	669	676	PF00069	0.216
DOC_MAPK_MEF2A_6	687	694	PF00069	0.253
DOC_MAPK_NFAT4_5	616	624	PF00069	0.336
DOC_PP1_RVXF_1	180	186	PF00149	0.189
DOC_PP1_RVXF_1	225	232	PF00149	0.189
DOC_PP4_FxxP_1	520	523	PF00568	0.370
DOC_USP7_MATH_1	380	384	PF00917	0.424
DOC_USP7_MATH_1	407	411	PF00917	0.430
DOC_USP7_MATH_1	438	442	PF00917	0.298
DOC_USP7_MATH_1	59	63	PF00917	0.292
DOC_USP7_MATH_2	532	538	PF00917	0.336
DOC_USP7_UBL2_3	223	227	PF12436	0.300
LIG_14-3-3_CanoR_1	173	181	PF00244	0.268
LIG_14-3-3_CanoR_1	437	443	PF00244	0.400
LIG_14-3-3_CanoR_1	445	451	PF00244	0.405
LIG_14-3-3_CanoR_1	669	673	PF00244	0.380
LIG_14-3-3_CanoR_1	731	737	PF00244	0.373
LIG_Actin_WH2_2	109	127	PF00022	0.336
LIG_BRCT_BRCA1_1	47	51	PF00533	0.412
LIG_BRCT_BRCA1_1	574	578	PF00533	0.313
LIG_deltaCOP1_diTrp_1	3	9	PF00928	0.519
LIG_eIF4E_1	34	40	PF01652	0.189
LIG_eIF4E_1	559	565	PF01652	0.391
LIG_FHA_1	212	218	PF00498	0.399
LIG_FHA_1	340	346	PF00498	0.461
LIG_FHA_1	382	388	PF00498	0.457
LIG_FHA_1	569	575	PF00498	0.243
LIG_FHA_1	618	624	PF00498	0.196
LIG_FHA_1	652	658	PF00498	0.246
LIG_FHA_1	669	675	PF00498	0.246
LIG_FHA_1	698	704	PF00498	0.452
LIG_FHA_2	148	154	PF00498	0.211
LIG_FHA_2	173	179	PF00498	0.288
LIG_FHA_2	283	289	PF00498	0.335
LIG_FHA_2	331	337	PF00498	0.245
LIG_FHA_2	574	580	PF00498	0.336
LIG_FHA_2	678	684	PF00498	0.196
LIG_LIR_Apic_2	562	566	PF02991	0.391
LIG_LIR_Gen_1	177	185	PF02991	0.384
LIG_LIR_Gen_1	214	222	PF02991	0.336
LIG_LIR_Gen_1	250	261	PF02991	0.301
LIG_LIR_Gen_1	304	312	PF02991	0.284
LIG_LIR_Gen_1	575	584	PF02991	0.313
LIG_LIR_Gen_1	671	679	PF02991	0.326
LIG_LIR_Gen_1	712	721	PF02991	0.361
LIG_LIR_Nem_3	177	183	PF02991	0.325
LIG_LIR_Nem_3	214	219	PF02991	0.376
LIG_LIR_Nem_3	250	256	PF02991	0.298
LIG_LIR_Nem_3	304	308	PF02991	0.284
LIG_LIR_Nem_3	310	314	PF02991	0.288
LIG_LIR_Nem_3	433	439	PF02991	0.274
LIG_LIR_Nem_3	449	453	PF02991	0.274
LIG_LIR_Nem_3	537	543	PF02991	0.380
LIG_LIR_Nem_3	575	581	PF02991	0.313
LIG_LIR_Nem_3	671	676	PF02991	0.319
LIG_LIR_Nem_3	712	717	PF02991	0.333
LIG_LIR_Nem_3	722	728	PF02991	0.319
LIG_NRBOX	119	125	PF00104	0.336
LIG_PCNA_PIPBox_1	730	739	PF02747	0.232
LIG_Pex14_1	5	9	PF04695	0.555
LIG_Pex14_2	51	55	PF04695	0.276
LIG_Rb_pABgroove_1	572	580	PF01858	0.189
LIG_REV1ctd_RIR_1	53	62	PF16727	0.333
LIG_SH2_GRB2like	34	37	PF00017	0.274
LIG_SH2_PTP2	180	183	PF00017	0.279
LIG_SH2_PTP2	472	475	PF00017	0.298
LIG_SH2_SRC	34	37	PF00017	0.336
LIG_SH2_SRC	394	397	PF00017	0.373
LIG_SH2_SRC	87	90	PF00017	0.333
LIG_SH2_STAP1	168	172	PF00017	0.431
LIG_SH2_STAP1	21	25	PF00017	0.389
LIG_SH2_STAP1	232	236	PF00017	0.274
LIG_SH2_STAP1	249	253	PF00017	0.274
LIG_SH2_STAP1	87	91	PF00017	0.248
LIG_SH2_STAT3	142	145	PF00017	0.352
LIG_SH2_STAT5	142	145	PF00017	0.336
LIG_SH2_STAT5	180	183	PF00017	0.339
LIG_SH2_STAT5	184	187	PF00017	0.344
LIG_SH2_STAT5	207	210	PF00017	0.352
LIG_SH2_STAT5	394	397	PF00017	0.439
LIG_SH2_STAT5	466	469	PF00017	0.307
LIG_SH2_STAT5	472	475	PF00017	0.286
LIG_SH2_STAT5	519	522	PF00017	0.298
LIG_SH2_STAT5	543	546	PF00017	0.274
LIG_SH2_STAT5	563	566	PF00017	0.155
LIG_SH3_3	126	132	PF00018	0.380
LIG_SH3_3	88	94	PF00018	0.189
LIG_SUMO_SIM_anti_2	452	457	PF11976	0.324
LIG_SUMO_SIM_anti_2	688	694	PF11976	0.213
LIG_SUMO_SIM_par_1	279	285	PF11976	0.189
LIG_SUMO_SIM_par_1	452	457	PF11976	0.286
LIG_TRAF2_1	398	401	PF00917	0.498
LIG_TRAF2_1	680	683	PF00917	0.189
LIG_UBA3_1	120	126	PF00899	0.391
LIG_UBA3_1	78	85	PF00899	0.336
LIG_WRC_WIRS_1	308	313	PF05994	0.298
LIG_WRC_WIRS_1	52	57	PF05994	0.333
LIG_WRC_WIRS_1	733	738	PF05994	0.342
LIG_WW_3	9	13	PF00397	0.501
MOD_CK1_1	252	258	PF00069	0.321
MOD_CK1_1	259	265	PF00069	0.273
MOD_CK1_1	307	313	PF00069	0.270
MOD_CK1_1	382	388	PF00069	0.411
MOD_CK1_1	410	416	PF00069	0.421
MOD_CK1_1	449	455	PF00069	0.391
MOD_CK1_1	62	68	PF00069	0.189
MOD_CK2_1	236	242	PF00069	0.453
MOD_CK2_1	268	274	PF00069	0.278
MOD_CK2_1	380	386	PF00069	0.508
MOD_CK2_1	394	400	PF00069	0.238
MOD_CK2_1	677	683	PF00069	0.256
MOD_Cter_Amidation	109	112	PF01082	0.398
MOD_GlcNHglycan	270	273	PF01048	0.446
MOD_GlcNHglycan	321	324	PF01048	0.336
MOD_GlcNHglycan	356	360	PF01048	0.456
MOD_GlcNHglycan	396	399	PF01048	0.268
MOD_GlcNHglycan	515	518	PF01048	0.330
MOD_GSK3_1	147	154	PF00069	0.257
MOD_GSK3_1	207	214	PF00069	0.328
MOD_GSK3_1	252	259	PF00069	0.324
MOD_GSK3_1	303	310	PF00069	0.282
MOD_GSK3_1	390	397	PF00069	0.513
MOD_GSK3_1	568	575	PF00069	0.336
MOD_N-GLC_1	259	264	PF02516	0.324
MOD_NEK2_1	151	156	PF00069	0.336
MOD_NEK2_1	211	216	PF00069	0.336
MOD_NEK2_1	236	241	PF00069	0.391
MOD_NEK2_1	256	261	PF00069	0.292
MOD_NEK2_1	267	272	PF00069	0.383
MOD_NEK2_1	327	332	PF00069	0.407
MOD_NEK2_1	51	56	PF00069	0.298
MOD_NEK2_1	617	622	PF00069	0.292
MOD_NEK2_1	721	726	PF00069	0.392
MOD_NEK2_1	729	734	PF00069	0.316
MOD_PIKK_1	140	146	PF00454	0.391
MOD_PIKK_1	184	190	PF00454	0.336
MOD_PIKK_1	259	265	PF00454	0.391
MOD_PKA_1	677	683	PF00069	0.313
MOD_PKA_2	11	17	PF00069	0.476
MOD_PKA_2	172	178	PF00069	0.386
MOD_PKA_2	211	217	PF00069	0.220
MOD_PKA_2	45	51	PF00069	0.225
MOD_PKA_2	668	674	PF00069	0.380
MOD_Plk_1	259	265	PF00069	0.334
MOD_Plk_1	327	333	PF00069	0.336
MOD_Plk_1	490	496	PF00069	0.298
MOD_Plk_1	572	578	PF00069	0.336
MOD_Plk_1	721	727	PF00069	0.428
MOD_Plk_2-3	573	579	PF00069	0.336
MOD_Plk_2-3	93	99	PF00069	0.336
MOD_Plk_4	304	310	PF00069	0.277
MOD_Plk_4	330	336	PF00069	0.286
MOD_Plk_4	339	345	PF00069	0.267
MOD_Plk_4	390	396	PF00069	0.442
MOD_Plk_4	407	413	PF00069	0.373
MOD_Plk_4	431	437	PF00069	0.339
MOD_Plk_4	480	486	PF00069	0.274
MOD_Plk_4	490	496	PF00069	0.274
MOD_Plk_4	51	57	PF00069	0.274
MOD_Plk_4	573	579	PF00069	0.438
MOD_Plk_4	668	674	PF00069	0.478
MOD_Plk_4	732	738	PF00069	0.431
MOD_Plk_4	87	93	PF00069	0.195
MOD_SUMO_for_1	222	225	PF00179	0.336
MOD_SUMO_for_1	41	44	PF00179	0.336
MOD_SUMO_for_1	694	697	PF00179	0.259
MOD_SUMO_rev_2	241	250	PF00179	0.470
MOD_SUMO_rev_2	646	654	PF00179	0.296
TRG_DiLeu_BaEn_4	400	406	PF01217	0.415
TRG_DiLeu_BaLyEn_6	716	721	PF01217	0.395
TRG_ENDOCYTIC_2	180	183	PF00928	0.328
TRG_ENDOCYTIC_2	205	208	PF00928	0.302
TRG_ENDOCYTIC_2	351	354	PF00928	0.407
TRG_ENDOCYTIC_2	472	475	PF00928	0.298
TRG_ENDOCYTIC_2	543	546	PF00928	0.274
TRG_ER_diArg_1	470	472	PF00400	0.313
TRG_ER_diArg_1	495	497	PF00400	0.274
TRG_ER_diArg_1	56	58	PF00400	0.189
TRG_ER_diArg_1	707	710	PF00400	0.371
TRG_NES_CRM1_1	477	488	PF08389	0.274
TRG_NES_CRM1_1	685	697	PF08389	0.313

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4IRK5	Bodo saltans	49%	94%
A0A1X0P7U9	Trypanosomatidae	49%	100%
A0A3S7WV99	Leishmania donovani	82%	100%
A0A422ND06	Trypanosoma rangeli	50%	99%
A4HY44	Leishmania infantum	82%	100%
E9ARX3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
Q4QDJ9	Leishmania major	80%	100%
V5C1S4	Trypanosoma cruzi	43%	99%