LeishMANIAdb
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Protein kinase domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Protein kinase domain-containing protein
Gene product:
Associated kinase of Tb14-3-3, putative
Species:
Leishmania braziliensis
UniProt:
A4H9X1_LEIBR
TriTrypDb:
LbrM.19.0450 , LBRM2903_190009100 *
Length:
631

Annotations

LeishMANIAdb annotations

A large and apprently artificial collection of diverse kinetoplastid protein kinases. None of them appear to be TM.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 12
NetGPI no yes: 0, no: 12
Cellular components
Term Name Level Count
GO:0005634 nucleus 5 1
GO:0005737 cytoplasm 2 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0110165 cellular anatomical entity 1 2
GO:0016020 membrane 2 1

Expansion

Sequence features

A4H9X1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H9X1

Function

Biological processes
Term Name Level Count
GO:0006468 protein phosphorylation 5 13
GO:0006793 phosphorus metabolic process 3 13
GO:0006796 phosphate-containing compound metabolic process 4 13
GO:0006807 nitrogen compound metabolic process 2 13
GO:0008152 metabolic process 1 13
GO:0009987 cellular process 1 13
GO:0016310 phosphorylation 5 13
GO:0019538 protein metabolic process 3 13
GO:0036211 protein modification process 4 13
GO:0043170 macromolecule metabolic process 3 13
GO:0043412 macromolecule modification 4 13
GO:0044237 cellular metabolic process 2 13
GO:0044238 primary metabolic process 2 13
GO:0071704 organic substance metabolic process 2 13
GO:1901564 organonitrogen compound metabolic process 3 13
GO:0007165 signal transduction 2 1
GO:0018105 peptidyl-serine phosphorylation 6 1
GO:0018193 peptidyl-amino acid modification 5 1
GO:0018209 peptidyl-serine modification 6 1
GO:0035556 intracellular signal transduction 3 1
GO:0046777 protein autophosphorylation 6 1
GO:0050789 regulation of biological process 2 1
GO:0050794 regulation of cellular process 3 1
GO:0065007 biological regulation 1 1
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 13
GO:0003824 catalytic activity 1 13
GO:0004672 protein kinase activity 3 13
GO:0005488 binding 1 13
GO:0005524 ATP binding 5 13
GO:0016301 kinase activity 4 13
GO:0016740 transferase activity 2 13
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 13
GO:0016773 phosphotransferase activity, alcohol group as acceptor 4 13
GO:0017076 purine nucleotide binding 4 13
GO:0030554 adenyl nucleotide binding 5 13
GO:0032553 ribonucleotide binding 3 13
GO:0032555 purine ribonucleotide binding 4 13
GO:0032559 adenyl ribonucleotide binding 5 13
GO:0035639 purine ribonucleoside triphosphate binding 4 13
GO:0036094 small molecule binding 2 13
GO:0043167 ion binding 2 13
GO:0043168 anion binding 3 13
GO:0097159 organic cyclic compound binding 2 13
GO:0097367 carbohydrate derivative binding 2 13
GO:0140096 catalytic activity, acting on a protein 2 13
GO:1901265 nucleoside phosphate binding 3 13
GO:1901363 heterocyclic compound binding 2 13
GO:0004674 protein serine/threonine kinase activity 4 2
GO:0004683 calmodulin-dependent protein kinase activity 5 1
GO:0005515 protein binding 2 1
GO:0005516 calmodulin binding 3 1
GO:0008017 microtubule binding 5 1
GO:0008092 cytoskeletal protein binding 3 1
GO:0009931 calcium-dependent protein serine/threonine kinase activity 5 1
GO:0010857 calcium-dependent protein kinase activity 4 1
GO:0015631 tubulin binding 4 1
GO:0042802 identical protein binding 3 1
GO:0042803 protein homodimerization activity 4 1
GO:0046983 protein dimerization activity 3 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 22 26 PF00656 0.517
CLV_NRD_NRD_1 403 405 PF00675 0.605
CLV_NRD_NRD_1 436 438 PF00675 0.658
CLV_NRD_NRD_1 451 453 PF00675 0.661
CLV_NRD_NRD_1 472 474 PF00675 0.605
CLV_PCSK_KEX2_1 186 188 PF00082 0.278
CLV_PCSK_KEX2_1 219 221 PF00082 0.278
CLV_PCSK_KEX2_1 315 317 PF00082 0.265
CLV_PCSK_KEX2_1 403 405 PF00082 0.620
CLV_PCSK_KEX2_1 436 438 PF00082 0.658
CLV_PCSK_KEX2_1 451 453 PF00082 0.661
CLV_PCSK_KEX2_1 472 474 PF00082 0.605
CLV_PCSK_KEX2_1 83 85 PF00082 0.295
CLV_PCSK_PC1ET2_1 186 188 PF00082 0.278
CLV_PCSK_PC1ET2_1 219 221 PF00082 0.297
CLV_PCSK_PC1ET2_1 315 317 PF00082 0.281
CLV_PCSK_PC1ET2_1 83 85 PF00082 0.262
CLV_PCSK_PC7_1 215 221 PF00082 0.297
CLV_PCSK_SKI1_1 109 113 PF00082 0.359
CLV_PCSK_SKI1_1 149 153 PF00082 0.291
CLV_PCSK_SKI1_1 162 166 PF00082 0.334
CLV_PCSK_SKI1_1 280 284 PF00082 0.265
CLV_PCSK_SKI1_1 431 435 PF00082 0.621
CLV_PCSK_SKI1_1 509 513 PF00082 0.700
CLV_PCSK_SKI1_1 618 622 PF00082 0.268
DEG_Nend_UBRbox_3 1 3 PF02207 0.688
DOC_CKS1_1 227 232 PF01111 0.262
DOC_CKS1_1 287 292 PF01111 0.356
DOC_CKS1_1 39 44 PF01111 0.368
DOC_CYCLIN_yCln2_LP_2 291 297 PF00134 0.311
DOC_CYCLIN_yCln2_LP_2 323 329 PF00134 0.381
DOC_MAPK_gen_1 162 171 PF00069 0.308
DOC_MAPK_gen_1 568 576 PF00069 0.262
DOC_MAPK_JIP1_4 165 171 PF00069 0.308
DOC_PP2B_LxvP_1 206 209 PF13499 0.322
DOC_PP4_FxxP_1 612 615 PF00568 0.262
DOC_USP7_MATH_1 185 189 PF00917 0.275
DOC_USP7_MATH_1 424 428 PF00917 0.537
DOC_USP7_MATH_1 450 454 PF00917 0.655
DOC_USP7_MATH_1 484 488 PF00917 0.642
DOC_USP7_MATH_1 495 499 PF00917 0.625
DOC_USP7_MATH_1 519 523 PF00917 0.695
DOC_USP7_MATH_1 530 534 PF00917 0.598
DOC_USP7_UBL2_3 311 315 PF12436 0.306
DOC_USP7_UBL2_3 56 60 PF12436 0.304
DOC_WW_Pin1_4 226 231 PF00397 0.253
DOC_WW_Pin1_4 269 274 PF00397 0.403
DOC_WW_Pin1_4 286 291 PF00397 0.336
DOC_WW_Pin1_4 295 300 PF00397 0.305
DOC_WW_Pin1_4 314 319 PF00397 0.445
DOC_WW_Pin1_4 38 43 PF00397 0.310
DOC_WW_Pin1_4 397 402 PF00397 0.621
DOC_WW_Pin1_4 404 409 PF00397 0.647
DOC_WW_Pin1_4 425 430 PF00397 0.599
DOC_WW_Pin1_4 457 462 PF00397 0.598
DOC_WW_Pin1_4 472 477 PF00397 0.601
DOC_WW_Pin1_4 480 485 PF00397 0.608
DOC_WW_Pin1_4 486 491 PF00397 0.570
DOC_WW_Pin1_4 509 514 PF00397 0.614
DOC_WW_Pin1_4 515 520 PF00397 0.580
DOC_WW_Pin1_4 526 531 PF00397 0.534
LIG_14-3-3_CanoR_1 220 230 PF00244 0.278
LIG_14-3-3_CanoR_1 31 37 PF00244 0.268
LIG_14-3-3_CanoR_1 344 348 PF00244 0.536
LIG_14-3-3_CanoR_1 413 421 PF00244 0.699
LIG_14-3-3_CanoR_1 425 429 PF00244 0.535
LIG_14-3-3_CanoR_1 503 513 PF00244 0.695
LIG_14-3-3_CanoR_1 515 519 PF00244 0.530
LIG_14-3-3_CanoR_1 623 630 PF00244 0.273
LIG_Actin_WH2_2 75 92 PF00022 0.278
LIG_APCC_ABBA_1 111 116 PF00400 0.263
LIG_BRCT_BRCA1_1 265 269 PF00533 0.262
LIG_BRCT_BRCA1_1 578 582 PF00533 0.356
LIG_BRCT_BRCA1_1 9 13 PF00533 0.383
LIG_Clathr_ClatBox_1 112 116 PF01394 0.262
LIG_Dynein_DLC8_1 239 245 PF01221 0.278
LIG_FHA_1 142 148 PF00498 0.278
LIG_FHA_1 252 258 PF00498 0.262
LIG_FHA_1 421 427 PF00498 0.617
LIG_FHA_1 548 554 PF00498 0.689
LIG_FHA_2 20 26 PF00498 0.411
LIG_FHA_2 243 249 PF00498 0.262
LIG_FHA_2 98 104 PF00498 0.278
LIG_LIR_Apic_2 229 235 PF02991 0.308
LIG_LIR_Gen_1 10 21 PF02991 0.502
LIG_LIR_Gen_1 108 118 PF02991 0.262
LIG_LIR_Gen_1 144 152 PF02991 0.262
LIG_LIR_Gen_1 236 247 PF02991 0.288
LIG_LIR_Gen_1 261 270 PF02991 0.291
LIG_LIR_Gen_1 317 328 PF02991 0.300
LIG_LIR_Gen_1 63 71 PF02991 0.171
LIG_LIR_Nem_3 10 16 PF02991 0.547
LIG_LIR_Nem_3 100 104 PF02991 0.298
LIG_LIR_Nem_3 108 114 PF02991 0.320
LIG_LIR_Nem_3 144 148 PF02991 0.266
LIG_LIR_Nem_3 236 242 PF02991 0.276
LIG_LIR_Nem_3 245 250 PF02991 0.320
LIG_LIR_Nem_3 261 265 PF02991 0.279
LIG_LIR_Nem_3 281 286 PF02991 0.262
LIG_LIR_Nem_3 317 323 PF02991 0.300
LIG_LIR_Nem_3 63 69 PF02991 0.171
LIG_Pex14_2 111 115 PF04695 0.270
LIG_Pex14_2 238 242 PF04695 0.262
LIG_REV1ctd_RIR_1 112 121 PF16727 0.403
LIG_SH2_CRK 145 149 PF00017 0.262
LIG_SH2_CRK 320 324 PF00017 0.297
LIG_SH2_CRK 34 38 PF00017 0.414
LIG_SH2_PTP2 262 265 PF00017 0.323
LIG_SH2_PTP2 46 49 PF00017 0.403
LIG_SH2_SRC 145 148 PF00017 0.267
LIG_SH2_SRC 46 49 PF00017 0.297
LIG_SH2_STAP1 143 147 PF00017 0.278
LIG_SH2_STAT3 143 146 PF00017 0.262
LIG_SH2_STAT3 21 24 PF00017 0.366
LIG_SH2_STAT5 104 107 PF00017 0.309
LIG_SH2_STAT5 143 146 PF00017 0.262
LIG_SH2_STAT5 21 24 PF00017 0.345
LIG_SH2_STAT5 262 265 PF00017 0.309
LIG_SH2_STAT5 46 49 PF00017 0.322
LIG_SH2_STAT5 57 60 PF00017 0.159
LIG_SH2_STAT5 611 614 PF00017 0.262
LIG_SH2_STAT5 66 69 PF00017 0.228
LIG_SH3_3 267 273 PF00018 0.403
LIG_SH3_3 36 42 PF00018 0.274
LIG_SH3_3 387 393 PF00018 0.564
LIG_SH3_3 423 429 PF00018 0.624
LIG_SUMO_SIM_anti_2 376 383 PF11976 0.370
LIG_SUMO_SIM_anti_2 65 71 PF11976 0.171
LIG_SUMO_SIM_anti_2 85 90 PF11976 0.295
LIG_SUMO_SIM_par_1 199 204 PF11976 0.352
LIG_SxIP_EBH_1 38 49 PF03271 0.301
LIG_TRAF2_1 394 397 PF00917 0.740
LIG_TYR_ITIM 260 265 PF00017 0.323
LIG_UBA3_1 67 72 PF00899 0.297
LIG_WRC_WIRS_1 98 103 PF05994 0.278
MOD_CDC14_SPxK_1 428 431 PF00782 0.583
MOD_CDK_SPK_2 226 231 PF00069 0.262
MOD_CDK_SPxK_1 397 403 PF00069 0.587
MOD_CDK_SPxK_1 425 431 PF00069 0.585
MOD_CDK_SPxK_1 472 478 PF00069 0.601
MOD_CDK_SPxK_1 480 486 PF00069 0.598
MOD_CDK_SPxK_1 509 515 PF00069 0.634
MOD_CDK_SPxxK_3 286 293 PF00069 0.407
MOD_CDK_SPxxK_3 397 404 PF00069 0.574
MOD_CDK_SPxxK_3 457 464 PF00069 0.598
MOD_CK1_1 272 278 PF00069 0.403
MOD_CK1_1 314 320 PF00069 0.446
MOD_CK1_1 346 352 PF00069 0.573
MOD_CK1_1 409 415 PF00069 0.646
MOD_CK1_1 440 446 PF00069 0.715
MOD_CK1_1 453 459 PF00069 0.541
MOD_CK1_1 532 538 PF00069 0.662
MOD_CK1_1 7 13 PF00069 0.475
MOD_CK2_1 275 281 PF00069 0.356
MOD_CK2_1 97 103 PF00069 0.278
MOD_Cter_Amidation 217 220 PF01082 0.278
MOD_DYRK1A_RPxSP_1 404 408 PF00069 0.594
MOD_DYRK1A_RPxSP_1 425 429 PF00069 0.641
MOD_DYRK1A_RPxSP_1 486 490 PF00069 0.605
MOD_DYRK1A_RPxSP_1 526 530 PF00069 0.611
MOD_GlcNHglycan 131 134 PF01048 0.403
MOD_GlcNHglycan 265 268 PF01048 0.262
MOD_GlcNHglycan 348 351 PF01048 0.531
MOD_GlcNHglycan 353 356 PF01048 0.520
MOD_GlcNHglycan 408 411 PF01048 0.697
MOD_GlcNHglycan 444 447 PF01048 0.690
MOD_GlcNHglycan 453 456 PF01048 0.591
MOD_GlcNHglycan 464 467 PF01048 0.544
MOD_GlcNHglycan 486 489 PF01048 0.629
MOD_GlcNHglycan 497 500 PF01048 0.512
MOD_GlcNHglycan 521 524 PF01048 0.705
MOD_GlcNHglycan 532 535 PF01048 0.576
MOD_GlcNHglycan 543 546 PF01048 0.577
MOD_GlcNHglycan 6 9 PF01048 0.678
MOD_GSK3_1 129 136 PF00069 0.334
MOD_GSK3_1 137 144 PF00069 0.305
MOD_GSK3_1 190 197 PF00069 0.306
MOD_GSK3_1 261 268 PF00069 0.276
MOD_GSK3_1 282 289 PF00069 0.281
MOD_GSK3_1 342 349 PF00069 0.409
MOD_GSK3_1 4 11 PF00069 0.509
MOD_GSK3_1 409 416 PF00069 0.689
MOD_GSK3_1 420 427 PF00069 0.618
MOD_GSK3_1 431 438 PF00069 0.648
MOD_GSK3_1 441 448 PF00069 0.707
MOD_GSK3_1 453 460 PF00069 0.589
MOD_GSK3_1 480 487 PF00069 0.764
MOD_GSK3_1 491 498 PF00069 0.515
MOD_GSK3_1 501 508 PF00069 0.508
MOD_GSK3_1 509 516 PF00069 0.641
MOD_GSK3_1 526 533 PF00069 0.601
MOD_GSK3_1 596 603 PF00069 0.262
MOD_LATS_1 435 441 PF00433 0.652
MOD_N-GLC_1 275 280 PF02516 0.377
MOD_N-GLC_1 524 529 PF02516 0.666
MOD_N-GLC_1 576 581 PF02516 0.356
MOD_NEK2_1 128 133 PF00069 0.403
MOD_NEK2_1 201 206 PF00069 0.405
MOD_NEK2_1 242 247 PF00069 0.260
MOD_NEK2_1 265 270 PF00069 0.271
MOD_NEK2_1 304 309 PF00069 0.370
MOD_NEK2_1 343 348 PF00069 0.529
MOD_NEK2_1 395 400 PF00069 0.735
MOD_NEK2_1 462 467 PF00069 0.599
MOD_NEK2_1 491 496 PF00069 0.501
MOD_NEK2_1 547 552 PF00069 0.700
MOD_NEK2_1 576 581 PF00069 0.390
MOD_PIKK_1 240 246 PF00454 0.262
MOD_PIKK_1 622 628 PF00454 0.262
MOD_PKA_1 451 457 PF00069 0.661
MOD_PKA_2 334 340 PF00069 0.457
MOD_PKA_2 343 349 PF00069 0.529
MOD_PKA_2 414 420 PF00069 0.720
MOD_PKA_2 424 430 PF00069 0.628
MOD_PKA_2 435 441 PF00069 0.630
MOD_PKA_2 450 456 PF00069 0.615
MOD_PKA_2 491 497 PF00069 0.628
MOD_PKA_2 502 508 PF00069 0.542
MOD_PKA_2 514 520 PF00069 0.480
MOD_PKA_2 622 628 PF00069 0.262
MOD_Plk_1 201 207 PF00069 0.403
MOD_Plk_2-3 601 607 PF00069 0.262
MOD_Plk_4 258 264 PF00069 0.306
MOD_Plk_4 304 310 PF00069 0.370
MOD_Plk_4 32 38 PF00069 0.341
MOD_Plk_4 334 340 PF00069 0.450
MOD_Plk_4 343 349 PF00069 0.573
MOD_Plk_4 601 607 PF00069 0.276
MOD_Plk_4 97 103 PF00069 0.278
MOD_ProDKin_1 226 232 PF00069 0.253
MOD_ProDKin_1 269 275 PF00069 0.403
MOD_ProDKin_1 286 292 PF00069 0.336
MOD_ProDKin_1 295 301 PF00069 0.305
MOD_ProDKin_1 314 320 PF00069 0.445
MOD_ProDKin_1 38 44 PF00069 0.310
MOD_ProDKin_1 397 403 PF00069 0.624
MOD_ProDKin_1 404 410 PF00069 0.647
MOD_ProDKin_1 425 431 PF00069 0.602
MOD_ProDKin_1 457 463 PF00069 0.596
MOD_ProDKin_1 472 478 PF00069 0.601
MOD_ProDKin_1 480 486 PF00069 0.598
MOD_ProDKin_1 509 515 PF00069 0.614
MOD_ProDKin_1 526 532 PF00069 0.533
MOD_SUMO_for_1 164 167 PF00179 0.308
MOD_SUMO_for_1 82 85 PF00179 0.262
MOD_SUMO_rev_2 131 140 PF00179 0.300
MOD_SUMO_rev_2 158 166 PF00179 0.262
TRG_DiLeu_BaEn_1 108 113 PF01217 0.278
TRG_DiLeu_BaEn_1 63 68 PF01217 0.278
TRG_DiLeu_BaEn_4 137 143 PF01217 0.356
TRG_DiLeu_BaEn_4 361 367 PF01217 0.558
TRG_DiLeu_BaLyEn_6 212 217 PF01217 0.297
TRG_ENDOCYTIC_2 145 148 PF00928 0.262
TRG_ENDOCYTIC_2 239 242 PF00928 0.281
TRG_ENDOCYTIC_2 247 250 PF00928 0.319
TRG_ENDOCYTIC_2 262 265 PF00928 0.321
TRG_ENDOCYTIC_2 320 323 PF00928 0.297
TRG_ENDOCYTIC_2 34 37 PF00928 0.415
TRG_ENDOCYTIC_2 66 69 PF00928 0.171
TRG_ER_diArg_1 450 452 PF00400 0.659
TRG_ER_diArg_1 471 473 PF00400 0.568
TRG_ER_diLys_1 628 631 PF00400 0.565

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I1M7 Leptomonas seymouri 82% 98%
A0A0S4IX25 Bodo saltans 45% 97%
A0A0S4JVD7 Bodo saltans 24% 100%
A0A1X0P6L8 Trypanosomatidae 66% 100%
A0A3R7LU08 Trypanosoma rangeli 64% 100%
A0A3S7WV74 Leishmania donovani 92% 100%
A0A3S7WY10 Leishmania donovani 24% 100%
A0A3S7X8Z8 Leishmania donovani 26% 100%
A4H4S9 Leishmania braziliensis 26% 100%
A4HCD7 Leishmania braziliensis 30% 100%
A4IB02 Leishmania infantum 26% 100%
D0A0D2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 60% 99%
E9AGR6 Leishmania infantum 92% 100%
E9AH34 Leishmania infantum 24% 100%
E9ARW5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 92% 100%
E9AWL2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 25% 100%
E9AYR2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 24% 96%
E9B5Y5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 24% 100%
Q13555 Homo sapiens 26% 100%
Q19469 Caenorhabditis elegans 27% 69%
Q4QAV8 Leishmania major 27% 100%
Q4QDK7 Leishmania major 91% 100%
Q63553 Rattus norvegicus 26% 85%
Q8VDU5 Mus musculus 25% 84%
Q9NRH2 Homo sapiens 26% 82%
Q9QYZ4 Mus musculus 24% 100%
V5DTI3 Trypanosoma cruzi 63% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS