Derlin

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Derlin

Gene product:

Der1-like family, putative

Species:

Leishmania braziliensis

UniProt:

A4H9X0_LEIBR

TriTrypDb:

LbrM.19.0440 , LBRM2903_190009000

Length:

253

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0000151	ubiquitin ligase complex	3	1
GO:0000153	cytoplasmic ubiquitin ligase complex	4	1
GO:0000835	ER ubiquitin ligase complex	3	1
GO:0000836	Hrd1p ubiquitin ligase complex	4	1
GO:0000839	Hrd1p ubiquitin ligase ERAD-L complex	5	1
GO:0005789	endoplasmic reticulum membrane	4	11
GO:0016020	membrane	2	11
GO:0031090	organelle membrane	3	11
GO:0032991	protein-containing complex	1	1
GO:0098796	membrane protein complex	2	1

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Expansion

Sequence features

A4H9X0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H9X0

Function

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Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	1
GO:0006511	ubiquitin-dependent protein catabolic process	7	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0006950	response to stress	2	12
GO:0007165	signal transduction	2	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009057	macromolecule catabolic process	4	1
GO:0009987	cellular process	1	1
GO:0010033	response to organic substance	3	1

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Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0051787	misfolded protein binding	3	1

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	202	204	PF00675	0.384
CLV_NRD_NRD_1	230	232	PF00675	0.426
CLV_PCSK_KEX2_1	132	134	PF00082	0.253
CLV_PCSK_KEX2_1	202	204	PF00082	0.423
CLV_PCSK_KEX2_1	230	232	PF00082	0.426
CLV_PCSK_PC1ET2_1	132	134	PF00082	0.253
CLV_PCSK_SKI1_1	183	187	PF00082	0.277
CLV_PCSK_SKI1_1	54	58	PF00082	0.472
DOC_CKS1_1	195	200	PF01111	0.453
DOC_CKS1_1	41	46	PF01111	0.177

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HV02	Leptomonas seymouri	76%	99%
A0A0S4IV51	Bodo saltans	42%	100%
A0A0S4KDZ1	Bodo saltans	25%	100%
A0A1X0NMT1	Trypanosomatidae	40%	99%
A0A3S5H750	Leishmania donovani	91%	100%
A0A3S7X6X1	Leishmania donovani	28%	100%
A0A422NV56	Trypanosoma rangeli	47%	100%
A4HLP0	Leishmania braziliensis	27%	100%
A4I975	Leishmania infantum	28%	100%
D0A9D5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%

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