QA-SNARE protein putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

QA-SNARE protein putative

Species:

Leishmania braziliensis

UniProt:

A4H9W9_LEIBR

TriTrypDb:

LbrM.19.0430 , LBRM2903_190008900

Length:

228

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11
GO:0012505	endomembrane system	2	1
GO:0031201	SNARE complex	3	1
GO:0031982	vesicle	4	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0098796	membrane protein complex	2	1

Expansion

Sequence features

A4H9W9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H9W9

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	6
GO:0006886	intracellular protein transport	4	1
GO:0006906	vesicle fusion	6	1
GO:0006996	organelle organization	4	1
GO:0008104	protein localization	4	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0016043	cellular component organization	3	1
GO:0016050	vesicle organization	5	1
GO:0022406	membrane docking	2	1
GO:0033036	macromolecule localization	2	1
GO:0045184	establishment of protein localization	3	1
GO:0046907	intracellular transport	3	1
GO:0048278	vesicle docking	4	1
GO:0048284	organelle fusion	5	1
GO:0051179	localization	1	6
GO:0051234	establishment of localization	2	6
GO:0051640	organelle localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0061024	membrane organization	4	1
GO:0061025	membrane fusion	5	1
GO:0070727	cellular macromolecule localization	3	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0090174	organelle membrane fusion	6	1
GO:0140056	organelle localization by membrane tethering	3	1
GO:0016192	vesicle-mediated transport	4	5

Molecular functions
Term	Name	Level	Count
GO:0000149	SNARE binding	3	1
GO:0005484	SNAP receptor activity	3	1
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0030674	protein-macromolecule adaptor activity	2	1
GO:0060090	molecular adaptor activity	1	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	32	36	PF00656	0.612
CLV_C14_Caspase3-7	99	103	PF00656	0.597
CLV_NRD_NRD_1	202	204	PF00675	0.272
CLV_NRD_NRD_1	90	92	PF00675	0.369
CLV_PCSK_KEX2_1	90	92	PF00082	0.398
CLV_PCSK_SKI1_1	78	82	PF00082	0.435
CLV_PCSK_SKI1_1	93	97	PF00082	0.389
DEG_APCC_DBOX_1	136	144	PF00400	0.584
DEG_APCC_DBOX_1	38	46	PF00400	0.593
DOC_MAPK_gen_1	39	47	PF00069	0.567
DOC_MAPK_gen_1	90	97	PF00069	0.517
DOC_MAPK_MEF2A_6	41	49	PF00069	0.536
DOC_USP7_MATH_1	111	115	PF00917	0.666
DOC_USP7_MATH_1	23	27	PF00917	0.609
LIG_14-3-3_CanoR_1	198	203	PF00244	0.552
LIG_Actin_WH2_2	139	156	PF00022	0.632
LIG_CtBP_PxDLS_1	123	127	PF00389	0.707
LIG_DLG_GKlike_1	198	205	PF00625	0.400
LIG_EH1_1	42	50	PF00400	0.459
LIG_FHA_1	173	179	PF00498	0.478
LIG_FHA_1	212	218	PF00498	0.372
LIG_FHA_2	115	121	PF00498	0.737
LIG_FHA_2	154	160	PF00498	0.580
LIG_FHA_2	30	36	PF00498	0.576
LIG_FHA_2	87	93	PF00498	0.620
LIG_FHA_2	97	103	PF00498	0.682
LIG_LIR_Gen_1	117	126	PF02991	0.587
LIG_LIR_Gen_1	156	164	PF02991	0.612
LIG_LIR_Nem_3	117	121	PF02991	0.661
LIG_LIR_Nem_3	156	160	PF02991	0.605
LIG_LIR_Nem_3	201	205	PF02991	0.553
LIG_SUMO_SIM_anti_2	211	217	PF11976	0.352
LIG_SUMO_SIM_par_1	222	227	PF11976	0.396
LIG_TRAF2_1	156	159	PF00917	0.669
MOD_CK1_1	114	120	PF00069	0.718
MOD_CK2_1	114	120	PF00069	0.737
MOD_CK2_1	153	159	PF00069	0.578
MOD_CK2_1	180	186	PF00069	0.478
MOD_CK2_1	23	29	PF00069	0.645
MOD_CK2_1	58	64	PF00069	0.579
MOD_CK2_1	86	92	PF00069	0.618
MOD_GlcNHglycan	208	211	PF01048	0.447
MOD_GSK3_1	124	131	PF00069	0.654
MOD_GSK3_1	172	179	PF00069	0.485
MOD_GSK3_1	18	25	PF00069	0.611
MOD_GSK3_1	194	201	PF00069	0.400
MOD_GSK3_1	96	103	PF00069	0.666
MOD_N-GLC_1	176	181	PF02516	0.296
MOD_NEK2_1	153	158	PF00069	0.581
MOD_NEK2_1	9	14	PF00069	0.543
MOD_NEK2_2	23	28	PF00069	0.617
MOD_PIKK_1	111	117	PF00454	0.669
MOD_PKA_2	172	178	PF00069	0.518
MOD_Plk_2-3	128	134	PF00069	0.729
MOD_Plk_2-3	180	186	PF00069	0.552
MOD_Plk_4	159	165	PF00069	0.650
MOD_Plk_4	180	186	PF00069	0.433
MOD_Plk_4	208	214	PF00069	0.323
MOD_SUMO_rev_2	147	156	PF00179	0.669
TRG_DiLeu_BaEn_1	159	164	PF01217	0.602
TRG_DiLeu_BaEn_1	180	185	PF01217	0.552
TRG_DiLeu_BaEn_2	91	97	PF01217	0.518
TRG_DiLeu_BaLyEn_6	43	48	PF01217	0.561
TRG_ENDOCYTIC_2	157	160	PF00928	0.616
TRG_ER_diArg_1	44	47	PF00400	0.616
TRG_Pf-PMV_PEXEL_1	11	15	PF00026	0.369
TRG_Pf-PMV_PEXEL_1	46	50	PF00026	0.339

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3K8	Leptomonas seymouri	70%	100%
A0A0S4IVI2	Bodo saltans	36%	93%
A0A1X0P7H4	Trypanosomatidae	46%	95%
A0A3Q8IJV6	Leishmania donovani	80%	100%
A0A422ND16	Trypanosoma rangeli	42%	96%
E9AGR4	Leishmania infantum	80%	100%
E9ARW3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
Q4QDK9	Leishmania major	81%	100%
V5BBT6	Trypanosoma cruzi	47%	96%