Clathrin light chain

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H9W8_LEIBR

TriTrypDb:

LbrM.19.0420 , LBRM2903_190008800

Length:

162

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0030117	membrane coat	3	6
GO:0030118	clathrin coat	4	6
GO:0030120	vesicle coat	4	6
GO:0030125	clathrin vesicle coat	5	6
GO:0030130	clathrin coat of trans-Golgi network vesicle	6	6
GO:0030132	clathrin coat of coated pit	4	6
GO:0032991	protein-containing complex	1	6
GO:0098796	membrane protein complex	2	6
GO:0098797	plasma membrane protein complex	3	6

Expansion

Sequence features

A4H9W8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H9W8

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	6
GO:0006886	intracellular protein transport	4	6
GO:0008104	protein localization	4	6
GO:0009987	cellular process	1	6
GO:0015031	protein transport	4	6
GO:0016192	vesicle-mediated transport	4	6
GO:0033036	macromolecule localization	2	6
GO:0045184	establishment of protein localization	3	6
GO:0046907	intracellular transport	3	6
GO:0051179	localization	1	6
GO:0051234	establishment of localization	2	6
GO:0051641	cellular localization	2	6
GO:0051649	establishment of localization in cell	3	6
GO:0070727	cellular macromolecule localization	3	6
GO:0071702	organic substance transport	4	6
GO:0071705	nitrogen compound transport	4	6

Molecular functions
Term	Name	Level	Count
GO:0005198	structural molecule activity	1	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	95	97	PF00675	0.178
CLV_PCSK_KEX2_1	60	62	PF00082	0.247
CLV_PCSK_KEX2_1	95	97	PF00082	0.203
CLV_PCSK_PC1ET2_1	60	62	PF00082	0.247
CLV_PCSK_SKI1_1	151	155	PF00082	0.198
CLV_PCSK_SKI1_1	61	65	PF00082	0.357
CLV_PCSK_SKI1_1	80	84	PF00082	0.308
CLV_Separin_Metazoa	148	152	PF03568	0.178
DEG_APCC_DBOX_1	150	158	PF00400	0.198
DEG_Nend_UBRbox_3	1	3	PF02207	0.518
DEG_SCF_FBW7_1	13	20	PF00400	0.496
DOC_CKS1_1	41	46	PF01111	0.553
DOC_USP7_MATH_1	103	107	PF00917	0.247
DOC_USP7_MATH_2	44	50	PF00917	0.477
DOC_USP7_UBL2_3	104	108	PF12436	0.267
DOC_WW_Pin1_4	13	18	PF00397	0.669
DOC_WW_Pin1_4	30	35	PF00397	0.493
DOC_WW_Pin1_4	40	45	PF00397	0.477
DOC_WW_Pin1_4	6	11	PF00397	0.509
LIG_14-3-3_CanoR_1	151	161	PF00244	0.196
LIG_14-3-3_CanoR_1	61	70	PF00244	0.184
LIG_BRCT_BRCA1_1	24	28	PF00533	0.505
LIG_FHA_1	113	119	PF00498	0.463
LIG_FHA_2	41	47	PF00498	0.482
LIG_SH2_STAT5	88	91	PF00017	0.198
LIG_SH3_2	42	47	PF14604	0.470
LIG_SH3_3	35	41	PF00018	0.560
LIG_SH3_3	4	10	PF00018	0.528
LIG_SH3_3	42	48	PF00018	0.563
LIG_TRAF2_1	76	79	PF00917	0.184
LIG_UBA3_1	133	139	PF00899	0.229
MOD_CDC14_SPxK_1	37	40	PF00782	0.476
MOD_CDK_SPxK_1	34	40	PF00069	0.487
MOD_CDK_SPxxK_3	40	47	PF00069	0.483
MOD_CK1_1	144	150	PF00069	0.198
MOD_CK1_1	152	158	PF00069	0.198
MOD_CK2_1	29	35	PF00069	0.503
MOD_CK2_1	40	46	PF00069	0.472
MOD_CK2_1	6	12	PF00069	0.509
MOD_DYRK1A_RPxSP_1	40	44	PF00069	0.464
MOD_GlcNHglycan	157	160	PF01048	0.413
MOD_GSK3_1	13	20	PF00069	0.541
MOD_GSK3_1	149	156	PF00069	0.231
MOD_GSK3_1	30	37	PF00069	0.710
MOD_NEK2_1	149	154	PF00069	0.212
MOD_NEK2_1	28	33	PF00069	0.715
MOD_PK_1	47	53	PF00069	0.431
MOD_ProDKin_1	13	19	PF00069	0.669
MOD_ProDKin_1	30	36	PF00069	0.495
MOD_ProDKin_1	40	46	PF00069	0.478
MOD_ProDKin_1	6	12	PF00069	0.509
MOD_SUMO_for_1	76	79	PF00179	0.281
MOD_SUMO_rev_2	110	118	PF00179	0.228

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0P7W0	Trypanosomatidae	44%	70%
D0A0D1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	86%
E9ARW2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	66%	100%
Q4QDL0	Leishmania major	66%	100%