Putative fibrillarin

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

fibrillarin, putative

Species:

Leishmania braziliensis

UniProt:

A4H9W7_LEIBR

TriTrypDb:

LbrM.19.0410 , LBRM2903_190008700

Length:

433

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005730	nucleolus	5	1
GO:0005732	sno(s)RNA-containing ribonucleoprotein complex	3	1
GO:0030684	preribosome	3	1
GO:0031428	box C/D RNP complex	4	1
GO:0032040	small-subunit processome	4	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

A4H9W7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H9W7

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	7
GO:0006364	rRNA processing	8	7
GO:0006396	RNA processing	6	7
GO:0006725	cellular aromatic compound metabolic process	3	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	7
GO:0009987	cellular process	1	7
GO:0016070	RNA metabolic process	5	7
GO:0016072	rRNA metabolic process	7	7
GO:0032259	methylation	2	7
GO:0034470	ncRNA processing	7	7
GO:0034641	cellular nitrogen compound metabolic process	3	7
GO:0034660	ncRNA metabolic process	6	7
GO:0043170	macromolecule metabolic process	3	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0046483	heterocycle metabolic process	3	7
GO:0071704	organic substance metabolic process	2	7
GO:0090304	nucleic acid metabolic process	4	7
GO:1901360	organic cyclic compound metabolic process	3	7
GO:0000154	rRNA modification	6	1
GO:0000494	box C/D RNA 3'-end processing	10	1
GO:0001510	RNA methylation	4	1
GO:0006479	protein methylation	4	1
GO:0008213	protein alkylation	5	1
GO:0009451	RNA modification	5	1
GO:0016074	sno(s)RNA metabolic process	7	1
GO:0016570	histone modification	5	1
GO:0016571	histone methylation	5	1
GO:0018364	peptidyl-glutamine methylation	5	1
GO:0019538	protein metabolic process	3	1
GO:0031123	RNA 3'-end processing	7	1
GO:0031126	sno(s)RNA 3'-end processing	9	1
GO:0031167	rRNA methylation	5	1
GO:0033967	box C/D RNA metabolic process	8	1
GO:0034963	box C/D RNA processing	9	1
GO:0036211	protein modification process	4	1
GO:0043144	sno(s)RNA processing	8	1
GO:0043412	macromolecule modification	4	1
GO:0043414	macromolecule methylation	3	1
GO:0043628	regulatory ncRNA 3'-end processing	8	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1990258	histone glutamine methylation	6	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	7
GO:0003723	RNA binding	4	7
GO:0003824	catalytic activity	1	7
GO:0005488	binding	1	7
GO:0008168	methyltransferase activity	4	7
GO:0016740	transferase activity	2	7
GO:0016741	transferase activity, transferring one-carbon groups	3	7
GO:0097159	organic cyclic compound binding	2	7
GO:1901363	heterocyclic compound binding	2	7
GO:0008170	N-methyltransferase activity	5	1
GO:0008173	RNA methyltransferase activity	4	1
GO:0008276	protein methyltransferase activity	3	1
GO:0008649	rRNA methyltransferase activity	5	1
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	5	1
GO:0036009	protein-glutamine N-methyltransferase activity	4	1
GO:0042054	histone methyltransferase activity	4	1
GO:0140096	catalytic activity, acting on a protein	2	1
GO:0140098	catalytic activity, acting on RNA	3	1
GO:0140102	catalytic activity, acting on a rRNA	4	1
GO:0140640	catalytic activity, acting on a nucleic acid	2	1
GO:1990259	histone H2AQ104 methyltransferase activity	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	106	108	PF00675	0.694
CLV_NRD_NRD_1	318	320	PF00675	0.516
CLV_PCSK_KEX2_1	101	103	PF00082	0.676
CLV_PCSK_KEX2_1	105	107	PF00082	0.686
CLV_PCSK_KEX2_1	231	233	PF00082	0.369
CLV_PCSK_KEX2_1	317	319	PF00082	0.508
CLV_PCSK_PC1ET2_1	101	103	PF00082	0.566
CLV_PCSK_PC1ET2_1	231	233	PF00082	0.369
CLV_PCSK_PC1ET2_1	317	319	PF00082	0.410
CLV_PCSK_PC7_1	102	108	PF00082	0.556
DEG_Nend_UBRbox_1	1	4	PF02207	0.478
DEG_SPOP_SBC_1	36	40	PF00917	0.483
DOC_ANK_TNKS_1	218	225	PF00023	0.357
DOC_MAPK_DCC_7	219	227	PF00069	0.357
DOC_MAPK_gen_1	317	325	PF00069	0.369
DOC_MAPK_gen_1	405	412	PF00069	0.368
DOC_MAPK_MEF2A_6	219	227	PF00069	0.373
DOC_PP2B_LxvP_1	42	45	PF13499	0.470
DOC_USP7_MATH_1	223	227	PF00917	0.357
DOC_USP7_MATH_1	238	242	PF00917	0.235
DOC_USP7_MATH_1	251	255	PF00917	0.266
DOC_USP7_MATH_1	37	41	PF00917	0.488
DOC_USP7_MATH_1	45	49	PF00917	0.441
DOC_USP7_MATH_1	69	73	PF00917	0.497
DOC_USP7_MATH_2	406	412	PF00917	0.369
DOC_WW_Pin1_4	189	194	PF00397	0.595
LIG_14-3-3_CanoR_1	41	45	PF00244	0.478
LIG_14-3-3_CanoR_1	59	67	PF00244	0.443
LIG_14-3-3_CanoR_1	80	86	PF00244	0.490
LIG_Actin_WH2_2	19	36	PF00022	0.478
LIG_APCC_ABBA_1	225	230	PF00400	0.369
LIG_BRCT_BRCA1_1	242	246	PF00533	0.357
LIG_FHA_1	216	222	PF00498	0.366
LIG_FHA_1	50	56	PF00498	0.464
LIG_FHA_1	86	92	PF00498	0.500
LIG_IBAR_NPY_1	250	252	PF08397	0.369
LIG_LIR_Apic_2	266	271	PF02991	0.357
LIG_LIR_Gen_1	112	119	PF02991	0.518
LIG_LIR_Gen_1	344	353	PF02991	0.420
LIG_LIR_Gen_1	52	60	PF02991	0.473
LIG_LIR_Nem_3	112	117	PF02991	0.522
LIG_LIR_Nem_3	258	264	PF02991	0.494
LIG_LIR_Nem_3	344	350	PF02991	0.435
LIG_LIR_Nem_3	423	429	PF02991	0.379
LIG_LIR_Nem_3	52	57	PF02991	0.469
LIG_MYND_3	323	327	PF01753	0.357
LIG_Pex14_2	114	118	PF04695	0.519
LIG_Pex14_2	54	58	PF04695	0.473
LIG_SH2_CRK	261	265	PF00017	0.464
LIG_SH2_CRK	335	339	PF00017	0.516
LIG_SH2_CRK	426	430	PF00017	0.520
LIG_SH2_STAP1	300	304	PF00017	0.369
LIG_SH2_STAT5	208	211	PF00017	0.490
LIG_SH2_STAT5	277	280	PF00017	0.369
LIG_SH3_3	245	251	PF00018	0.470
LIG_SH3_3	347	353	PF00018	0.369
LIG_WW_3	93	97	PF00397	0.500
MOD_CDK_SPK_2	189	194	PF00069	0.595
MOD_CK1_1	217	223	PF00069	0.368
MOD_CK1_1	226	232	PF00069	0.291
MOD_CK1_1	282	288	PF00069	0.457
MOD_CK1_1	305	311	PF00069	0.358
MOD_CK1_1	32	38	PF00069	0.485
MOD_CK1_1	40	46	PF00069	0.467
MOD_CK1_1	61	67	PF00069	0.472
MOD_GlcNHglycan	151	154	PF01048	0.573
MOD_GlcNHglycan	257	260	PF01048	0.391
MOD_GlcNHglycan	272	275	PF01048	0.242
MOD_GlcNHglycan	281	284	PF01048	0.288
MOD_GlcNHglycan	307	310	PF01048	0.371
MOD_GlcNHglycan	4	7	PF01048	0.475
MOD_GlcNHglycan	401	404	PF01048	0.357
MOD_GlcNHglycan	63	66	PF01048	0.479
MOD_GSK3_1	13	20	PF00069	0.481
MOD_GSK3_1	251	258	PF00069	0.410
MOD_GSK3_1	313	320	PF00069	0.357
MOD_GSK3_1	32	39	PF00069	0.453
MOD_GSK3_1	40	47	PF00069	0.463
MOD_GSK3_1	81	88	PF00069	0.494
MOD_GSK3_1	96	103	PF00069	0.524
MOD_N-GLC_1	233	238	PF02516	0.357
MOD_N-GLC_2	205	207	PF02516	0.357
MOD_NEK2_1	373	378	PF00069	0.362
MOD_NEK2_1	399	404	PF00069	0.358
MOD_NEK2_1	58	63	PF00069	0.477
MOD_NEK2_1	85	90	PF00069	0.498
MOD_NEK2_2	223	228	PF00069	0.369
MOD_NEK2_2	263	268	PF00069	0.369
MOD_OFUCOSY	87	93	PF10250	0.502
MOD_PKA_1	317	323	PF00069	0.357
MOD_PKA_2	317	323	PF00069	0.357
MOD_PKA_2	40	46	PF00069	0.480
MOD_PKA_2	58	64	PF00069	0.447
MOD_Plk_2-3	408	414	PF00069	0.369
MOD_Plk_4	223	229	PF00069	0.357
MOD_Plk_4	263	269	PF00069	0.412
MOD_Plk_4	49	55	PF00069	0.463
MOD_Plk_4	69	75	PF00069	0.468
MOD_ProDKin_1	189	195	PF00069	0.583
TRG_ENDOCYTIC_2	261	264	PF00928	0.464
TRG_ENDOCYTIC_2	335	338	PF00928	0.516
TRG_ENDOCYTIC_2	426	429	PF00928	0.522
TRG_ER_diArg_1	105	107	PF00400	0.693
TRG_Pf-PMV_PEXEL_1	310	314	PF00026	0.369

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8ID71	Leishmania donovani	99%	100%
A0A3S5H830	Leishmania donovani	68%	100%
E9AGR2	Leishmania infantum	99%	100%
E9ARW1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	99%	100%
Q4QDL1	Leishmania major	99%	100%