J domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H9W6_LEIBR

TriTrypDb:

LbrM.19.0400 , LBRM2903_190008600

Length:

403

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

A4H9W6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H9W6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	285	289	PF00656	0.339
CLV_C14_Caspase3-7	294	298	PF00656	0.343
CLV_NRD_NRD_1	16	18	PF00675	0.411
CLV_NRD_NRD_1	184	186	PF00675	0.543
CLV_NRD_NRD_1	265	267	PF00675	0.644
CLV_NRD_NRD_1	298	300	PF00675	0.610
CLV_PCSK_KEX2_1	16	18	PF00082	0.411
CLV_PCSK_KEX2_1	183	185	PF00082	0.583
CLV_PCSK_KEX2_1	265	267	PF00082	0.618
CLV_PCSK_KEX2_1	393	395	PF00082	0.484
CLV_PCSK_PC1ET2_1	265	267	PF00082	0.618
CLV_PCSK_PC1ET2_1	393	395	PF00082	0.509
CLV_PCSK_SKI1_1	16	20	PF00082	0.486
CLV_PCSK_SKI1_1	195	199	PF00082	0.603
CLV_PCSK_SKI1_1	235	239	PF00082	0.613
CLV_PCSK_SKI1_1	267	271	PF00082	0.509
CLV_PCSK_SKI1_1	34	38	PF00082	0.350
CLV_PCSK_SKI1_1	88	92	PF00082	0.276
DEG_SPOP_SBC_1	250	254	PF00917	0.474
DOC_MAPK_gen_1	333	341	PF00069	0.497
DOC_MAPK_gen_1	85	95	PF00069	0.519
DOC_MAPK_MEF2A_6	335	343	PF00069	0.491
DOC_MAPK_MEF2A_6	88	97	PF00069	0.416
DOC_PP1_RVXF_1	218	225	PF00149	0.291
DOC_USP7_MATH_1	399	403	PF00917	0.576
DOC_USP7_MATH_2	166	172	PF00917	0.422
DOC_USP7_UBL2_3	261	265	PF12436	0.447
DOC_WW_Pin1_4	152	157	PF00397	0.546
DOC_WW_Pin1_4	162	167	PF00397	0.575
DOC_WW_Pin1_4	251	256	PF00397	0.485
LIG_14-3-3_CanoR_1	251	255	PF00244	0.459
LIG_14-3-3_CanoR_1	314	323	PF00244	0.437
LIG_14-3-3_CanoR_1	34	39	PF00244	0.690
LIG_14-3-3_CanoR_1	65	73	PF00244	0.646
LIG_14-3-3_CanoR_1	9	15	PF00244	0.683
LIG_Actin_WH2_2	357	375	PF00022	0.495
LIG_eIF4E_1	89	95	PF01652	0.449
LIG_FHA_1	143	149	PF00498	0.409
LIG_FHA_1	228	234	PF00498	0.464
LIG_FHA_1	245	251	PF00498	0.503
LIG_FHA_1	352	358	PF00498	0.328
LIG_FHA_2	163	169	PF00498	0.427
LIG_FHA_2	270	276	PF00498	0.485
LIG_FHA_2	67	73	PF00498	0.641
LIG_LIR_Gen_1	140	148	PF02991	0.367
LIG_LIR_Gen_1	223	233	PF02991	0.371
LIG_LIR_Gen_1	288	298	PF02991	0.334
LIG_LIR_Gen_1	72	77	PF02991	0.628
LIG_LIR_Nem_3	103	107	PF02991	0.490
LIG_LIR_Nem_3	140	146	PF02991	0.365
LIG_LIR_Nem_3	203	208	PF02991	0.500
LIG_LIR_Nem_3	223	229	PF02991	0.373
LIG_LIR_Nem_3	236	241	PF02991	0.345
LIG_LIR_Nem_3	288	293	PF02991	0.327
LIG_LIR_Nem_3	331	337	PF02991	0.417
LIG_LIR_Nem_3	72	76	PF02991	0.628
LIG_NRBOX	236	242	PF00104	0.271
LIG_Pex14_2	87	91	PF04695	0.477
LIG_SH2_CRK	143	147	PF00017	0.429
LIG_SH2_CRK	205	209	PF00017	0.514
LIG_SH2_CRK	226	230	PF00017	0.357
LIG_SH2_CRK	334	338	PF00017	0.428
LIG_SH2_NCK_1	290	294	PF00017	0.418
LIG_SH2_PTP2	347	350	PF00017	0.344
LIG_SH2_SRC	290	293	PF00017	0.412
LIG_SH2_STAP1	107	111	PF00017	0.394
LIG_SH2_STAT5	302	305	PF00017	0.377
LIG_SH2_STAT5	347	350	PF00017	0.334
LIG_SH2_STAT5	89	92	PF00017	0.449
LIG_SH3_4	308	315	PF00018	0.306
LIG_SUMO_SIM_par_1	98	103	PF11976	0.418
LIG_TRAF2_1	165	168	PF00917	0.523
LIG_TRAF2_1	282	285	PF00917	0.348
LIG_TRAF2_1	389	392	PF00917	0.633
LIG_UBA3_1	237	245	PF00899	0.448
LIG_UBA3_1	364	373	PF00899	0.609
LIG_UBA3_1	99	106	PF00899	0.399
LIG_WRC_WIRS_1	101	106	PF05994	0.346
MOD_CDK_SPK_2	152	157	PF00069	0.400
MOD_CK1_1	160	166	PF00069	0.580
MOD_CK1_1	249	255	PF00069	0.411
MOD_CK2_1	162	168	PF00069	0.560
MOD_CK2_1	66	72	PF00069	0.634
MOD_DYRK1A_RPxSP_1	251	255	PF00069	0.484
MOD_GlcNHglycan	119	122	PF01048	0.640
MOD_GlcNHglycan	171	174	PF01048	0.619
MOD_GlcNHglycan	21	25	PF01048	0.397
MOD_GlcNHglycan	81	85	PF01048	0.404
MOD_GSK3_1	246	253	PF00069	0.459
MOD_N-GLC_1	152	157	PF02516	0.759
MOD_N-GLC_1	168	173	PF02516	0.704
MOD_NEK2_1	100	105	PF00069	0.421
MOD_NEK2_1	20	25	PF00069	0.599
MOD_NEK2_1	363	368	PF00069	0.483
MOD_NEK2_1	372	377	PF00069	0.590
MOD_PIKK_1	228	234	PF00454	0.349
MOD_PIKK_1	372	378	PF00454	0.609
MOD_PIKK_1	66	72	PF00454	0.645
MOD_PKA_2	250	256	PF00069	0.481
MOD_PKA_2	46	52	PF00069	0.657
MOD_Plk_4	46	52	PF00069	0.770
MOD_ProDKin_1	152	158	PF00069	0.550
MOD_ProDKin_1	162	168	PF00069	0.574
MOD_ProDKin_1	251	257	PF00069	0.484
MOD_SUMO_for_1	18	21	PF00179	0.681
MOD_SUMO_for_1	260	263	PF00179	0.477
MOD_SUMO_rev_2	216	222	PF00179	0.350
MOD_SUMO_rev_2	243	250	PF00179	0.404
MOD_SUMO_rev_2	284	289	PF00179	0.356
MOD_SUMO_rev_2	386	395	PF00179	0.664
TRG_DiLeu_BaEn_1	236	241	PF01217	0.270
TRG_DiLeu_BaEn_1	72	77	PF01217	0.641
TRG_ENDOCYTIC_2	143	146	PF00928	0.361
TRG_ENDOCYTIC_2	205	208	PF00928	0.506
TRG_ENDOCYTIC_2	226	229	PF00928	0.358
TRG_ENDOCYTIC_2	290	293	PF00928	0.326
TRG_ENDOCYTIC_2	301	304	PF00928	0.354
TRG_ENDOCYTIC_2	334	337	PF00928	0.428
TRG_ENDOCYTIC_2	347	350	PF00928	0.223
TRG_ER_diArg_1	16	18	PF00400	0.641
TRG_ER_diArg_1	182	185	PF00400	0.392
TRG_Pf-PMV_PEXEL_1	377	381	PF00026	0.442

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3L0	Leptomonas seymouri	72%	100%
A0A0S4IRI9	Bodo saltans	46%	92%
A0A1X0P6G2	Trypanosomatidae	57%	100%
A0A3S5IQZ2	Trypanosoma rangeli	58%	100%
A0A3S7WV59	Leishmania donovani	87%	100%
D0A0B6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	57%	100%
E9AGR1	Leishmania infantum	87%	100%
E9ARW0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4QDL2	Leishmania major	85%	100%
V5C1R6	Trypanosoma cruzi	57%	100%