J domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DnaJ domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4H9W5_LEIBR

TriTrypDb:

LbrM.19.0390 , LBRM2903_190008500

Length:

432

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H9W5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H9W5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	296	300	PF00656	0.649
CLV_C14_Caspase3-7	97	101	PF00656	0.625
CLV_NRD_NRD_1	104	106	PF00675	0.709
CLV_NRD_NRD_1	157	159	PF00675	0.551
CLV_NRD_NRD_1	179	181	PF00675	0.505
CLV_NRD_NRD_1	190	192	PF00675	0.475
CLV_NRD_NRD_1	214	216	PF00675	0.512
CLV_NRD_NRD_1	266	268	PF00675	0.537
CLV_NRD_NRD_1	302	304	PF00675	0.599
CLV_NRD_NRD_1	334	336	PF00675	0.543
CLV_NRD_NRD_1	375	377	PF00675	0.632
CLV_NRD_NRD_1	387	389	PF00675	0.544
CLV_NRD_NRD_1	397	399	PF00675	0.511
CLV_NRD_NRD_1	69	71	PF00675	0.552
CLV_PCSK_KEX2_1	157	159	PF00082	0.579
CLV_PCSK_KEX2_1	179	181	PF00082	0.500
CLV_PCSK_KEX2_1	189	191	PF00082	0.478
CLV_PCSK_KEX2_1	214	216	PF00082	0.535
CLV_PCSK_KEX2_1	258	260	PF00082	0.550
CLV_PCSK_KEX2_1	265	267	PF00082	0.509
CLV_PCSK_KEX2_1	302	304	PF00082	0.627
CLV_PCSK_KEX2_1	334	336	PF00082	0.647
CLV_PCSK_KEX2_1	377	379	PF00082	0.642
CLV_PCSK_KEX2_1	387	389	PF00082	0.572
CLV_PCSK_KEX2_1	59	61	PF00082	0.347
CLV_PCSK_KEX2_1	69	71	PF00082	0.552
CLV_PCSK_PC1ET2_1	258	260	PF00082	0.598
CLV_PCSK_PC1ET2_1	334	336	PF00082	0.707
CLV_PCSK_PC1ET2_1	377	379	PF00082	0.602
CLV_PCSK_PC1ET2_1	59	61	PF00082	0.347
CLV_PCSK_PC7_1	175	181	PF00082	0.580
CLV_PCSK_PC7_1	185	191	PF00082	0.552
CLV_PCSK_PC7_1	210	216	PF00082	0.609
CLV_PCSK_PC7_1	65	71	PF00082	0.642
CLV_PCSK_SKI1_1	108	112	PF00082	0.681
CLV_PCSK_SKI1_1	137	141	PF00082	0.512
CLV_PCSK_SKI1_1	200	204	PF00082	0.608
CLV_PCSK_SKI1_1	210	214	PF00082	0.606
CLV_PCSK_SKI1_1	416	420	PF00082	0.544
CLV_PCSK_SKI1_1	65	69	PF00082	0.636
DEG_Nend_UBRbox_2	1	3	PF02207	0.652
DEG_SPOP_SBC_1	93	97	PF00917	0.523
DOC_CYCLIN_RxL_1	22	35	PF00134	0.323
DOC_USP7_MATH_1	101	105	PF00917	0.564
DOC_USP7_MATH_1	417	421	PF00917	0.528
DOC_USP7_MATH_1	84	88	PF00917	0.676
DOC_USP7_MATH_1	91	95	PF00917	0.642
DOC_WW_Pin1_4	123	128	PF00397	0.748
DOC_WW_Pin1_4	85	90	PF00397	0.640
LIG_14-3-3_CanoR_1	108	116	PF00244	0.671
LIG_14-3-3_CanoR_1	137	145	PF00244	0.688
LIG_14-3-3_CanoR_1	342	349	PF00244	0.721
LIG_14-3-3_CanoR_1	365	372	PF00244	0.772
LIG_14-3-3_CanoR_1	416	425	PF00244	0.430
LIG_Actin_WH2_2	401	418	PF00022	0.529
LIG_APCC_ABBA_1	30	35	PF00400	0.323
LIG_FHA_1	367	373	PF00498	0.725
LIG_FHA_1	399	405	PF00498	0.536
LIG_FHA_1	422	428	PF00498	0.670
LIG_FHA_2	142	148	PF00498	0.664
LIG_FHA_2	366	372	PF00498	0.756
LIG_FHA_2	51	57	PF00498	0.440
LIG_FHA_2	66	72	PF00498	0.647
LIG_LIR_Gen_1	234	242	PF02991	0.620
LIG_LIR_Gen_1	5	15	PF02991	0.323
LIG_LIR_Nem_3	118	123	PF02991	0.588
LIG_LIR_Nem_3	234	239	PF02991	0.568
LIG_LIR_Nem_3	41	47	PF02991	0.324
LIG_LIR_Nem_3	5	10	PF02991	0.323
LIG_PCNA_PIPBox_1	244	253	PF02747	0.518
LIG_Pex14_2	145	149	PF04695	0.546
LIG_RPA_C_Fungi	261	273	PF08784	0.621
LIG_SH2_CRK	51	55	PF00017	0.336
LIG_SH2_CRK	7	11	PF00017	0.336
LIG_SH2_NCK_1	236	240	PF00017	0.536
LIG_SH2_SRC	236	239	PF00017	0.598
LIG_SH2_STAP1	169	173	PF00017	0.530
LIG_SH2_STAP1	63	67	PF00017	0.485
LIG_SH2_STAT5	7	10	PF00017	0.418
LIG_SH3_3	83	89	PF00018	0.661
LIG_TRAF2_1	338	341	PF00917	0.688
LIG_TRAF2_1	361	364	PF00917	0.733
MOD_CK1_1	141	147	PF00069	0.651
MOD_CK1_1	421	427	PF00069	0.653
MOD_CK1_1	94	100	PF00069	0.570
MOD_CK2_1	141	147	PF00069	0.591
MOD_CK2_1	214	220	PF00069	0.594
MOD_CK2_1	341	347	PF00069	0.702
MOD_CK2_1	365	371	PF00069	0.794
MOD_CK2_1	65	71	PF00069	0.552
MOD_GlcNHglycan	128	131	PF01048	0.669
MOD_GlcNHglycan	391	397	PF01048	0.665
MOD_GlcNHglycan	420	423	PF01048	0.533
MOD_GlcNHglycan	60	63	PF01048	0.436
MOD_GlcNHglycan	96	99	PF01048	0.650
MOD_GSK3_1	137	144	PF00069	0.494
MOD_GSK3_1	417	424	PF00069	0.431
MOD_NEK2_1	10	15	PF00069	0.418
MOD_PIKK_1	253	259	PF00454	0.573
MOD_PKA_1	214	220	PF00069	0.379
MOD_PKA_1	398	404	PF00069	0.538
MOD_PKA_2	214	220	PF00069	0.594
MOD_PKA_2	282	288	PF00069	0.642
MOD_PKA_2	341	347	PF00069	0.579
MOD_PKA_2	366	372	PF00069	0.774
MOD_Plk_1	392	398	PF00069	0.662
MOD_Plk_2-3	341	347	PF00069	0.763
MOD_Plk_4	5	11	PF00069	0.418
MOD_ProDKin_1	123	129	PF00069	0.750
MOD_ProDKin_1	85	91	PF00069	0.645
MOD_SUMO_for_1	165	168	PF00179	0.611
MOD_SUMO_for_1	324	327	PF00179	0.728
MOD_SUMO_for_1	410	413	PF00179	0.610
MOD_SUMO_rev_2	223	231	PF00179	0.584
MOD_SUMO_rev_2	299	308	PF00179	0.536
MOD_SUMO_rev_2	402	410	PF00179	0.575
MOD_SUMO_rev_2	428	432	PF00179	0.624
TRG_DiLeu_BaEn_4	263	269	PF01217	0.570
TRG_ENDOCYTIC_2	236	239	PF00928	0.505
TRG_ENDOCYTIC_2	51	54	PF00928	0.323
TRG_ENDOCYTIC_2	6	9	PF00928	0.337
TRG_ER_diArg_1	156	158	PF00400	0.661
TRG_ER_diArg_1	189	191	PF00400	0.539
TRG_ER_diArg_1	213	215	PF00400	0.536
TRG_ER_diArg_1	265	267	PF00400	0.495
TRG_ER_diArg_1	301	303	PF00400	0.629
TRG_ER_diArg_1	376	379	PF00400	0.734
TRG_NLS_MonoCore_2	104	109	PF00514	0.770
TRG_Pf-PMV_PEXEL_1	249	253	PF00026	0.566
TRG_Pf-PMV_PEXEL_1	259	263	PF00026	0.472
TRG_Pf-PMV_PEXEL_1	266	270	PF00026	0.442
TRG_Pf-PMV_PEXEL_1	350	355	PF00026	0.709

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0G8	Leptomonas seymouri	71%	100%
A0A0S4IRH8	Bodo saltans	44%	97%
A0A0S4JH45	Bodo saltans	27%	100%
A0A1X0P7B2	Trypanosomatidae	49%	97%
A0A3Q8IA51	Leishmania donovani	90%	100%
A0A3R7MIW9	Trypanosoma rangeli	48%	97%
D0A0C8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	98%
E9AGR0	Leishmania infantum	90%	100%
E9ARV9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
Q4QDL3	Leishmania major	90%	100%
V5BWX2	Trypanosoma cruzi	50%	97%