Histone H2B

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Histone H2B

Gene product:

histone H2B

Species:

Leishmania braziliensis

UniProt:

A4H9W0_LEIBR

TriTrypDb:

LbrM.19.0340 , LBRM2903_190008300

Length:

182

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 40

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 16

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0000786	nucleosome	3	9
GO:0005634	nucleus	5	9
GO:0032991	protein-containing complex	1	9
GO:0032993	protein-DNA complex	2	9
GO:0043226	organelle	2	9
GO:0043227	membrane-bounded organelle	3	9
GO:0043229	intracellular organelle	3	9
GO:0043231	intracellular membrane-bounded organelle	4	9
GO:0044815	DNA packaging complex	2	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

A4H9W0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H9W0

Function

Biological processes
Term	Name	Level	Count
GO:0006325	chromatin organization	4	1
GO:0006334	nucleosome assembly	7	1
GO:0006338	chromatin remodeling	5	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0034728	nucleosome organization	6	1
GO:0043933	protein-containing complex organization	4	1
GO:0065003	protein-containing complex assembly	5	1
GO:0065004	protein-DNA complex assembly	6	1
GO:0071824	protein-DNA complex subunit organization	5	1
GO:0071840	cellular component organization or biogenesis	2	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	9
GO:0003677	DNA binding	4	9
GO:0005198	structural molecule activity	1	9
GO:0005488	binding	1	9
GO:0005515	protein binding	2	9
GO:0030527	structural constituent of chromatin	2	9
GO:0046982	protein heterodimerization activity	4	9
GO:0046983	protein dimerization activity	3	9
GO:0097159	organic cyclic compound binding	2	9
GO:1901363	heterocyclic compound binding	2	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	79	81	PF00675	0.833
CLV_NRD_NRD_1	89	91	PF00675	0.386
CLV_PCSK_KEX2_1	145	147	PF00082	0.385
CLV_PCSK_KEX2_1	93	95	PF00082	0.414
CLV_PCSK_PC1ET2_1	145	147	PF00082	0.385
CLV_PCSK_PC1ET2_1	93	95	PF00082	0.451
CLV_PCSK_PC7_1	141	147	PF00082	0.385
CLV_PCSK_SKI1_1	102	106	PF00082	0.472
CLV_PCSK_SKI1_1	158	162	PF00082	0.509
DEG_SCF_FBW7_1	1	6	PF00400	0.500
DOC_CKS1_1	57	62	PF01111	0.509
DOC_CYCLIN_yCln2_LP_2	159	165	PF00134	0.565
DOC_CYCLIN_yCln2_LP_2	54	60	PF00134	0.502
DOC_MAPK_gen_1	90	100	PF00069	0.580
DOC_PP2B_LxvP_1	159	162	PF13499	0.559
DOC_PP2B_LxvP_1	19	22	PF13499	0.525
DOC_PP4_FxxP_1	11	14	PF00568	0.521
DOC_PP4_FxxP_1	65	68	PF00568	0.518
DOC_PP4_MxPP_1	1	4	PF00568	0.504
DOC_USP7_MATH_1	106	110	PF00917	0.496
DOC_USP7_MATH_1	92	96	PF00917	0.574
DOC_USP7_UBL2_3	87	91	PF12436	0.600
DOC_WW_Pin1_4	25	30	PF00397	0.536
DOC_WW_Pin1_4	56	61	PF00397	0.505
LIG_14-3-3_CanoR_1	131	140	PF00244	0.634
LIG_14-3-3_CanoR_1	69	73	PF00244	0.555
LIG_14-3-3_CanoR_1	84	92	PF00244	0.509
LIG_EVH1_2	37	41	PF00568	0.481
LIG_EVH1_2	4	8	PF00568	0.498
LIG_FHA_1	124	130	PF00498	0.612
LIG_FHA_1	172	178	PF00498	0.713
LIG_FHA_1	57	63	PF00498	0.578
LIG_FHA_1	69	75	PF00498	0.525
LIG_FHA_1	7	13	PF00498	0.512
LIG_LIR_Apic_2	9	14	PF02991	0.521
LIG_LIR_Gen_1	6	16	PF02991	0.505
LIG_LIR_Nem_3	6	11	PF02991	0.519
LIG_LIR_Nem_3	95	99	PF02991	0.570
LIG_Pex14_1	46	50	PF04695	0.501
LIG_SH2_STAT5	124	127	PF00017	0.600
LIG_SH2_STAT5	44	47	PF00017	0.544
LIG_SH2_STAT5	99	102	PF00017	0.685
LIG_SH3_3	54	60	PF00018	0.505
LIG_WRC_WIRS_1	8	13	PF05994	0.511
MOD_CK1_1	109	115	PF00069	0.567
MOD_CK1_1	123	129	PF00069	0.516
MOD_CK1_1	20	26	PF00069	0.516
MOD_CK1_1	6	12	PF00069	0.510
MOD_GSK3_1	131	138	PF00069	0.560
MOD_GSK3_1	171	178	PF00069	0.592
MOD_GSK3_1	3	10	PF00069	0.497
MOD_GSK3_1	63	70	PF00069	0.547
MOD_N-GLC_1	6	11	PF02516	0.511
MOD_N-GLC_2	179	181	PF02516	0.465
MOD_NEK2_1	111	116	PF00069	0.556
MOD_NEK2_1	63	68	PF00069	0.573
MOD_NEK2_1	72	77	PF00069	0.672
MOD_PKA_1	144	150	PF00069	0.600
MOD_PKA_1	80	86	PF00069	0.470
MOD_PKA_2	68	74	PF00069	0.567
MOD_Plk_1	6	12	PF00069	0.510
MOD_Plk_4	120	126	PF00069	0.685
MOD_Plk_4	135	141	PF00069	0.496
MOD_Plk_4	7	13	PF00069	0.512
MOD_ProDKin_1	25	31	PF00069	0.535
MOD_ProDKin_1	56	62	PF00069	0.509
TRG_ER_diArg_1	53	56	PF00400	0.515
TRG_NLS_Bipartite_1	80	94	PF00514	0.504
TRG_NLS_MonoCore_2	89	94	PF00514	0.600
TRG_NLS_MonoExtC_3	89	94	PF00514	0.600
TRG_NLS_MonoExtN_4	141	148	PF00514	0.585
TRG_NLS_MonoExtN_4	87	94	PF00514	0.616

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H7I6	Leishmania donovani	41%	100%
A4H9W1	Leishmania braziliensis	99%	100%
A4HG62	Leishmania braziliensis	43%	100%
A4HY42	Leishmania infantum	75%	100%
A4I394	Leishmania infantum	41%	100%
E9AZI2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	43%	100%
Q4Q8P9	Leishmania major	43%	100%