DNA translocase FtsK

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H9V9_LEIBR

TriTrypDb:

LbrM.19.0330 , LBRM2903_190008100

Length:

253

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0005730	nucleolus	5	1
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H9V9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H9V9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	13	17	PF00082	0.535
DEG_SCF_FBW7_1	126	132	PF00400	0.587
DOC_CKS1_1	126	131	PF01111	0.524
DOC_PP2B_LxvP_1	84	87	PF13499	0.427
DOC_USP7_MATH_1	168	172	PF00917	0.692
DOC_USP7_MATH_1	198	202	PF00917	0.655
DOC_USP7_MATH_1	50	54	PF00917	0.699
DOC_WW_Pin1_4	125	130	PF00397	0.522
DOC_WW_Pin1_4	15	20	PF00397	0.672
DOC_WW_Pin1_4	28	33	PF00397	0.720
LIG_14-3-3_CanoR_1	149	154	PF00244	0.677
LIG_14-3-3_CanoR_1	221	228	PF00244	0.599
LIG_14-3-3_CanoR_1	233	240	PF00244	0.562
LIG_14-3-3_CanoR_1	242	246	PF00244	0.669
LIG_14-3-3_CanoR_1	96	101	PF00244	0.571
LIG_BRCT_BRCA1_1	186	190	PF00533	0.665
LIG_FHA_1	141	147	PF00498	0.649
LIG_FHA_1	29	35	PF00498	0.802
LIG_MAD2	96	104	PF02301	0.562
LIG_Pex14_2	218	222	PF04695	0.638
LIG_SH2_GRB2like	177	180	PF00017	0.564
LIG_SH2_STAT5	90	93	PF00017	0.518
LIG_SH3_3	123	129	PF00018	0.536
LIG_SH3_3	135	141	PF00018	0.560
LIG_SH3_3	29	35	PF00018	0.663
LIG_SH3_3	39	45	PF00018	0.683
LIG_SH3_3	61	67	PF00018	0.702
LIG_SH3_3	73	79	PF00018	0.425
LIG_SH3_3	82	88	PF00018	0.536
LIG_SH3_3	97	103	PF00018	0.415
LIG_SUMO_SIM_anti_2	51	63	PF11976	0.573
LIG_SUMO_SIM_par_1	52	63	PF11976	0.687
LIG_SUMO_SIM_par_1	68	74	PF11976	0.453
LIG_SUMO_SIM_par_1	90	95	PF11976	0.515
LIG_TRAF2_1	53	56	PF00917	0.710
LIG_TRAF2_2	41	46	PF00917	0.524
LIG_WW_1	87	90	PF00397	0.416
LIG_WW_3	102	106	PF00397	0.577
MOD_CK1_1	152	158	PF00069	0.632
MOD_CK1_1	201	207	PF00069	0.659
MOD_CK1_1	244	250	PF00069	0.663
MOD_CK2_1	50	56	PF00069	0.602
MOD_CK2_1	71	77	PF00069	0.511
MOD_GlcNHglycan	119	122	PF01048	0.553
MOD_GlcNHglycan	170	173	PF01048	0.742
MOD_GlcNHglycan	203	206	PF01048	0.618
MOD_GlcNHglycan	213	216	PF01048	0.667
MOD_GlcNHglycan	229	232	PF01048	0.531
MOD_GlcNHglycan	235	238	PF01048	0.577
MOD_GSK3_1	125	132	PF00069	0.596
MOD_GSK3_1	145	152	PF00069	0.649
MOD_GSK3_1	206	213	PF00069	0.583
MOD_GSK3_1	24	31	PF00069	0.793
MOD_N-GLC_1	178	183	PF02516	0.490
MOD_NEK2_1	190	195	PF00069	0.644
MOD_PIKK_1	104	110	PF00454	0.660
MOD_PIKK_1	170	176	PF00454	0.654
MOD_PIKK_1	190	196	PF00454	0.629
MOD_PIKK_1	24	30	PF00454	0.634
MOD_PIKK_1	241	247	PF00454	0.678
MOD_PIKK_1	34	40	PF00454	0.711
MOD_PK_1	96	102	PF00069	0.621
MOD_PKA_2	104	110	PF00069	0.625
MOD_PKA_2	211	217	PF00069	0.723
MOD_PKA_2	222	228	PF00069	0.497
MOD_PKA_2	241	247	PF00069	0.429
MOD_Plk_2-3	51	57	PF00069	0.710
MOD_Plk_2-3	71	77	PF00069	0.452
MOD_ProDKin_1	125	131	PF00069	0.524
MOD_ProDKin_1	15	21	PF00069	0.674
MOD_ProDKin_1	28	34	PF00069	0.720
TRG_ER_diArg_1	2	5	PF00400	0.724

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYE1	Leptomonas seymouri	73%	67%
A0A1X0P6F6	Trypanosomatidae	37%	76%
A0A3Q8IB46	Leishmania donovani	83%	98%
A0A3R7JZB4	Trypanosoma rangeli	33%	75%
A4HY41	Leishmania infantum	83%	98%
E9ARV4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	68%
Q4QDL9	Leishmania major	84%	100%
V5BBT3	Trypanosoma cruzi	35%	75%