t-SNARE coiled-coil homology domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Qb-SNARE protein, putative

Species:

Leishmania braziliensis

UniProt:

A4H9V8_LEIBR

TriTrypDb:

LbrM.19.0320 , LBRM2903_190008000

Length:

322

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	14
GO:0110165	cellular anatomical entity	1	14
GO:0012505	endomembrane system	2	1
GO:0031201	SNARE complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0098796	membrane protein complex	2	1

Expansion

Sequence features

A4H9V8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H9V8

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0006886	intracellular protein transport	4	1
GO:0006906	vesicle fusion	6	1
GO:0006996	organelle organization	4	1
GO:0008104	protein localization	4	1
GO:0009987	cellular process	1	1
GO:0015031	protein transport	4	1
GO:0016043	cellular component organization	3	1
GO:0016050	vesicle organization	5	1
GO:0022406	membrane docking	2	1
GO:0033036	macromolecule localization	2	1
GO:0045184	establishment of protein localization	3	1
GO:0046907	intracellular transport	3	1
GO:0048278	vesicle docking	4	1
GO:0048284	organelle fusion	5	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051640	organelle localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0061024	membrane organization	4	1
GO:0061025	membrane fusion	5	1
GO:0070727	cellular macromolecule localization	3	1
GO:0071702	organic substance transport	4	1
GO:0071705	nitrogen compound transport	4	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0090174	organelle membrane fusion	6	1
GO:0140056	organelle localization by membrane tethering	3	1

Molecular functions
Term	Name	Level	Count
GO:0000149	SNARE binding	3	1
GO:0005484	SNAP receptor activity	3	1
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0030674	protein-macromolecule adaptor activity	2	1
GO:0060090	molecular adaptor activity	1	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	202	206	PF00656	0.777
CLV_NRD_NRD_1	100	102	PF00675	0.351
CLV_NRD_NRD_1	115	117	PF00675	0.408
CLV_NRD_NRD_1	135	137	PF00675	0.443
CLV_NRD_NRD_1	186	188	PF00675	0.512
CLV_NRD_NRD_1	20	22	PF00675	0.382
CLV_NRD_NRD_1	284	286	PF00675	0.385
CLV_NRD_NRD_1	86	88	PF00675	0.369
CLV_PCSK_KEX2_1	135	137	PF00082	0.419
CLV_PCSK_KEX2_1	174	176	PF00082	0.479
CLV_PCSK_KEX2_1	186	188	PF00082	0.437
CLV_PCSK_KEX2_1	20	22	PF00082	0.367
CLV_PCSK_KEX2_1	284	286	PF00082	0.382
CLV_PCSK_PC1ET2_1	174	176	PF00082	0.542
CLV_PCSK_PC7_1	16	22	PF00082	0.374
CLV_PCSK_PC7_1	280	286	PF00082	0.421
CLV_PCSK_SKI1_1	110	114	PF00082	0.429
CLV_PCSK_SKI1_1	284	288	PF00082	0.402
DEG_APCC_DBOX_1	178	186	PF00400	0.675
DEG_APCC_DBOX_1	86	94	PF00400	0.643
DEG_APCC_KENBOX_2	112	116	PF00400	0.605
DEG_Nend_UBRbox_2	1	3	PF02207	0.705
DOC_MAPK_gen_1	116	127	PF00069	0.599
DOC_MAPK_MEF2A_6	246	254	PF00069	0.584
DOC_USP7_MATH_1	120	124	PF00917	0.654
DOC_USP7_MATH_1	29	33	PF00917	0.710
DOC_USP7_UBL2_3	113	117	PF12436	0.609
DOC_USP7_UBL2_3	287	291	PF12436	0.661
LIG_14-3-3_CanoR_1	12	16	PF00244	0.573
LIG_14-3-3_CanoR_1	135	143	PF00244	0.653
LIG_AP2alpha_2	43	45	PF02296	0.604
LIG_CaM_IQ_9	122	138	PF13499	0.598
LIG_CaM_IQ_9	167	183	PF13499	0.708
LIG_FHA_1	274	280	PF00498	0.598
LIG_FHA_1	304	310	PF00498	0.479
LIG_FHA_1	5	11	PF00498	0.672
LIG_FHA_2	12	18	PF00498	0.571
LIG_FHA_2	164	170	PF00498	0.721
LIG_FHA_2	216	222	PF00498	0.606
LIG_FHA_2	94	100	PF00498	0.568
LIG_LIR_Gen_1	43	53	PF02991	0.646
LIG_LIR_Nem_3	43	48	PF02991	0.631
LIG_Pex14_2	315	319	PF04695	0.485
LIG_SH2_GRB2like	139	142	PF00017	0.647
LIG_SH2_STAP1	139	143	PF00017	0.647
LIG_SH2_STAT5	3	6	PF00017	0.619
LIG_SH2_STAT5	301	304	PF00017	0.397
LIG_SUMO_SIM_anti_2	200	205	PF11976	0.778
LIG_TRAF2_1	166	169	PF00917	0.731
LIG_UBA3_1	182	188	PF00899	0.733
MOD_CK1_1	268	274	PF00069	0.704
MOD_CK2_1	163	169	PF00069	0.701
MOD_CK2_1	215	221	PF00069	0.613
MOD_CK2_1	93	99	PF00069	0.567
MOD_Cter_Amidation	133	136	PF01082	0.440
MOD_Cter_Amidation	172	175	PF01082	0.445
MOD_GlcNHglycan	39	43	PF01048	0.498
MOD_GSK3_1	11	18	PF00069	0.590
MOD_N-GLC_1	205	210	PF02516	0.395
MOD_N-GLC_1	215	220	PF02516	0.539
MOD_NEK2_1	10	15	PF00069	0.585
MOD_NEK2_1	93	98	PF00069	0.574
MOD_PIKK_1	134	140	PF00454	0.599
MOD_PIKK_1	273	279	PF00454	0.537
MOD_PKA_2	11	17	PF00069	0.575
MOD_PKA_2	134	140	PF00069	0.616
MOD_Plk_1	268	274	PF00069	0.543
MOD_Plk_4	303	309	PF00069	0.248
MOD_Plk_4	93	99	PF00069	0.484
MOD_SUMO_for_1	231	234	PF00179	0.496
TRG_DiLeu_BaEn_1	99	104	PF01217	0.614
TRG_ER_diArg_1	185	187	PF00400	0.691
TRG_ER_diArg_1	19	21	PF00400	0.575
TRG_ER_diArg_1	284	286	PF00400	0.582
TRG_NLS_Bipartite_1	101	122	PF00514	0.527
TRG_NLS_MonoCore_2	115	120	PF00514	0.641
TRG_NLS_MonoExtC_3	115	120	PF00514	0.610
TRG_NLS_MonoExtN_4	113	120	PF00514	0.615
TRG_Pf-PMV_PEXEL_1	101	105	PF00026	0.427

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1P9J7	Leptomonas seymouri	75%	100%
A0A0S4IV64	Bodo saltans	45%	94%
A0A0S4IVZ4	Bodo saltans	37%	97%
A0A0S4IZ68	Bodo saltans	45%	98%
A0A1X0P6H2	Trypanosomatidae	59%	100%
A0A3R7LL06	Trypanosoma rangeli	53%	100%
A0A3S7WV65	Leishmania donovani	78%	100%
A4HY40	Leishmania infantum	78%	100%
D0A0C4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	100%
E9ARV3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
Q4QDM0	Leishmania major	76%	100%
V5BS89	Trypanosoma cruzi	54%	100%