COPIIcoated_ERV domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC)/Endoplasmic reticulum vesicle transporter, putative

Species:

Leishmania braziliensis

UniProt:

A4H9V6_LEIBR

TriTrypDb:

LbrM.19.0300 , LBRM2903_190007800

Length:

309

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11
GO:0005783	endoplasmic reticulum	5	1
GO:0030134	COPII-coated ER to Golgi transport vesicle	8	1
GO:0030135	coated vesicle	7	1
GO:0031410	cytoplasmic vesicle	6	1
GO:0031982	vesicle	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0097708	intracellular vesicle	5	1

Expansion

Sequence features

A4H9V6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H9V6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	20	24	PF00656	0.262
CLV_NRD_NRD_1	152	154	PF00675	0.518
CLV_NRD_NRD_1	156	158	PF00675	0.525
CLV_NRD_NRD_1	218	220	PF00675	0.522
CLV_NRD_NRD_1	72	74	PF00675	0.595
CLV_PCSK_KEX2_1	152	154	PF00082	0.477
CLV_PCSK_KEX2_1	156	158	PF00082	0.477
CLV_PCSK_KEX2_1	306	308	PF00082	0.277
CLV_PCSK_KEX2_1	72	74	PF00082	0.595
CLV_PCSK_PC1ET2_1	306	308	PF00082	0.277
CLV_PCSK_PC7_1	152	158	PF00082	0.380
CLV_PCSK_SKI1_1	224	228	PF00082	0.550
DEG_APCC_DBOX_1	156	164	PF00400	0.180
DOC_MAPK_gen_1	141	149	PF00069	0.264
DOC_MAPK_MEF2A_6	141	149	PF00069	0.338
DOC_USP7_MATH_1	10	14	PF00917	0.212
DOC_USP7_MATH_1	226	230	PF00917	0.334
DOC_USP7_MATH_1	235	239	PF00917	0.333
DOC_USP7_MATH_1	89	93	PF00917	0.334
DOC_USP7_UBL2_3	106	110	PF12436	0.332
DOC_USP7_UBL2_3	50	54	PF12436	0.461
LIG_14-3-3_CanoR_1	156	161	PF00244	0.209
LIG_14-3-3_CanoR_1	199	205	PF00244	0.241
LIG_14-3-3_CanoR_1	270	280	PF00244	0.278
LIG_APCC_ABBA_1	1	6	PF00400	0.385
LIG_APCC_ABBA_1	102	107	PF00400	0.338
LIG_BIR_III_4	23	27	PF00653	0.298
LIG_BRCT_BRCA1_1	75	79	PF00533	0.294
LIG_Clathr_ClatBox_1	254	258	PF01394	0.357
LIG_deltaCOP1_diTrp_1	299	304	PF00928	0.603
LIG_FHA_1	166	172	PF00498	0.277
LIG_FHA_1	205	211	PF00498	0.316
LIG_FHA_1	31	37	PF00498	0.343
LIG_FHA_2	201	207	PF00498	0.338
LIG_FHA_2	50	56	PF00498	0.418
LIG_FHA_2	63	69	PF00498	0.470
LIG_GBD_Chelix_1	283	291	PF00786	0.320
LIG_IRF3_LxIS_1	36	42	PF10401	0.219
LIG_LIR_Gen_1	299	305	PF02991	0.533
LIG_LIR_Nem_3	109	115	PF02991	0.220
LIG_LIR_Nem_3	299	304	PF02991	0.587
LIG_LIR_Nem_3	76	82	PF02991	0.370
LIG_LIR_Nem_3	99	105	PF02991	0.257
LIG_NRP_CendR_1	306	309	PF00754	0.378
LIG_Pex14_1	300	304	PF04695	0.578
LIG_Pex14_2	5	9	PF04695	0.375
LIG_SH2_SRC	231	234	PF00017	0.263
LIG_SH2_STAP1	231	235	PF00017	0.265
LIG_SH2_STAT3	117	120	PF00017	0.314
LIG_SH2_STAT3	233	236	PF00017	0.263
LIG_SH2_STAT5	117	120	PF00017	0.338
LIG_SH2_STAT5	209	212	PF00017	0.251
LIG_SH3_3	187	193	PF00018	0.240
LIG_SH3_3	4	10	PF00018	0.297
LIG_SUMO_SIM_anti_2	18	23	PF11976	0.305
MOD_CK1_1	97	103	PF00069	0.304
MOD_CK2_1	200	206	PF00069	0.338
MOD_CK2_1	226	232	PF00069	0.316
MOD_CK2_1	293	299	PF00069	0.284
MOD_CK2_1	97	103	PF00069	0.264
MOD_Cter_Amidation	154	157	PF01082	0.380
MOD_GlcNHglycan	232	236	PF01048	0.499
MOD_GlcNHglycan	246	249	PF01048	0.493
MOD_GlcNHglycan	41	44	PF01048	0.526
MOD_GSK3_1	198	205	PF00069	0.319
MOD_GSK3_1	214	221	PF00069	0.188
MOD_GSK3_1	227	234	PF00069	0.257
MOD_N-GLC_1	30	35	PF02516	0.537
MOD_NEK2_1	166	171	PF00069	0.263
MOD_NEK2_1	200	205	PF00069	0.281
MOD_NEK2_1	293	298	PF00069	0.367
MOD_NEK2_1	30	35	PF00069	0.370
MOD_NEK2_1	62	67	PF00069	0.424
MOD_NEK2_2	32	37	PF00069	0.395
MOD_NEK2_2	49	54	PF00069	0.458
MOD_PIKK_1	236	242	PF00454	0.318
MOD_PKA_1	156	162	PF00069	0.293
MOD_PKA_2	15	21	PF00069	0.357
MOD_PKA_2	151	157	PF00069	0.337
MOD_PKA_2	183	189	PF00069	0.257
MOD_PKA_2	198	204	PF00069	0.268
MOD_PKA_2	218	224	PF00069	0.311
MOD_Plk_1	166	172	PF00069	0.240
MOD_Plk_1	294	300	PF00069	0.420
MOD_Plk_4	143	149	PF00069	0.331
MOD_Plk_4	97	103	PF00069	0.297
MOD_SUMO_rev_2	137	143	PF00179	0.338
TRG_DiLeu_BaEn_1	206	211	PF01217	0.357
TRG_ENDOCYTIC_2	105	108	PF00928	0.357
TRG_ER_diArg_1	151	153	PF00400	0.329
TRG_ER_diArg_1	156	158	PF00400	0.335
TRG_NLS_Bipartite_1	156	177	PF00514	0.338

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2S9	Leptomonas seymouri	56%	78%
A0A0N0P4A5	Leptomonas seymouri	27%	76%
A0A0S4JE72	Bodo saltans	25%	77%
A0A0S4JXT2	Bodo saltans	33%	73%
A0A1X0NIB7	Trypanosomatidae	26%	79%
A0A1X0NVX1	Trypanosomatidae	41%	78%
A0A3Q8IGE1	Leishmania donovani	26%	66%
A0A3R7MPC0	Trypanosoma rangeli	42%	79%
A0A3S5H6H6	Leishmania donovani	75%	84%
A4HUR4	Leishmania infantum	75%	84%
A4I779	Leishmania infantum	26%	66%
C9ZMG0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	76%
C9ZWM5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	76%
D0A7P8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	79%
E9ANE8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	84%
E9B273	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	76%
Q09895	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	25%	79%
Q4Q5Y6	Leishmania major	26%	66%
Q4QH78	Leishmania major	76%	100%
Q4R8X1	Macaca fascicularis	25%	81%
Q54DW2	Dictyostelium discoideum	23%	81%
Q5EAE0	Bos taurus	25%	81%
Q5R8G3	Pongo abelii	25%	81%
Q66KH2	Xenopus laevis	25%	79%
Q6NVS2	Xenopus tropicalis	25%	80%
Q803I2	Danio rerio	27%	81%
Q9CQE7	Mus musculus	25%	81%
Q9Y282	Homo sapiens	25%	81%
V5AS26	Trypanosoma cruzi	26%	76%
V5BGJ7	Trypanosoma cruzi	39%	79%