Gamma carbonic dehydratase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Bacterial transferase hexapeptide (six repeats), putative

Species:

Leishmania braziliensis

UniProt:

A4H9V5_LEIBR

TriTrypDb:

LbrM.19.0290 , LBRM2903_190007700

Length:

307

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H9V5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H9V5

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0016740	transferase activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	245	249	PF00656	0.546
CLV_C14_Caspase3-7	81	85	PF00656	0.425
CLV_NRD_NRD_1	101	103	PF00675	0.363
CLV_NRD_NRD_1	277	279	PF00675	0.525
CLV_NRD_NRD_1	283	285	PF00675	0.521
CLV_PCSK_KEX2_1	28	30	PF00082	0.478
CLV_PCSK_KEX2_1	283	285	PF00082	0.645
CLV_PCSK_KEX2_1	78	80	PF00082	0.441
CLV_PCSK_PC1ET2_1	28	30	PF00082	0.508
CLV_PCSK_PC1ET2_1	78	80	PF00082	0.453
CLV_PCSK_SKI1_1	220	224	PF00082	0.446
CLV_PCSK_SKI1_1	250	254	PF00082	0.609
CLV_PCSK_SKI1_1	38	42	PF00082	0.446
CLV_PCSK_SKI1_1	45	49	PF00082	0.407
CLV_PCSK_SKI1_1	71	75	PF00082	0.434
CLV_Separin_Metazoa	272	276	PF03568	0.517
DEG_Nend_Nbox_1	1	3	PF02207	0.629
DEG_ODPH_VHL_1	88	100	PF01847	0.346
DOC_CDC14_PxL_1	66	74	PF14671	0.459
DOC_MAPK_gen_1	220	230	PF00069	0.391
DOC_MAPK_gen_1	261	270	PF00069	0.537
DOC_MAPK_gen_1	27	36	PF00069	0.477
DOC_MAPK_MEF2A_6	223	230	PF00069	0.388
DOC_MAPK_MEF2A_6	27	36	PF00069	0.485
DOC_MAPK_NFAT4_5	29	37	PF00069	0.513
DOC_PP4_FxxP_1	2	5	PF00568	0.593
DOC_PP4_FxxP_1	87	90	PF00568	0.348
DOC_USP7_MATH_1	158	162	PF00917	0.341
DOC_USP7_MATH_1	222	226	PF00917	0.502
DOC_USP7_UBL2_3	74	78	PF12436	0.519
DOC_WW_Pin1_4	1	6	PF00397	0.437
DOC_WW_Pin1_4	282	287	PF00397	0.526
DOC_WW_Pin1_4	293	298	PF00397	0.572
LIG_14-3-3_CanoR_1	29	35	PF00244	0.427
LIG_BRCT_BRCA1_1	158	162	PF00533	0.341
LIG_Clathr_ClatBox_1	227	231	PF01394	0.387
LIG_deltaCOP1_diTrp_1	234	240	PF00928	0.433
LIG_eIF4E_1	67	73	PF01652	0.457
LIG_FHA_1	294	300	PF00498	0.578
LIG_FHA_1	46	52	PF00498	0.525
LIG_FHA_1	93	99	PF00498	0.414
LIG_FHA_2	142	148	PF00498	0.382
LIG_FHA_2	209	215	PF00498	0.423
LIG_FHA_2	237	243	PF00498	0.453
LIG_FHA_2	283	289	PF00498	0.530
LIG_FHA_2	79	85	PF00498	0.469
LIG_LIR_Apic_2	64	70	PF02991	0.484
LIG_LIR_Apic_2	84	90	PF02991	0.187
LIG_LIR_Gen_1	237	245	PF02991	0.452
LIG_LIR_Gen_1	30	36	PF02991	0.483
LIG_LIR_Nem_3	237	243	PF02991	0.454
LIG_LIR_Nem_3	251	256	PF02991	0.462
LIG_LIR_Nem_3	30	34	PF02991	0.488
LIG_LIR_Nem_3	4	9	PF02991	0.596
LIG_Pex14_2	2	6	PF04695	0.649
LIG_SH2_CRK	108	112	PF00017	0.363
LIG_SH2_CRK	67	71	PF00017	0.476
LIG_SH2_SRC	256	259	PF00017	0.590
LIG_SH2_STAT5	105	108	PF00017	0.342
LIG_SH2_STAT5	209	212	PF00017	0.315
LIG_SH2_STAT5	269	272	PF00017	0.520
LIG_SH2_STAT5	31	34	PF00017	0.473
LIG_SH3_2	273	278	PF14604	0.517
LIG_SH3_3	270	276	PF00018	0.522
LIG_SUMO_SIM_par_1	225	231	PF11976	0.406
LIG_SUMO_SIM_par_1	48	55	PF11976	0.489
LIG_TRAF2_1	239	242	PF00917	0.464
LIG_TRAF2_1	285	288	PF00917	0.396
LIG_TRAF2_1	62	65	PF00917	0.561
LIG_TYR_ITIM	106	111	PF00017	0.357
LIG_WW_3	272	276	PF00397	0.517
MOD_CDK_SPxxK_3	1	8	PF00069	0.437
MOD_CK1_1	174	180	PF00069	0.452
MOD_CK1_1	293	299	PF00069	0.590
MOD_CK2_1	141	147	PF00069	0.381
MOD_CK2_1	208	214	PF00069	0.424
MOD_CK2_1	236	242	PF00069	0.451
MOD_CK2_1	256	262	PF00069	0.266
MOD_CK2_1	282	288	PF00069	0.523
MOD_Cter_Amidation	100	103	PF01082	0.354
MOD_Cter_Amidation	281	284	PF01082	0.621
MOD_Cter_Amidation	76	79	PF01082	0.480
MOD_GlcNHglycan	153	156	PF01048	0.406
MOD_GlcNHglycan	176	179	PF01048	0.305
MOD_GlcNHglycan	188	191	PF01048	0.378
MOD_GlcNHglycan	194	197	PF01048	0.265
MOD_GlcNHglycan	220	223	PF01048	0.292
MOD_GlcNHglycan	75	78	PF01048	0.465
MOD_GlcNHglycan	90	93	PF01048	0.275
MOD_GSK3_1	132	139	PF00069	0.372
MOD_GSK3_1	182	189	PF00069	0.347
MOD_GSK3_1	218	225	PF00069	0.434
MOD_GSK3_1	232	239	PF00069	0.404
MOD_GSK3_1	88	95	PF00069	0.343
MOD_N-GLC_1	136	141	PF02516	0.447
MOD_NEK2_1	122	127	PF00069	0.373
MOD_NEK2_1	299	304	PF00069	0.570
MOD_NEK2_1	73	78	PF00069	0.480
MOD_PK_1	171	177	PF00069	0.467
MOD_PKA_1	27	33	PF00069	0.330
MOD_PKA_1	78	84	PF00069	0.504
MOD_PKA_2	78	84	PF00069	0.402
MOD_Plk_1	136	142	PF00069	0.486
MOD_Plk_1	236	242	PF00069	0.470
MOD_Plk_4	158	164	PF00069	0.334
MOD_Plk_4	182	188	PF00069	0.377
MOD_Plk_4	222	228	PF00069	0.479
MOD_Plk_4	78	84	PF00069	0.414
MOD_ProDKin_1	1	7	PF00069	0.436
MOD_ProDKin_1	282	288	PF00069	0.523
MOD_ProDKin_1	293	299	PF00069	0.570
MOD_SUMO_for_1	62	65	PF00179	0.561
TRG_DiLeu_BaLyEn_6	68	73	PF01217	0.415
TRG_ENDOCYTIC_2	108	111	PF00928	0.372
TRG_ENDOCYTIC_2	31	34	PF00928	0.511
TRG_NLS_MonoExtN_4	275	282	PF00514	0.652

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0A3	Leptomonas seymouri	84%	100%
A0A0N1ICC0	Leptomonas seymouri	27%	100%
A0A0S4JVD5	Bodo saltans	64%	96%
A0A1X0NVC1	Trypanosomatidae	73%	100%
A0A3S7WQ41	Leishmania donovani	28%	100%
A0A3S7WRH8	Leishmania donovani	92%	100%
A4H585	Leishmania braziliensis	27%	100%
A4HTG9	Leishmania infantum	28%	100%
A4HUR5	Leishmania infantum	92%	100%
C9ZPP8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
D0A7P7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	73%	100%
E9ANE9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
Q4QH77	Leishmania major	91%	100%
Q4QIF1	Leishmania major	28%	100%
Q54JC2	Dictyostelium discoideum	30%	100%
Q9C6B3	Arabidopsis thaliana	34%	100%
V5BBY5	Trypanosoma cruzi	76%	100%