RRM domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H9V0_LEIBR

TriTrypDb:

LbrM.19.0240 , LBRM2903_190007200

Length:

215

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H9V0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H9V0

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	10
GO:0003723	RNA binding	4	10
GO:0005488	binding	1	10
GO:0097159	organic cyclic compound binding	2	10
GO:1901363	heterocyclic compound binding	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	45	49	PF00656	0.742
CLV_NRD_NRD_1	175	177	PF00675	0.471
CLV_NRD_NRD_1	180	182	PF00675	0.466
CLV_NRD_NRD_1	31	33	PF00675	0.582
CLV_NRD_NRD_1	76	78	PF00675	0.633
CLV_PCSK_KEX2_1	3	5	PF00082	0.552
CLV_PCSK_KEX2_1	30	32	PF00082	0.577
CLV_PCSK_KEX2_1	76	78	PF00082	0.542
CLV_PCSK_KEX2_1	83	85	PF00082	0.513
CLV_PCSK_PC1ET2_1	3	5	PF00082	0.567
CLV_PCSK_PC1ET2_1	30	32	PF00082	0.599
CLV_PCSK_PC1ET2_1	83	85	PF00082	0.547
CLV_PCSK_PC7_1	27	33	PF00082	0.587
CLV_PCSK_SKI1_1	103	107	PF00082	0.267
CLV_PCSK_SKI1_1	153	157	PF00082	0.468
CLV_PCSK_SKI1_1	203	207	PF00082	0.523
CLV_PCSK_SKI1_1	62	66	PF00082	0.673
CLV_PCSK_SKI1_1	78	82	PF00082	0.566
DEG_SCF_TRCP1_1	45	51	PF00400	0.488
DOC_CYCLIN_RxL_1	4	16	PF00134	0.414
DOC_CYCLIN_yClb5_NLxxxL_5	156	165	PF00134	0.334
DOC_MAPK_RevD_3	163	178	PF00069	0.496
DOC_PP2B_PxIxI_1	110	116	PF00149	0.400
DOC_PP4_FxxP_1	92	95	PF00568	0.435
DOC_USP7_UBL2_3	173	177	PF12436	0.571
DOC_USP7_UBL2_3	178	182	PF12436	0.563
DOC_USP7_UBL2_3	74	78	PF12436	0.599
LIG_14-3-3_CanoR_1	31	40	PF00244	0.560
LIG_FHA_2	102	108	PF00498	0.501
LIG_LIR_Gen_1	127	134	PF02991	0.485
LIG_LIR_Nem_3	104	109	PF02991	0.487
LIG_LIR_Nem_3	127	132	PF02991	0.485
LIG_Pex14_2	201	205	PF04695	0.462
LIG_WRC_WIRS_1	131	136	PF05994	0.476
MOD_CK1_1	63	69	PF00069	0.695
MOD_CK2_1	101	107	PF00069	0.517
MOD_Cter_Amidation	1	4	PF01082	0.689
MOD_GlcNHglycan	210	213	PF01048	0.659
MOD_GlcNHglycan	45	48	PF01048	0.620
MOD_GSK3_1	13	20	PF00069	0.680
MOD_GSK3_1	143	150	PF00069	0.488
MOD_GSK3_1	165	172	PF00069	0.564
MOD_GSK3_1	48	55	PF00069	0.649
MOD_GSK3_1	56	63	PF00069	0.637
MOD_GSK3_1	66	73	PF00069	0.597
MOD_N-GLC_1	124	129	PF02516	0.287
MOD_NEK2_1	124	129	PF00069	0.504
MOD_NEK2_1	147	152	PF00069	0.501
MOD_NEK2_1	156	161	PF00069	0.420
MOD_NEK2_1	165	170	PF00069	0.422
MOD_NEK2_2	101	106	PF00069	0.517
MOD_NEK2_2	130	135	PF00069	0.476
MOD_PIKK_1	124	130	PF00454	0.512
MOD_PIKK_1	32	38	PF00454	0.478
MOD_PKA_1	82	88	PF00069	0.560
MOD_Plk_1	124	130	PF00069	0.487
MOD_Plk_4	13	19	PF00069	0.419
MOD_SUMO_for_1	111	114	PF00179	0.501
MOD_SUMO_rev_2	107	113	PF00179	0.487
TRG_DiLeu_BaEn_2	196	202	PF01217	0.521
TRG_NLS_MonoCore_2	80	85	PF00514	0.574
TRG_NLS_MonoExtC_3	180	186	PF00514	0.478
TRG_NLS_MonoExtN_4	173	180	PF00514	0.379
TRG_NLS_MonoExtN_4	27	34	PF00514	0.605
TRG_NLS_MonoExtN_4	78	85	PF00514	0.560
TRG_Pf-PMV_PEXEL_1	4	9	PF00026	0.541

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4P3	Leptomonas seymouri	73%	99%
A0A0S4JVA8	Bodo saltans	49%	96%
A0A1X0NV88	Trypanosomatidae	58%	95%
A0A3R7KAH2	Trypanosoma rangeli	52%	100%
A0A3S7WRD9	Leishmania donovani	83%	96%
A4HUS0	Leishmania infantum	83%	96%
D0A7P3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	98%
E9ANF4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	99%
Q4QH72	Leishmania major	82%	100%
V5BRH6	Trypanosoma cruzi	53%	78%