MORN repeat family protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

MORN repeat, putative

Species:

Leishmania braziliensis

UniProt:

A4H9U9_LEIBR

TriTrypDb:

LbrM.19.0230 , LBRM2903_050016800 , LBRM2903_190007000 , LBRM2903_190007100

Length:

666

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005930	axoneme	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H9U9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H9U9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	310	314	PF00656	0.589
CLV_C14_Caspase3-7	540	544	PF00656	0.577
CLV_MEL_PAP_1	414	420	PF00089	0.543
CLV_NRD_NRD_1	376	378	PF00675	0.419
CLV_NRD_NRD_1	393	395	PF00675	0.506
CLV_NRD_NRD_1	661	663	PF00675	0.663
CLV_PCSK_KEX2_1	290	292	PF00082	0.186
CLV_PCSK_KEX2_1	376	378	PF00082	0.445
CLV_PCSK_KEX2_1	393	395	PF00082	0.440
CLV_PCSK_KEX2_1	532	534	PF00082	0.640
CLV_PCSK_KEX2_1	661	663	PF00082	0.663
CLV_PCSK_PC1ET2_1	290	292	PF00082	0.186
CLV_PCSK_PC1ET2_1	532	534	PF00082	0.576
CLV_PCSK_SKI1_1	230	234	PF00082	0.394
CLV_PCSK_SKI1_1	368	372	PF00082	0.528
CLV_PCSK_SKI1_1	661	665	PF00082	0.655
CLV_Separin_Metazoa	429	433	PF03568	0.528
DEG_APCC_DBOX_1	551	559	PF00400	0.626
DEG_Nend_UBRbox_2	1	3	PF02207	0.514
DOC_CYCLIN_RxL_1	365	373	PF00134	0.604
DOC_MAPK_gen_1	376	383	PF00069	0.557
DOC_MAPK_gen_1	393	401	PF00069	0.457
DOC_PP1_RVXF_1	573	579	PF00149	0.637
DOC_PP2B_LxvP_1	241	244	PF13499	0.484
DOC_SPAK_OSR1_1	417	421	PF12202	0.417
DOC_USP7_MATH_1	128	132	PF00917	0.351
DOC_USP7_MATH_1	151	155	PF00917	0.352
DOC_USP7_MATH_1	276	280	PF00917	0.292
DOC_USP7_MATH_1	30	34	PF00917	0.383
DOC_USP7_MATH_1	488	492	PF00917	0.568
DOC_USP7_MATH_1	644	648	PF00917	0.470
DOC_USP7_UBL2_3	209	213	PF12436	0.342
DOC_USP7_UBL2_3	368	372	PF12436	0.536
DOC_WW_Pin1_4	184	189	PF00397	0.342
DOC_WW_Pin1_4	234	239	PF00397	0.519
DOC_WW_Pin1_4	326	331	PF00397	0.678
DOC_WW_Pin1_4	335	340	PF00397	0.702
DOC_WW_Pin1_4	565	570	PF00397	0.649
LIG_14-3-3_CanoR_1	172	179	PF00244	0.258
LIG_14-3-3_CanoR_1	18	23	PF00244	0.623
LIG_14-3-3_CanoR_1	376	384	PF00244	0.612
LIG_14-3-3_CanoR_1	398	408	PF00244	0.593
LIG_14-3-3_CanoR_1	442	448	PF00244	0.558
LIG_14-3-3_CanoR_1	526	532	PF00244	0.576
LIG_14-3-3_CanoR_1	546	552	PF00244	0.647
LIG_14-3-3_CanoR_1	560	566	PF00244	0.456
LIG_14-3-3_CanoR_1	79	86	PF00244	0.224
LIG_Actin_WH2_2	572	588	PF00022	0.440
LIG_BRCT_BRCA1_1	269	273	PF00533	0.186
LIG_eIF4E_1	61	67	PF01652	0.222
LIG_FHA_1	108	114	PF00498	0.303
LIG_FHA_1	173	179	PF00498	0.406
LIG_FHA_1	237	243	PF00498	0.635
LIG_FHA_1	295	301	PF00498	0.352
LIG_FHA_1	353	359	PF00498	0.613
LIG_FHA_1	36	42	PF00498	0.427
LIG_FHA_1	400	406	PF00498	0.613
LIG_FHA_1	442	448	PF00498	0.488
LIG_FHA_1	652	658	PF00498	0.502
LIG_FHA_2	323	329	PF00498	0.745
LIG_FHA_2	346	352	PF00498	0.676
LIG_FHA_2	384	390	PF00498	0.552
LIG_FHA_2	443	449	PF00498	0.373
LIG_FHA_2	554	560	PF00498	0.398
LIG_FHA_2	593	599	PF00498	0.749
LIG_FHA_2	637	643	PF00498	0.574
LIG_FHA_2	648	654	PF00498	0.540
LIG_LIR_Apic_2	245	250	PF02991	0.435
LIG_LIR_Gen_1	223	233	PF02991	0.550
LIG_LIR_Gen_1	54	63	PF02991	0.421
LIG_LIR_Gen_1	627	638	PF02991	0.507
LIG_LIR_Gen_1	8	19	PF02991	0.490
LIG_LIR_LC3C_4	239	243	PF02991	0.336
LIG_LIR_Nem_3	21	25	PF02991	0.520
LIG_LIR_Nem_3	369	374	PF02991	0.520
LIG_LIR_Nem_3	43	49	PF02991	0.475
LIG_LIR_Nem_3	460	466	PF02991	0.612
LIG_LIR_Nem_3	62	66	PF02991	0.327
LIG_LIR_Nem_3	627	633	PF02991	0.524
LIG_LIR_Nem_3	8	14	PF02991	0.480
LIG_LYPXL_yS_3	46	49	PF13949	0.346
LIG_NRBOX	341	347	PF00104	0.680
LIG_PCNA_yPIPBox_3	364	377	PF02747	0.509
LIG_SH2_CRK	11	15	PF00017	0.477
LIG_SH2_CRK	247	251	PF00017	0.544
LIG_SH2_NCK_1	247	251	PF00017	0.480
LIG_SH2_SRC	275	278	PF00017	0.285
LIG_SH2_STAT3	363	366	PF00017	0.383
LIG_SH2_STAT5	109	112	PF00017	0.318
LIG_SH2_STAT5	133	136	PF00017	0.263
LIG_SH2_STAT5	225	228	PF00017	0.327
LIG_SH2_STAT5	247	250	PF00017	0.478
LIG_SH2_STAT5	258	261	PF00017	0.314
LIG_SH2_STAT5	34	37	PF00017	0.341
LIG_SH3_3	223	229	PF00018	0.269
LIG_SH3_3	351	357	PF00018	0.398
LIG_SH3_3	378	384	PF00018	0.651
LIG_SH3_3	83	89	PF00018	0.285
LIG_SUMO_SIM_anti_2	318	325	PF11976	0.608
LIG_SUMO_SIM_anti_2	327	336	PF11976	0.514
LIG_SUMO_SIM_par_1	239	245	PF11976	0.325
LIG_SUMO_SIM_par_1	653	658	PF11976	0.446
LIG_TRAF2_1	316	319	PF00917	0.577
LIG_TRAF2_1	325	328	PF00917	0.530
LIG_TRFH_1	232	236	PF08558	0.400
MOD_CK1_1	131	137	PF00069	0.371
MOD_CK1_1	184	190	PF00069	0.342
MOD_CK1_1	21	27	PF00069	0.578
MOD_CK1_1	245	251	PF00069	0.456
MOD_CK1_1	329	335	PF00069	0.712
MOD_CK1_1	416	422	PF00069	0.644
MOD_CK1_1	550	556	PF00069	0.584
MOD_CK1_1	588	594	PF00069	0.747
MOD_CK1_1	647	653	PF00069	0.384
MOD_CK2_1	151	157	PF00069	0.319
MOD_CK2_1	276	282	PF00069	0.317
MOD_CK2_1	322	328	PF00069	0.704
MOD_CK2_1	341	347	PF00069	0.513
MOD_CK2_1	442	448	PF00069	0.378
MOD_CK2_1	553	559	PF00069	0.469
MOD_CK2_1	592	598	PF00069	0.695
MOD_CK2_1	626	632	PF00069	0.494
MOD_CK2_1	636	642	PF00069	0.441
MOD_Cter_Amidation	374	377	PF01082	0.420
MOD_GlcNHglycan	138	141	PF01048	0.279
MOD_GlcNHglycan	198	202	PF01048	0.503
MOD_GlcNHglycan	269	272	PF01048	0.186
MOD_GlcNHglycan	297	300	PF01048	0.425
MOD_GlcNHglycan	377	380	PF01048	0.673
MOD_GlcNHglycan	42	45	PF01048	0.463
MOD_GlcNHglycan	421	424	PF01048	0.327
MOD_GlcNHglycan	451	454	PF01048	0.363
MOD_GlcNHglycan	490	493	PF01048	0.621
MOD_GlcNHglycan	608	611	PF01048	0.703
MOD_GlcNHglycan	646	649	PF01048	0.526
MOD_GlcNHglycan	71	75	PF01048	0.259
MOD_GlcNHglycan	97	100	PF01048	0.442
MOD_GSK3_1	220	227	PF00069	0.388
MOD_GSK3_1	322	329	PF00069	0.692
MOD_GSK3_1	341	348	PF00069	0.526
MOD_GSK3_1	362	369	PF00069	0.557
MOD_GSK3_1	561	568	PF00069	0.424
MOD_GSK3_1	588	595	PF00069	0.676
MOD_GSK3_1	647	654	PF00069	0.505
MOD_GSK3_1	78	85	PF00069	0.245
MOD_GSK3_1	91	98	PF00069	0.426
MOD_N-GLC_2	168	170	PF02516	0.342
MOD_NEK2_1	113	118	PF00069	0.436
MOD_NEK2_1	171	176	PF00069	0.342
MOD_NEK2_1	352	357	PF00069	0.594
MOD_NEK2_1	362	367	PF00069	0.496
MOD_NEK2_1	399	404	PF00069	0.566
MOD_NEK2_1	558	563	PF00069	0.616
MOD_NEK2_1	585	590	PF00069	0.497
MOD_NEK2_1	606	611	PF00069	0.534
MOD_NEK2_1	633	638	PF00069	0.583
MOD_NEK2_2	151	156	PF00069	0.346
MOD_NEK2_2	269	274	PF00069	0.340
MOD_NEK2_2	276	281	PF00069	0.363
MOD_NEK2_2	51	56	PF00069	0.266
MOD_NEK2_2	547	552	PF00069	0.586
MOD_NEK2_2	97	102	PF00069	0.295
MOD_PIKK_1	144	150	PF00454	0.342
MOD_PIKK_1	242	248	PF00454	0.467
MOD_PIKK_1	362	368	PF00454	0.380
MOD_PIKK_1	399	405	PF00454	0.518
MOD_PKA_2	120	126	PF00069	0.292
MOD_PKA_2	131	137	PF00069	0.324
MOD_PKA_2	171	177	PF00069	0.380
MOD_PKA_2	375	381	PF00069	0.425
MOD_PKA_2	397	403	PF00069	0.609
MOD_PKA_2	416	422	PF00069	0.527
MOD_PKA_2	441	447	PF00069	0.381
MOD_PKA_2	585	591	PF00069	0.646
MOD_PKA_2	644	650	PF00069	0.392
MOD_PKA_2	78	84	PF00069	0.224
MOD_Plk_1	558	564	PF00069	0.405
MOD_Plk_1	626	632	PF00069	0.563
MOD_Plk_2-3	537	543	PF00069	0.578
MOD_Plk_4	120	126	PF00069	0.418
MOD_Plk_4	151	157	PF00069	0.293
MOD_Plk_4	221	227	PF00069	0.263
MOD_Plk_4	228	234	PF00069	0.456
MOD_Plk_4	269	275	PF00069	0.258
MOD_Plk_4	30	36	PF00069	0.467
MOD_Plk_4	319	325	PF00069	0.743
MOD_Plk_4	329	335	PF00069	0.727
MOD_Plk_4	341	347	PF00069	0.607
MOD_Plk_4	366	372	PF00069	0.550
MOD_Plk_4	509	515	PF00069	0.576
MOD_Plk_4	51	57	PF00069	0.325
MOD_Plk_4	626	632	PF00069	0.525
MOD_Plk_4	633	639	PF00069	0.431
MOD_Plk_4	651	657	PF00069	0.322
MOD_ProDKin_1	184	190	PF00069	0.342
MOD_ProDKin_1	234	240	PF00069	0.517
MOD_ProDKin_1	326	332	PF00069	0.674
MOD_ProDKin_1	335	341	PF00069	0.701
MOD_ProDKin_1	565	571	PF00069	0.642
MOD_SUMO_for_1	579	582	PF00179	0.639
MOD_SUMO_rev_2	206	214	PF00179	0.425
TRG_DiLeu_BaEn_1	62	67	PF01217	0.222
TRG_DiLeu_BaLyEn_6	354	359	PF01217	0.435
TRG_ENDOCYTIC_2	11	14	PF00928	0.410
TRG_ENDOCYTIC_2	204	207	PF00928	0.338
TRG_ENDOCYTIC_2	225	228	PF00928	0.499
TRG_ENDOCYTIC_2	46	49	PF00928	0.393
TRG_ENDOCYTIC_2	463	466	PF00928	0.466
TRG_ENDOCYTIC_2	535	538	PF00928	0.584
TRG_ENDOCYTIC_2	56	59	PF00928	0.325
TRG_ER_diArg_1	393	395	PF00400	0.533
TRG_ER_diArg_1	661	663	PF00400	0.536
TRG_NLS_MonoExtC_3	14	19	PF00514	0.417
TRG_Pf-PMV_PEXEL_1	661	666	PF00026	0.554

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HV83	Leptomonas seymouri	54%	98%
A0A1X0NVA0	Trypanosomatidae	35%	98%
A0A3Q8IHC4	Leishmania donovani	84%	100%
A0A3R7LGF2	Trypanosoma rangeli	31%	100%
A4HUS1	Leishmania infantum	84%	100%
D0A7P2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9ANF5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
Q4QH71	Leishmania major	84%	100%
V5BB15	Trypanosoma cruzi	36%	100%