NERD domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H9U6_LEIBR

TriTrypDb:

LbrM.19.0200 , LBRM2903_190006700

Length:

189

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H9U6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H9U6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	131	133	PF00675	0.430
CLV_NRD_NRD_1	9	11	PF00675	0.446
CLV_NRD_NRD_1	93	95	PF00675	0.398
CLV_PCSK_KEX2_1	131	133	PF00082	0.432
CLV_PCSK_KEX2_1	9	11	PF00082	0.446
CLV_PCSK_KEX2_1	93	95	PF00082	0.398
CLV_PCSK_SKI1_1	32	36	PF00082	0.461
DEG_Nend_Nbox_1	1	3	PF02207	0.571
DOC_MAPK_gen_1	28	37	PF00069	0.445
DOC_MAPK_gen_1	75	82	PF00069	0.541
DOC_MAPK_gen_1	9	16	PF00069	0.394
DOC_MAPK_gen_1	93	100	PF00069	0.276
DOC_PP4_FxxP_1	60	63	PF00568	0.382
DOC_WW_Pin1_4	160	165	PF00397	0.402
LIG_14-3-3_CanoR_1	32	38	PF00244	0.462
LIG_APCC_ABBA_1	14	19	PF00400	0.389
LIG_BRCT_BRCA1_1	102	106	PF00533	0.382
LIG_BRCT_BRCA1_1	142	146	PF00533	0.406
LIG_BRCT_BRCA1_1	75	79	PF00533	0.398
LIG_FHA_2	34	40	PF00498	0.375
LIG_FHA_2	53	59	PF00498	0.471
LIG_LIR_Apic_2	58	63	PF02991	0.369
LIG_LIR_Gen_1	11	18	PF02991	0.414
LIG_LIR_Gen_1	143	154	PF02991	0.515
LIG_LIR_Gen_1	76	87	PF02991	0.356
LIG_LIR_Nem_3	103	109	PF02991	0.272
LIG_LIR_Nem_3	11	16	PF02991	0.404
LIG_LIR_Nem_3	166	170	PF02991	0.379
LIG_LIR_Nem_3	76	82	PF02991	0.353
LIG_LIR_Nem_3	86	91	PF02991	0.339
LIG_PCNA_yPIPBox_3	43	54	PF02747	0.307
LIG_SH2_STAT5	13	16	PF00017	0.364
LIG_SH2_STAT5	170	173	PF00017	0.344
LIG_SH2_STAT5	53	56	PF00017	0.303
LIG_SH3_3	151	157	PF00018	0.548
LIG_SH3_3	60	66	PF00018	0.469
LIG_SUMO_SIM_anti_2	95	101	PF11976	0.375
LIG_TRAF2_1	18	21	PF00917	0.601
LIG_TRAF2_1	36	39	PF00917	0.279
LIG_TRAF2_1	56	59	PF00917	0.233
MOD_CK1_1	108	114	PF00069	0.401
MOD_CK1_1	126	132	PF00069	0.287
MOD_CK2_1	160	166	PF00069	0.469
MOD_CK2_1	33	39	PF00069	0.382
MOD_CK2_1	46	52	PF00069	0.385
MOD_CK2_1	53	59	PF00069	0.248
MOD_Cter_Amidation	7	10	PF01082	0.400
MOD_GlcNHglycan	125	128	PF01048	0.499
MOD_GlcNHglycan	137	140	PF01048	0.356
MOD_GlcNHglycan	146	149	PF01048	0.398
MOD_GlcNHglycan	6	9	PF01048	0.429
MOD_GSK3_1	100	107	PF00069	0.424
MOD_GSK3_1	140	147	PF00069	0.558
MOD_GSK3_1	83	90	PF00069	0.396
MOD_N-GLC_1	104	109	PF02516	0.390
MOD_NEK2_1	123	128	PF00069	0.359
MOD_NEK2_1	73	78	PF00069	0.437
MOD_PIKK_1	100	106	PF00454	0.436
MOD_Plk_1	104	110	PF00069	0.387
MOD_Plk_2-3	46	52	PF00069	0.450
MOD_Plk_4	65	71	PF00069	0.461
MOD_Plk_4	83	89	PF00069	0.542
MOD_ProDKin_1	160	166	PF00069	0.392
TRG_ENDOCYTIC_2	120	123	PF00928	0.416
TRG_ENDOCYTIC_2	13	16	PF00928	0.364
TRG_ER_diArg_1	131	133	PF00400	0.368
TRG_Pf-PMV_PEXEL_1	121	125	PF00026	0.402

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAM1	Leptomonas seymouri	67%	100%
A0A3Q8I8Z4	Leishmania donovani	84%	100%
A4HUS4	Leishmania infantum	84%	100%
E9ANF8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4QH68	Leishmania major	87%	100%