PSP1 C-terminal domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H9U4_LEIBR

TriTrypDb:

LbrM.19.0180 , LBRM2903_190006500

Length:

379

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H9U4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H9U4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	209	211	PF00675	0.649
CLV_NRD_NRD_1	237	239	PF00675	0.451
CLV_NRD_NRD_1	341	343	PF00675	0.280
CLV_NRD_NRD_1	86	88	PF00675	0.617
CLV_PCSK_FUR_1	207	211	PF00082	0.717
CLV_PCSK_KEX2_1	207	209	PF00082	0.613
CLV_PCSK_KEX2_1	237	239	PF00082	0.451
CLV_PCSK_KEX2_1	341	343	PF00082	0.419
CLV_PCSK_KEX2_1	85	87	PF00082	0.653
CLV_PCSK_PC1ET2_1	237	239	PF00082	0.391
CLV_PCSK_SKI1_1	20	24	PF00082	0.344
CLV_PCSK_SKI1_1	239	243	PF00082	0.416
CLV_PCSK_SKI1_1	342	346	PF00082	0.277
DEG_Nend_Nbox_1	1	3	PF02207	0.402
DOC_CKS1_1	150	155	PF01111	0.579
DOC_CKS1_1	216	221	PF01111	0.580
DOC_CYCLIN_RxL_1	17	27	PF00134	0.343
DOC_MAPK_gen_1	291	301	PF00069	0.297
DOC_MAPK_MEF2A_6	20	28	PF00069	0.336
DOC_PP1_RVXF_1	340	347	PF00149	0.277
DOC_PP1_RVXF_1	351	357	PF00149	0.277
DOC_PP2B_LxvP_1	54	57	PF13499	0.365
DOC_PP4_FxxP_1	13	16	PF00568	0.374
DOC_USP7_MATH_1	375	379	PF00917	0.495
DOC_USP7_MATH_1	57	61	PF00917	0.390
DOC_USP7_UBL2_3	287	291	PF12436	0.495
DOC_WW_Pin1_4	12	17	PF00397	0.377
DOC_WW_Pin1_4	149	154	PF00397	0.571
DOC_WW_Pin1_4	164	169	PF00397	0.696
DOC_WW_Pin1_4	194	199	PF00397	0.485
DOC_WW_Pin1_4	215	220	PF00397	0.605
DOC_WW_Pin1_4	243	248	PF00397	0.411
LIG_14-3-3_CanoR_1	294	299	PF00244	0.297
LIG_14-3-3_CanoR_1	341	347	PF00244	0.277
LIG_14-3-3_CanoR_1	47	57	PF00244	0.348
LIG_14-3-3_CanoR_1	87	95	PF00244	0.437
LIG_Actin_WH2_2	18	34	PF00022	0.331
LIG_APCC_ABBA_1	143	148	PF00400	0.602
LIG_BRCT_BRCA1_1	14	18	PF00533	0.362
LIG_BRCT_BRCA1_1	59	63	PF00533	0.392
LIG_BRCT_BRCA1_1	9	13	PF00533	0.396
LIG_Clathr_ClatBox_1	3	7	PF01394	0.409
LIG_DCNL_PONY_1	1	4	PF03556	0.399
LIG_FHA_1	311	317	PF00498	0.357
LIG_FHA_1	49	55	PF00498	0.344
LIG_FHA_1	89	95	PF00498	0.640
LIG_FHA_2	219	225	PF00498	0.695
LIG_FHA_2	307	313	PF00498	0.286
LIG_LIR_Apic_2	10	16	PF02991	0.384
LIG_LIR_Apic_2	224	229	PF02991	0.525
LIG_LIR_Apic_2	246	252	PF02991	0.411
LIG_LIR_Gen_1	345	356	PF02991	0.357
LIG_LIR_Nem_3	355	359	PF02991	0.277
LIG_LIR_Nem_3	362	367	PF02991	0.277
LIG_NRBOX	21	27	PF00104	0.333
LIG_PDZ_Class_1	374	379	PF00595	0.433
LIG_SH2_CRK	226	230	PF00017	0.481
LIG_SH2_NCK_1	244	248	PF00017	0.452
LIG_SH2_PTP2	249	252	PF00017	0.412
LIG_SH2_STAP1	182	186	PF00017	0.518
LIG_SH2_STAT5	109	112	PF00017	0.377
LIG_SH2_STAT5	249	252	PF00017	0.412
LIG_SH3_3	195	201	PF00018	0.700
LIG_SH3_3	213	219	PF00018	0.661
LIG_SH3_5	222	226	PF00018	0.558
LIG_SUMO_SIM_anti_2	27	32	PF11976	0.325
LIG_SUMO_SIM_par_1	2	7	PF11976	0.407
LIG_SUMO_SIM_par_1	297	302	PF11976	0.371
LIG_SUMO_SIM_par_1	91	97	PF11976	0.507
LIG_TRAF2_1	201	204	PF00917	0.683
LIG_TYR_ITIM	180	185	PF00017	0.544
LIG_WRC_WIRS_1	364	369	PF05994	0.277
LIG_WW_3	152	156	PF00397	0.724
MOD_CDK_SPxK_1	149	155	PF00069	0.574
MOD_CK1_1	215	221	PF00069	0.778
MOD_CK1_1	61	67	PF00069	0.390
MOD_CK2_1	218	224	PF00069	0.729
MOD_CK2_1	294	300	PF00069	0.286
MOD_CK2_1	306	312	PF00069	0.259
MOD_GlcNHglycan	102	105	PF01048	0.521
MOD_GlcNHglycan	164	167	PF01048	0.771
MOD_GSK3_1	169	176	PF00069	0.650
MOD_GSK3_1	2	9	PF00069	0.431
MOD_GSK3_1	306	313	PF00069	0.459
MOD_GSK3_1	48	55	PF00069	0.341
MOD_GSK3_1	57	64	PF00069	0.360
MOD_N-GLC_1	162	167	PF02516	0.750
MOD_N-GLC_1	89	94	PF02516	0.656
MOD_NEK2_1	116	121	PF00069	0.516
MOD_NEK2_1	299	304	PF00069	0.277
MOD_NEK2_1	363	368	PF00069	0.277
MOD_NEK2_1	48	53	PF00069	0.334
MOD_NEK2_1	58	63	PF00069	0.362
MOD_NEK2_1	6	11	PF00069	0.409
MOD_NEK2_1	88	93	PF00069	0.641
MOD_NEK2_2	141	146	PF00069	0.459
MOD_NEK2_2	347	352	PF00069	0.357
MOD_PIKK_1	299	305	PF00454	0.277
MOD_PIKK_1	80	86	PF00454	0.514
MOD_PK_1	294	300	PF00069	0.423
MOD_PKA_1	342	348	PF00069	0.277
MOD_Plk_1	299	305	PF00069	0.285
MOD_Plk_1	6	12	PF00069	0.409
MOD_Plk_1	66	72	PF00069	0.384
MOD_Plk_1	89	95	PF00069	0.652
MOD_Plk_4	24	30	PF00069	0.324
MOD_Plk_4	294	300	PF00069	0.383
MOD_Plk_4	342	348	PF00069	0.289
MOD_Plk_4	89	95	PF00069	0.606
MOD_ProDKin_1	12	18	PF00069	0.377
MOD_ProDKin_1	149	155	PF00069	0.575
MOD_ProDKin_1	164	170	PF00069	0.694
MOD_ProDKin_1	194	200	PF00069	0.477
MOD_ProDKin_1	215	221	PF00069	0.602
MOD_ProDKin_1	243	249	PF00069	0.412
TRG_DiLeu_BaEn_1	264	269	PF01217	0.357
TRG_DiLeu_BaLyEn_6	44	49	PF01217	0.392
TRG_ENDOCYTIC_2	182	185	PF00928	0.546
TRG_ENDOCYTIC_2	348	351	PF00928	0.408
TRG_ENDOCYTIC_2	364	367	PF00928	0.183
TRG_ER_diArg_1	207	210	PF00400	0.617
TRG_ER_diArg_1	238	241	PF00400	0.382
TRG_ER_diArg_1	367	370	PF00400	0.277
TRG_ER_diArg_1	85	87	PF00400	0.613
TRG_NES_CRM1_1	126	137	PF08389	0.526
TRG_NLS_MonoCore_2	236	241	PF00514	0.389
TRG_NLS_MonoExtN_4	237	242	PF00514	0.390
TRG_Pf-PMV_PEXEL_1	128	132	PF00026	0.573
TRG_Pf-PMV_PEXEL_1	240	245	PF00026	0.372
TRG_Pf-PMV_PEXEL_1	357	362	PF00026	0.277

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAZ1	Leptomonas seymouri	83%	100%
A0A0S4JV55	Bodo saltans	50%	100%
A0A1X0NWX9	Trypanosomatidae	55%	100%
A0A3Q8I8Y8	Leishmania donovani	92%	100%
A0A3S5ISC8	Trypanosoma rangeli	53%	100%
A4HUS6	Leishmania infantum	92%	100%
D0A7N8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	100%
E9ANG0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4QH66	Leishmania major	92%	100%
V5BB20	Trypanosoma cruzi	57%	100%