Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H9U3_LEIBR

TriTrypDb:

LbrM.19.0170 , LBRM2903_190006400

Length:

883

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H9U3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H9U3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	120	124	PF00656	0.848
CLV_C14_Caspase3-7	147	151	PF00656	0.643
CLV_NRD_NRD_1	182	184	PF00675	0.823
CLV_NRD_NRD_1	253	255	PF00675	0.697
CLV_NRD_NRD_1	28	30	PF00675	0.799
CLV_NRD_NRD_1	289	291	PF00675	0.733
CLV_NRD_NRD_1	344	346	PF00675	0.571
CLV_NRD_NRD_1	45	47	PF00675	0.602
CLV_NRD_NRD_1	503	505	PF00675	0.761
CLV_NRD_NRD_1	510	512	PF00675	0.731
CLV_NRD_NRD_1	540	542	PF00675	0.692
CLV_NRD_NRD_1	719	721	PF00675	0.600
CLV_NRD_NRD_1	724	726	PF00675	0.579
CLV_NRD_NRD_1	822	824	PF00675	0.668
CLV_NRD_NRD_1	83	85	PF00675	0.831
CLV_NRD_NRD_1	96	98	PF00675	0.637
CLV_PCSK_FUR_1	820	824	PF00082	0.483
CLV_PCSK_FUR_1	96	100	PF00082	0.698
CLV_PCSK_KEX2_1	182	184	PF00082	0.813
CLV_PCSK_KEX2_1	244	246	PF00082	0.670
CLV_PCSK_KEX2_1	253	255	PF00082	0.548
CLV_PCSK_KEX2_1	289	291	PF00082	0.733
CLV_PCSK_KEX2_1	344	346	PF00082	0.571
CLV_PCSK_KEX2_1	45	47	PF00082	0.849
CLV_PCSK_KEX2_1	503	505	PF00082	0.758
CLV_PCSK_KEX2_1	510	512	PF00082	0.718
CLV_PCSK_KEX2_1	540	542	PF00082	0.804
CLV_PCSK_KEX2_1	719	721	PF00082	0.600
CLV_PCSK_KEX2_1	723	725	PF00082	0.584
CLV_PCSK_KEX2_1	822	824	PF00082	0.650
CLV_PCSK_KEX2_1	83	85	PF00082	0.831
CLV_PCSK_KEX2_1	87	89	PF00082	0.778
CLV_PCSK_KEX2_1	96	98	PF00082	0.637
CLV_PCSK_PC1ET2_1	244	246	PF00082	0.670
CLV_PCSK_PC1ET2_1	83	85	PF00082	0.831
CLV_PCSK_PC1ET2_1	87	89	PF00082	0.778
CLV_PCSK_PC1ET2_1	98	100	PF00082	0.600
CLV_PCSK_PC7_1	719	725	PF00082	0.598
CLV_PCSK_SKI1_1	188	192	PF00082	0.555
CLV_PCSK_SKI1_1	224	228	PF00082	0.649
CLV_PCSK_SKI1_1	487	491	PF00082	0.838
CLV_PCSK_SKI1_1	503	507	PF00082	0.573
CLV_PCSK_SKI1_1	643	647	PF00082	0.723
CLV_PCSK_SKI1_1	843	847	PF00082	0.715
DEG_APCC_DBOX_1	722	730	PF00400	0.590
DEG_Nend_UBRbox_2	1	3	PF02207	0.773
DEG_SCF_FBW7_1	329	335	PF00400	0.668
DEG_SPOP_SBC_1	125	129	PF00917	0.748
DEG_SPOP_SBC_1	159	163	PF00917	0.819
DEG_SPOP_SBC_1	166	170	PF00917	0.692
DEG_SPOP_SBC_1	332	336	PF00917	0.564
DOC_CKS1_1	329	334	PF01111	0.737
DOC_CKS1_1	418	423	PF01111	0.703
DOC_CKS1_1	873	878	PF01111	0.718
DOC_CYCLIN_yCln2_LP_2	568	571	PF00134	0.838
DOC_MAPK_gen_1	344	351	PF00069	0.580
DOC_MAPK_gen_1	487	495	PF00069	0.651
DOC_MAPK_gen_1	622	630	PF00069	0.575
DOC_MAPK_gen_1	719	729	PF00069	0.834
DOC_MAPK_gen_1	820	829	PF00069	0.481
DOC_MAPK_MEF2A_6	203	212	PF00069	0.481
DOC_PP2B_LxvP_1	568	571	PF13499	0.838
DOC_PP2B_LxvP_1	760	763	PF13499	0.773
DOC_PP2B_PxIxI_1	207	213	PF00149	0.460
DOC_PP4_FxxP_1	587	590	PF00568	0.834
DOC_PP4_FxxP_1	778	781	PF00568	0.790
DOC_PP4_MxPP_1	789	792	PF00568	0.806
DOC_SPAK_OSR1_1	260	264	PF12202	0.634
DOC_USP7_MATH_1	125	129	PF00917	0.636
DOC_USP7_MATH_1	140	144	PF00917	0.677
DOC_USP7_MATH_1	159	163	PF00917	0.659
DOC_USP7_MATH_1	333	337	PF00917	0.573
DOC_USP7_MATH_1	374	378	PF00917	0.643
DOC_USP7_MATH_1	383	387	PF00917	0.752
DOC_USP7_MATH_1	483	487	PF00917	0.842
DOC_USP7_MATH_1	718	722	PF00917	0.667
DOC_USP7_MATH_1	74	78	PF00917	0.747
DOC_USP7_MATH_1	834	838	PF00917	0.496
DOC_USP7_MATH_1	847	851	PF00917	0.594
DOC_USP7_UBL2_3	83	87	PF12436	0.835
DOC_WW_Pin1_4	278	283	PF00397	0.742
DOC_WW_Pin1_4	328	333	PF00397	0.772
DOC_WW_Pin1_4	363	368	PF00397	0.806
DOC_WW_Pin1_4	392	397	PF00397	0.601
DOC_WW_Pin1_4	417	422	PF00397	0.592
DOC_WW_Pin1_4	544	549	PF00397	0.729
DOC_WW_Pin1_4	571	576	PF00397	0.726
DOC_WW_Pin1_4	633	638	PF00397	0.753
DOC_WW_Pin1_4	652	657	PF00397	0.473
DOC_WW_Pin1_4	68	73	PF00397	0.600
DOC_WW_Pin1_4	692	697	PF00397	0.713
DOC_WW_Pin1_4	732	737	PF00397	0.604
DOC_WW_Pin1_4	872	877	PF00397	0.714
LIG_14-3-3_CanoR_1	253	257	PF00244	0.708
LIG_14-3-3_CanoR_1	289	295	PF00244	0.751
LIG_14-3-3_CanoR_1	527	535	PF00244	0.653
LIG_14-3-3_CanoR_1	719	727	PF00244	0.797
LIG_14-3-3_CanoR_1	852	861	PF00244	0.568
LIG_14-3-3_CanoR_1	99	104	PF00244	0.851
LIG_APCC_ABBA_1	493	498	PF00400	0.586
LIG_BRCT_BRCA1_1	257	261	PF00533	0.502
LIG_BRCT_BRCA1_1	829	833	PF00533	0.692
LIG_BRCT_BRCA1_1	99	103	PF00533	0.851
LIG_CtBP_PxDLS_1	359	363	PF00389	0.576
LIG_CtBP_PxDLS_1	764	768	PF00389	0.579
LIG_EVH1_1	569	573	PF00568	0.792
LIG_EVH1_1	760	764	PF00568	0.595
LIG_EVH1_1	778	782	PF00568	0.721
LIG_FHA_1	114	120	PF00498	0.619
LIG_FHA_1	279	285	PF00498	0.741
LIG_FHA_1	364	370	PF00498	0.712
LIG_FHA_1	373	379	PF00498	0.782
LIG_FHA_1	702	708	PF00498	0.607
LIG_FHA_2	392	398	PF00498	0.744
LIG_FHA_2	577	583	PF00498	0.596
LIG_FHA_2	618	624	PF00498	0.576
LIG_FHA_2	783	789	PF00498	0.562
LIG_GSK3_LRP6_1	571	577	PF00069	0.798
LIG_LIR_Apic_2	651	656	PF02991	0.781
LIG_LIR_Apic_2	777	781	PF02991	0.797
LIG_LIR_Gen_1	206	217	PF02991	0.437
LIG_LIR_Gen_1	565	573	PF02991	0.589
LIG_LIR_Nem_3	206	212	PF02991	0.460
LIG_LIR_Nem_3	565	569	PF02991	0.601
LIG_LIR_Nem_3	644	648	PF02991	0.734
LIG_LIR_Nem_3	735	741	PF02991	0.554
LIG_LYPXL_yS_3	738	741	PF13949	0.561
LIG_MYND_1	660	664	PF01753	0.575
LIG_Pex14_1	825	829	PF04695	0.615
LIG_Pex14_2	829	833	PF04695	0.551
LIG_PROFILIN_1	64	70	PF00235	0.821
LIG_Rb_LxCxE_1	644	658	PF01857	0.764
LIG_RPA_C_Fungi	506	518	PF08784	0.737
LIG_SH2_GRB2like	47	50	PF00017	0.849
LIG_SH2_PTP2	209	212	PF00017	0.457
LIG_SH2_PTP2	653	656	PF00017	0.791
LIG_SH2_SRC	23	26	PF00017	0.620
LIG_SH2_SRC	313	316	PF00017	0.489
LIG_SH2_STAP1	27	31	PF00017	0.658
LIG_SH2_STAP1	313	317	PF00017	0.491
LIG_SH2_STAT3	594	597	PF00017	0.593
LIG_SH2_STAT5	209	212	PF00017	0.442
LIG_SH2_STAT5	287	290	PF00017	0.479
LIG_SH2_STAT5	309	312	PF00017	0.738
LIG_SH2_STAT5	47	50	PF00017	0.800
LIG_SH2_STAT5	632	635	PF00017	0.578
LIG_SH2_STAT5	653	656	PF00017	0.791
LIG_SH2_STAT5	826	829	PF00017	0.477
LIG_SH3_1	415	421	PF00018	0.852
LIG_SH3_1	61	67	PF00018	0.842
LIG_SH3_1	870	876	PF00018	0.557
LIG_SH3_2	41	46	PF14604	0.835
LIG_SH3_3	353	359	PF00018	0.820
LIG_SH3_3	38	44	PF00018	0.838
LIG_SH3_3	415	421	PF00018	0.701
LIG_SH3_3	477	483	PF00018	0.632
LIG_SH3_3	567	573	PF00018	0.833
LIG_SH3_3	605	611	PF00018	0.573
LIG_SH3_3	61	67	PF00018	0.714
LIG_SH3_3	733	739	PF00018	0.556
LIG_SH3_3	756	762	PF00018	0.646
LIG_SH3_3	773	779	PF00018	0.715
LIG_SH3_3	870	876	PF00018	0.666
LIG_SH3_4	191	198	PF00018	0.515
LIG_SUMO_SIM_anti_2	346	354	PF11976	0.799
LIG_SUMO_SIM_par_1	273	281	PF11976	0.736
LIG_SUMO_SIM_par_1	358	364	PF11976	0.661
LIG_SUMO_SIM_par_1	435	442	PF11976	0.601
LIG_TRAF2_1	283	286	PF00917	0.733
LIG_TRAF2_1	312	315	PF00917	0.488
LIG_WW_2	41	44	PF00397	0.576
MOD_CDK_SPK_2	363	368	PF00069	0.571
MOD_CDK_SPxxK_3	417	424	PF00069	0.761
MOD_CK1_1	102	108	PF00069	0.849
MOD_CK1_1	11	17	PF00069	0.548
MOD_CK1_1	114	120	PF00069	0.529
MOD_CK1_1	121	127	PF00069	0.692
MOD_CK1_1	128	134	PF00069	0.580
MOD_CK1_1	135	141	PF00069	0.574
MOD_CK1_1	145	151	PF00069	0.678
MOD_CK1_1	155	161	PF00069	0.676
MOD_CK1_1	162	168	PF00069	0.646
MOD_CK1_1	170	176	PF00069	0.654
MOD_CK1_1	255	261	PF00069	0.488
MOD_CK1_1	298	304	PF00069	0.762
MOD_CK1_1	361	367	PF00069	0.826
MOD_CK1_1	438	444	PF00069	0.597
MOD_CK1_1	544	550	PF00069	0.695
MOD_CK1_1	574	580	PF00069	0.736
MOD_CK1_1	59	65	PF00069	0.673
MOD_CK1_1	655	661	PF00069	0.547
MOD_CK1_1	698	704	PF00069	0.724
MOD_CK1_1	708	714	PF00069	0.800
MOD_CK1_1	837	843	PF00069	0.593
MOD_CK1_1	850	856	PF00069	0.530
MOD_CK2_1	146	152	PF00069	0.772
MOD_CK2_1	175	181	PF00069	0.817
MOD_CK2_1	309	315	PF00069	0.483
MOD_CK2_1	391	397	PF00069	0.741
MOD_CK2_1	526	532	PF00069	0.816
MOD_CK2_1	533	539	PF00069	0.787
MOD_CK2_1	576	582	PF00069	0.595
MOD_CK2_1	617	623	PF00069	0.582
MOD_CK2_1	794	800	PF00069	0.790
MOD_GlcNHglycan	10	13	PF01048	0.542
MOD_GlcNHglycan	106	109	PF01048	0.677
MOD_GlcNHglycan	123	126	PF01048	0.850
MOD_GlcNHglycan	135	138	PF01048	0.657
MOD_GlcNHglycan	140	143	PF01048	0.626
MOD_GlcNHglycan	157	160	PF01048	0.601
MOD_GlcNHglycan	164	167	PF01048	0.691
MOD_GlcNHglycan	196	199	PF01048	0.498
MOD_GlcNHglycan	295	298	PF01048	0.756
MOD_GlcNHglycan	317	320	PF01048	0.519
MOD_GlcNHglycan	363	366	PF01048	0.835
MOD_GlcNHglycan	385	388	PF01048	0.697
MOD_GlcNHglycan	415	418	PF01048	0.660
MOD_GlcNHglycan	471	474	PF01048	0.852
MOD_GlcNHglycan	528	531	PF01048	0.741
MOD_GlcNHglycan	597	600	PF01048	0.592
MOD_GlcNHglycan	61	64	PF01048	0.856
MOD_GlcNHglycan	680	683	PF01048	0.724
MOD_GlcNHglycan	707	710	PF01048	0.835
MOD_GlcNHglycan	78	81	PF01048	0.582
MOD_GlcNHglycan	814	817	PF01048	0.679
MOD_GlcNHglycan	836	839	PF01048	0.619
MOD_GlcNHglycan	862	865	PF01048	0.828
MOD_GlcNHglycan	99	102	PF01048	0.762
MOD_GSK3_1	110	117	PF00069	0.513
MOD_GSK3_1	121	128	PF00069	0.679
MOD_GSK3_1	129	136	PF00069	0.666
MOD_GSK3_1	138	145	PF00069	0.577
MOD_GSK3_1	148	155	PF00069	0.576
MOD_GSK3_1	157	164	PF00069	0.593
MOD_GSK3_1	165	172	PF00069	0.615
MOD_GSK3_1	199	206	PF00069	0.498
MOD_GSK3_1	289	296	PF00069	0.680
MOD_GSK3_1	328	335	PF00069	0.663
MOD_GSK3_1	413	420	PF00069	0.855
MOD_GSK3_1	542	549	PF00069	0.735
MOD_GSK3_1	574	581	PF00069	0.630
MOD_GSK3_1	613	620	PF00069	0.580
MOD_GSK3_1	644	651	PF00069	0.743
MOD_GSK3_1	692	699	PF00069	0.654
MOD_GSK3_1	701	708	PF00069	0.713
MOD_GSK3_1	8	15	PF00069	0.541
MOD_GSK3_1	871	878	PF00069	0.627
MOD_GSK3_1	97	104	PF00069	0.851
MOD_N-GLC_1	31	36	PF02516	0.590
MOD_N-GLC_2	801	803	PF02516	0.556
MOD_N-GLC_2	812	814	PF02516	0.449
MOD_NEK2_1	103	108	PF00069	0.737
MOD_NEK2_1	194	199	PF00069	0.506
MOD_NEK2_1	277	282	PF00069	0.743
MOD_NEK2_1	288	293	PF00069	0.557
MOD_NEK2_1	295	300	PF00069	0.481
MOD_NEK2_1	372	377	PF00069	0.574
MOD_NEK2_1	402	407	PF00069	0.793
MOD_NEK2_1	413	418	PF00069	0.674
MOD_NEK2_1	630	635	PF00069	0.580
MOD_OFUCOSY	824	831	PF10250	0.506
MOD_PIKK_1	428	434	PF00454	0.599
MOD_PIKK_1	550	556	PF00454	0.868
MOD_PIKK_1	593	599	PF00454	0.832
MOD_PIKK_1	748	754	PF00454	0.587
MOD_PIKK_1	847	853	PF00454	0.585
MOD_PK_1	115	121	PF00069	0.590
MOD_PKA_1	289	295	PF00069	0.615
MOD_PKA_1	719	725	PF00069	0.598
MOD_PKA_1	87	93	PF00069	0.600
MOD_PKA_1	97	103	PF00069	0.560
MOD_PKA_2	114	120	PF00069	0.678
MOD_PKA_2	152	158	PF00069	0.813
MOD_PKA_2	252	258	PF00069	0.708
MOD_PKA_2	288	294	PF00069	0.741
MOD_PKA_2	526	532	PF00069	0.652
MOD_PKA_2	617	623	PF00069	0.807
MOD_PKA_2	718	724	PF00069	0.743
MOD_PKA_2	87	93	PF00069	0.629
MOD_PKB_1	511	519	PF00069	0.818
MOD_PKB_1	97	105	PF00069	0.851
MOD_Plk_1	402	408	PF00069	0.825
MOD_Plk_1	541	547	PF00069	0.605
MOD_Plk_2-3	397	403	PF00069	0.847
MOD_Plk_2-3	794	800	PF00069	0.790
MOD_Plk_4	397	403	PF00069	0.686
MOD_Plk_4	644	650	PF00069	0.713
MOD_ProDKin_1	278	284	PF00069	0.742
MOD_ProDKin_1	328	334	PF00069	0.773
MOD_ProDKin_1	363	369	PF00069	0.805
MOD_ProDKin_1	392	398	PF00069	0.599
MOD_ProDKin_1	417	423	PF00069	0.593
MOD_ProDKin_1	544	550	PF00069	0.732
MOD_ProDKin_1	571	577	PF00069	0.727
MOD_ProDKin_1	633	639	PF00069	0.749
MOD_ProDKin_1	652	658	PF00069	0.473
MOD_ProDKin_1	68	74	PF00069	0.605
MOD_ProDKin_1	692	698	PF00069	0.712
MOD_ProDKin_1	732	738	PF00069	0.607
MOD_ProDKin_1	872	878	PF00069	0.716
MOD_SUMO_for_1	233	236	PF00179	0.399
MOD_SUMO_for_1	367	370	PF00179	0.558
MOD_SUMO_for_1	464	467	PF00179	0.592
MOD_SUMO_rev_2	641	648	PF00179	0.737
TRG_DiLeu_BaEn_1	236	241	PF01217	0.392
TRG_DiLeu_BaEn_1	397	402	PF01217	0.850
TRG_DiLeu_BaEn_4	236	242	PF01217	0.391
TRG_DiLeu_BaLyEn_6	321	326	PF01217	0.813
TRG_DiLeu_LyEn_5	236	241	PF01217	0.406
TRG_ENDOCYTIC_2	209	212	PF00928	0.442
TRG_ENDOCYTIC_2	738	741	PF00928	0.561
TRG_ENDOCYTIC_2	826	829	PF00928	0.477
TRG_ER_diArg_1	288	290	PF00400	0.731
TRG_ER_diArg_1	44	46	PF00400	0.841
TRG_ER_diArg_1	503	505	PF00400	0.768
TRG_ER_diArg_1	510	513	PF00400	0.718
TRG_ER_diArg_1	718	720	PF00400	0.596
TRG_ER_diArg_1	723	725	PF00400	0.580
TRG_ER_diArg_1	727	730	PF00400	0.551
TRG_ER_diArg_1	820	823	PF00400	0.484
TRG_ER_diArg_1	96	99	PF00400	0.802
TRG_NES_CRM1_1	266	279	PF08389	0.643
TRG_NLS_Bipartite_1	83	101	PF00514	0.808
TRG_NLS_MonoExtC_3	187	192	PF00514	0.546
TRG_NLS_MonoExtC_3	82	87	PF00514	0.839
TRG_NLS_MonoExtN_4	83	88	PF00514	0.836
TRG_NLS_MonoExtN_4	96	101	PF00514	0.634
TRG_Pf-PMV_PEXEL_1	239	243	PF00026	0.658
TRG_Pf-PMV_PEXEL_1	487	492	PF00026	0.588
TRG_Pf-PMV_PEXEL_1	517	522	PF00026	0.610
TRG_Pf-PMV_PEXEL_1	852	857	PF00026	0.803

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8I8W5	Leishmania donovani	65%	100%
A4HUS7	Leishmania infantum	65%	100%
E9ANG1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	58%	100%
Q4QH65	Leishmania major	63%	99%