Exocyst complex component Sec8

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H9U2_LEIBR

TriTrypDb:

LbrM.19.0160 , LBRM2903_190006300

Length:

1043

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0000145	exocyst	3	1
GO:0032991	protein-containing complex	1	1
GO:0099023	vesicle tethering complex	2	1

Expansion

Sequence features

A4H9U2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H9U2

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	12
GO:0006886	intracellular protein transport	4	12
GO:0008104	protein localization	4	12
GO:0009987	cellular process	1	12
GO:0015031	protein transport	4	12
GO:0016043	cellular component organization	3	12
GO:0033036	macromolecule localization	2	12
GO:0045184	establishment of protein localization	3	12
GO:0046907	intracellular transport	3	12
GO:0051179	localization	1	12
GO:0051234	establishment of localization	2	12
GO:0051641	cellular localization	2	12
GO:0051649	establishment of localization in cell	3	12
GO:0070727	cellular macromolecule localization	3	12
GO:0071702	organic substance transport	4	12
GO:0071705	nitrogen compound transport	4	12
GO:0071840	cellular component organization or biogenesis	2	12
GO:0090522	vesicle tethering involved in exocytosis	3	12
GO:0099022	vesicle tethering	4	12
GO:0140029	exocytic process	2	12
GO:0006887	exocytosis	4	1
GO:0006892	post-Golgi vesicle-mediated transport	6	1
GO:0006893	Golgi to plasma membrane transport	5	1
GO:0016192	vesicle-mediated transport	4	1
GO:0032940	secretion by cell	3	1
GO:0046903	secretion	4	1
GO:0048193	Golgi vesicle transport	5	1
GO:0051668	localization within membrane	3	1
GO:0098876	vesicle-mediated transport to the plasma membrane	4	1
GO:0140352	export from cell	2	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	117	121	PF00656	0.616
CLV_C14_Caspase3-7	191	195	PF00656	0.731
CLV_C14_Caspase3-7	241	245	PF00656	0.442
CLV_C14_Caspase3-7	302	306	PF00656	0.470
CLV_C14_Caspase3-7	339	343	PF00656	0.528
CLV_NRD_NRD_1	219	221	PF00675	0.717
CLV_NRD_NRD_1	27	29	PF00675	0.599
CLV_NRD_NRD_1	58	60	PF00675	0.388
CLV_NRD_NRD_1	868	870	PF00675	0.455
CLV_NRD_NRD_1	871	873	PF00675	0.501
CLV_NRD_NRD_1	959	961	PF00675	0.436
CLV_PCSK_KEX2_1	27	29	PF00082	0.599
CLV_PCSK_KEX2_1	58	60	PF00082	0.438
CLV_PCSK_KEX2_1	868	870	PF00082	0.474
CLV_PCSK_KEX2_1	959	961	PF00082	0.411
CLV_PCSK_PC7_1	864	870	PF00082	0.308
CLV_PCSK_SKI1_1	106	110	PF00082	0.654
CLV_PCSK_SKI1_1	134	138	PF00082	0.530
CLV_PCSK_SKI1_1	328	332	PF00082	0.508
CLV_PCSK_SKI1_1	348	352	PF00082	0.409
CLV_PCSK_SKI1_1	381	385	PF00082	0.399
CLV_PCSK_SKI1_1	41	45	PF00082	0.542
CLV_PCSK_SKI1_1	59	63	PF00082	0.240
CLV_PCSK_SKI1_1	677	681	PF00082	0.414
CLV_PCSK_SKI1_1	751	755	PF00082	0.472
CLV_PCSK_SKI1_1	76	80	PF00082	0.448
CLV_PCSK_SKI1_1	774	778	PF00082	0.396
CLV_Separin_Metazoa	382	386	PF03568	0.265
DEG_APCC_DBOX_1	340	348	PF00400	0.505
DEG_APCC_DBOX_1	96	104	PF00400	0.406
DEG_APCC_KENBOX_2	273	277	PF00400	0.504
DEG_Nend_UBRbox_4	1	3	PF02207	0.468
DEG_SCF_TRCP1_1	194	199	PF00400	0.582
DOC_CDC14_PxL_1	887	895	PF14671	0.349
DOC_CYCLIN_RxL_1	345	352	PF00134	0.504
DOC_CYCLIN_RxL_1	36	47	PF00134	0.567
DOC_CYCLIN_RxL_1	827	838	PF00134	0.412
DOC_CYCLIN_yCln2_LP_2	523	529	PF00134	0.479
DOC_MAPK_gen_1	328	336	PF00069	0.433
DOC_MAPK_gen_1	567	575	PF00069	0.475
DOC_MAPK_MEF2A_6	686	694	PF00069	0.383
DOC_MAPK_MEF2A_6	774	781	PF00069	0.379
DOC_MAPK_MEF2A_6	948	956	PF00069	0.375
DOC_MAPK_NFAT4_5	774	782	PF00069	0.376
DOC_PP1_RVXF_1	39	45	PF00149	0.573
DOC_PP1_RVXF_1	715	722	PF00149	0.234
DOC_PP2B_LxvP_1	386	389	PF13499	0.495
DOC_PP2B_LxvP_1	692	695	PF13499	0.365
DOC_USP7_MATH_1	1030	1034	PF00917	0.634
DOC_USP7_MATH_1	203	207	PF00917	0.489
DOC_USP7_MATH_1	238	242	PF00917	0.444
DOC_USP7_MATH_1	456	460	PF00917	0.498
DOC_USP7_MATH_1	878	882	PF00917	0.484
DOC_USP7_MATH_1	924	928	PF00917	0.338
DOC_USP7_MATH_1	966	970	PF00917	0.484
DOC_USP7_MATH_2	534	540	PF00917	0.489
DOC_USP7_UBL2_3	1015	1019	PF12436	0.579
DOC_USP7_UBL2_3	827	831	PF12436	0.397
DOC_WW_Pin1_4	18	23	PF00397	0.459
DOC_WW_Pin1_4	36	41	PF00397	0.460
DOC_WW_Pin1_4	530	535	PF00397	0.515
DOC_WW_Pin1_4	560	565	PF00397	0.516
LIG_14-3-3_CanoR_1	1031	1039	PF00244	0.637
LIG_14-3-3_CanoR_1	14	18	PF00244	0.570
LIG_14-3-3_CanoR_1	41	51	PF00244	0.541
LIG_14-3-3_CanoR_1	686	691	PF00244	0.433
LIG_14-3-3_CanoR_1	839	848	PF00244	0.496
LIG_14-3-3_CanoR_1	851	856	PF00244	0.312
LIG_14-3-3_CanoR_1	87	92	PF00244	0.424
LIG_14-3-3_CanoR_1	97	101	PF00244	0.427
LIG_Actin_WH2_1	370	387	PF00022	0.269
LIG_Actin_WH2_2	837	855	PF00022	0.276
LIG_APCC_ABBA_1	475	480	PF00400	0.484
LIG_APCC_ABBA_1	498	503	PF00400	0.491
LIG_BRCT_BRCA1_1	660	664	PF00533	0.495
LIG_BRCT_BRCA1_1	74	78	PF00533	0.466
LIG_CaM_IQ_9	1018	1033	PF13499	0.617
LIG_Clathr_ClatBox_1	768	772	PF01394	0.429
LIG_deltaCOP1_diTrp_1	460	468	PF00928	0.510
LIG_FHA_1	126	132	PF00498	0.529
LIG_FHA_1	154	160	PF00498	0.467
LIG_FHA_1	238	244	PF00498	0.502
LIG_FHA_1	315	321	PF00498	0.554
LIG_FHA_1	329	335	PF00498	0.540
LIG_FHA_1	361	367	PF00498	0.397
LIG_FHA_1	37	43	PF00498	0.599
LIG_FHA_1	406	412	PF00498	0.353
LIG_FHA_1	518	524	PF00498	0.388
LIG_FHA_1	6	12	PF00498	0.536
LIG_FHA_1	68	74	PF00498	0.469
LIG_FHA_1	697	703	PF00498	0.411
LIG_FHA_1	726	732	PF00498	0.411
LIG_FHA_2	21	27	PF00498	0.624
LIG_FHA_2	377	383	PF00498	0.462
LIG_FHA_2	526	532	PF00498	0.507
LIG_FHA_2	636	642	PF00498	0.477
LIG_FHA_2	668	674	PF00498	0.298
LIG_FHA_2	686	692	PF00498	0.464
LIG_FHA_2	757	763	PF00498	0.381
LIG_FHA_2	99	105	PF00498	0.506
LIG_HCF-1_HBM_1	285	288	PF13415	0.617
LIG_LIR_Gen_1	125	131	PF02991	0.421
LIG_LIR_Gen_1	234	243	PF02991	0.449
LIG_LIR_Gen_1	249	258	PF02991	0.437
LIG_LIR_Gen_1	421	430	PF02991	0.359
LIG_LIR_Gen_1	66	73	PF02991	0.363
LIG_LIR_Gen_1	673	682	PF02991	0.374
LIG_LIR_Gen_1	723	731	PF02991	0.494
LIG_LIR_Gen_1	919	929	PF02991	0.375
LIG_LIR_Nem_3	125	129	PF02991	0.406
LIG_LIR_Nem_3	234	239	PF02991	0.463
LIG_LIR_Nem_3	244	250	PF02991	0.512
LIG_LIR_Nem_3	285	291	PF02991	0.479
LIG_LIR_Nem_3	421	425	PF02991	0.417
LIG_LIR_Nem_3	539	544	PF02991	0.452
LIG_LIR_Nem_3	65	71	PF02991	0.341
LIG_LIR_Nem_3	673	678	PF02991	0.274
LIG_LIR_Nem_3	723	729	PF02991	0.517
LIG_LIR_Nem_3	75	81	PF02991	0.359
LIG_LIR_Nem_3	754	760	PF02991	0.358
LIG_LIR_Nem_3	919	925	PF02991	0.419
LIG_LYPXL_yS_3	288	291	PF13949	0.598
LIG_MAD2	41	49	PF02301	0.554
LIG_MAD2	424	432	PF02301	0.481
LIG_NRBOX	379	385	PF00104	0.316
LIG_NRBOX	590	596	PF00104	0.491
LIG_PCNA_yPIPBox_3	623	636	PF02747	0.357
LIG_PCNA_yPIPBox_3	827	841	PF02747	0.381
LIG_Pex14_1	804	808	PF04695	0.492
LIG_REV1ctd_RIR_1	826	835	PF16727	0.482
LIG_RPA_C_Fungi	199	211	PF08784	0.492
LIG_RPA_C_Fungi	82	94	PF08784	0.436
LIG_SH2_CRK	250	254	PF00017	0.471
LIG_SH2_CRK	30	34	PF00017	0.519
LIG_SH2_CRK	726	730	PF00017	0.389
LIG_SH2_CRK	752	756	PF00017	0.231
LIG_SH2_CRK	922	926	PF00017	0.263
LIG_SH2_NCK_1	922	926	PF00017	0.263
LIG_SH2_PTP2	236	239	PF00017	0.523
LIG_SH2_PTP2	60	63	PF00017	0.443
LIG_SH2_SRC	393	396	PF00017	0.441
LIG_SH2_SRC	929	932	PF00017	0.472
LIG_SH2_STAP1	69	73	PF00017	0.412
LIG_SH2_STAP1	698	702	PF00017	0.425
LIG_SH2_STAP1	707	711	PF00017	0.305
LIG_SH2_STAP1	726	730	PF00017	0.351
LIG_SH2_STAP1	81	85	PF00017	0.383
LIG_SH2_STAT3	414	417	PF00017	0.467
LIG_SH2_STAT3	946	949	PF00017	0.431
LIG_SH2_STAT5	15	18	PF00017	0.567
LIG_SH2_STAT5	236	239	PF00017	0.432
LIG_SH2_STAT5	250	253	PF00017	0.538
LIG_SH2_STAT5	360	363	PF00017	0.455
LIG_SH2_STAT5	398	401	PF00017	0.354
LIG_SH2_STAT5	505	508	PF00017	0.399
LIG_SH2_STAT5	510	513	PF00017	0.372
LIG_SH2_STAT5	544	547	PF00017	0.308
LIG_SH2_STAT5	60	63	PF00017	0.390
LIG_SH2_STAT5	69	72	PF00017	0.299
LIG_SH2_STAT5	698	701	PF00017	0.476
LIG_SH2_STAT5	885	888	PF00017	0.356
LIG_SH2_STAT5	922	925	PF00017	0.265
LIG_SH3_3	399	405	PF00018	0.433
LIG_Sin3_3	773	780	PF02671	0.472
LIG_SUMO_SIM_par_1	127	133	PF11976	0.549
LIG_SUMO_SIM_par_1	524	531	PF11976	0.369
LIG_SUMO_SIM_par_1	727	735	PF11976	0.326
LIG_SUMO_SIM_par_1	789	794	PF11976	0.392
LIG_TRAF2_1	477	480	PF00917	0.421
LIG_TRAF2_1	942	945	PF00917	0.395
LIG_TRAF2_1	981	984	PF00917	0.446
LIG_TYR_ITIM	750	755	PF00017	0.345
LIG_UBA3_1	1006	1015	PF00899	0.656
LIG_UBA3_1	265	274	PF00899	0.531
LIG_UBA3_1	840	846	PF00899	0.407
LIG_UBA3_1	886	892	PF00899	0.394
MOD_CDK_SPK_2	36	41	PF00069	0.471
MOD_CDK_SPxK_1	18	24	PF00069	0.437
MOD_CDK_SPxxK_3	18	25	PF00069	0.431
MOD_CDK_SPxxK_3	560	567	PF00069	0.487
MOD_CK1_1	127	133	PF00069	0.515
MOD_CK1_1	13	19	PF00069	0.471
MOD_CK1_1	184	190	PF00069	0.657
MOD_CK1_1	195	201	PF00069	0.602
MOD_CK1_1	314	320	PF00069	0.500
MOD_CK1_1	337	343	PF00069	0.513
MOD_CK1_1	349	355	PF00069	0.396
MOD_CK1_1	448	454	PF00069	0.603
MOD_CK1_1	696	702	PF00069	0.502
MOD_CK1_1	854	860	PF00069	0.286
MOD_CK1_1	920	926	PF00069	0.478
MOD_CK2_1	111	117	PF00069	0.752
MOD_CK2_1	185	191	PF00069	0.652
MOD_CK2_1	297	303	PF00069	0.509
MOD_CK2_1	376	382	PF00069	0.451
MOD_CK2_1	530	536	PF00069	0.457
MOD_CK2_1	565	571	PF00069	0.349
MOD_CK2_1	667	673	PF00069	0.305
MOD_CK2_1	685	691	PF00069	0.464
MOD_CK2_1	756	762	PF00069	0.337
MOD_CK2_1	791	797	PF00069	0.298
MOD_CK2_1	878	884	PF00069	0.461
MOD_GlcNHglycan	1032	1035	PF01048	0.549
MOD_GlcNHglycan	134	137	PF01048	0.460
MOD_GlcNHglycan	151	154	PF01048	0.349
MOD_GlcNHglycan	18	21	PF01048	0.589
MOD_GlcNHglycan	183	186	PF01048	0.665
MOD_GlcNHglycan	194	197	PF01048	0.694
MOD_GlcNHglycan	200	203	PF01048	0.721
MOD_GlcNHglycan	205	208	PF01048	0.721
MOD_GlcNHglycan	311	316	PF01048	0.480
MOD_GlcNHglycan	579	582	PF01048	0.496
MOD_GlcNHglycan	707	710	PF01048	0.319
MOD_GlcNHglycan	841	844	PF01048	0.511
MOD_GlcNHglycan	926	929	PF01048	0.325
MOD_GlcNHglycan	968	971	PF01048	0.505
MOD_GSK3_1	1	8	PF00069	0.472
MOD_GSK3_1	111	118	PF00069	0.706
MOD_GSK3_1	149	156	PF00069	0.494
MOD_GSK3_1	16	23	PF00069	0.421
MOD_GSK3_1	181	188	PF00069	0.667
MOD_GSK3_1	192	199	PF00069	0.695
MOD_GSK3_1	311	318	PF00069	0.410
MOD_GSK3_1	577	584	PF00069	0.294
MOD_GSK3_1	63	70	PF00069	0.490
MOD_GSK3_1	693	700	PF00069	0.395
MOD_GSK3_1	701	708	PF00069	0.303
MOD_GSK3_1	720	727	PF00069	0.369
MOD_GSK3_1	756	763	PF00069	0.431
MOD_GSK3_1	892	899	PF00069	0.359
MOD_GSK3_1	901	908	PF00069	0.343
MOD_GSK3_1	916	923	PF00069	0.341
MOD_GSK3_1	92	99	PF00069	0.444
MOD_N-GLC_1	598	603	PF02516	0.331
MOD_NEK2_1	1	6	PF00069	0.584
MOD_NEK2_1	149	154	PF00069	0.499
MOD_NEK2_1	169	174	PF00069	0.450
MOD_NEK2_1	319	324	PF00069	0.447
MOD_NEK2_1	334	339	PF00069	0.413
MOD_NEK2_1	62	67	PF00069	0.436
MOD_NEK2_1	643	648	PF00069	0.416
MOD_NEK2_1	72	77	PF00069	0.482
MOD_NEK2_1	756	761	PF00069	0.319
MOD_NEK2_1	829	834	PF00069	0.362
MOD_NEK2_1	89	94	PF00069	0.337
MOD_NEK2_1	897	902	PF00069	0.372
MOD_NEK2_1	916	921	PF00069	0.290
MOD_NEK2_2	376	381	PF00069	0.348
MOD_PIKK_1	365	371	PF00454	0.511
MOD_PIKK_1	405	411	PF00454	0.374
MOD_PIKK_1	720	726	PF00454	0.422
MOD_PIKK_1	810	816	PF00454	0.524
MOD_PIKK_1	999	1005	PF00454	0.547
MOD_PK_1	851	857	PF00069	0.390
MOD_PK_1	87	93	PF00069	0.458
MOD_PK_1	892	898	PF00069	0.407
MOD_PKA_1	328	334	PF00069	0.541
MOD_PKA_2	1030	1036	PF00069	0.762
MOD_PKA_2	13	19	PF00069	0.490
MOD_PKA_2	203	209	PF00069	0.489
MOD_PKA_2	337	343	PF00069	0.518
MOD_PKA_2	685	691	PF00069	0.464
MOD_PKA_2	96	102	PF00069	0.533
MOD_Plk_1	124	130	PF00069	0.456
MOD_Plk_1	248	254	PF00069	0.468
MOD_Plk_4	238	244	PF00069	0.503
MOD_Plk_4	315	321	PF00069	0.407
MOD_Plk_4	418	424	PF00069	0.340
MOD_Plk_4	544	550	PF00069	0.454
MOD_Plk_4	610	616	PF00069	0.410
MOD_Plk_4	643	649	PF00069	0.389
MOD_Plk_4	67	73	PF00069	0.438
MOD_Plk_4	725	731	PF00069	0.413
MOD_Plk_4	751	757	PF00069	0.248
MOD_Plk_4	784	790	PF00069	0.341
MOD_Plk_4	856	862	PF00069	0.511
MOD_Plk_4	885	891	PF00069	0.429
MOD_Plk_4	892	898	PF00069	0.321
MOD_Plk_4	917	923	PF00069	0.325
MOD_ProDKin_1	18	24	PF00069	0.456
MOD_ProDKin_1	36	42	PF00069	0.453
MOD_ProDKin_1	530	536	PF00069	0.512
MOD_ProDKin_1	560	566	PF00069	0.509
MOD_SUMO_rev_2	127	136	PF00179	0.562
TRG_DiLeu_BaEn_1	261	266	PF01217	0.479
TRG_DiLeu_BaEn_1	47	52	PF01217	0.298
TRG_DiLeu_BaEn_4	261	267	PF01217	0.505
TRG_DiLeu_BaLyEn_6	46	51	PF01217	0.302
TRG_DiLeu_BaLyEn_6	836	841	PF01217	0.411
TRG_ENDOCYTIC_2	236	239	PF00928	0.429
TRG_ENDOCYTIC_2	250	253	PF00928	0.468
TRG_ENDOCYTIC_2	288	291	PF00928	0.454
TRG_ENDOCYTIC_2	30	33	PF00928	0.512
TRG_ENDOCYTIC_2	60	63	PF00928	0.404
TRG_ENDOCYTIC_2	69	72	PF00928	0.328
TRG_ENDOCYTIC_2	726	729	PF00928	0.365
TRG_ENDOCYTIC_2	752	755	PF00928	0.334
TRG_ENDOCYTIC_2	922	925	PF00928	0.265
TRG_ER_diArg_1	27	29	PF00400	0.599
TRG_ER_diArg_1	566	569	PF00400	0.473
TRG_ER_diArg_1	58	60	PF00400	0.454
TRG_ER_diArg_1	867	869	PF00400	0.372
TRG_ER_diArg_1	959	961	PF00400	0.415
TRG_NLS_MonoCore_2	219	224	PF00514	0.696
TRG_NLS_MonoExtC_3	220	226	PF00514	0.699
TRG_NLS_MonoExtN_4	220	225	PF00514	0.697
TRG_Pf-PMV_PEXEL_1	173	177	PF00026	0.804
TRG_Pf-PMV_PEXEL_1	424	428	PF00026	0.372
TRG_Pf-PMV_PEXEL_1	959	963	PF00026	0.530

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3J5	Leptomonas seymouri	74%	100%
A0A0S4JSF8	Bodo saltans	31%	92%
A0A1X0NVP2	Trypanosomatidae	41%	100%
A0A3S7WRE4	Leishmania donovani	88%	100%
A0A422NYQ9	Trypanosoma rangeli	44%	100%
A4HUS8	Leishmania infantum	88%	100%
D0A7N6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
E9ANG2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4QH64	Leishmania major	87%	100%
V5BW65	Trypanosoma cruzi	44%	100%