3-PAP domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

myotubularin-associated protein, putative

Species:

Leishmania braziliensis

UniProt:

A4H9U1_LEIBR

TriTrypDb:

LbrM.19.0150 , LBRM2903_190006200

Length:

703

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H9U1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H9U1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	232	236	PF00656	0.691
CLV_C14_Caspase3-7	249	253	PF00656	0.667
CLV_C14_Caspase3-7	526	530	PF00656	0.816
CLV_C14_Caspase3-7	553	557	PF00656	0.758
CLV_C14_Caspase3-7	605	609	PF00656	0.673
CLV_C14_Caspase3-7	64	68	PF00656	0.538
CLV_NRD_NRD_1	164	166	PF00675	0.416
CLV_NRD_NRD_1	318	320	PF00675	0.739
CLV_NRD_NRD_1	450	452	PF00675	0.581
CLV_NRD_NRD_1	519	521	PF00675	0.628
CLV_NRD_NRD_1	534	536	PF00675	0.645
CLV_PCSK_KEX2_1	117	119	PF00082	0.435
CLV_PCSK_KEX2_1	166	168	PF00082	0.523
CLV_PCSK_KEX2_1	318	320	PF00082	0.739
CLV_PCSK_KEX2_1	519	521	PF00082	0.599
CLV_PCSK_KEX2_1	533	535	PF00082	0.539
CLV_PCSK_PC1ET2_1	117	119	PF00082	0.352
CLV_PCSK_PC1ET2_1	166	168	PF00082	0.523
CLV_PCSK_PC1ET2_1	533	535	PF00082	0.594
CLV_PCSK_SKI1_1	13	17	PF00082	0.339
CLV_PCSK_SKI1_1	133	137	PF00082	0.657
CLV_PCSK_SKI1_1	361	365	PF00082	0.544
CLV_PCSK_SKI1_1	525	529	PF00082	0.776
CLV_PCSK_SKI1_1	93	97	PF00082	0.306
DEG_APCC_DBOX_1	143	151	PF00400	0.610
DEG_APCC_DBOX_1	682	690	PF00400	0.713
DEG_COP1_1	426	434	PF00400	0.587
DEG_SCF_FBW7_1	208	214	PF00400	0.575
DEG_SCF_FBW7_1	545	552	PF00400	0.831
DEG_SPOP_SBC_1	438	442	PF00917	0.592
DEG_SPOP_SBC_1	469	473	PF00917	0.603
DOC_CKS1_1	208	213	PF01111	0.576
DOC_CKS1_1	546	551	PF01111	0.829
DOC_CYCLIN_RxL_1	90	100	PF00134	0.483
DOC_CYCLIN_yClb5_NLxxxL_5	138	147	PF00134	0.605
DOC_MAPK_gen_1	131	138	PF00069	0.658
DOC_MAPK_gen_1	92	98	PF00069	0.483
DOC_MAPK_MEF2A_6	224	231	PF00069	0.559
DOC_MAPK_MEF2A_6	319	328	PF00069	0.597
DOC_MAPK_MEF2A_6	36	44	PF00069	0.636
DOC_PP2B_LxvP_1	184	187	PF13499	0.704
DOC_PP2B_LxvP_1	194	197	PF13499	0.679
DOC_PP2B_LxvP_1	277	280	PF13499	0.636
DOC_PP2B_PxIxI_1	226	232	PF00149	0.558
DOC_PP4_FxxP_1	18	21	PF00568	0.636
DOC_USP7_MATH_1	187	191	PF00917	0.770
DOC_USP7_MATH_1	300	304	PF00917	0.701
DOC_USP7_MATH_1	324	328	PF00917	0.662
DOC_USP7_MATH_1	396	400	PF00917	0.682
DOC_USP7_MATH_1	423	427	PF00917	0.590
DOC_USP7_MATH_1	446	450	PF00917	0.709
DOC_USP7_MATH_1	459	463	PF00917	0.690
DOC_USP7_MATH_1	469	473	PF00917	0.629
DOC_USP7_MATH_1	488	492	PF00917	0.783
DOC_USP7_MATH_1	503	507	PF00917	0.572
DOC_USP7_MATH_1	588	592	PF00917	0.829
DOC_USP7_MATH_1	616	620	PF00917	0.790
DOC_USP7_MATH_1	622	626	PF00917	0.689
DOC_WW_Pin1_4	207	212	PF00397	0.582
DOC_WW_Pin1_4	304	309	PF00397	0.827
DOC_WW_Pin1_4	330	335	PF00397	0.730
DOC_WW_Pin1_4	411	416	PF00397	0.822
DOC_WW_Pin1_4	430	435	PF00397	0.526
DOC_WW_Pin1_4	439	444	PF00397	0.787
DOC_WW_Pin1_4	455	460	PF00397	0.549
DOC_WW_Pin1_4	483	488	PF00397	0.754
DOC_WW_Pin1_4	490	495	PF00397	0.826
DOC_WW_Pin1_4	499	504	PF00397	0.656
DOC_WW_Pin1_4	539	544	PF00397	0.781
DOC_WW_Pin1_4	545	550	PF00397	0.688
DOC_WW_Pin1_4	593	598	PF00397	0.579
DOC_WW_Pin1_4	632	637	PF00397	0.805
DOC_WW_Pin1_4	649	654	PF00397	0.525
LIG_14-3-3_CanoR_1	118	123	PF00244	0.500
LIG_14-3-3_CanoR_1	13	19	PF00244	0.636
LIG_14-3-3_CanoR_1	144	148	PF00244	0.590
LIG_14-3-3_CanoR_1	165	172	PF00244	0.409
LIG_14-3-3_CanoR_1	189	197	PF00244	0.575
LIG_14-3-3_CanoR_1	262	267	PF00244	0.818
LIG_14-3-3_CanoR_1	28	33	PF00244	0.458
LIG_14-3-3_CanoR_1	318	326	PF00244	0.748
LIG_14-3-3_CanoR_1	361	370	PF00244	0.552
LIG_14-3-3_CanoR_1	451	459	PF00244	0.831
LIG_14-3-3_CanoR_1	519	528	PF00244	0.601
LIG_14-3-3_CanoR_1	534	541	PF00244	0.518
LIG_14-3-3_CanoR_1	623	628	PF00244	0.595
LIG_14-3-3_CanoR_1	655	663	PF00244	0.823
LIG_Actin_WH2_2	131	146	PF00022	0.650
LIG_Actin_WH2_2	23	38	PF00022	0.455
LIG_Actin_WH2_2	45	62	PF00022	0.455
LIG_BIR_II_1	1	5	PF00653	0.542
LIG_BIR_III_2	305	309	PF00653	0.579
LIG_Clathr_ClatBox_1	147	151	PF01394	0.515
LIG_Clathr_ClatBox_1	586	590	PF01394	0.832
LIG_EVH1_1	484	488	PF00568	0.588
LIG_FHA_1	138	144	PF00498	0.646
LIG_FHA_1	189	195	PF00498	0.544
LIG_FHA_1	239	245	PF00498	0.736
LIG_FHA_1	365	371	PF00498	0.469
LIG_FHA_1	426	432	PF00498	0.586
LIG_FHA_1	439	445	PF00498	0.534
LIG_FHA_1	636	642	PF00498	0.613
LIG_FHA_2	127	133	PF00498	0.472
LIG_FHA_2	331	337	PF00498	0.559
LIG_FHA_2	363	369	PF00498	0.438
LIG_GBD_Chelix_1	171	179	PF00786	0.619
LIG_LIR_Apic_2	16	21	PF02991	0.636
LIG_LIR_Gen_1	116	127	PF02991	0.636
LIG_LIR_Nem_3	116	122	PF02991	0.636
LIG_LIR_Nem_3	223	229	PF02991	0.558
LIG_LIR_Nem_3	283	287	PF02991	0.703
LIG_LYPXL_yS_3	226	229	PF13949	0.553
LIG_NRBOX	685	691	PF00104	0.709
LIG_NRP_CendR_1	700	703	PF00754	0.764
LIG_PCNA_APIM_2	287	293	PF02747	0.436
LIG_SH2_STAP1	359	363	PF00017	0.689
LIG_SH2_STAT5	14	17	PF00017	0.636
LIG_SH2_STAT5	266	269	PF00017	0.617
LIG_SH2_STAT5	290	293	PF00017	0.693
LIG_SH3_1	273	279	PF00018	0.539
LIG_SH3_1	482	488	PF00018	0.592
LIG_SH3_2	629	634	PF14604	0.859
LIG_SH3_3	205	211	PF00018	0.635
LIG_SH3_3	27	33	PF00018	0.636
LIG_SH3_3	273	279	PF00018	0.678
LIG_SH3_3	323	329	PF00018	0.790
LIG_SH3_3	428	434	PF00018	0.726
LIG_SH3_3	482	488	PF00018	0.731
LIG_SH3_3	626	632	PF00018	0.829
LIG_SH3_3	638	644	PF00018	0.615
LIG_SUMO_SIM_anti_2	41	46	PF11976	0.531
LIG_SUMO_SIM_anti_2	583	588	PF11976	0.832
LIG_SUMO_SIM_par_1	134	140	PF11976	0.650
LIG_SUMO_SIM_par_1	94	101	PF11976	0.455
LIG_WRC_WIRS_1	15	20	PF05994	0.455
LIG_WRC_WIRS_1	341	346	PF05994	0.723
LIG_WRC_WIRS_1	508	513	PF05994	0.835
LIG_WW_1	628	631	PF00397	0.833
MOD_CDC14_SPxK_1	486	489	PF00782	0.587
MOD_CDC14_SPxK_1	652	655	PF00782	0.551
MOD_CDK_SPK_2	330	335	PF00069	0.614
MOD_CDK_SPxK_1	483	489	PF00069	0.592
MOD_CDK_SPxK_1	649	655	PF00069	0.556
MOD_CDK_SPxxK_3	413	420	PF00069	0.800
MOD_CK1_1	100	106	PF00069	0.446
MOD_CK1_1	137	143	PF00069	0.607
MOD_CK1_1	243	249	PF00069	0.790
MOD_CK1_1	253	259	PF00069	0.608
MOD_CK1_1	265	271	PF00069	0.626
MOD_CK1_1	343	349	PF00069	0.491
MOD_CK1_1	411	417	PF00069	0.594
MOD_CK1_1	426	432	PF00069	0.742
MOD_CK1_1	458	464	PF00069	0.594
MOD_CK1_1	50	56	PF00069	0.597
MOD_CK1_1	592	598	PF00069	0.820
MOD_CK1_1	600	606	PF00069	0.706
MOD_CK1_1	645	651	PF00069	0.600
MOD_CK1_1	659	665	PF00069	0.731
MOD_CK1_1	668	674	PF00069	0.698
MOD_CK1_1	84	90	PF00069	0.636
MOD_CK2_1	126	132	PF00069	0.472
MOD_CK2_1	28	34	PF00069	0.525
MOD_CK2_1	362	368	PF00069	0.436
MOD_GlcNHglycan	107	110	PF01048	0.435
MOD_GlcNHglycan	167	170	PF01048	0.405
MOD_GlcNHglycan	255	258	PF01048	0.817
MOD_GlcNHglycan	298	301	PF01048	0.675
MOD_GlcNHglycan	425	428	PF01048	0.654
MOD_GlcNHglycan	452	455	PF01048	0.834
MOD_GlcNHglycan	464	467	PF01048	0.658
MOD_GlcNHglycan	49	52	PF01048	0.435
MOD_GlcNHglycan	490	493	PF01048	0.862
MOD_GlcNHglycan	564	567	PF01048	0.716
MOD_GlcNHglycan	618	621	PF01048	0.704
MOD_GlcNHglycan	625	628	PF01048	0.722
MOD_GlcNHglycan	644	647	PF01048	0.567
MOD_GSK3_1	207	214	PF00069	0.746
MOD_GSK3_1	238	245	PF00069	0.593
MOD_GSK3_1	246	253	PF00069	0.706
MOD_GSK3_1	258	265	PF00069	0.496
MOD_GSK3_1	296	303	PF00069	0.764
MOD_GSK3_1	330	337	PF00069	0.816
MOD_GSK3_1	357	364	PF00069	0.545
MOD_GSK3_1	419	426	PF00069	0.692
MOD_GSK3_1	446	453	PF00069	0.753
MOD_GSK3_1	455	462	PF00069	0.715
MOD_GSK3_1	495	502	PF00069	0.629
MOD_GSK3_1	503	510	PF00069	0.691
MOD_GSK3_1	529	536	PF00069	0.830
MOD_GSK3_1	541	548	PF00069	0.613
MOD_GSK3_1	558	565	PF00069	0.631
MOD_GSK3_1	588	595	PF00069	0.821
MOD_GSK3_1	597	604	PF00069	0.704
MOD_GSK3_1	645	652	PF00069	0.763
MOD_GSK3_1	655	662	PF00069	0.707
MOD_GSK3_1	665	672	PF00069	0.538
MOD_GSK3_1	97	104	PF00069	0.455
MOD_LATS_1	26	32	PF00433	0.636
MOD_N-GLC_1	478	483	PF02516	0.862
MOD_N-GLC_1	529	534	PF02516	0.595
MOD_NEK2_1	1	6	PF00069	0.729
MOD_NEK2_1	143	148	PF00069	0.635
MOD_NEK2_1	150	155	PF00069	0.525
MOD_NEK2_1	188	193	PF00069	0.588
MOD_NEK2_1	379	384	PF00069	0.453
MOD_NEK2_1	445	450	PF00069	0.825
MOD_NEK2_1	511	516	PF00069	0.786
MOD_NEK2_1	589	594	PF00069	0.837
MOD_NEK2_1	679	684	PF00069	0.475
MOD_NEK2_1	81	86	PF00069	0.636
MOD_NEK2_2	446	451	PF00069	0.709
MOD_NEK2_2	55	60	PF00069	0.636
MOD_PIKK_1	372	378	PF00454	0.700
MOD_PIKK_1	673	679	PF00454	0.770
MOD_PIKK_1	84	90	PF00454	0.636
MOD_PK_1	218	224	PF00069	0.570
MOD_PK_1	28	34	PF00069	0.636
MOD_PKA_1	165	171	PF00069	0.412
MOD_PKA_1	218	224	PF00069	0.572
MOD_PKA_1	318	324	PF00069	0.629
MOD_PKA_1	519	525	PF00069	0.602
MOD_PKA_1	533	539	PF00069	0.525
MOD_PKA_2	143	149	PF00069	0.648
MOD_PKA_2	188	194	PF00069	0.681
MOD_PKA_2	296	302	PF00069	0.764
MOD_PKA_2	317	323	PF00069	0.763
MOD_PKA_2	334	340	PF00069	0.676
MOD_PKA_2	419	425	PF00069	0.598
MOD_PKA_2	450	456	PF00069	0.831
MOD_PKA_2	518	524	PF00069	0.597
MOD_PKA_2	533	539	PF00069	0.521
MOD_PKA_2	622	628	PF00069	0.595
MOD_PKA_2	672	678	PF00069	0.689
MOD_PKA_2	679	685	PF00069	0.698
MOD_Plk_1	150	156	PF00069	0.655
MOD_Plk_1	246	252	PF00069	0.821
MOD_Plk_1	40	46	PF00069	0.455
MOD_Plk_1	589	595	PF00069	0.615
MOD_Plk_4	1	7	PF00069	0.730
MOD_Plk_4	143	149	PF00069	0.495
MOD_Plk_4	262	268	PF00069	0.606
MOD_Plk_4	340	346	PF00069	0.731
MOD_Plk_4	40	46	PF00069	0.544
MOD_Plk_4	507	513	PF00069	0.784
MOD_Plk_4	541	547	PF00069	0.574
MOD_Plk_4	567	573	PF00069	0.597
MOD_ProDKin_1	207	213	PF00069	0.579
MOD_ProDKin_1	304	310	PF00069	0.830
MOD_ProDKin_1	330	336	PF00069	0.724
MOD_ProDKin_1	411	417	PF00069	0.822
MOD_ProDKin_1	430	436	PF00069	0.526
MOD_ProDKin_1	439	445	PF00069	0.785
MOD_ProDKin_1	455	461	PF00069	0.551
MOD_ProDKin_1	483	489	PF00069	0.756
MOD_ProDKin_1	490	496	PF00069	0.820
MOD_ProDKin_1	499	505	PF00069	0.654
MOD_ProDKin_1	539	545	PF00069	0.783
MOD_ProDKin_1	593	599	PF00069	0.583
MOD_ProDKin_1	632	638	PF00069	0.805
MOD_ProDKin_1	649	655	PF00069	0.527
MOD_SUMO_for_1	173	176	PF00179	0.654
MOD_SUMO_rev_2	158	168	PF00179	0.411
TRG_ENDOCYTIC_2	119	122	PF00928	0.636
TRG_ENDOCYTIC_2	226	229	PF00928	0.553
TRG_NLS_Bipartite_1	519	537	PF00514	0.596
TRG_NLS_MonoExtC_3	91	97	PF00514	0.483
TRG_Pf-PMV_PEXEL_1	198	202	PF00026	0.561
TRG_Pf-PMV_PEXEL_1	203	207	PF00026	0.556
TRG_Pf-PMV_PEXEL_1	7	11	PF00026	0.277
TRG_Pf-PMV_PEXEL_1	93	97	PF00026	0.283

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WRG7	Leishmania donovani	65%	98%
A4HUS9	Leishmania infantum	65%	98%
E9ANG3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	62%	98%
Q4QH63	Leishmania major	66%	100%