PUA domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H9U0_LEIBR

TriTrypDb:

LbrM.19.0140 , LBRM2903_190006100

Length:

196

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	12
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

A4H9U0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H9U0

Function

Biological processes
Term	Name	Level	Count
GO:0001731	formation of translation preinitiation complex	7	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0022618	ribonucleoprotein complex assembly	6	1
GO:0043933	protein-containing complex organization	4	1
GO:0065003	protein-containing complex assembly	5	1
GO:0071826	ribonucleoprotein complex subunit organization	5	1
GO:0071840	cellular component organization or biogenesis	2	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003723	RNA binding	4	12
GO:0005488	binding	1	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	9	13	PF00082	0.244
DOC_MAPK_gen_1	51	57	PF00069	0.456
DOC_MAPK_MEF2A_6	148	156	PF00069	0.369
DOC_USP7_MATH_1	20	24	PF00917	0.505
DOC_USP7_MATH_1	50	54	PF00917	0.469
DOC_USP7_UBL2_3	91	95	PF12436	0.456
LIG_APCC_ABBA_1	141	146	PF00400	0.444
LIG_BIR_II_1	1	5	PF00653	0.418
LIG_BRCT_BRCA1_1	52	56	PF00533	0.549
LIG_FHA_2	1	7	PF00498	0.492
LIG_LIR_Apic_2	181	187	PF02991	0.479
LIG_LIR_Gen_1	43	50	PF02991	0.448
LIG_LIR_Nem_3	36	41	PF02991	0.445
LIG_LIR_Nem_3	43	48	PF02991	0.440
LIG_LIR_Nem_3	6	11	PF02991	0.419
LIG_LYPXL_yS_3	38	41	PF13949	0.456
LIG_LYPXL_yS_3	96	99	PF13949	0.487
LIG_PDZ_Class_2	191	196	PF00595	0.605
LIG_SH2_SRC	144	147	PF00017	0.485
LIG_SH2_STAT5	144	147	PF00017	0.475
LIG_SH3_3	82	88	PF00018	0.456
LIG_TRAF2_1	160	163	PF00917	0.423
MOD_CK2_1	157	163	PF00069	0.464
MOD_CK2_1	20	26	PF00069	0.464
MOD_CK2_1	69	75	PF00069	0.475
MOD_GlcNHglycan	114	117	PF01048	0.244
MOD_GlcNHglycan	125	128	PF01048	0.244
MOD_GlcNHglycan	189	192	PF01048	0.449
MOD_GlcNHglycan	3	6	PF01048	0.435
MOD_GSK3_1	65	72	PF00069	0.505
MOD_NEK2_1	189	194	PF00069	0.424
MOD_NEK2_1	69	74	PF00069	0.482
MOD_PIKK_1	69	75	PF00454	0.505
MOD_PKA_1	9	15	PF00069	0.444
MOD_SUMO_rev_2	21	30	PF00179	0.506
TRG_ENDOCYTIC_2	38	41	PF00928	0.446
TRG_ENDOCYTIC_2	96	99	PF00928	0.487

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4P0	Leptomonas seymouri	81%	100%
A0A0S4JUH4	Bodo saltans	70%	94%
A0A1X0NV76	Trypanosomatidae	69%	100%
A0A3B3IRV3	Homo sapiens	43%	100%
A0A3S5H6H9	Leishmania donovani	92%	100%
A0A3S5ISC7	Trypanosoma rangeli	71%	100%
A4HUT0	Leishmania infantum	92%	100%
D0A7N4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	67%	97%
E9ANG4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
P87313	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	37%	100%
P89886	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	41%	100%
Q2KIE4	Bos taurus	43%	100%
Q4G009	Rattus norvegicus	43%	100%
Q4QH62	Leishmania major	89%	100%
Q58827	Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)	32%	100%
Q5PPY1	Xenopus laevis	43%	100%
Q5ZI42	Gallus gallus	42%	100%
Q6DER1	Xenopus tropicalis	43%	100%
Q6NRJ7	Xenopus laevis	42%	100%
Q75AA8	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	39%	100%
Q7ZV34	Danio rerio	43%	100%
Q86KL4	Dictyostelium discoideum	43%	100%
Q9CQ21	Mus musculus	42%	100%
Q9DB27	Mus musculus	43%	100%
Q9ULC4	Homo sapiens	43%	100%
Q9W445	Drosophila melanogaster	43%	100%
V5BWL1	Trypanosoma cruzi	69%	100%