DEAD-boc ATP-dependent (RNA) helicase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DEAD-boc ATP-dependent (RNA) helicase

Species:

Leishmania braziliensis

UniProt:

A4H9T9_LEIBR

TriTrypDb:

LbrM.19.0130 , LBRM2903_190006000

Length:

652

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005681	spliceosomal complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0071013	catalytic step 2 spliceosome	3	1
GO:0140513	nuclear protein-containing complex	2	1
GO:1902494	catalytic complex	2	1
GO:1990904	ribonucleoprotein complex	2	1
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4H9T9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H9T9

Function

Biological processes
Term	Name	Level	Count
GO:0000375	RNA splicing, via transesterification reactions	8	1
GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	9	1
GO:0000398	mRNA splicing, via spliceosome	8	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006396	RNA processing	6	1
GO:0006397	mRNA processing	7	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0008380	RNA splicing	7	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0016071	mRNA metabolic process	6	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003676	nucleic acid binding	3	12
GO:0003824	catalytic activity	1	12
GO:0004386	helicase activity	2	12
GO:0005488	binding	1	12
GO:0005524	ATP binding	5	12
GO:0017076	purine nucleotide binding	4	12
GO:0030554	adenyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032559	adenyl ribonucleotide binding	5	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:0140640	catalytic activity, acting on a nucleic acid	2	12
GO:0140657	ATP-dependent activity	1	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12
GO:0003723	RNA binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	26	28	PF00675	0.762
CLV_NRD_NRD_1	298	300	PF00675	0.240
CLV_NRD_NRD_1	337	339	PF00675	0.281
CLV_NRD_NRD_1	444	446	PF00675	0.569
CLV_NRD_NRD_1	487	489	PF00675	0.638
CLV_PCSK_FUR_1	296	300	PF00082	0.156
CLV_PCSK_FUR_1	335	339	PF00082	0.281
CLV_PCSK_KEX2_1	166	168	PF00082	0.485
CLV_PCSK_KEX2_1	26	28	PF00082	0.739
CLV_PCSK_KEX2_1	298	300	PF00082	0.240
CLV_PCSK_KEX2_1	337	339	PF00082	0.274
CLV_PCSK_KEX2_1	39	41	PF00082	0.604
CLV_PCSK_KEX2_1	444	446	PF00082	0.550
CLV_PCSK_KEX2_1	486	488	PF00082	0.796
CLV_PCSK_PC1ET2_1	166	168	PF00082	0.514
CLV_PCSK_PC1ET2_1	39	41	PF00082	0.584
CLV_PCSK_PC7_1	22	28	PF00082	0.462
CLV_PCSK_SKI1_1	10	14	PF00082	0.409
CLV_PCSK_SKI1_1	40	44	PF00082	0.593
CLV_PCSK_SKI1_1	400	404	PF00082	0.477
CLV_PCSK_SKI1_1	417	421	PF00082	0.296
CLV_PCSK_SKI1_1	51	55	PF00082	0.445
CLV_PCSK_SKI1_1	634	638	PF00082	0.419
DEG_APCC_DBOX_1	9	17	PF00400	0.410
DEG_SPOP_SBC_1	489	493	PF00917	0.698
DOC_ANK_TNKS_1	443	450	PF00023	0.617
DOC_ANK_TNKS_1	582	589	PF00023	0.555
DOC_CKS1_1	276	281	PF01111	0.425
DOC_CYCLIN_RxL_1	397	405	PF00134	0.355
DOC_CYCLIN_yClb5_NLxxxL_5	324	333	PF00134	0.457
DOC_CYCLIN_yCln2_LP_2	157	163	PF00134	0.468
DOC_MAPK_DCC_7	51	61	PF00069	0.392
DOC_MAPK_gen_1	296	306	PF00069	0.414
DOC_MAPK_gen_1	411	420	PF00069	0.316
DOC_MAPK_gen_1	51	61	PF00069	0.382
DOC_MAPK_MEF2A_6	153	161	PF00069	0.276
DOC_MAPK_MEF2A_6	200	208	PF00069	0.516
DOC_MAPK_MEF2A_6	400	408	PF00069	0.345
DOC_MAPK_MEF2A_6	54	61	PF00069	0.396
DOC_PP1_RVXF_1	415	422	PF00149	0.348
DOC_PP2B_LxvP_1	157	160	PF13499	0.472
DOC_PP2B_LxvP_1	593	596	PF13499	0.360
DOC_PP2B_LxvP_1	6	9	PF13499	0.389
DOC_PP2B_LxvP_1	609	612	PF13499	0.341
DOC_USP7_MATH_1	254	258	PF00917	0.457
DOC_USP7_MATH_1	567	571	PF00917	0.494
DOC_USP7_MATH_1	612	616	PF00917	0.480
DOC_USP7_MATH_1	632	636	PF00917	0.349
DOC_USP7_MATH_1	638	642	PF00917	0.613
DOC_WW_Pin1_4	148	153	PF00397	0.417
DOC_WW_Pin1_4	275	280	PF00397	0.425
DOC_WW_Pin1_4	286	291	PF00397	0.425
DOC_WW_Pin1_4	4	9	PF00397	0.396
LIG_14-3-3_CanoR_1	172	180	PF00244	0.267
LIG_14-3-3_CanoR_1	220	225	PF00244	0.414
LIG_14-3-3_CanoR_1	371	377	PF00244	0.413
LIG_14-3-3_CanoR_1	40	45	PF00244	0.570
LIG_14-3-3_CanoR_1	488	498	PF00244	0.686
LIG_14-3-3_CanoR_1	617	625	PF00244	0.512
LIG_14-3-3_CanoR_1	631	640	PF00244	0.636
LIG_APCC_ABBA_1	418	423	PF00400	0.415
LIG_APCC_ABBAyCdc20_2	417	423	PF00400	0.421
LIG_APCC_ABBAyCdc20_2	506	512	PF00400	0.486
LIG_BIR_II_1	1	5	PF00653	0.418
LIG_CaM_IQ_9	41	56	PF13499	0.368
LIG_deltaCOP1_diTrp_1	237	243	PF00928	0.414
LIG_FHA_1	156	162	PF00498	0.468
LIG_FHA_1	221	227	PF00498	0.417
LIG_FHA_1	245	251	PF00498	0.437
LIG_FHA_1	367	373	PF00498	0.425
LIG_FHA_1	558	564	PF00498	0.414
LIG_FHA_1	9	15	PF00498	0.404
LIG_FHA_2	362	368	PF00498	0.556
LIG_FHA_2	420	426	PF00498	0.378
LIG_FHA_2	433	439	PF00498	0.441
LIG_LIR_Gen_1	508	518	PF02991	0.664
LIG_LIR_LC3C_4	538	543	PF02991	0.516
LIG_LIR_Nem_3	384	390	PF02991	0.298
LIG_LIR_Nem_3	48	53	PF02991	0.403
LIG_LIR_Nem_3	508	513	PF02991	0.650
LIG_NBox_RRM_1	202	212	PF00076	0.414
LIG_PCNA_yPIPBox_3	211	225	PF02747	0.414
LIG_Pex14_1	239	243	PF04695	0.414
LIG_SH2_SRC	510	513	PF00017	0.707
LIG_SH2_SRC	55	58	PF00017	0.400
LIG_SH2_STAP1	236	240	PF00017	0.414
LIG_SH2_STAP1	83	87	PF00017	0.564
LIG_SH2_STAT3	146	149	PF00017	0.489
LIG_SH2_STAT3	319	322	PF00017	0.516
LIG_SH2_STAT3	74	77	PF00017	0.466
LIG_SH2_STAT5	388	391	PF00017	0.291
LIG_SH2_STAT5	526	529	PF00017	0.542
LIG_SH2_STAT5	55	58	PF00017	0.403
LIG_SH2_STAT5	74	77	PF00017	0.466
LIG_SH2_STAT5	93	96	PF00017	0.455
LIG_SH3_3	222	228	PF00018	0.516
LIG_SH3_3	273	279	PF00018	0.425
LIG_SH3_3	476	482	PF00018	0.801
LIG_SH3_3	496	502	PF00018	0.454
LIG_SH3_3	589	595	PF00018	0.360
LIG_SUMO_SIM_anti_2	223	231	PF11976	0.425
LIG_SUMO_SIM_anti_2	589	594	PF11976	0.420
LIG_SUMO_SIM_par_1	223	231	PF11976	0.425
LIG_TRAF2_1	228	231	PF00917	0.407
LIG_TRAF2_1	259	262	PF00917	0.356
LIG_TRAF2_1	494	497	PF00917	0.522
LIG_TRFH_1	4	8	PF08558	0.402
LIG_WW_3	7	11	PF00397	0.392
MOD_CDC14_SPxK_1	7	10	PF00782	0.390
MOD_CDK_SPK_2	148	153	PF00069	0.386
MOD_CDK_SPxK_1	275	281	PF00069	0.425
MOD_CDK_SPxK_1	4	10	PF00069	0.399
MOD_CK1_1	100	106	PF00069	0.610
MOD_CK1_1	131	137	PF00069	0.674
MOD_CK1_1	467	473	PF00069	0.642
MOD_CK1_1	531	537	PF00069	0.497
MOD_CK1_1	547	553	PF00069	0.367
MOD_CK2_1	372	378	PF00069	0.420
MOD_CK2_1	419	425	PF00069	0.381
MOD_CK2_1	432	438	PF00069	0.394
MOD_CK2_1	505	511	PF00069	0.558
MOD_CK2_1	604	610	PF00069	0.492
MOD_CK2_1	616	622	PF00069	0.358
MOD_GlcNHglycan	106	109	PF01048	0.685
MOD_GlcNHglycan	324	327	PF01048	0.232
MOD_GlcNHglycan	348	351	PF01048	0.214
MOD_GlcNHglycan	435	438	PF01048	0.511
MOD_GlcNHglycan	466	469	PF01048	0.601
MOD_GlcNHglycan	569	572	PF01048	0.304
MOD_GlcNHglycan	597	600	PF01048	0.406
MOD_GlcNHglycan	614	617	PF01048	0.356
MOD_GlcNHglycan	618	621	PF01048	0.419
MOD_GlcNHglycan	62	66	PF01048	0.519
MOD_GlcNHglycan	626	629	PF01048	0.462
MOD_GlcNHglycan	634	637	PF01048	0.428
MOD_GlcNHglycan	642	645	PF01048	0.664
MOD_GlcNHglycan	78	81	PF01048	0.566
MOD_GSK3_1	127	134	PF00069	0.667
MOD_GSK3_1	191	198	PF00069	0.531
MOD_GSK3_1	366	373	PF00069	0.465
MOD_GSK3_1	377	384	PF00069	0.335
MOD_GSK3_1	4	11	PF00069	0.399
MOD_GSK3_1	429	436	PF00069	0.457
MOD_GSK3_1	464	471	PF00069	0.529
MOD_GSK3_1	544	551	PF00069	0.434
MOD_GSK3_1	612	619	PF00069	0.570
MOD_GSK3_1	630	637	PF00069	0.445
MOD_GSK3_1	97	104	PF00069	0.543
MOD_N-GLC_1	100	105	PF02516	0.555
MOD_N-GLC_1	528	533	PF02516	0.312
MOD_N-GLC_1	548	553	PF02516	0.122
MOD_NEK2_1	127	132	PF00069	0.563
MOD_NEK2_1	372	377	PF00069	0.425
MOD_NEK2_1	390	395	PF00069	0.267
MOD_NEK2_1	402	407	PF00069	0.455
MOD_NEK2_1	548	553	PF00069	0.549
MOD_NEK2_1	640	645	PF00069	0.602
MOD_NEK2_1	70	75	PF00069	0.473
MOD_NEK2_2	505	510	PF00069	0.558
MOD_PIKK_1	109	115	PF00454	0.488
MOD_PIKK_1	128	134	PF00454	0.377
MOD_PIKK_1	245	251	PF00454	0.438
MOD_PIKK_1	87	93	PF00454	0.414
MOD_PKA_1	97	103	PF00069	0.414
MOD_PKA_2	171	177	PF00069	0.256
MOD_PKA_2	30	36	PF00069	0.734
MOD_PKA_2	322	328	PF00069	0.437
MOD_PKA_2	370	376	PF00069	0.400
MOD_PKA_2	505	511	PF00069	0.733
MOD_PKA_2	616	622	PF00069	0.501
MOD_PKA_2	630	636	PF00069	0.629
MOD_PKB_1	486	494	PF00069	0.516
MOD_Plk_1	366	372	PF00069	0.463
MOD_Plk_1	377	383	PF00069	0.341
MOD_Plk_1	528	534	PF00069	0.253
MOD_Plk_4	220	226	PF00069	0.414
MOD_Plk_4	288	294	PF00069	0.414
MOD_Plk_4	372	378	PF00069	0.453
MOD_Plk_4	429	435	PF00069	0.523
MOD_Plk_4	505	511	PF00069	0.558
MOD_Plk_4	70	76	PF00069	0.454
MOD_ProDKin_1	148	154	PF00069	0.417
MOD_ProDKin_1	275	281	PF00069	0.425
MOD_ProDKin_1	286	292	PF00069	0.425
MOD_ProDKin_1	4	10	PF00069	0.399
MOD_SUMO_for_1	494	497	PF00179	0.522
MOD_SUMO_rev_2	532	542	PF00179	0.516
TRG_DiLeu_BaEn_1	399	404	PF01217	0.393
TRG_DiLeu_BaEn_1	429	434	PF01217	0.459
TRG_DiLeu_BaEn_1	587	592	PF01217	0.417
TRG_DiLeu_BaLyEn_6	179	184	PF01217	0.506
TRG_DiLeu_BaLyEn_6	48	53	PF01217	0.539
TRG_ENDOCYTIC_2	510	513	PF00928	0.707
TRG_ENDOCYTIC_2	93	96	PF00928	0.514
TRG_ER_diArg_1	167	170	PF00400	0.479
TRG_ER_diArg_1	296	299	PF00400	0.415
TRG_ER_diArg_1	321	324	PF00400	0.457
TRG_ER_diArg_1	334	337	PF00400	0.398
TRG_ER_diArg_1	411	414	PF00400	0.363
TRG_ER_diArg_1	443	445	PF00400	0.558
TRG_ER_diArg_1	486	488	PF00400	0.657
TRG_NES_CRM1_1	215	231	PF08389	0.425
TRG_NES_CRM1_1	295	310	PF08389	0.414
TRG_Pf-PMV_PEXEL_1	211	215	PF00026	0.225

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJV4	Leptomonas seymouri	74%	100%
A0A0S4JYL8	Bodo saltans	48%	98%
A0A1X0NV90	Trypanosomatidae	59%	100%
A0A3Q8ICA8	Leishmania donovani	87%	100%
A0A3R7MZZ8	Trypanosoma rangeli	59%	100%
A0A3R7N587	Trypanosoma rangeli	23%	79%
A4HUT1	Leishmania infantum	87%	100%
A5DPU0	Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324)	23%	86%
A7EM78	Sclerotinia sclerotiorum (strain ATCC 18683 / 1980 / Ss-1)	23%	100%
D0A7N1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	56%	100%
E9ANG5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q09719	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	24%	77%
Q4P7M1	Ustilago maydis (strain 521 / FGSC 9021)	25%	95%
Q4QH61	Leishmania major	87%	100%
Q6C7X8	Yarrowia lipolytica (strain CLIB 122 / E 150)	26%	70%
Q8W4E1	Arabidopsis thaliana	23%	100%
V5BG99	Trypanosoma cruzi	24%	79%
V5C100	Trypanosoma cruzi	61%	100%