Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4H9T8_LEIBR

TriTrypDb:

LbrM.19.0120 , LBRM2903_190005800

Length:

229

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4H9T8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4H9T8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	135	137	PF00675	0.479
CLV_NRD_NRD_1	203	205	PF00675	0.404
CLV_NRD_NRD_1	209	211	PF00675	0.420
CLV_NRD_NRD_1	36	38	PF00675	0.499
CLV_PCSK_KEX2_1	135	137	PF00082	0.476
CLV_PCSK_KEX2_1	203	205	PF00082	0.404
CLV_PCSK_KEX2_1	209	211	PF00082	0.420
CLV_PCSK_KEX2_1	49	51	PF00082	0.596
CLV_PCSK_PC1ET2_1	49	51	PF00082	0.500
CLV_PCSK_SKI1_1	195	199	PF00082	0.478
CLV_PCSK_SKI1_1	37	41	PF00082	0.486
CLV_PCSK_SKI1_1	71	75	PF00082	0.375
CLV_Separin_Metazoa	122	126	PF03568	0.461
DEG_SCF_TRCP1_1	158	163	PF00400	0.486
DEG_SPOP_SBC_1	5	9	PF00917	0.450
DEG_SPOP_SBC_1	82	86	PF00917	0.539
DOC_CKS1_1	148	153	PF01111	0.499
DOC_CYCLIN_yCln2_LP_2	62	68	PF00134	0.465
DOC_MAPK_gen_1	187	196	PF00069	0.469
DOC_MAPK_HePTP_8	186	198	PF00069	0.472
DOC_MAPK_MEF2A_6	189	198	PF00069	0.476
DOC_MAPK_RevD_3	194	210	PF00069	0.325
DOC_PP2B_LxvP_1	23	26	PF13499	0.489
DOC_PP4_FxxP_1	13	16	PF00568	0.472
DOC_USP7_MATH_1	156	160	PF00917	0.537
DOC_USP7_MATH_1	6	10	PF00917	0.456
DOC_USP7_MATH_1	82	86	PF00917	0.568
DOC_WW_Pin1_4	107	112	PF00397	0.506
DOC_WW_Pin1_4	147	152	PF00397	0.602
DOC_WW_Pin1_4	55	60	PF00397	0.592
DOC_WW_Pin1_4	83	88	PF00397	0.674
LIG_APCC_ABBA_1	171	176	PF00400	0.317
LIG_BIR_II_1	1	5	PF00653	0.458
LIG_CaM_IQ_9	179	194	PF13499	0.398
LIG_FHA_1	118	124	PF00498	0.422
LIG_FHA_1	18	24	PF00498	0.489
LIG_FHA_1	28	34	PF00498	0.490
LIG_FHA_1	58	64	PF00498	0.681
LIG_FHA_1	72	78	PF00498	0.467
LIG_LIR_Nem_3	132	137	PF02991	0.607
LIG_PDZ_Class_2	224	229	PF00595	0.461
LIG_SH2_CRK	134	138	PF00017	0.624
LIG_SH2_STAT3	145	148	PF00017	0.579
LIG_SH2_STAT5	174	177	PF00017	0.321
LIG_SH3_3	61	67	PF00018	0.544
LIG_SH3_3	84	90	PF00018	0.524
LIG_SUMO_SIM_par_1	73	78	PF11976	0.453
LIG_TRAF2_1	129	132	PF00917	0.456
MOD_CDK_SPK_2	152	157	PF00069	0.511
MOD_CK1_1	149	155	PF00069	0.541
MOD_CK1_1	57	63	PF00069	0.597
MOD_CK2_1	96	102	PF00069	0.645
MOD_GlcNHglycan	151	154	PF01048	0.605
MOD_GlcNHglycan	158	161	PF01048	0.687
MOD_GSK3_1	113	120	PF00069	0.536
MOD_GSK3_1	152	159	PF00069	0.594
MOD_GSK3_1	54	61	PF00069	0.606
MOD_N-GLC_1	220	225	PF02516	0.332
MOD_NEK2_1	197	202	PF00069	0.336
MOD_NEK2_1	220	225	PF00069	0.479
MOD_NEK2_1	96	101	PF00069	0.630
MOD_PIKK_1	144	150	PF00454	0.609
MOD_PKA_2	156	162	PF00069	0.504
MOD_Plk_4	113	119	PF00069	0.428
MOD_Plk_4	167	173	PF00069	0.475
MOD_Plk_4	58	64	PF00069	0.502
MOD_Plk_4	6	12	PF00069	0.459
MOD_ProDKin_1	107	113	PF00069	0.507
MOD_ProDKin_1	147	153	PF00069	0.603
MOD_ProDKin_1	55	61	PF00069	0.588
MOD_ProDKin_1	83	89	PF00069	0.680
MOD_SUMO_for_1	214	217	PF00179	0.426
TRG_ENDOCYTIC_2	134	137	PF00928	0.626
TRG_ENDOCYTIC_2	174	177	PF00928	0.377
TRG_ER_diArg_1	134	136	PF00400	0.484
TRG_ER_diArg_1	202	204	PF00400	0.414
TRG_NLS_MonoExtN_4	35	41	PF00514	0.481

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4P1	Leptomonas seymouri	40%	100%
A0A3S7WRH9	Leishmania donovani	74%	100%
A4HUT2	Leishmania infantum	74%	100%
E9ANG6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	100%
Q4QH60	Leishmania major	75%	100%